Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| ttfA Rv0383c |
mtbc0_000403 |
hypothetical protein | Trehalose monomycolate transport factor TtfA. Pfam: Treh_trans_TtfA (PF28092.1). | Treh_trans_TtfA |
Resolved |
| Rv0387c Rv0387c |
|
Conserved hypothetical protein | PPE family | PPE-SVP |
Family assigned |
| Rv0390 Rv0390 |
mtbc0_000409 |
hypothetical protein | Rhodanese-like domain-containing protein. Pfam: Rhodanese (PF00581.26). | Rhodanese |
Family assigned |
| Rv0393 Rv0393 |
- |
hypothetical protein | Member of the conserved 13E12 (REP13E12) repeat protein family. RefSeq leaves it of unknown function. Identified as a conserved component (P95201) of M. tuberculosis extracellular vesicles, proposed as an MEV marker (Ryan 2025). The REP13E12 repeats serve as prophage (phiRv1) attachment sites. Molecular function unfixed. | DUF222 |
Family assigned |
| Rv0394c Rv0394c |
mtbc0_000413 |
hypothetical protein | Hyaluronidase / chondroitin-sulfatase; lets M. tuberculosis use host hyaluronan as an alternative carbon source (Yuan 2013). | Resolved | |
| Rv0395 Rv0395 |
mtbc0_000414 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8csp-assembly1_5 Human mitochondrial small subunit assembly intermedia (prob 0.57, TM 0.50). | Still unknown | |
| Rv0396 Rv0396 |
mtbc0_000415 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5qhm-assembly1_A PanDDA analysis group deposition of models with model (prob 0.66, TM 0.69). | Still unknown | |
| Rv0397 Rv0397 |
- |
hypothetical protein | HNH endonuclease (eggNOG COG1403, defense COG category V), a member of the conserved 13E12-repeat protein family of M. tuberculosis. RefSeq leaves it 'hypothetical protein'. The HNH motif marks a nuclease active site; the cleavage target is undetermined. | Family assigned | |
| Rv0397A Rv0397A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7cjt-assembly1_D Crystal Structure of SETDB1 Tudor domain in complexed (prob 0.14, TM 0.67). | Still unknown | |
| Rv0398c Rv0398c |
mtbc0_000418 |
hypothetical protein | Secreted protein with a solved structure (PDB 7YD4, Rv0398c itself); fold characterised, precise function not established. | Family assigned | |
| Rv0421c Rv0421c |
mtbc0_000442 |
hypothetical protein | Alpha/beta family hydrolase. Pfam: Abhydrolase_11 (PF20408.5). | Abhydrolase_11 |
Family assigned |
| Rv0424c Rv0424c |
mtbc0_000445 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| napA Rv0430 |
mtbc0_000452 |
hypothetical protein | NapA, a nucleoid-associated protein (NAP) and DNA topology modulator. RefSeq leaves this locus 'hypothetical protein'. Rv0430 binds DNA in a length- and supercoil-dependent manner, prefers A/T-rich sequences, bridges distant DNA segments, coats DNA into inflexible rods, protects DNA from damaging agents, modulates supercoiling and stimulates the DNA-relaxation activity of topoisomerase I. It is the first gene of an operon harbouring the virulence regulators virR and sodC, controls their expression and stimulates its own promoter in a supercoiling-dependent manner, making it a supercoiling-responsive virulence regulator (Datta 2019). Experimentally characterised. | DUF3263 |
Resolved |
| Rv0434 Rv0434 |
mtbc0_000456 |
hypothetical protein | LON peptidase substrate-binding domain-containing protein. Pfam: LON_substr_bdg (PF02190.23). | LON_substr_bdg |
Family assigned |
| Rv0441c Rv0441c |
mtbc0_000463 |
hypothetical protein | Pyridoxamine 5'-phosphate oxidase family protein. | Family assigned | |
| Rv0443 Rv0443 |
mtbc0_000465 |
hypothetical protein | Mycothiol transferase. Pfam: MST (PF04978.18), DinB_2 (PF12867.13). | MST DinB_2 |
Resolved |
| Rv0448c Rv0448c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF1365. Function unknown. Foldseek best (non-significant) hit: 5n48-assembly2_C Structure of Anticalin N9B in complex with extra-doma (prob 0.04, TM 0.38). | DUF1365 |
Still unknown |
| Rv0449c Rv0449c |
mtbc0_000471 |
hypothetical protein | NAD(P)/FAD-dependent oxidoreductase. Pfam: NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | NAD_binding_8 Amino_oxidase |
Resolved |
| Rv0454 Rv0454 |
|
Conserved hypothetical protein | — | Still unknown | |
| Rv0455c Rv0455c |
mtbc0_000477 |
hypothetical protein | DUF5078; structure solved (PDB 8DRI, Rv0455c); fold characterised, function not established. | DUF5078 |
Family assigned |
| Rv0459 Rv0459 |
mtbc0_000483 |
hypothetical protein | Fe-S cluster assembly protein of the IscA/SufA/HesB (A-type Fe-S carrier, ATC) family: a scaffold/carrier delivering [2Fe-2S]/[4Fe-4S] clusters to apo-proteins. RefSeq/Mycobrowser leave it DUF779/hypothetical. RefSeq leaves this locus uncharacterised. | DUF779 |
Family assigned |
| Rv0460 Rv0460 |
- |
hypothetical protein | Contains Holin_9 (PF16936.11) domain(s); putative function inferred from the domain architecture. | Holin_9 |
Family assigned |
| Rv0464c Rv0464c |
mtbc0_000488 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| Rv0466 Rv0466 |
mtbc0_000490 |
hypothetical protein | Acyl-[acyl-carrier-protein] thioesterase. Pfam: Acyl-ACP_TE (PF01643.24), Acyl-ACP_TE_C (PF20791.4). | Acyl-ACP_TE Acyl-ACP_TE_C |
Resolved |
| Rv0470A Rv0470A |
- |
hypothetical protein | Candidate UbiA/MenA-family prenyltransferase (menaquinone-biosynthesis-related). Family handle from eggNOG COG1575 ('Belongs to the MenA family. Type 1 subfamily'), concordant with the UniProt TrEMBL name '1,4-dihydroxy-2-naphthoate prenyltransferase'. Family-level assignment only, not experimentally validated; carries a pseudogene-candidate flag and relaxed intra-MTBC selection, consistent with a possibly degrading paralogue of the primary menA (Rv0534c). | Family assigned | |
| Rv0471c Rv0471c |
mtbc0_000496 |
hypothetical protein | 1%2C4-dihydroxy-2-naphthoate prenyltransferase. | Resolved | |
| Rv0477 Rv0477 |
mtbc0_000502 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2599. Function unknown. Foldseek best (non-significant) hit: 3tgo-assembly2_D Crystal structure of the E. coli BamCD complex (prob 0.01, TM 0.15). | DUF2599 |
Still unknown |
| Rv0481c Rv0481c |
mtbc0_000506 |
hypothetical protein | DUF2505; ESMFold matches a START-like / Ups1 lipid-transfer fold (PDB 5JQM); putative lipid-binding protein. | DUF2505 |
Family assigned |
| Rv0487 Rv0487 |
mtbc0_000512 |
hypothetical protein | YbjN domain-containing protein. Pfam: YbjN (PF10722.15). | YbjN |
Family assigned |
| Rv0492A Rv0492A |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv0493c Rv0493c |
- |
hypothetical protein | Contains Tocopherol_cycl (PF14249.13) domain(s); putative function inferred from the domain architecture. | Tocopherol_cycl |
Family assigned |
| Rv0495c Rv0495c |
- |
hypothetical protein | Contains Rv0495c (PF11307.14) domain(s); putative function inferred from the domain architecture. | Rv0495c |
Family assigned |
| Rv0496 Rv0496 |
- |
hypothetical protein | Contains Ppx-GppA (PF02541.23) domain(s); putative function inferred from the domain architecture. | Ppx-GppA |
Family assigned |
| Rv0498 Rv0498 |
mtbc0_000524 |
hypothetical protein | Sugar phosphate isomerase/epimerase. Pfam: AP_endonuc_2 (PF01261.31). | AP_endonuc_2 |
Resolved |
| Rv0499 Rv0499 |
mtbc0_000525 |
hypothetical protein | Thioesterase family protein. Pfam: 4HBT_3 (PF13622.13), 4HBT_3C (PF20789.4). | 4HBT_3 4HBT_3C |
Family assigned |
| Rv0500B Rv0500B |
|
Conserved hypothetical protein | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds rRNA | COX24_C |
Family assigned |
| Rv0502 Rv0502 |
mtbc0_000530 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| Rv0504c Rv0504c |
mtbc0_000532 |
hypothetical protein | MaoC family dehydratase N-terminal domain-containing protein. Pfam: FAS1_DH_region (PF13452.12). | FAS1_DH_region |
Family assigned |
| Rv0508 Rv0508 |
mtbc0_000536 |
hypothetical protein | Glutaredoxin family protein. Pfam: Glrx-like (PF05768.21). | Glrx-like |
Family assigned |
| Rv0515 Rv0515 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat protein family (eggNOG COG1403, defense COG category V). RefSeq leaves it 'hypothetical protein'. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv0518 Rv0518 |
mtbc0_000546 |
hypothetical protein | SGNH/GDSL hydrolase family protein. Pfam: Lipase_GDSL (PF00657.29), Lipase_GDSL_2 (PF13472.13). | Lipase_GDSL Lipase_GDSL_2 |
Family assigned |
| Rv0523c Rv0523c |
mtbc0_000551 |
hypothetical protein | Nitroreductase family deazaflavin-dependent oxidoreductase. | Family assigned | |
| Rv0525 Rv0525 |
mtbc0_000553 |
hypothetical protein | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| Rv0530 Rv0530 |
mtbc0_000558 |
hypothetical protein | MinD/ParA family protein. Pfam: CbiA (PF01656.30), AAA_31 (PF13614.13), CBP_BcsQ (PF06564.19). | CbiA AAA_31 CBP_BcsQ |
Family assigned |
| Rv0530A Rv0530A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0540 Rv0540 |
mtbc0_000569 |
hypothetical protein | DUF2064; fold of a putative nucleotide-diphospho-sugar transferase (PDB 3CGX); putative sugar/nucleotidyl transferase. | DUF2064 |
Family assigned |
| Rv0543c Rv0543c |
mtbc0_000572 |
hypothetical protein | Member of the DUF3349 (PF11829) protein superfamily, found predominantly in Mycobacterium and Rhodococcus. The inaugural DUF3349 structure was solved for Rv0543c by NMR: a monomeric five-alpha-helix bundle (Buchko 2011); comparative structures show two structural subfamilies (Buchko 2020). Biological function unknown but family-restricted to these genera. | DUF3349 |
Family assigned |
| Rv0546c Rv0546c |
mtbc0_000575 |
hypothetical protein | VOC family protein. Pfam: Glyoxalase (PF00903.32). | Glyoxalase |
Family assigned |
| Rv0552 Rv0552 |
mtbc0_000581 |
hypothetical protein | Amidohydrolase. Pfam: Amidohydro_3 (PF07969.18), Amidohydro_1 (PF01979.27). | Amidohydro_3 Amidohydro_1 |
Resolved |
| Rv0559c Rv0559c |
mtbc0_000588 |
hypothetical protein | Lipoprotein of the LprJ-like family (secreted, salicylate/rifampicin-stress-induced). RefSeq leaves it 'hypothetical protein'. | DUF732 |
Family assigned |