Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| dlaT Rv2215 |
mtbc0_002351 |
pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase | 2-oxoglutarate dehydrogenase%2C E2 component%2C dihydrolipoamide succinyltransferase. Pfam: Biotin_lipoyl (PF00364.29), E3_binding (PF02817.23), 2-oxoacid_dh (PF00198.29). | Biotin_lipoyl E3_binding 2-oxoacid_dh |
Resolved |
| Rv2216 Rv2216 |
mtbc0_002352 |
epimerase family protein | TIGR01777 family oxidoreductase. Pfam: Epimerase (PF01370.28), DUF1731 (PF08338.17). | Epimerase DUF1731 |
Family assigned |
| lipB Rv2217 |
mtbc0_002353 |
octanoyltransferase | Lipoyl(octanoyl) transferase LipB. Pfam: LplA-B_cat (PF21948.2). | LplA-B_cat |
Resolved |
| lipA Rv2218 |
mtbc0_002354 |
lipoyl synthase | Lipoyl synthase. Pfam: LIAS_N (PF16881.11), Radical_SAM (PF04055.28). | LIAS_N Radical_SAM |
Resolved |
| Rv2219 Rv2219 |
mtbc0_002355 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF4191. Function unknown. | DUF4191 |
Still unknown |
| Rv2219A Rv2219A |
- |
membrane protein | Membrane protein. Pfam: RDD (PF06271.19). | RDD |
Family assigned |
| glnA1 Rv2220 |
mtbc0_002357 |
glutamine synthetase | Type I glutamate--ammonia ligase. Pfam: Gln-synt_N (PF03951.25), Gln-synt_C (PF00120.30). | Gln-synt_N Gln-synt_C |
Resolved |
| glnE Rv2221c |
mtbc0_002358 |
[glutamate--ammonia-ligase | Bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase. Pfam: GlnD_UR_UTase (PF08335.17), GlnE (PF03710.22). | GlnD_UR_UTase GlnE |
Resolved |
| glnA2 Rv2222c |
mtbc0_002359 |
glutamine synthetase | Glutamine synthetase family protein. Pfam: Gln-synt_N (PF03951.25), Gln-synt_C (PF00120.30). | Gln-synt_N Gln-synt_C |
Family assigned |
| caeB Rv2223c |
mtbc0_002360 |
carboxylesterase B | Carboxylesterase CaeB. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_4 |
Resolved |
| caeA Rv2224c |
mtbc0_002361 |
carboxylesterase A | Carboxylesterase CaeA. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Abhydrolase_4 |
Resolved |
| Rv2224d Rv2224d |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| panB Rv2225 |
mtbc0_002363 |
3-methyl-2-oxobutanoate hydroxymethyltransferase | 3-methyl-2-oxobutanoate hydroxymethyltransferase. Pfam: Pantoate_transf (PF02548.22). | Pantoate_transf |
Resolved |
| Rv2226 Rv2226 |
mtbc0_002364 |
hypothetical protein | CYTH and CHAD domain-containing protein. Pfam: CYTH (PF01928.27), CHAD (PF05235.20). | CYTH CHAD |
Family assigned |
| Rv2227 Rv2227 |
- |
hypothetical protein | Contains Oxygenase-NA (PF09859.16) domain(s); putative function inferred from the domain architecture. | Oxygenase-NA |
Family assigned |
| Rv2228c Rv2228c |
- |
multifunctional RNASE H/alpha-ribazole phosphatase/acid phosphatase | Multifunctional RNASE H/alpha-ribazole phosphatase/acid phosphatase. Pfam: RNase_H (PF00075.31), RVT_3 (PF13456.13), His_Phos_1 (PF00300.28). | RNase_H RVT_3 His_Phos_1 |
Resolved |
| Rv2229c Rv2229c |
mtbc0_002368 |
hypothetical protein | Zinc ribbon domain-containing protein. Pfam: CT398_CC (PF24481.3), Zn_ribbon_9 (PF02591.21). | CT398_CC Zn_ribbon_9 |
Family assigned |
| Rv2230c Rv2230c |
mtbc0_002369 |
GTP cyclohydrolase | Nif3-like dinuclear metal center hexameric protein. | DUF34_NIF3 |
Resolved |
| vapC16 Rv2231A |
- |
ribonuclease VapC16 | Ribonuclease VapC16. | Resolved | |
| vapB16 Rv2231B |
- |
antitoxin VapB16 | Antitoxin VapB16. | Resolved | |
| cobC Rv2231c |
- |
aminotransferase | Aminotransferase. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Resolved |
| ptkA Rv2232 |
- |
protein tyrosine kinase transcriptional regulator PtkA | Protein tyrosine kinase transcriptional regulator PtkA. Pfam: Hydrolase (PF00702.33), HAD_2 (PF13419.13), HAD (PF12710.14), Hydrolase_like (PF13242.13). | Hydrolase HAD_2 HAD Hydrolase_like |
Family assigned |
| ptpA Rv2234 |
mtbc0_002374 |
protein-tyrosine-phosphatase | Protein-tyrosine-phosphatase. Pfam: LMWPc (PF01451.28). | LMWPc |
Resolved |
| Rv2235 Rv2235 |
mtbc0_002375 |
transmembrane protein | SURF1 family protein. Pfam: SURF1 (PF02104.21). | SURF1 |
Family assigned |
| cobD Rv2236c |
mtbc0_002376 |
cobalamin biosynthesis transmembrane protein CobD | Cobalamin biosynthesis protein. Pfam: CobD_Cbib (PF03186.19). | CobD_Cbib |
Resolved |
| Rv2237 Rv2237 |
- |
hypothetical protein | Contains MPAB_Lcp_cat (PF09995.16) domain(s); putative function inferred from the domain architecture. | MPAB_Lcp_cat |
Family assigned |
| Rv2237A Rv2237A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| ahpE Rv2238c |
mtbc0_002380 |
peroxiredoxin | Peroxiredoxin AhpE. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17). | AhpC-TSA Redoxin |
Resolved |
| Rv2239c Rv2239c |
- |
hypothetical protein | S-adenosyl-methionine (SAM)-dependent methyltransferase fold. RefSeq leaves it 'hypothetical protein' (Pfam DUF3052). The AlphaFold model superposes on an O-methyltransferase bound to the product SAH (PDB 8bif; Foldseek prob 1.0, E 2e-5, TM 0.55). STRING context: peroxiredoxin ahpE (Rv2238c). A SAM-MTase fold assignment; the acceptor substrate is not determined. | DUF3052 |
Family assigned |
| Rv2240c Rv2240c |
mtbc0_002382 |
hypothetical protein | Contains Rv2240c (PF27150.1) domain(s); putative function inferred from the domain architecture. | Rv2240c |
Family assigned |
| aceE Rv2241 |
- |
pyruvate dehydrogenase E1 component | Pyruvate dehydrogenase E1 component. Pfam: PDH_E1_N (PF28598.1), Transketolase_N (PF00456.27), PDH_E1_M (PF17831.6), Transketolase_C_1 (PF22613.2). | PDH_E1_N Transketolase_N PDH_E1_M Transketolase_C_1 |
Resolved |
| Rv2242 Rv2242 |
mtbc0_002384 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| fabD Rv2243 |
mtbc0_002385 |
malonyl CoA-acyl carrier protein transacylase | Malonyl CoA-acyl carrier protein transacylase. Pfam: Acyl_transf_1 (PF00698.27). | Acyl_transf_1 |
Resolved |
| acpM Rv2244 |
mtbc0_002386 |
meromycolate extension acyl carrier protein | Meromycolate extension acyl carrier protein AcpM. Pfam: PP-binding (PF00550.32). | PP-binding |
Resolved |
| kasA Rv2245 |
mtbc0_002387 |
3-oxoacyl-ACP synthase 1 | 3-oxoacyl-ACP synthase KasA. Pfam: ketoacyl-synt (PF00109.33), Thiolase_N (PF00108.30), Ketoacyl-synt_C (PF02801.29). | ketoacyl-synt Thiolase_N Ketoacyl-synt_C |
Resolved |
| kasB Rv2246 |
- |
3-oxoacyl-ACP synthase 2 | 3-oxoacyl-ACP synthase 2. Pfam: ketoacyl-synt (PF00109.33), Thiolase_N (PF00108.30), Ketoacyl-synt_C (PF02801.29). | ketoacyl-synt Thiolase_N Ketoacyl-synt_C |
Resolved |
| accD6 Rv2247 |
mtbc0_002389 |
acetyl-/propionyl-CoA carboxylase subunit beta | Acyl-CoA carboxylase subunit beta. Pfam: Carboxyl_trans (PF01039.28), ACCA (PF03255.20), MdcE (PF06833.17). | Carboxyl_trans ACCA MdcE |
Family assigned |
| Rv2248 Rv2248 |
- |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| glpD1 Rv2249c |
mtbc0_002391 |
glycerol-3-phosphate dehydrogenase | Glycerol-3-phosphate dehydrogenase/oxidase. Pfam: DAO (PF01266.31), FAD_binding_2 (PF00890.31), DAO_C (PF16901.11). | DAO FAD_binding_2 DAO_C |
Resolved |
| Rv2250c Rv2250c |
mtbc0_002392 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv2251 Rv2251 |
- |
flavoprotein | Flavoprotein. Pfam: FAD_binding_4 (PF01565.29), FAD-oxidase_C (PF02913.25). | FAD_binding_4 FAD-oxidase_C |
Resolved |
| Rv2252 Rv2252 |
mtbc0_002394 |
diacylglycerol kinase | Diacylglycerol kinase. Pfam: DAGK_cat (PF00781.30), YegS_C (PF19279.5). | DAGK_cat YegS_C |
Resolved |
| Rv2253 Rv2253 |
mtbc0_002395 |
hypothetical protein | Membrane protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard). Same sensor fold as Rv3491. | Family assigned | |
| Rv2254c Rv2254c |
mtbc0_002396 |
integral membrane protein | LysE family transporter. | Family assigned | |
| Rv2256a Rv2256a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2256c Rv2256c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3145. Function unknown. Foldseek best (non-significant) hit: 6bwo-assembly1_A LarC2, the C-terminal domain of a cyclometallase invo (prob 0.77, TM 0.32). | DUF3145 |
Still unknown |
| Rv2257c Rv2257c |
mtbc0_002400 |
hypothetical protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| Rv2258c Rv2258c |
mtbc0_002401 |
transcriptional regulator | Class I SAM-dependent methyltransferase. Pfam: WHD_Rv2258c (PF21320.4), Methyltransf_23 (PF13489.13), MTS (PF05175.21), PrmA (PF06325.20), PCMT (PF01135.26), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), Methyltransf_2 (PF00891.25), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | WHD_Rv2258c Methyltransf_23 MTS PrmA PCMT Methyltransf_31 Ubie_methyltran Methyltransf_2 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| mscR Rv2259 |
mtbc0_002402 |
S-nitrosomycothiol reductase MscR | S-(hydroxymethyl)mycothiol dehydrogenase. Pfam: ADH_N (PF08240.18), ADH_zinc_N (PF00107.33), ADH_zinc_N_2 (PF13602.13). | ADH_N ADH_zinc_N ADH_zinc_N_2 |
Resolved |
| Rv2260 Rv2260 |
mtbc0_002403 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |