Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pknL Rv2176 |
mtbc0_002310 |
serine/threonine-protein kinase PknL | Protein kinase. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24). | Pkinase PK_Tyr_Ser-Thr |
Resolved |
| Rv2177c Rv2177c |
- |
transposase | Transposase. Pfam: Transposase_20 (PF02371.23). | Transposase_20 |
Resolved |
| aroG Rv2178c |
mtbc0_002313 |
phospho-2-dehydro-3-deoxyheptonate aldolase AroG | 3-deoxy-7-phosphoheptulonate synthase class II. Pfam: DAHP_synth_2 (PF01474.23). | DAHP_synth_2 |
Resolved |
| Rv2179c Rv2179c |
mtbc0_002314 |
3'-5' exoribonuclease | Polyadenylate-specific 3'-exoribonuclease AS. Pfam: Rv2179c-like (PF16473.12). | Rv2179c-like |
Resolved |
| Rv2180c Rv2180c |
mtbc0_002315 |
integral membrane protein | Integral membrane protein. | Family assigned | |
| Rv2181 Rv2181 |
mtbc0_002316 |
alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase | Alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase. Pfam: GT87 (PF09594.17). | GT87 |
Resolved |
| Rv2182c Rv2182c |
mtbc0_002317 |
1-acylglycerol-3-phosphate O-acyltransferase | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| Rv2183c Rv2183c |
mtbc0_002318 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2184c Rv2184c |
- |
hypothetical protein | Contains ArsA_ATPase (PF02374.22), ArsA_HSP20 (PF17886.8) domain(s); putative function inferred from the domain architecture. | ArsA_ATPase ArsA_HSP20 |
Family assigned |
| TB16.3 Rv2185c |
mtbc0_002320 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv2186c Rv2186c |
mtbc0_002321 |
hypothetical protein | Polyketide cyclase / dehydrase and lipid transport. | Resolved | |
| fadD15 Rv2187 |
mtbc0_002322 |
long-chain-fatty-acid--CoA ligase FadD15 | Long-chain fatty acid--CoA ligase. Pfam: AMP-binding (PF00501.35), AMP-binding_C_3 (PF23562.3). | AMP-binding AMP-binding_C_3 |
Resolved |
| pimB Rv2188c |
mtbc0_002323 |
alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase | GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase. Pfam: Glyco_transf_4 (PF13439.13), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| Rv2189c Rv2189c |
mtbc0_002324 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real M1 alanyl-aminopeptidase PepN is Rv2467 (paralogue-of-fold). | Still unknown | |
| ripC Rv2190c |
mtbc0_002325 |
endopeptidase | Peptidoglycan hydrolase RipC. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Resolved |
| Rv2191 Rv2191 |
- |
hypothetical protein | Contains RNase_T (PF00929.32), UvrC_M (PF27096.1) domain(s); putative function inferred from the domain architecture. | RNase_T UvrC_M |
Family assigned |
| trpD Rv2192c |
mtbc0_002328 |
anthranilate phosphoribosyltransferase | Anthranilate phosphoribosyltransferase. Pfam: Glycos_trans_3N (PF02885.23), Glycos_transf_3 (PF00591.28). | Glycos_trans_3N Glycos_transf_3 |
Resolved |
| ctaE Rv2193 |
mtbc0_002329 |
cytochrome C oxidase subunit III | Heme-copper oxidase subunit III. Pfam: COX3 (PF00510.24). | COX3 |
Family assigned |
| qcrC Rv2194 |
mtbc0_002330 |
ubiquinol-cytochrome C reductase cytochrome subunit C | Cytochrome c. Pfam: Cytochrom_C (PF00034.27), Cytochrome_CBB3 (PF13442.12). | Cytochrom_C Cytochrome_CBB3 |
Resolved |
| qcrA Rv2195 |
mtbc0_002331 |
ubiquinol-cytochrome C reductase rieske iron-sulfur subunit | QcrA, the Rieske iron-sulfur protein of the cytochrome bcc (bc1) complex of the respiratory chain. RefSeq leaves this locus uncharacterised, but Rv2195 is qcrA, part of the qcrCAB operon (with qcrB/Rv2196, the target of telacebec/Q203). Resistance to QcrB inhibitors can arise via QcrA mutations in the stigmatellin pocket (Lupien 2020), and qcrA is an essential, human-homolog-free drug target (Cloete 2016). | QcrA_N Rieske |
Resolved |
| qcrB Rv2196 |
mtbc0_002332 |
ubiquinol-cytochrome C reductase cytochrome subunit B | Cytochrome bc complex cytochrome b subunit. Pfam: Cytochrome_B (PF00033.25), Cytochrom_B_N_2 (PF13631.12). | Cytochrome_B Cytochrom_B_N_2 |
Family assigned |
| Rv2197c Rv2197c |
- |
transmembrane protein | Transmembrane protein. | DUF2561 |
Resolved |
| mmpS3 Rv2198c |
mtbc0_002334 |
membrane protein MmpS3 | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv2199c Rv2199c |
mtbc0_002335 |
cytochrome c oxidase polypeptide 4 | Cytochrome c oxidase subunit 4. Pfam: Cyt_c_ox_IV (PF12270.14). | Cyt_c_ox_IV |
Family assigned |
| ctaC Rv2200c |
mtbc0_002336 |
cytochrome C oxidase subunit II | Cytochrome c oxidase subunit II. Pfam: COX2 (PF00116.27). | COX2 |
Family assigned |
| asnB Rv2201 |
mtbc0_002337 |
asparagine synthetase | Asparagine synthase (glutamine-hydrolyzing). Pfam: GATase_6 (PF13522.12), GATase_7 (PF13537.12), Asn_synthase (PF00733.28). | GATase_6 GATase_7 Asn_synthase |
Resolved |
| adoK Rv2202c |
mtbc0_002338 |
adenosine kinase | Carbohydrate kinase family protein. Pfam: PfkB (PF00294.30). | PfkB |
Family assigned |
| Rv2203 Rv2203 |
mtbc0_002339 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF8174. Function unknown. | DUF8174 |
Still unknown |
| Rv2204c Rv2204c |
mtbc0_002340 |
hypothetical protein | Iron-sulfur cluster assembly accessory protein. Pfam: Fe-S_biosyn (PF01521.27). | Fe-S_biosyn |
Resolved |
| Rv2205c Rv2205c |
mtbc0_002341 |
hypothetical protein | Glycerate kinase. Pfam: Gly_kinase (PF02595.21). | Gly_kinase |
Resolved |
| Rv2206 Rv2206 |
mtbc0_002342 |
transmembrane protein | Candidate accessory component of the de novo cobalamin (vitamin B12) biosynthesis (nucleotide-loop assembly operon), coupled to the cobalamin nucleotide-loop assembly operon (cobT Rv2207 / cobS Rv2208). Rv2206 is a genomic neighbour within the operon and STRING context partner (synteny corroborates the neighborhood channel) of cobT:789;cobS:787 (context-driven, text-mining excluded). It is under strong purifying selection on 145,209 MTBC genomes (4 segregating sites). No dedicated functional study of Rv2206 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | DUF3043 |
Family assigned |
| cobT Rv2207 |
mtbc0_002343 |
nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. Pfam: DBI_PRT (PF02277.23). | DBI_PRT |
Resolved |
| cobS Rv2208 |
mtbc0_002344 |
adenosylcobinamide-GDP ribazoletransferase | Adenosylcobinamide-GDP ribazoletransferase. Pfam: CobS (PF02654.21). | CobS |
Resolved |
| Rv2209 Rv2209 |
mtbc0_002345 |
integral membrane protein | MFS transporter. | Resolved | |
| ilvE Rv2210c |
mtbc0_002346 |
branched-chain amino acid aminotransferase | Branched-chain amino acid aminotransferase. Pfam: Aminotran_4 (PF01063.25). | Aminotran_4 |
Resolved |
| gcvT Rv2211c |
- |
aminomethyltransferase | Aminomethyltransferase. Pfam: GCV_T (PF01571.27), GCV_T_C (PF08669.18). | GCV_T GCV_T_C |
Resolved |
| Rv2212 Rv2212 |
mtbc0_002348 |
adenylyl cyclase | Adenylyl cyclase. Pfam: Guanylate_cyc (PF00211.26). | Guanylate_cyc |
Resolved |
| pepB Rv2213 |
mtbc0_002349 |
cytosol aminopeptidase | Leucyl aminopeptidase. Pfam: Peptidase_M17_N (PF02789.24), Peptidase_M17 (PF00883.27). | Peptidase_M17_N Peptidase_M17 |
Resolved |
| ephD Rv2214c |
mtbc0_002350 |
oxidoreductase EphD | SDR family oxidoreductase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14), adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 adh_short KR adh_short_C2 |
Family assigned |
| dlaT Rv2215 |
mtbc0_002351 |
pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase | 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoamide succinyltransferase. Pfam: Biotin_lipoyl (PF00364.29), E3_binding (PF02817.23), 2-oxoacid_dh (PF00198.29). | Biotin_lipoyl E3_binding 2-oxoacid_dh |
Resolved |
| Rv2216 Rv2216 |
mtbc0_002352 |
epimerase family protein | TIGR01777 family oxidoreductase. Pfam: Epimerase (PF01370.28), DUF1731 (PF08338.17). | Epimerase DUF1731 |
Family assigned |
| lipB Rv2217 |
mtbc0_002353 |
octanoyltransferase | Lipoyl(octanoyl) transferase LipB. Pfam: LplA-B_cat (PF21948.2). | LplA-B_cat |
Resolved |
| lipA Rv2218 |
mtbc0_002354 |
lipoyl synthase | Lipoyl synthase. Pfam: LIAS_N (PF16881.11), Radical_SAM (PF04055.28). | LIAS_N Radical_SAM |
Resolved |
| Rv2219 Rv2219 |
mtbc0_002355 |
transmembrane protein | Membrane protein (2 predicted TM helices) co-transcribed with lipB and lipA — the octanoyltransferase and lipoyl synthase of lipoic-acid cofactor biosynthesis — in the lipB-lipA-Rv2219 operon, under purifying selection. Contextual candidate: a component associated with lipoyl-cofactor biosynthesis/utilisation. Its molecular role is not established. | DUF4191 |
Family assigned |
| Rv2219A Rv2219A |
- |
membrane protein | Membrane protein. Pfam: RDD (PF06271.19). | RDD |
Family assigned |
| glnA1 Rv2220 |
mtbc0_002357 |
glutamine synthetase | Type I glutamate--ammonia ligase. Pfam: Gln-synt_N (PF03951.25), Gln-synt_C (PF00120.30). | Gln-synt_N Gln-synt_C |
Resolved |
| glnE Rv2221c |
mtbc0_002358 |
[glutamate--ammonia-ligase | Bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase. Pfam: GlnD_UR_UTase (PF08335.17), GlnE (PF03710.22). | GlnD_UR_UTase GlnE |
Resolved |
| glnA2 Rv2222c |
mtbc0_002359 |
glutamine synthetase | Glutamine synthetase family protein. Pfam: Gln-synt_N (PF03951.25), Gln-synt_C (PF00120.30). | Gln-synt_N Gln-synt_C |
Family assigned |
| caeB Rv2223c |
mtbc0_002360 |
carboxylesterase B | Carboxylesterase CaeB. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_4 |
Resolved |
| caeA Rv2224c |
mtbc0_002361 |
carboxylesterase A | Carboxylesterase CaeA. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_4 |
Resolved |