Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2074 Rv2074 |
mtbc0_002208 |
pyridoxamine 5'-phosphate oxidase | F420-dependent biliverdin reductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv2075c Rv2075c |
mtbc0_002209 |
hypothetical protein | Contains PI-PLC_cat (PF26178.1) domain(s); putative function inferred from the domain architecture. | PI-PLC_cat |
Family assigned |
| Rv2076c Rv2076c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv2077A Rv2077A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6uuj-assembly2_E Structure of PE5-PPE4-EspG3 complex from the type VII (prob 0.90, TM 0.69). | Still unknown | |
| Rv2077c Rv2077c |
mtbc0_002210 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2078 Rv2078 |
mtbc0_002212 |
hypothetical protein | DUF2563 family protein. | DUF2563 |
Family assigned |
| Rv2079 Rv2079 |
mtbc0_002213 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Hydro_N_hd (PF22905.3), Abhydrolase_8 (PF06259.19). | Hydro_N_hd Abhydrolase_8 |
Family assigned |
| lppJ Rv2080 |
mtbc0_002214 |
lipoprotein LppJ | Contains LppJ (PF27220.1) domain(s); putative function inferred from the domain architecture. | LppJ |
Family assigned |
| Rv2081c Rv2081c |
mtbc0_002216 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2082 Rv2082 |
mtbc0_002218 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5632, DUF5631. Function unknown. | DUF5632 DUF5631 |
Still unknown |
| Rv2083 Rv2083 |
mtbc0_002219 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2084 Rv2084 |
mtbc0_002220 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 1l7c-assembly1_A alpha-catenin fragment, residues 385-651 (prob 0.21, TM 0.26). | Still unknown | |
| Rv2085 Rv2085 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2963, transposase; COG category L). A mobile-element function. | Family assigned | |
| Rv2086 Rv2086 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2801, DDE transposase; COG category L). A mobile-element function. | Family assigned | |
| Rv2087 Rv2087 |
|
Conserved hypothetical protein | transposition | Family assigned | |
| pknJ Rv2088 |
mtbc0_002222 |
transmembrane serine/threonine-protein kinase PknJ | Serine/threonine protein kinase PknJ. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), PknH_C (PF14032.13). | Pkinase PK_Tyr_Ser-Thr PknH_C |
Resolved |
| pepE Rv2089c |
mtbc0_002223 |
dipeptidase PepE | Xaa-Pro peptidase family protein. Pfam: Creatinase_N (PF01321.25), Peptidase_M24 (PF00557.30). | Creatinase_N Peptidase_M24 |
Family assigned |
| Rv2090 Rv2090 |
- |
5'-3' exonuclease | 5'-3' exonuclease. Pfam: 5_3_exonuc_N (PF02739.23), 5_3_exonuc (PF01367.26). | 5_3_exonuc_N 5_3_exonuc |
Resolved |
| Rv2091c Rv2091c |
mtbc0_002225 |
membrane protein | Membrane protein (1 predicted TM helix, DUF4333) co-transcribed with tatC and tatA — the twin-arginine translocation (Tat) protein-secretion system — under purifying selection. Contextual candidate: associated with the Tat secretion system. Its molecular role is not established. | DUF4333 |
Family assigned |
| helY Rv2092c |
mtbc0_002226 |
ATP-dependent DNA helicase HelY | RNA helicase. Pfam: ResIII (PF04851.22), DEAD (PF00270.36), Helicase_C (PF00271.38), SH3_HelY (PF26090.1), DSHCT (PF08148.18). | ResIII DEAD Helicase_C SH3_HelY DSHCT |
Resolved |
| tatC Rv2093c |
mtbc0_002227 |
Sec-independent protein translocase transmembrane protein TatC | Twin-arginine translocase subunit TatC. Pfam: TatC (PF00902.24). | TatC |
Family assigned |
| tatA Rv2094c |
mtbc0_002228 |
Sec-independent protein translocase membrane-bound protein TatA | Sec-independent protein translocase subunit TatA. Pfam: TatA_B_E (PF02416.22). | TatA_B_E |
Family assigned |
| pafC Rv2095c |
mtbc0_002229 |
proteasome accessory factor C | YafY family protein. Pfam: HTH_PafC (PF19187.7), WYL (PF13280.13), WCX (PF25583.2). | HTH_PafC WYL WCX |
Family assigned |
| pafB Rv2096c |
mtbc0_002230 |
proteasome accessory factor B | YafY family protein. Pfam: WYL (PF13280.13), WCX (PF25583.2). | WYL WCX |
Family assigned |
| pafA Rv2097c |
mtbc0_002231 |
proteasome accessory factor PafA | Pup--protein ligase. Pfam: Pup_ligase (PF03136.21). | Pup_ligase |
Resolved |
| Rv2100 Rv2100 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). Lies in a region-of-difference (RDcap_Asia3) context. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| helZ Rv2101 |
mtbc0_002234 |
helicase HelZ | DEAD/DEAH box helicase. Pfam: DUF3670 (PF12419.14), SNF2-rel_dom (PF00176.30), Helicase_C (PF00271.38). | DUF3670 SNF2-rel_dom Helicase_C |
Resolved |
| Rv2102 Rv2102 |
- |
hypothetical protein | Contains SWIM (PF04434.23) domain(s); putative function inferred from the domain architecture. | SWIM |
Family assigned |
| vapC37 Rv2103c |
mtbc0_002236 |
ribonuclease VapC37 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv2104a Rv2104a |
- |
hypothetical protein | Proteasome-alpha-subunit-family protein, located in the M. tuberculosis proteasome gene region. HHpred: 25/25 top hits are 20S-proteasome alpha-type subunits (incl. the M.tb proteasome alpha 3MI0, 88.4%); eggNOG COG0638 (20S proteasome alpha/beta) with EC 3.4.25.1. Genomic context: immediately flanked by the proteasome core/Pup genes prcA (Rv2109c), prcB (Rv2110c) and pafA (Rv2097c); under purifying selection. At 85 aa it is a small/partial proteasome-alpha-fold protein - whether a bona fide additional subunit or a proteasome-associated protein is undetermined (the canonical alpha subunit is prcA/Rv2109c). | Family assigned | |
| vapB37 Rv2104c |
mtbc0_002237 |
antitoxin VapB37 | Antitoxin. | Resolved | |
| PE22 Rv2107 |
- |
PE family protein PE22 | PE family protein PE22. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PPE36 Rv2108 |
- |
PPE family protein PPE36 | PPE family protein PPE36. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| prcA Rv2109c |
mtbc0_002241 |
proteasome subunit alpha | Proteasome subunit alpha. Pfam: Proteasome (PF00227.32). | Proteasome |
Family assigned |
| prcB Rv2110c |
mtbc0_002242 |
proteasome subunit beta | Proteasome subunit beta. Pfam: Proteasome (PF00227.32). | Proteasome |
Family assigned |
| pup Rv2111c |
- |
ubiquitin-like protein Pup | Ubiquitin-like protein Pup. Pfam: Pup (PF05639.17). | Pup |
Family assigned |
| dop Rv2112c |
- |
pup deamidase/depupylase | Pup deamidase/depupylase. Pfam: Pup_ligase (PF03136.21). | Pup_ligase |
Resolved |
| Rv2113 Rv2113 |
mtbc0_002245 |
integral membrane protein | Integral membrane protein. | Family assigned | |
| Rv2114 Rv2114 |
mtbc0_002246 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8b6h-assembly1_ES Cryo-EM structure of cytochrome c oxidase dimer (com (prob 0.08, TM 0.34). | Still unknown | |
| mpa Rv2115c |
mtbc0_002247 |
proteasome-associated ATPase | Proteasome ATPase. Pfam: Prot_ATP_ID_OB_N (PF17758.8), Prot_ATP_ID_OB_C (PF16450.12), AAA (PF00004.36). | Prot_ATP_ID_OB_N Prot_ATP_ID_OB_C AAA |
Resolved |
| lppK Rv2116 |
mtbc0_002248 |
lipoprotein LppK | Contains Mtb12_C (PF26580.1) domain(s); putative function inferred from the domain architecture. | Mtb12_C |
Family assigned |
| Rv2117 Rv2117 |
mtbc0_002249 |
hypothetical protein | DUF503 domain-containing protein. | DUF503 |
Family assigned |
| trmI Rv2118c |
mtbc0_002250 |
tRNA (adenine(58)-N(1))-methyltransferase | TRNA (adenine(58)-N(1))-methyltransferase TrmI. Pfam: TrmI-like_N (PF14801.13), GCD14 (PF08704.17), PCMT (PF01135.26), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | TrmI-like_N GCD14 PCMT Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv2119 Rv2119 |
mtbc0_002251 |
hypothetical protein | RecB family exonuclease. Pfam: PDDEXK_1 (PF12705.14). | PDDEXK_1 |
Family assigned |
| Rv2120c Rv2120c |
mtbc0_002252 |
integral membrane protein | Glycine zipper 2TM domain-containing protein. Pfam: Rick_17kDa_Anti (PF05433.21). | Rick_17kDa_Anti |
Family assigned |
| hisG Rv2121c |
mtbc0_002253 |
ATP phosphoribosyltransferase | ATP phosphoribosyltransferase. Pfam: HisG (PF01634.24), HisG_C (PF08029.17). | HisG HisG_C |
Resolved |
| hisE Rv2122c |
- |
phosphoribosyl-ATP pyrophosphatase | Phosphoribosyl-ATP pyrophosphatase. Pfam: PRA-PH (PF01503.23), MazG (PF03819.23). | PRA-PH MazG |
Resolved |
| PPE37 Rv2123 |
- |
PPE family protein PPE37 | PPE family protein PPE37. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| metH Rv2124c |
mtbc0_002256 |
methionine synthase | Methionine synthase. Pfam: S-methyl_trans (PF02574.23), Pterin_bind (PF00809.29), B12-binding_2 (PF02607.23), B12-binding (PF02310.25), Met_synt_B12 (PF02965.23). | S-methyl_trans Pterin_bind B12-binding_2 B12-binding Met_synt_B12 |
Resolved |
| Rv2125 Rv2125 |
mtbc0_002257 |
hypothetical protein | PAC2 family protein. Pfam: PAC2 (PF09754.16). | PAC2 |
Family assigned |