Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2312 Rv2312 |
mtbc0_002460 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dz1-assembly1_A Crystal structure of Dihydrodipicolinate Synthase fro (prob 0.01, TM 0.27). | Still unknown | |
| Rv2313c Rv2313c |
mtbc0_002461 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. | Family assigned | |
| Rv2314c Rv2314c |
mtbc0_002462 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_3rd |
Family assigned |
| Rv2315c Rv2315c |
mtbc0_002463 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_1st (PF01523.22), PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_1st PmbA_TldD_3rd |
Family assigned |
| uspA Rv2316 |
mtbc0_002464 |
sugar ABC transporter permease UspA | Sugar ABC transporter permease. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| uspB Rv2317 |
- |
sugar ABC transporter permease UspB | Sugar ABC transporter permease UspB. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| uspC Rv2318 |
mtbc0_002466 |
sugar ABC transporter substrate-binding lipoprotein UspC | Sugar ABC transporter substrate-binding protein. Pfam: SBP_bac_1 (PF01547.31), SBP_bac_8 (PF13416.12). | SBP_bac_1 SBP_bac_8 |
Family assigned |
| Rv2319c Rv2319c |
mtbc0_002467 |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| rocE Rv2320c |
mtbc0_002468 |
cationic amino acid transporter permease RocE | Amino acid permease. Pfam: AA_permease_2 (PF13520.13), AA_permease (PF00324.28), AA_permease_C (PF13906.13). | AA_permease_2 AA_permease AA_permease_C |
Resolved |
| Rv2323c Rv2323c |
- |
hypothetical protein | Contains DDAH_eukar (PF19420.6) domain(s); putative function inferred from the domain architecture. | DDAH_eukar |
Family assigned |
| Rv2324 Rv2324 |
mtbc0_002472 |
AsnC family transcriptional regulator | Lrp/AsnC family transcriptional regulator. Pfam: HTH_AsnC-type (PF13404.13), HTH_24 (PF13412.13), AsnC_trans_reg (PF01037.29). | HTH_AsnC-type HTH_24 AsnC_trans_reg |
Family assigned |
| Rv2325c Rv2325c |
mtbc0_002473 |
hypothetical protein | CbiQ family ECF transporter T component. Pfam: CbiQ (PF02361.22). | CbiQ |
Family assigned |
| Rv2326c Rv2326c |
- |
ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Family assigned |
| Rv2327 Rv2327 |
mtbc0_002475 |
hypothetical protein | MarR family winged helix-turn-helix transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29), HTH_27 (PF13463.13). | MarR_2 MarR HTH_27 |
Family assigned |
| PE23 Rv2328 |
- |
PE family protein PE23 | PE family protein PE23. Pfam: PE (PF00934.26). | PE |
Family assigned |
| narK1 Rv2329c |
mtbc0_002478 |
nitrate/nitrite transporter | Nitrate/nitrite transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| lppP Rv2330c |
mtbc0_002479 |
lipoprotein LppP | LppP/LprE family lipoprotein. Pfam: Lipoprotein_21 (PF14041.12). | Lipoprotein_21 |
Family assigned |
| Rv2331 Rv2331 |
mtbc0_002480 |
hypothetical protein | Molybdopterin-containing oxidoreductase-family domain (eggNOG COG0243, EC 1.17.1.9/1.8.1.2; energy-metabolism COG category C). Short ORF matching the molybdopterin oxidoreductase family; complete enzyme context undetermined. | Family assigned | |
| Rv2331A Rv2331A |
- |
hypothetical protein | FAD-binding oxidoreductase domain (eggNOG COG0369, monooxygenase/reductase EC set; COG category P). A flavin-binding domain; full enzymatic role undetermined. | Family assigned | |
| mez Rv2332 |
mtbc0_002482 |
malate oxidoreductase | NAD-dependent malic enzyme. Pfam: malic (PF00390.25), Malic_M (PF03949.22). | malic Malic_M |
Resolved |
| stp Rv2333c |
mtbc0_002483 |
multidrug resistance protein | Multidrug resistance protein Stp. Pfam: MFS_1 (PF07690.22), Sugar_tr (PF00083.31). | MFS_1 Sugar_tr |
Resolved |
| cysK1 Rv2334 |
- |
O-acetylserine sulfhydrylase | O-acetylserine sulfhydrylase. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| cysE Rv2335 |
mtbc0_002485 |
serine acetyltransferase | Serine O-acetyltransferase. | Resolved | |
| tyzA Rv2336 |
mtbc0_002486 |
hypothetical protein | TyzA, an N-acyltransferase of the tyz (tyrazolone) gene cluster that initiates the biosynthesis of acyl-oxazolones, a novel class of M. tuberculosis lipids. RefSeq leaves this locus 'hypothetical protein'. Heterologous expression of tyzA (Rv2336), tyzB (Rv2338c) and tyzC (Rv2337c) produces C12:0-tyrazolone, also found in Mtb lipid extracts; TyzA catalyses the N-acylation of L-amino acids with highest specificity for L-Tyr/L-Phe and lauroyl-CoA (kcat/KM = 5.9e3 M-1 s-1) (Grigg 2023). The tyz cluster was previously implicated in oxidative-stress resistance and macrophage survival. Experimentally characterised enzyme. | Resolved | |
| tyzC Rv2337c |
mtbc0_002487 |
hypothetical protein | TyzC, a flavin-dependent oxidase (FDO) of the nitroreductase (NTR) superfamily acting in acyl-oxazolone biosynthesis. RefSeq leaves this locus 'hypothetical protein'. In the tyz cluster, TyzC catalyses the O2-dependent desaturation of the N-acyl-L-Tyr produced by TyzA, while TyzB (a ThiF homolog) catalyses its ATP-dependent cyclisation to the acyl-oxazolone; the substrate preferences of TyzB/TyzC set the identity of the final lipid (Grigg 2023). This work expands the NTR superfamily to a set of broadly distributed FDOs (five in Mtb) that desaturate lipid species. Experimentally characterised enzyme. | Resolved | |
| moeW Rv2338c |
mtbc0_002488 |
molybdopterin biosynthesis protein MoeW | ThiF family adenylyltransferase. Pfam: ThiF (PF00899.28). | ThiF |
Family assigned |
| mmpL9 Rv2339 |
mtbc0_002489 |
transmembrane transport protein MmpL9 | RND transporter MmpL9. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| PE_PGRS39 Rv2340c |
- |
PE-PGRS family protein PE_PGRS39 | PE-PGRS family protein PE_PGRS39. Pfam: PE (PF00934.26). | PE |
Family assigned |
| lppQ Rv2341 |
mtbc0_002493 |
lipoprotein LppQ | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2342 Rv2342 |
mtbc0_002494 |
hypothetical protein | Candidate accessory component of the cell-wall arabinan / arabinogalactan biosynthesis machinery (Emb/Aft arabinofuranosyltransferases), coupled to the AftB/AftC arabinofuranosyltransferases (terminal and alpha1->3-branching steps of cell-wall arabinan). Rv2342 is a STRING context partner by phylogenetic cooccurrence (not a genomic neighbour) of Rv3802c:762;aftC:757;Rv1476:752;aftB:742;Rv1610:741;lpqB:715;Rv0227c:694 (context-driven, text-mining excluded). It is under purifying selection on 145,209 MTBC genomes (7 segregating sites). No dedicated functional study of Rv2342 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Still unknown | |
| dnaG Rv2343c |
mtbc0_002495 |
DNA primase | DNA primase. Pfam: Zn_ribbon_DnaG (PF01807.26), DNAG_N (PF08275.18), Toprim_4 (PF13662.13), Toprim (PF01751.29), Toprim_2 (PF13155.13), DnaB_bind (PF10410.15), DnaG_DnaB_bind (PF08278.17). | Zn_ribbon_DnaG DNAG_N Toprim_4 Toprim Toprim_2 DnaB_bind DnaG_DnaB_bind |
Resolved |
| dgt Rv2344c |
mtbc0_002496 |
deoxyguanosine triphosphate triphosphohydrolase | Deoxyguanosinetriphosphate triphosphohydrolase. Pfam: HD (PF01966.29), HD_assoc (PF13286.12). | HD HD_assoc |
Resolved |
| Rv2345 Rv2345 |
mtbc0_002497 |
transmembrane protein | TPM domain-containing protein. Pfam: TPM_phosphatase (PF04536.21). | TPM_phosphatase |
Family assigned |
| esxO Rv2346c |
mtbc0_002498 |
ESAT-6 like protein EsxO | Type VII secretion system effector EsxO. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| esxP Rv2347c |
mtbc0_002499 |
ESAT-6 like protein EsxP | Type VII secretion system ESX-5 protein EsxJ. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| Rv2348c Rv2348c |
mtbc0_002500 |
hypothetical protein | T-cell-stimulating antigen used (with EspC and EspF) in an ESAT-6-free IGRA; a non-synonymous variant (I101M) shows a genome-to-genome association with human PRDM15. Despite this immunological/genetic characterisation, its molecular function remains unknown (verdict kept 'dark'). | Still unknown | |
| plcC Rv2349c |
mtbc0_002501 |
phospholipase C | Phospholipase C. Pfam: Phosphoesterase (PF04185.20). | Phosphoesterase |
Resolved |
| plcB Rv2350c |
- |
membrane-associated phospholipase B | Membrane-associated phospholipase B. Pfam: Phosphoesterase (PF04185.20). | Phosphoesterase |
Resolved |
| plcA Rv2351c |
- |
membrane-associated phospholipase A | Membrane-associated phospholipase A. Pfam: Phosphoesterase (PF04185.20). | Phosphoesterase |
Resolved |
| PPE38 Rv2352c |
- |
PPE family protein PPE38 | PPE family protein PPE38. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PPE39 Rv2353c |
- |
PPE family protein PPE39 | PPE family protein PPE39. Pfam: Pentapeptide_2 (PF01469.25). | Pentapeptide_2 |
Family assigned |
| glyS Rv2357c |
mtbc0_002509 |
glycine--tRNA ligase | Glycine--tRNA ligase. Pfam: tRNA-synt_2b (PF00587.31), HGTP_anticodon (PF03129.26). | tRNA-synt_2b HGTP_anticodon |
Resolved |
| smtB Rv2358 |
mtbc0_002510 |
HTH-type transcriptional regulator SmtB | Metalloregulator ArsR/SmtB family transcription factor. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27). | HTH_20 HTH_5 |
Family assigned |
| zur Rv2359 |
mtbc0_002511 |
zinc uptake regulation protein | Zinc uptake transcriptional repressor Zur. Pfam: FUR (PF01475.26), WHD_RNase_R (PF08461.17). | FUR WHD_RNase_R |
Resolved |
| Rv2360c Rv2360c |
mtbc0_002512 |
hypothetical protein | Small dimeric alpha/beta fold of the CesT/SycE/YbjN structural superfamily (the SCOP "type III secretion system chaperone-like" fold, shared by T3SS effector chaperones, YbjN-type regulatory/adaptor proteins, and several uncharacterised DUFs). The molecular function is open: it is definitively NOT a type III secretion chaperone (M. tuberculosis has no T3SS) and could be a secretion chaperone/adaptor (M. tuberculosis does use T7SS/ESX chaperones) OR a YbjN-like regulatory protein. RefSeq leaves it hypothetical. | Family assigned | |
| Rv2361c Rv2361c |
mtbc0_002513 |
decaprenyl diphosphate synthase | Decaprenyl diphosphate synthase. Pfam: Prenyltransf (PF01255.25). | Prenyltransf |
Resolved |
| recO Rv2362c |
mtbc0_002514 |
DNA repair protein RecO | DNA repair protein RecO. Pfam: RecO_N (PF11967.15), RecO_C (PF02565.22). | RecO_N RecO_C |
Resolved |
| amiA2 Rv2363 |
mtbc0_002515 |
amidase | Amidase. Pfam: Amidase (PF01425.27). | Amidase |
Resolved |
| era Rv2364c |
- |
GTPase Era | GTPase Era. Pfam: MMR_HSR1 (PF01926.30), FeoB_N (PF02421.25), PduV-EutP (PF10662.16), GTP_EFTU (PF00009.34), KH_2 (PF07650.24). | MMR_HSR1 FeoB_N PduV-EutP GTP_EFTU KH_2 |
Resolved |
| Rv2365c Rv2365c |
mtbc0_002517 |
hypothetical protein | Cytidine deaminase. Pfam: CDL (PF26947.1). | CDL |
Resolved |