Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| iniC Rv0343 |
mtbc0_000363 |
iIsoniazid inductible protein IniC | Isoniazid-induced dynamin-like GTPase IniC. Pfam: MMR_HSR1 (PF01926.30), Dynamin_N (PF00350.30). | MMR_HSR1 Dynamin_N |
Resolved |
| lpqJ Rv0344c |
mtbc0_000364 |
lipoprotein LpqJ | Lipoprotein LpqJ with an LpqN/LpqE-like lipid-binding fold (HHpred). Previously flagged as possibly supercomplex-associated because the supercomplex subunit LpqE shares this fold, but the LpqE resemblance is fold-level only, with NO corroboration that LpqJ is a supercomplex subunit. Real feature: secreted lipoprotein with an LpqN/LpqE lipid-binding fold; specific function undetermined. | Family assigned | |
| Rv0345 Rv0345 |
- |
hypothetical protein | Contains NTP_transf_3 (PF12804.14) domain(s); putative function inferred from the domain architecture. | NTP_transf_3 |
Family assigned |
| ansP2 Rv0346c |
- |
L-asparagine permease | L-asparagine permease. Pfam: AA_permease (PF00324.28), AA_permease_2 (PF13520.13). | AA_permease AA_permease_2 |
Resolved |
| Rv0347 Rv0347 |
- |
membrane protein | Membrane protein. | Family assigned | |
| mosR Rv0348 |
mtbc0_000368 |
transcriptional regulator | Hypoxia/intracellular survival transcriptional regulator MosR. | Family assigned | |
| Rv0349 Rv0349 |
- |
hypothetical protein | MazF/PemK-family ribonuclease fold (candidate toxin of a type II toxin-antitoxin system). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on MazF (PDB 9g2g; Foldseek prob 1.0, TM 0.72). A distinct locus from the named M. tuberculosis MazF paralogues. Fold-level TA-toxin assignment; the cognate antitoxin and cleavage specificity are undemonstrated. | Family assigned | |
| dnaK Rv0350 |
mtbc0_000371 |
chaperone protein DnaK | Molecular chaperone DnaK. Pfam: HSP70 (PF00012.27), MreB_Mbl (PF06723.20). | HSP70 MreB_Mbl |
Resolved |
| grpE Rv0351 |
mtbc0_000372 |
stress response protein GrpE | Nucleotide exchange factor GrpE. Pfam: GrpE (PF01025.25). | GrpE |
Resolved |
| dnaJ1 Rv0352 |
- |
chaperone protein DnaJ | Chaperone protein DnaJ. Pfam: DnaJ (PF00226.37), DnaJ_C (PF01556.24), DnaJ_CXXCXGXG (PF00684.26). | DnaJ DnaJ_C DnaJ_CXXCXGXG |
Resolved |
| hspR Rv0353 |
mtbc0_000374 |
heat shock protein transcriptional repressor HspR | Heat shock transcriptional regulator HspR. Pfam: MerR_1 (PF13411.13), MerR (PF00376.30), MerR_2 (PF13591.13). | MerR_1 MerR MerR_2 |
Family assigned |
| PPE7 Rv0354c |
- |
PPE family protein PPE7 | PPE family protein PPE7. | Family assigned | |
| PPE8 Rv0355c |
- |
PPE family protein PPE8 | PPE family protein PPE8. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv0356c Rv0356c |
mtbc0_000376 |
hypothetical protein | PaaI family thioesterase. Pfam: 4HBT (PF03061.29). | 4HBT |
Family assigned |
| purA Rv0357c |
mtbc0_000377 |
adenylosuccinate synthetase | Adenylosuccinate synthase. Pfam: Adenylsucc_synt (PF00709.28). | Adenylsucc_synt |
Resolved |
| Rv0358 Rv0358 |
mtbc0_000378 |
hypothetical protein | Peptidase M50. | Resolved | |
| Rv0359 Rv0359 |
mtbc0_000379 |
zinc metalloprotease | Site-2 protease family protein. | Family assigned | |
| Rv0360c Rv0360c |
- |
hypothetical protein | Tetratricopeptide-repeat (TPR) protein: an all-alpha helical-repeat protein-protein interaction scaffold. The interaction partners are undetermined. RefSeq leaves this locus uncharacterised. | DUF3151 |
Family assigned |
| Rv0361 Rv0361 |
mtbc0_000381 |
membrane protein | Cell-division / septum-assembly-associated membrane protein (eggNOG COG3115, COG category D 'cell septum assembly'). RefSeq leaves it a 'conserved membrane protein'. Pathway-level role in division; molecular detail undetermined. | Family assigned | |
| mgtE Rv0362 |
mtbc0_000382 |
Mg2+ transport transmembrane protein MgtE | Magnesium transporter. Pfam: MgtE_N (PF03448.23), CBS (PF00571.34), MgtE (PF01769.22). | MgtE_N CBS MgtE |
Resolved |
| fba Rv0363c |
mtbc0_000383 |
fructose-bisphosphate aldolase | Class II fructose-bisphosphate aldolase. Pfam: F_bP_aldolase (PF01116.27). | F_bP_aldolase |
Resolved |
| Rv0364 Rv0364 |
mtbc0_000384 |
transmembrane protein | VTT domain-containing protein. Pfam: VTT_dom (PF09335.17). | VTT_dom |
Family assigned |
| Rv0365c Rv0365c |
mtbc0_000385 |
hypothetical protein | Glycoside hydrolase family 76 protein. Pfam: Glyco_hydro_76 (PF03663.21). | Glyco_hydro_76 |
Family assigned |
| Rv0366c Rv0366c |
mtbc0_000386 |
hypothetical protein | Zeta toxin family protein. Pfam: Zeta_toxin (PF06414.19), AAA_33 (PF13671.13). | Zeta_toxin AAA_33 |
Family assigned |
| Rv0367c Rv0367c |
mtbc0_000387 |
hypothetical protein | Contains ParD_like (PF11903.15) domain(s); putative function inferred from the domain architecture. | ParD_like |
Family assigned |
| Rv0368c Rv0368c |
mtbc0_000388 |
hypothetical protein | VWA domain-containing protein. Pfam: VWA_CoxE (PF05762.21). | VWA_CoxE |
Family assigned |
| Rv0369c Rv0369c |
- |
membrane oxidoreductase | Membrane oxidoreductase. Pfam: COXG (PF06240.20). | COXG |
Resolved |
| Rv0370c Rv0370c |
mtbc0_000390 |
oxidoreductase | MoxR family ATPase. Pfam: AAA_5 (PF07728.21), AAA (PF00004.36). | AAA_5 AAA |
Family assigned |
| Rv0371c Rv0371c |
mtbc0_000391 |
hypothetical protein | NTP transferase domain-containing protein. Pfam: NTP_transf_3 (PF12804.14). | NTP_transf_3 |
Family assigned |
| Rv0372c Rv0372c |
mtbc0_000392 |
hypothetical protein | XdhC family protein. Pfam: XdhC_CoxI (PF02625.22), XdhC_C (PF13478.13). | XdhC_CoxI XdhC_C |
Family assigned |
| Rv0373c Rv0373c |
mtbc0_000393 |
carbon monoxyde dehydrogenase large subunit | Aerobic carbon-monoxide dehydrogenase large subunit. Pfam: Ald_Xan_dh_C (PF01315.28), MoCoBD_1 (PF02738.24), MoCoBD_2 (PF20256.4). | Ald_Xan_dh_C MoCoBD_1 MoCoBD_2 |
Family assigned |
| Rv0374c Rv0374c |
mtbc0_000394 |
carbon monoxyde dehydrogenase small subunit | (2Fe-2S)-binding protein. Pfam: Fer2 (PF00111.33), Fer2_2 (PF01799.26). | Fer2 Fer2_2 |
Family assigned |
| Rv0375c Rv0375c |
- |
carbon monoxyde dehydrogenase medium subunit | Carbon monoxyde dehydrogenase medium subunit. Pfam: FAD_binding_5 (PF00941.28), CO_deh_flav_C (PF03450.23). | FAD_binding_5 CO_deh_flav_C |
Family assigned |
| Rv0376c Rv0376c |
- |
hypothetical protein | Contains XdhC_CoxI (PF02625.22), XdhC_C (PF13478.13) domain(s); putative function inferred from the domain architecture. | XdhC_CoxI XdhC_C |
Family assigned |
| Rv0377 Rv0377 |
mtbc0_000397 |
HTH-type transcriptional regulator | LysR family transcriptional regulator. Pfam: HTH_1 (PF00126.34), LysR_substrate (PF03466.26). | HTH_1 LysR_substrate |
Family assigned |
| Rv0378 Rv0378 |
mtbc0_000398 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2pne-assembly1_A Crystal Structure of the Snow Flea Antifreeze Protein (prob 0.06, TM 0.35). | Still unknown | |
| secE2 Rv0379 |
- |
protein translocase subunit SecE | Protein translocase subunit SecE. Pfam: Dodecin (PF07311.18). | Dodecin |
Family assigned |
| Rv0380c Rv0380c |
- |
RNA methyltransferase | RNA methyltransferase. Pfam: SpoU_methylase (PF00588.25). | SpoU_methylase |
Resolved |
| Rv0381c Rv0381c |
mtbc0_000401 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4j51-assembly2_B Cyrstal structure of protein tyrosine phosphatase Lyp (prob 0.33, TM 0.63). | Still unknown | |
| pyrE Rv0382c |
- |
orotate phosphoribosyltransferase | Orotate phosphoribosyltransferase. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Resolved |
| ttfA Rv0383c |
mtbc0_000403 |
hypothetical protein | Trehalose monomycolate transport factor TtfA. Pfam: Treh_trans_TtfA (PF28092.1). | Treh_trans_TtfA |
Resolved |
| clpB Rv0384c |
- |
chaperone protein ClpB | Chaperone protein ClpB. Pfam: Clp_N (PF02861.26), NBD_SMAX1 (PF23569.2), AAA (PF00004.36), AAA_lid_9 (PF17871.8), AAA_2 (PF07724.21), Sigma54_activat (PF00158.33), AAA_5 (PF07728.21), ClpB_D2-small (PF10431.16). | Clp_N NBD_SMAX1 AAA AAA_lid_9 AAA_2 Sigma54_activat AAA_5 ClpB_D2-small |
Resolved |
| Rv0385 Rv0385 |
mtbc0_000405 |
monooxygenase | FAD-binding oxidoreductase. Pfam: Globin (PF00042.29), FAD_binding_6 (PF00970.31), NAD_binding_1 (PF00175.27). | Globin FAD_binding_6 NAD_binding_1 |
Resolved |
| Rv0386 Rv0386 |
mtbc0_000406 |
transcriptional regulator | LuxR family transcriptional regulator. Pfam: HTH_77 (PF25872.1), GerE (PF00196.26). | HTH_77 GerE |
Family assigned |
| Rv0387c Rv0387c |
|
Conserved hypothetical protein | PPE family | PPE-SVP |
Family assigned |
| PPE9 Rv0388c |
|
PPE family protein PPE9 | PPE family protein PPE9 | PPE |
Family assigned |
| purT Rv0389 |
mtbc0_000408 |
phosphoribosylglycinamide formyltransferase PurT | Phosphoribosylglycinamide formyltransferase 2. Pfam: ATP-grasp (PF02222.28). | ATP-grasp |
Resolved |
| Rv0390 Rv0390 |
mtbc0_000409 |
hypothetical protein | Rhodanese-like domain-containing protein. Pfam: Rhodanese (PF00581.26). | Rhodanese |
Family assigned |
| metZ Rv0391 |
mtbc0_000410 |
O-succinylhomoserine sulfhydrylase | O-succinylhomoserine sulfhydrylase. Pfam: Cys_Met_Meta_PP (PF01053.27). | Cys_Met_Meta_PP |
Resolved |
| ndhA Rv0392c |
mtbc0_000411 |
NADH dehydrogenase NdhA | NAD(P)/FAD-dependent oxidoreductase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox (PF00070.34). | Pyr_redox_2 Pyr_redox |
Resolved |