Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1403c Rv1403c |
mtbc0_001504 |
methyltransferase | Class I SAM-dependent methyltransferase. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Ubie_methyltran Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| Rv1404 Rv1404 |
mtbc0_001505 |
transcriptional regulator | MarR family transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29). | MarR_2 MarR |
Family assigned |
| Rv1405c Rv1405c |
mtbc0_001506 |
methyltransferase | Virulence-associated methyltransferase. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Ubie_methyltran Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| fmt Rv1406 |
mtbc0_001507 |
methionyl-tRNA formyltransferase | Methionyl-tRNA formyltransferase. Pfam: Formyl_trans_N (PF00551.25), Formyl_trans_C (PF02911.24). | Formyl_trans_N Formyl_trans_C |
Resolved |
| fmu Rv1407 |
mtbc0_001508 |
16S rRNA m5C967 methyltransferase | 16S rRNA m5C967 methyltransferase. Pfam: NusB (PF01029.24), Methyltr_RsmB-F (PF01189.24). | NusB Methyltr_RsmB-F |
Resolved |
| rpe Rv1408 |
mtbc0_001509 |
ribulose-phosphate 3-epimerase | Ribulose-phosphate 3-epimerase. Pfam: Ribul_P_3_epim (PF00834.26). | Ribul_P_3_epim |
Resolved |
| ribG Rv1409 |
mtbc0_001510 |
bifunctional riboflavin biosynthesis diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase | Bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD. Pfam: dCMP_cyt_deam_1 (PF00383.30), MafB19-deam (PF14437.13), RibD_C (PF01872.23). | dCMP_cyt_deam_1 MafB19-deam RibD_C |
Resolved |
| Rv1410c Rv1410c |
mtbc0_001511 |
aminoglycosides/tetracycline-transport integral membrane protein | Aminoglycoside/tetracycline transporter. Pfam: MFS_1 (PF07690.22), TRI12 (PF06609.19), Sugar_tr (PF00083.31). | MFS_1 TRI12 Sugar_tr |
Resolved |
| lprG Rv1411c |
mtbc0_001512 |
lipoprotein LprG | Lipoarabinomannan carrier protein LprG. Pfam: LppX_LprAFG (PF07161.20). | LppX_LprAFG |
Resolved |
| ribC Rv1412 |
mtbc0_001513 |
riboflavin synthase | Riboflavin synthase. Pfam: Lum_binding (PF00677.24). | Lum_binding |
Resolved |
| Rv1413 Rv1413 |
- |
hypothetical protein | Contains Ala_racemase_N (PF01168.27) domain(s); putative function inferred from the domain architecture. | Ala_racemase_N |
Family assigned |
| Rv1414 Rv1414 |
- |
hypothetical protein | Contains D-ser_dehydrat (PF14031.14) domain(s); putative function inferred from the domain architecture. | D-ser_dehydrat |
Family assigned |
| ribA2 Rv1415 |
mtbc0_001515 |
bifunctional riboflavin biosynthesis GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase | Bifunctional 3%2C4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II. Pfam: DHBP_synthase (PF00926.25), GTP_cyclohydro2 (PF00925.26). | DHBP_synthase GTP_cyclohydro2 |
Resolved |
| ribH Rv1416 |
mtbc0_001516 |
6,7-dimethyl-8-ribityllumazine synthase | 6%2C7-dimethyl-8-ribityllumazine synthase. Pfam: DMRL_synthase (PF00885.25). | DMRL_synthase |
Resolved |
| Rv1417 Rv1417 |
mtbc0_001517 |
membrane protein | PH domain-containing protein. Pfam: bPH_6 (PF10756.16). | bPH_6 |
Family assigned |
| lprH Rv1418 |
mtbc0_001518 |
lipoprotein LprH | Lipoprotein LprH; a TLR2-stimulating lipoprotein of the M. tuberculosis complex (its over-expression enhances TLR2-dependent HIV infectivity of CD4+ T cells). Cell-envelope lipoprotein; precise molecular function unfixed. | Family assigned | |
| Rv1419 Rv1419 |
mtbc0_001519 |
hypothetical protein | Lectin. Pfam: Ricin_B_lectin (PF00652.29). | Ricin_B_lectin |
Resolved |
| uvrC Rv1420 |
mtbc0_001520 |
excinuclease ABC subunit UvrC | Excinuclease ABC subunit UvrC. Pfam: GIY-YIG (PF01541.31), UvrC_M (PF27096.1), UVR (PF02151.26), UvrC_RNaseH (PF22920.3), UvrC_RNaseH_dom (PF08459.18), HHH_5 (PF14520.13), HHH_2 (PF12826.14), HHH (PF00633.30). | GIY-YIG UvrC_M UVR UvrC_RNaseH UvrC_RNaseH_dom HHH_5 HHH_2 HHH |
Family assigned |
| rapZ Rv1421 |
mtbc0_001521 |
hypothetical protein | RNase adapter RapZ. Pfam: RapZ-like_N (PF03668.22), PapZ_C (PF22740.2). | RapZ-like_N PapZ_C |
Resolved |
| cuvA Rv1422 |
mtbc0_001522 |
hypothetical protein | Carbon utilization/virulence protein CuvA. Pfam: CofD (PF01933.24). | CofD |
Resolved |
| whiA Rv1423 |
mtbc0_001523 |
transcriptional regulator WhiA | DNA-binding protein WhiA. Pfam: WhiA_N (PF10298.15), LAGLIDADG_WhiA (PF14527.12), HTH_WhiA (PF02650.21). | WhiA_N LAGLIDADG_WhiA HTH_WhiA |
Family assigned |
| Rv1424c Rv1424c |
mtbc0_001524 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1425 Rv1425 |
mtbc0_001525 |
diacyglycerol O-acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| lipO Rv1426c |
mtbc0_001526 |
esterase LipO | Alpha/beta hydrolase. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), Peptidase_S9 (PF00326.28). | COesterase BD-FAE Abhydrolase_3 Peptidase_S9 |
Family assigned |
| fadD12 Rv1427c |
mtbc0_001527 |
acyl-CoA synthetase | Acyl-CoA ligase FadD12. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv1428c Rv1428c |
mtbc0_001528 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27), DAGAT (PF03982.19). | Acyltransferase DAGAT |
Family assigned |
| Rv1429 Rv1429 |
mtbc0_001529 |
hypothetical protein | PucR family transcriptional regulator. Pfam: RsbRD_N (PF14361.13), GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | RsbRD_N GGDEF_2 HTH_30 |
Family assigned |
| PE16 Rv1430 |
- |
PE family protein PE16 | PE family protein PE16. Pfam: PE (PF00934.26), PE-PPE (PF08237.18). | PE PE-PPE |
Family assigned |
| Rv1431 Rv1431 |
mtbc0_001531 |
hypothetical protein | Polytopic integral membrane protein with 11 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3556 |
Family assigned |
| Rv1432 Rv1432 |
mtbc0_001532 |
dehydrogenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), DAO (PF01266.31), Thi4 (PF01946.24), FAD_oxidored (PF12831.14), NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | FAD_binding_3 DAO Thi4 FAD_oxidored NAD_binding_8 Amino_oxidase |
Resolved |
| ldtMt3 Rv1433 |
mtbc0_001533 |
hypothetical protein | L%2CD-transpeptidase LdtMt3. Pfam: Big_10 (PF17964.8), YkuD (PF03734.20). | Big_10 YkuD |
Resolved |
| Rv1434 Rv1434 |
mtbc0_001534 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| hsr1 Rv1435c |
mtbc0_001535 |
hypothetical protein | Hsr1 (host splicing regulator 1), a secreted virulence factor that disrupts host snRNP biogenesis. RefSeq leaves it 'hypothetical'. Secreted Rv1435c/hsr1 targets specific exon-skipping events and facilitates a direct interaction between Mtb phagosomes and U5 snRNA and SNRPF; genetic deletion reverses the splicing changes and attenuates growth ex vivo and in vivo (Chauhan 2025). | Resolved | |
| gap Rv1436 |
mtbc0_001536 |
glyceraldehyde 3-phosphate dehydrogenase | Type I glyceraldehyde-3-phosphate dehydrogenase. Pfam: Gp_dh_N (PF00044.31), Gp_dh_C (PF02800.26). | Gp_dh_N Gp_dh_C |
Resolved |
| pgk Rv1437 |
mtbc0_001537 |
phosphoglycerate kinase | Phosphoglycerate kinase. Pfam: PGK (PF00162.25). | PGK |
Resolved |
| tpi Rv1438 |
mtbc0_001538 |
triosephosphate isomerase | Triose-phosphate isomerase. Pfam: TIM (PF00121.25). | TIM |
Resolved |
| Rv1439c Rv1439c |
mtbc0_001540 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_2 (PF12680.14). | SnoaL_2 |
Family assigned |
| secG Rv1440 |
mtbc0_001541 |
protein-export membrane protein SecG | Preprotein translocase subunit SecG. Pfam: SecG (PF03840.20). | SecG |
Family assigned |
| PE_PGRS26 Rv1441c |
- |
PE-PGRS family protein PE_PGRS26 | PE-PGRS family protein PE_PGRS26. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| bisC Rv1442 |
mtbc0_001543 |
biotin sulfoxide reductase BisC | Molybdopterin guanine dinucleotide-containing S/N-oxide reductase. Pfam: Molybdopterin_N (PF18364.7), Molybdopterin (PF00384.28), Molydop_binding (PF01568.28). | Molybdopterin_N Molybdopterin Molydop_binding |
Resolved |
| Rv1443c Rv1443c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1z94-assembly1_A X-Ray Crystal Structure of Protein CV1439 from Chromobacterium (prob 1.00, TM 0.76). Structure-based, putative. | DUF8410 |
Family assigned |
| Rv1444c Rv1444c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| devB Rv1445c |
mtbc0_001547 |
6-phosphogluconolactonase | 6-phosphogluconolactonase. Pfam: Glucosamine_iso (PF01182.27). | Glucosamine_iso |
Resolved |
| opcA Rv1446c |
mtbc0_001548 |
OXPP cycle protein OpcA | Glucose-6-phosphate dehydrogenase assembly protein OpcA. Pfam: OpcA_G6PD_assem (PF10128.16), OpcA_G6PD_C (PF20171.4). | OpcA_G6PD_assem OpcA_G6PD_C |
Resolved |
| zwf2 Rv1447c |
mtbc0_001549 |
glucose-6-phosphate 1-dehydrogenase | Glucose-6-phosphate dehydrogenase. Pfam: G6PD_N (PF00479.29), G6PD_C (PF02781.22). | G6PD_N G6PD_C |
Resolved |
| tal Rv1448c |
mtbc0_001550 |
transaldolase | Transaldolase. Pfam: TAL_FSA (PF00923.26). | TAL_FSA |
Resolved |
| tkt Rv1449c |
mtbc0_001551 |
transketolase | Transketolase. Pfam: Transketolase_N (PF00456.27), Transket_pyr (PF02779.30), Transketolase_C_1 (PF22613.2), Transketolase_C (PF02780.26). | Transketolase_N Transket_pyr Transketolase_C_1 Transketolase_C |
Resolved |
| PE_PGRS27 Rv1450c |
- |
PE-PGRS family protein PE_PGRS27 | PE-PGRS family protein PE_PGRS27. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| ctaB Rv1451 |
mtbc0_001553 |
protoheme IX farnesyltransferase | Heme o synthase. Pfam: UbiA (PF01040.24). | UbiA |
Resolved |
| PE_PGRS28 Rv1452c |
- |
PE-PGRS family protein PE_PGRS28 | PE-PGRS family protein PE_PGRS28. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |