Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1231c Rv1231c |
mtbc0_001320 |
membrane protein | Membrane protein (2 predicted TM helices) co-transcribed with mgtE (a CBS-domain Mg2+ transporter) as a two-gene operon, under purifying selection. Contextual candidate: associated with magnesium transport / homeostasis. Its molecular role is not established. | DUF1003 |
Family assigned |
| Rv1232c Rv1232c |
mtbc0_001321 |
hypothetical protein | Magnesium transporter. Pfam: SH3_actinomycetes (PF26205.1), MgtE_N (PF03448.23), CBS (PF00571.34). | SH3_actinomycetes MgtE_N CBS |
Resolved |
| Rv1233c Rv1233c |
mtbc0_001322 |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF4190 |
Family assigned |
| Rv1234 Rv1234 |
mtbc0_001323 |
transmembrane protein | General stress protein. Pfam: YflT (PF11181.14). | YflT |
Resolved |
| lpqY Rv1235 |
mtbc0_001324 |
trehalose ABC transporter substrate-binding lipoprotein LpqY | Trehalose ABC transporter substrate-binding protein LpqY. Pfam: SBP_bac_1 (PF01547.31), SBP_bac_8 (PF13416.12). | SBP_bac_1 SBP_bac_8 |
Family assigned |
| sugA Rv1236 |
mtbc0_001325 |
sugar ABC transporter permease SugA | Trehalose ABC transporter permease SugA. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| sugB Rv1237 |
mtbc0_001326 |
sugar ABC transporter permease SugB | Trehalose ABC transporter permease SugB. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| sugC Rv1238 |
mtbc0_001327 |
sugar ABC transporter ATP-binding protein SugC | Trehalose ABC transporter ATP-binding protein SugC. Pfam: ABC_tran (PF00005.34), OB_MalK (PF17912.8). | ABC_tran OB_MalK |
Family assigned |
| corA Rv1239c |
mtbc0_001328 |
magnesium and cobalt transport transmembrane protein CorA | Magnesium/cobalt transporter CorA. Pfam: CorA (PF01544.24). | CorA |
Resolved |
| mdh Rv1240 |
mtbc0_001329 |
malate dehydrogenase | Malate dehydrogenase. Pfam: Ldh_1_N (PF00056.30), Ldh_1_C (PF02866.24). | Ldh_1_N Ldh_1_C |
Resolved |
| vapB33 Rv1241 |
mtbc0_001330 |
antitoxin VapB33 | Type II toxin-antitoxin system antitoxin VapB33. | Resolved | |
| vapC33 Rv1242 |
mtbc0_001331 |
ribonuclease VapC33 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| PE_PGRS23 Rv1243c |
- |
PE-PGRS family protein PE_PGRS23 | PE-PGRS family protein PE_PGRS23. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| lpqZ Rv1244 |
mtbc0_001333 |
lipoprotein LpqZ | Glycine betaine ABC transporter substrate-binding protein. Pfam: OpuAC (PF04069.18). | OpuAC |
Family assigned |
| Rv1245c Rv1245c |
mtbc0_001334 |
short-chain type dehydrogenase/reductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| relE Rv1246c |
mtbc0_001335 |
toxin RelE | Type II toxin-antitoxin system mRNA interferase RelE. Pfam: ParE_toxin (PF05016.22). | ParE_toxin |
Resolved |
| relB Rv1247c |
mtbc0_001336 |
antitoxin RelB | Type II toxin-antitoxin system Phd/YefM family antitoxin. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Family assigned |
| Rv1248c Rv1248c |
mtbc0_001337 |
multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase | Multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit. Pfam: 2-oxogl_dehyd_N (PF16078.11), 2-oxoacid_dh (PF00198.29), E1_dh (PF00676.26), Transket_pyr (PF02779.30), OxoGdeHyase_C (PF16870.11). | 2-oxogl_dehyd_N 2-oxoacid_dh E1_dh Transket_pyr OxoGdeHyase_C |
Family assigned |
| Rv1249c Rv1249c |
mtbc0_001338 |
membrane protein | Hydantoinase / 5-oxoprolinase (ATP-hydrolysing) family enzyme (eggNOG COG1540, COG category R). RefSeq leaves it 'hypothetical protein'. ATP-dependent amidohydrolase activity; exact substrate undetermined. | Family assigned | |
| Rv1250 Rv1250 |
mtbc0_001339 |
MFS-type drug transporter | MFS transporter. Pfam: MFS_1 (PF07690.22), TRI12 (PF06609.19), Sugar_tr (PF00083.31), PUCC (PF03209.22). | MFS_1 TRI12 Sugar_tr PUCC |
Resolved |
| Rv1251c Rv1251c |
mtbc0_001340 |
hypothetical protein | TM0106 family RecB-like putative nuclease. Pfam: PDDEXK_1 (PF12705.14), RNase_H_2 (PF13482.13), AAA_19 (PF13245.13), AAA_30 (PF13604.13), NAT10_TcmA_helicase (PF05127.22), AAA_12 (PF13087.13). | PDDEXK_1 RNase_H_2 AAA_19 AAA_30 NAT10_TcmA_helicase AAA_12 |
Family assigned |
| lprE Rv1252c |
mtbc0_001341 |
lipoprotein LprE | LppP/LprE family lipoprotein. Pfam: Lipoprotein_21 (PF14041.12). | Lipoprotein_21 |
Family assigned |
| deaD Rv1253 |
mtbc0_001342 |
ATP-dependent RNA helicase DeaD | DEAD/DEAH box helicase. Pfam: DEAD (PF00270.36), Helicase_C (PF00271.38), DeaD_dimer (PF25399.2), DbpA (PF03880.22). | DEAD Helicase_C DeaD_dimer DbpA |
Resolved |
| Rv1254 Rv1254 |
mtbc0_001343 |
acyltransferase | Acyltransferase. Pfam: Acyl_transf_3 (PF01757.29). | Acyl_transf_3 |
Resolved |
| Rv1255c Rv1255c |
mtbc0_001344 |
HTH-type transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| cyp130 Rv1256c |
mtbc0_001345 |
cytochrome P450 Cyp130 | Cytochrome P450 Cyp130. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv1257c Rv1257c |
mtbc0_001346 |
oxidoreductase | FAD-linked oxidase C-terminal domain-containing protein. Pfam: FAD_binding_4 (PF01565.29), FAD-oxidase_C (PF02913.25). | FAD_binding_4 FAD-oxidase_C |
Family assigned |
| Rv1258c Rv1258c |
mtbc0_001347 |
multidrug-efflux transporter | MFS transporter. Pfam: MFS_1 (PF07690.22), MFS_3 (PF05977.20). | MFS_1 MFS_3 |
Resolved |
| udgB Rv1259 |
- |
uracil DNA glycosylase | Uracil DNA glycosylase. Pfam: UDG (PF03167.26). | UDG |
Resolved |
| Rv1260 Rv1260 |
mtbc0_001349 |
oxidoreductase | FAD-binding protein. Pfam: FAD_binding_3 (PF01494.26). | FAD_binding_3 |
Family assigned |
| Rv1261c Rv1261c |
mtbc0_001350 |
hypothetical protein | F420H(2)-dependent quinone reductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| Rv1262c Rv1262c |
mtbc0_001351 |
hypothetical protein | HIT family protein. Pfam: DcpS_C (PF11969.14), HIT (PF01230.30). | DcpS_C HIT |
Family assigned |
| amiB2 Rv1263 |
mtbc0_001352 |
amidase AmiB | Amidase. Pfam: Amidase (PF01425.27). | Amidase |
Resolved |
| Rv1264 Rv1264 |
mtbc0_001353 |
adenylyl cyclase | Adenylate cyclase. Pfam: Ad_Cy_reg (PF16701.11), Guanylate_cyc (PF00211.26). | Ad_Cy_reg Guanylate_cyc |
Resolved |
| Rv1265 Rv1265 |
- |
hypothetical protein | Contains Rv1265_N (PF27105.1), Mb1296_C (PF27540.1) domain(s); putative function inferred from the domain architecture. | Rv1265_N Mb1296_C |
Family assigned |
| pknH Rv1266c |
mtbc0_001355 |
serine/threonine-protein kinase PknH | Serine/threonine protein kinase PknH. Pfam: Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), PknH_C (PF14032.13). | Pkinase PK_Tyr_Ser-Thr PknH_C |
Resolved |
| embR Rv1267c |
mtbc0_001357 |
transcriptional regulator EmbR | Response regulator transcription factor EmbR. Pfam: Trans_reg_C (PF00486.35), BTAD (PF03704.24), Yop-YscD_cpl (PF16697.11), FHA (PF00498.32). | Trans_reg_C BTAD Yop-YscD_cpl FHA |
Resolved |
| Rv1268c Rv1268c |
mtbc0_001358 |
hypothetical protein | C39 family peptidase. Pfam: Peptidase_C39_2 (PF13529.14). | Peptidase_C39_2 |
Family assigned |
| Rv1269c Rv1269c |
mtbc0_001359 |
hypothetical protein | DUF4189; same fold as Rv1813c (PDB 7NHZ); secreted DUF4189-family protein. | DUF4189 |
Family assigned |
| lprA Rv1270c |
mtbc0_001360 |
lipoprotein LprA | TLR2 agonist LprA. Pfam: LppX_LprAFG (PF07161.20). | LppX_LprAFG |
Resolved |
| Rv1271c Rv1271c |
mtbc0_001361 |
hypothetical protein | Secreted protein recognised as an antigen (antibody responses during active TB). Pfam DUF732 (a mycobacterial domain of unknown function). Molecular function unfixed. | DUF732 |
Family assigned |
| Rv1272c Rv1272c |
mtbc0_001362 |
drug ABC transporter ATP-binding protein | Fatty acid ABC transporter ATP-binding protein/permease. Pfam: ABC_membrane (PF00664.29), ABC_tran (PF00005.34). | ABC_membrane ABC_tran |
Family assigned |
| Rv1273c Rv1273c |
mtbc0_001363 |
drug ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_membrane (PF00664.29), ABC_tran (PF00005.34). | ABC_membrane ABC_tran |
Family assigned |
| lprB Rv1274 |
mtbc0_001364 |
lipoprotein LprB | Ribosome-associated heat-shock protein of the Hsp15/RimP-like family (eggNOG COG1188, translation COG category J), containing an S4 RNA-binding domain implicated in 50S-subunit recycling. Ribosome-associated function at family level. | DUF3558 |
Family assigned |
| lprC Rv1275 |
mtbc0_001365 |
lipoprotein LprC | Lipoprotein of the Lpr (LprB/LprC) family. RefSeq product 'lipoprotein LprC'. | DUF3558 |
Family assigned |
| Rv1276c Rv1276c |
- |
hypothetical protein | Contains His_Phos_1 (PF00300.28) domain(s); putative function inferred from the domain architecture. | His_Phos_1 |
Family assigned |
| Rv1277 Rv1277 |
- |
hypothetical protein | Contains Metallophos (PF00149.34) domain(s); putative function inferred from the domain architecture. | Metallophos |
Family assigned |
| Rv1278 Rv1278 |
mtbc0_001368 |
hypothetical protein | AAA family ATPase. Pfam: AAA_15 (PF13175.13), AAA_27 (PF13514.13), AAA_23 (PF13476.13). | AAA_15 AAA_27 AAA_23 |
Family assigned |
| Rv1279 Rv1279 |
mtbc0_001369 |
GMC-type oxidoreductase | GMC family oxidoreductase N-terminal domain-containing protein. Pfam: GMC_oxred_N (PF00732.26), GMC_oxred_C (PF05199.20). | GMC_oxred_N GMC_oxred_C |
Family assigned |
| oppA Rv1280c |
mtbc0_001370 |
oligopeptide ABC transporter substrate-binding lipoprotein OppA | Oligopeptide ABC transporter substrate-binding protein OppA. Pfam: SBP_bac_5 (PF00496.28). | SBP_bac_5 |
Family assigned |