Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| PPE10 Rv0442c |
- |
PPE family protein PPE10 | PPE family protein PPE10. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv0443 Rv0443 |
mtbc0_000465 |
hypothetical protein | Mycothiol transferase. Pfam: MST (PF04978.18), DinB_2 (PF12867.13). | MST DinB_2 |
Resolved |
| rskA Rv0444c |
mtbc0_000466 |
anti-sigma-K factor RskA | Anti-sigma-K factor RskA. Pfam: RskA_N (PF22618.2), RskA_C (PF10099.15). | RskA_N RskA_C |
Resolved |
| sigK Rv0445c |
mtbc0_000467 |
ECF RNA polymerase sigma factor SigK | Sigma-70 family RNA polymerase sigma factor SigK. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Family assigned |
| Rv0446c Rv0446c |
mtbc0_000468 |
transmembrane protein | DUF1295 domain-containing protein. Pfam: DUF1295 (PF06966.18), PEMT (PF04191.19). | DUF1295 PEMT |
Family assigned |
| ufaA1 Rv0447c |
mtbc0_000469 |
cyclopropane-fatty-acyl-phospholipid synthase UfaA | Class I SAM-dependent methyltransferase. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| Rv0448c Rv0448c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF1365. Function unknown. Foldseek best (non-significant) hit: 5n48-assembly2_C Structure of Anticalin N9B in complex with extra-doma (prob 0.04, TM 0.38). | DUF1365 |
Still unknown |
| Rv0449c Rv0449c |
mtbc0_000471 |
hypothetical protein | NAD(P)/FAD-dependent oxidoreductase. Pfam: NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | NAD_binding_8 Amino_oxidase |
Resolved |
| mmpL4 Rv0450c |
- |
transmembrane transport protein MmpL4 | Transmembrane transport protein MmpL4. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| mmpS4 Rv0451c |
mtbc0_000473 |
membrane protein MmpS4 | Siderophore RND transporter accessory protein MmpS4. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Resolved |
| Rv0452 Rv0452 |
mtbc0_000474 |
transcriptional regulator | TetR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_34 (PF17929.8). | TetR_N TetR_C_34 |
Family assigned |
| PPE11 Rv0453 |
- |
PPE family protein PPE11 | PPE family protein PPE11. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| Rv0454 Rv0454 |
|
Conserved hypothetical protein | — | Still unknown | |
| Rv0455c Rv0455c |
mtbc0_000477 |
hypothetical protein | DUF5078; structure solved (PDB 8DRI, Rv0455c); fold characterised, function not established. | DUF5078 |
Family assigned |
| mazF1 Rv0456A |
- |
toxin MazF1 | Toxin MazF1. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Resolved |
| mazE1 Rv0456B |
- |
antitoxin MazE1 | Antitoxin MazE1. | Resolved | |
| echA2 Rv0456c |
mtbc0_000478 |
enoyl-CoA hydratase EchA2 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv0457c Rv0457c |
mtbc0_000481 |
peptidase | Prolyl oligopeptidase family protein. Pfam: Peptidase_S9_N (PF02897.22), Peptidase_S9 (PF00326.28). | Peptidase_S9_N Peptidase_S9 |
Family assigned |
| Rv0458 Rv0458 |
mtbc0_000482 |
aldehyde dehydrogenase | Aldehyde dehydrogenase family protein. Pfam: Aldedh (PF00171.28). | Aldedh |
Family assigned |
| Rv0459 Rv0459 |
mtbc0_000483 |
hypothetical protein | Fe-S cluster assembly protein of the IscA/SufA/HesB (A-type Fe-S carrier, ATC) family: a scaffold/carrier delivering [2Fe-2S]/[4Fe-4S] clusters to apo-proteins. RefSeq/Mycobrowser leave it DUF779/hypothetical. RefSeq leaves this locus uncharacterised. | DUF779 |
Family assigned |
| Rv0460 Rv0460 |
- |
hypothetical protein | Contains Holin_9 (PF16936.11) domain(s); putative function inferred from the domain architecture. | Holin_9 |
Family assigned |
| Rv0461 Rv0461 |
- |
transmembrane protein | Transmembrane protein. Pfam: Rv0461 (PF27066.1). | Rv0461 |
Resolved |
| lpdC Rv0462 |
mtbc0_000486 |
dihydrolipoamide dehydrogenase | Dihydrolipoyl dehydrogenase. Pfam: Pyr_redox_2 (PF07992.21), FAD_oxidored (PF12831.14), GIDA (PF01134.29), FAD_binding_2 (PF00890.31), Pyr_redox (PF00070.34), Pyr_redox_dim (PF02852.29). | Pyr_redox_2 FAD_oxidored GIDA FAD_binding_2 Pyr_redox Pyr_redox_dim |
Resolved |
| Rv0463 Rv0463 |
mtbc0_000487 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0464c Rv0464c |
mtbc0_000488 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| ramB Rv0465c |
mtbc0_000489 |
HTH-type transcriptional regulator | Acetate metabolism transcriptional regulator RamB. Pfam: HTH_19 (PF12844.14), HTH_31 (PF13560.13), HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20), ScfRs (PF09856.15). | HTH_19 HTH_31 HTH_3 Peptidase_M78 ScfRs |
Family assigned |
| Rv0466 Rv0466 |
mtbc0_000490 |
hypothetical protein | Acyl-[acyl-carrier-protein] thioesterase. Pfam: Acyl-ACP_TE (PF01643.24), Acyl-ACP_TE_C (PF20791.4). | Acyl-ACP_TE Acyl-ACP_TE_C |
Resolved |
| icl1 Rv0467 |
- |
isocitrate lyase | Isocitrate lyase. Pfam: ICL (PF00463.28), PEP_mutase (PF13714.13). | ICL PEP_mutase |
Resolved |
| fadB2 Rv0468 |
mtbc0_000492 |
3-hydroxybutyryl-CoA dehydrogenase | 3-hydroxybutyryl-CoA dehydrogenase FadB2. Pfam: 3HCDH_N (PF02737.25), 3HCDH (PF00725.28). | 3HCDH_N 3HCDH |
Resolved |
| umaA Rv0469 |
- |
mycolic acid synthase UmaA | Mycolic acid synthase UmaA. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| Rv0470A Rv0470A |
- |
hypothetical protein | Candidate UbiA/MenA-family prenyltransferase (menaquinone-biosynthesis-related). Family handle from eggNOG COG1575 ('Belongs to the MenA family. Type 1 subfamily'), concordant with the UniProt TrEMBL name '1,4-dihydroxy-2-naphthoate prenyltransferase'. Family-level assignment only, not experimentally validated; carries a pseudogene-candidate flag and relaxed intra-MTBC selection, consistent with a possibly degrading paralogue of the primary menA (Rv0534c). | Family assigned | |
| pcaA Rv0470c |
- |
cyclopropane mycolic acid synthase | Cyclopropane mycolic acid synthase. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv0471c Rv0471c |
mtbc0_000496 |
hypothetical protein | 1%2C4-dihydroxy-2-naphthoate prenyltransferase. | Resolved | |
| Rv0472c Rv0472c |
mtbc0_000497 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_32 (PF19344.5). | TetR_N TetR_C_32 |
Family assigned |
| Rv0473 Rv0473 |
mtbc0_000498 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF445. Function unknown. | DUF445 |
Still unknown |
| Rv0474 Rv0474 |
mtbc0_000499 |
HTH-type transcriptional regulator | Helix-turn-helix transcriptional regulator. Pfam: HTH_31 (PF13560.13), HTH_3 (PF01381.29). | HTH_31 HTH_3 |
Family assigned |
| hbhA Rv0475 |
mtbc0_000500 |
heparin binding hemagglutinin HbhA | Heparin-binding hemagglutinin HbhA. | Resolved | |
| Rv0476 Rv0476 |
- |
transmembrane protein | Transmembrane protein. | DUF2516 |
Resolved |
| Rv0477 Rv0477 |
mtbc0_000502 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2599. Function unknown. Foldseek best (non-significant) hit: 3tgo-assembly2_D Crystal structure of the E. coli BamCD complex (prob 0.01, TM 0.15). | DUF2599 |
Still unknown |
| deoC Rv0478 |
mtbc0_000503 |
2-deoxyribose-5-phosphate aldolase | Deoxyribose-phosphate aldolase. Pfam: DeoC (PF01791.16). | DeoC |
Resolved |
| Rv0479c Rv0479c |
mtbc0_000504 |
membrane protein | DUF2993 domain-containing protein. Pfam: LmeA (PF11209.14). | LmeA |
Family assigned |
| Rv0480c Rv0480c |
mtbc0_000505 |
amidohydrolase | Carbon-nitrogen hydrolase family protein. Pfam: CN_hydrolase (PF00795.28). | CN_hydrolase |
Family assigned |
| Rv0481c Rv0481c |
mtbc0_000506 |
hypothetical protein | DUF2505; ESMFold matches a START-like / Ups1 lipid-transfer fold (PDB 5JQM); putative lipid-binding protein. | DUF2505 |
Family assigned |
| murB Rv0482 |
mtbc0_000507 |
UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase. Pfam: FAD_binding_4 (PF01565.29), MurB_C (PF02873.22). | FAD_binding_4 MurB_C |
Resolved |
| lprQ Rv0483 |
mtbc0_000508 |
lipoprotein LprQ | L%2CD-transpeptidase LdtMt5. Pfam: Big_10 (PF17964.8), YkuD (PF03734.20). | Big_10 YkuD |
Resolved |
| Rv0484c Rv0484c |
mtbc0_000509 |
short-chain type oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13), NAD_binding_10 (PF13460.13). | adh_short KR Epimerase adh_short_C2 NAD_binding_10 |
Family assigned |
| Rv0485 Rv0485 |
mtbc0_000510 |
transcriptional regulator | Transcriptional regulator. Pfam: ROK (PF00480.27). | ROK |
Family assigned |
| mshA Rv0486 |
mtbc0_000511 |
D-inositol 3-phosphate glycosyltransferase | D-inositol-3-phosphate glycosyltransferase. Pfam: Glyco_trans_4_4 (PF13579.13), Glyco_transf_4 (PF13439.13), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13). | Glyco_trans_4_4 Glyco_transf_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 |
Resolved |
| Rv0487 Rv0487 |
mtbc0_000512 |
hypothetical protein | YbjN domain-containing protein. Pfam: YbjN (PF10722.15). | YbjN |
Family assigned |
| Rv0488 Rv0488 |
- |
amino acid transporter | Amino acid transporter. Pfam: LysE (PF01810.25). | LysE |
Resolved |