Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0393 Rv0393 |
- |
hypothetical protein | Member of the conserved 13E12 (REP13E12) repeat protein family. RefSeq leaves it of unknown function. Identified as a conserved component (P95201) of M. tuberculosis extracellular vesicles, proposed as an MEV marker (Ryan 2025). The REP13E12 repeats serve as prophage (phiRv1) attachment sites. Molecular function unfixed. | DUF222 |
Family assigned |
| Rv0394c Rv0394c |
mtbc0_000413 |
hypothetical protein | Hyaluronidase / chondroitin-sulfatase; lets M. tuberculosis use host hyaluronan as an alternative carbon source (Yuan 2013). | Resolved | |
| Rv0395 Rv0395 |
mtbc0_000414 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8csp-assembly1_5 Human mitochondrial small subunit assembly intermedia (prob 0.57, TM 0.50). | Still unknown | |
| Rv0396 Rv0396 |
mtbc0_000415 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5qhm-assembly1_A PanDDA analysis group deposition of models with model (prob 0.66, TM 0.69). | Still unknown | |
| Rv0397 Rv0397 |
- |
hypothetical protein | HNH endonuclease (eggNOG COG1403, defense COG category V), a member of the conserved 13E12-repeat protein family of M. tuberculosis. RefSeq leaves it 'hypothetical protein'. The HNH motif marks a nuclease active site; the cleavage target is undetermined. | Family assigned | |
| Rv0397A Rv0397A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7cjt-assembly1_D Crystal Structure of SETDB1 Tudor domain in complexed (prob 0.14, TM 0.67). | Still unknown | |
| Rv0398c Rv0398c |
mtbc0_000418 |
hypothetical protein | Secreted protein with a solved structure (PDB 7YD4, Rv0398c itself); fold characterised, precise function not established. | Family assigned | |
| lpqK Rv0399c |
mtbc0_000419 |
lipoprotein LpqK | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| fadE7 Rv0400c |
mtbc0_000420 |
acyl-CoA dehydrogenase FadE7 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Resolved |
| Rv0401 Rv0401 |
mtbc0_000421 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3054. Function unknown. | DUF3054 |
Still unknown |
| mmpL1 Rv0402c |
mtbc0_000422 |
transmembrane transport protein MmpL1 | RND transporter MmpL1. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| mmpS1 Rv0403c |
mtbc0_000423 |
membrane protein MmpS1 | MmpS family protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| fadD30 Rv0404 |
- |
long-chain-fatty-acid--AMP ligase FadD30 | Long-chain-fatty-acid--AMP ligase FadD30. Pfam: AMP-binding (PF00501.35), AMP-dom_DIP2-like (PF23024.2). | AMP-binding AMP-dom_DIP2-like |
Resolved |
| pks6 Rv0405 |
- |
membrane bound polyketide synthase | Membrane bound polyketide synthase. Pfam: ketoacyl-synt (PF00109.33), Ketoacyl-synt_C (PF02801.29), KAsynt_C_assoc (PF16197.12), CurL-like_PKS_C (PF22621.3), Acyl_transf_1 (PF00698.27), PP-binding (PF00550.32), Thioesterase (PF00975.27). | ketoacyl-synt Ketoacyl-synt_C KAsynt_C_assoc CurL-like_PKS_C Acyl_transf_1 PP-binding Thioesterase |
Resolved |
| Rv0406c Rv0406c |
- |
beta lactamase-like protein | Beta lactamase-like protein. Pfam: Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14). | Lactamase_B Lactamase_B_2 |
Family assigned |
| fgd1 Rv0407 |
mtbc0_000427 |
F420-dependent glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase (coenzyme-F420). Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| pta Rv0408 |
mtbc0_000428 |
phosphate acetyltransferase | Phosphate acetyltransferase. Pfam: AAA_26 (PF13500.13), DRTGG (PF07085.18), PTA_PTB (PF01515.25). | AAA_26 DRTGG PTA_PTB |
Resolved |
| ackA Rv0409 |
mtbc0_000429 |
acetate kinase | Acetate kinase. Pfam: Acetate_kinase (PF00871.24). | Acetate_kinase |
Resolved |
| pknG Rv0410c |
mtbc0_000430 |
serine/threonine-protein kinase PknG | Serine/threonine protein kinase PknG. Pfam: PknG_rubred (PF16919.12), Pkinase (PF00069.32), PK_Tyr_Ser-Thr (PF07714.24), PknG_TPR (PF16918.12). | PknG_rubred Pkinase PK_Tyr_Ser-Thr PknG_TPR |
Resolved |
| glnH Rv0411c |
mtbc0_000431 |
glutamine-binding lipoprotein GlnH | Glutamate ABC transporter substrate-binding protein. Pfam: SBP_bac_3 (PF00497.26). | SBP_bac_3 |
Family assigned |
| glnX Rv0412c |
mtbc0_000432 |
membrane protein | Protein kinase G-activating protein GlnX. Pfam: Sensor_actino (PF28326.1). | Sensor_actino |
Resolved |
| mutT3 Rv0413 |
- |
8-oxo-dGTP diphosphatase | 8-oxo-dGTP diphosphatase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| thiE Rv0414c |
mtbc0_000434 |
thiamine-phosphate synthase | Thiamine phosphate synthase. Pfam: TMP-TENI (PF02581.24). | TMP-TENI |
Resolved |
| thiO Rv0415 |
mtbc0_000435 |
thiamine biosynthesis oxidoreductase ThiO | Glycine oxidase ThiO. Pfam: DAO (PF01266.31). | DAO |
Resolved |
| thiS Rv0416 |
mtbc0_000436 |
sulfur carrier protein ThiS | Sulfur carrier protein ThiS. Pfam: ThiS (PF02597.27). | ThiS |
Resolved |
| thiG Rv0417 |
mtbc0_000437 |
thiazole synthase | Thiazole synthase. Pfam: ThiG (PF05690.21). | ThiG |
Resolved |
| lpqL Rv0418 |
mtbc0_000439 |
lipoprotein aminopeptidase LpqL | M28 family metallopeptidase. Pfam: PA (PF02225.28), Peptidase_M28 (PF04389.23), Peptidase_M20 (PF01546.34). | PA Peptidase_M28 Peptidase_M20 |
Family assigned |
| lpqM Rv0419 |
mtbc0_000440 |
lipoprotein peptidase LpqM | Neutral zinc metallopeptidase. | Resolved | |
| Rv0420c Rv0420c |
- |
transmembrane protein | Transmembrane protein. | Resolved | |
| Rv0421c Rv0421c |
mtbc0_000442 |
hypothetical protein | Alpha/beta family hydrolase. Pfam: Abhydrolase_11 (PF20408.5). | Abhydrolase_11 |
Family assigned |
| thiD Rv0422c |
- |
hydroxymethylpyrimidine/phosphomethylpyrimidine kinase | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. Pfam: Phos_pyr_kin (PF08543.18), PfkB (PF00294.30). | Phos_pyr_kin PfkB |
Resolved |
| thiC Rv0423c |
mtbc0_000444 |
phosphomethylpyrimidine synthase | Phosphomethylpyrimidine synthase ThiC. Pfam: ThiC-associated (PF13667.12), ThiC_Rad_SAM (PF01964.25). | ThiC-associated ThiC_Rad_SAM |
Resolved |
| Rv0424c Rv0424c |
mtbc0_000445 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| ctpH Rv0425c |
mtbc0_000447 |
metal cation transporting ATPase H | Cation-translocating P-type ATPase. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33), Cation_ATPase (PF13246.13), Cation_ATPase_C (PF00689.27). | E1-E2_ATPase Hydrolase Cation_ATPase Cation_ATPase_C |
Resolved |
| Rv0426c Rv0426c |
mtbc0_000448 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| xthA Rv0427c |
- |
exodeoxyribonuclease III protein XthA | Exodeoxyribonuclease III protein XthA. Pfam: Exo_endo_phos (PF03372.30). | Exo_endo_phos |
Resolved |
| Rv0428c Rv0428c |
mtbc0_000450 |
GCN5-like N-acetyltransferase | GNAT family N-acetyltransferase. Pfam: SH3_Rv0428c (PF24551.2), Rv0428c_C (PF24553.3). | SH3_Rv0428c Rv0428c_C |
Family assigned |
| def Rv0429c |
mtbc0_000451 |
polypeptide deformylase | Peptide deformylase. Pfam: Pep_deformylase (PF01327.27). | Pep_deformylase |
Resolved |
| napA Rv0430 |
mtbc0_000452 |
hypothetical protein | NapA, a nucleoid-associated protein (NAP) and DNA topology modulator. RefSeq leaves this locus 'hypothetical protein'. Rv0430 binds DNA in a length- and supercoil-dependent manner, prefers A/T-rich sequences, bridges distant DNA segments, coats DNA into inflexible rods, protects DNA from damaging agents, modulates supercoiling and stimulates the DNA-relaxation activity of topoisomerase I. It is the first gene of an operon harbouring the virulence regulators virR and sodC, controls their expression and stimulates its own promoter in a supercoiling-dependent manner, making it a supercoiling-responsive virulence regulator (Datta 2019). Experimentally characterised. | DUF3263 |
Resolved |
| Rv0431 Rv0431 |
- |
tuberculin-like peptide | Tuberculin-like peptide. Pfam: LytR_C (PF13399.12). | LytR_C |
Resolved |
| sodC Rv0432 |
mtbc0_000454 |
superoxide dismutase | Superoxide dismutase family protein. Pfam: Sod_Cu (PF00080.26). | Sod_Cu |
Family assigned |
| Rv0433 Rv0433 |
mtbc0_000455 |
carboxylate-amine ligase | Glutamate--cysteine ligase. Pfam: GCS2 (PF04107.19). | GCS2 |
Resolved |
| Rv0434 Rv0434 |
mtbc0_000456 |
hypothetical protein | LON peptidase substrate-binding domain-containing protein. Pfam: LON_substr_bdg (PF02190.23). | LON_substr_bdg |
Family assigned |
| Rv0435c Rv0435c |
mtbc0_000457 |
ATPase | AAA family ATPase. Pfam: CDC48_N (PF02359.25), AAA (PF00004.36), AAA_lid_3 (PF17862.8). | CDC48_N AAA AAA_lid_3 |
Family assigned |
| pssA Rv0436c |
mtbc0_000458 |
CDP-diacylglycerol--serine O-phosphatidyltransferase | CDP-diacylglycerol--serine O-phosphatidyltransferase. Pfam: CDP-OH_P_transf (PF01066.27). | CDP-OH_P_transf |
Resolved |
| psd Rv0437c |
mtbc0_000459 |
phosphatidylserine decarboxylase | Phosphatidylserine decarboxylase. Pfam: PS_Dcarbxylase (PF02666.21). | PS_Dcarbxylase |
Resolved |
| moeA2 Rv0438c |
- |
molybdopterin molybdenumtransferase | Molybdopterin molybdenumtransferase. Pfam: MoeA_N (PF03453.23), MoCF_biosynth (PF00994.30), MoeA_C (PF03454.21). | MoeA_N MoCF_biosynth MoeA_C |
Resolved |
| Rv0439c Rv0439c |
mtbc0_000461 |
dehydrogenase/reductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13). | adh_short KR Epimerase adh_short_C2 |
Family assigned |
| groEL2 Rv0440 |
mtbc0_000462 |
molecular chaperone GroEL | Chaperonin GroEL. Pfam: Cpn60_TCP1 (PF00118.30). | Cpn60_TCP1 |
Resolved |
| Rv0441c Rv0441c |
mtbc0_000463 |
hypothetical protein | Pyridoxamine 5'-phosphate oxidase family protein. | Family assigned |