Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3618 Rv3618 |
mtbc0_003835 |
monooxygenase | LLM class flavin-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| esxV Rv3619c |
- |
ESAT-6 like protein EsxV | ESAT-6 like protein EsxV. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| esxW Rv3620c |
mtbc0_003837 |
ESAT-6 like protein EsxW | Type VII secretion system protein EsxW. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| PPE65 Rv3621c |
- |
PPE family protein PPE65 | PPE family protein PPE65. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PE32 Rv3622c |
- |
PE family protein PE32 | PE family protein PE32. Pfam: PE (PF00934.26). | PE |
Family assigned |
| lpqG Rv3623 |
mtbc0_003840 |
lipoprotein LpqG | SIMPL domain-containing protein. Pfam: SIMPL (PF04402.20). | SIMPL |
Family assigned |
| hpt Rv3624c |
mtbc0_003841 |
hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine phosphoribosyltransferase. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Resolved |
| mesJ Rv3625c |
mtbc0_003842 |
tRNA(Ile)-lysidine synthase | TRNA lysidine(34) synthetase TilS. Pfam: ATP_bind_3 (PF01171.27), TilS (PF09179.17). | ATP_bind_3 TilS |
Resolved |
| Rv3626c Rv3626c |
mtbc0_003843 |
hypothetical protein | Zinc-dependent metalloprotease. Pfam: Zincin_2 (PF10103.16). | Zincin_2 |
Resolved |
| dacB Rv3627c |
mtbc0_003844 |
hypothetical protein | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase. Pfam: Rv3627c_N (PF23714.2), Peptidase_S13 (PF02113.21). | Rv3627c_N Peptidase_S13 |
Resolved |
| ppa Rv3628 |
mtbc0_003845 |
inorganic pyrophosphatase | Inorganic diphosphatase. Pfam: Pyrophosphatase (PF00719.25). | Pyrophosphatase |
Resolved |
| Rv3629c Rv3629c |
mtbc0_003846 |
integral membrane protein | DUF475 domain-containing protein. Pfam: TerC (PF03741.23), DUF475 (PF04332.22). | TerC DUF475 |
Family assigned |
| Rv3630 Rv3630 |
mtbc0_003847 |
integral membrane protein | Membrane lipid flippase / transporter (Lipid-III-flippase-like fold). RefSeq leaves it 'integral membrane protein'. Resolves the earlier MDR-transporter structural ambiguity toward a lipid-flipping membrane transporter. | Family assigned | |
| Rv3631 Rv3631 |
mtbc0_003848 |
transferase | Glycosyltransferase family 2 protein. Pfam: Glycos_transf_2 (PF00535.33). | Glycos_transf_2 |
Family assigned |
| Rv3632 Rv3632 |
mtbc0_003849 |
membrane protein | Small membrane protein that potentiates galactosamine modification of arabinogalactan. RefSeq leaves it of unknown function. Rv3632 is co-transcribed with ppgS (Rv3631, polyprenyl-phospho-N-acetyl-galactosaminyl synthase) and increases PpgS catalytic activity 40-50-fold, supporting the GalN modification of arabinogalactan (Skovierova 2010). Its cell-envelope peptides also bind host cells (adhesion). | DUF2304 |
Family assigned |
| Rv3633 Rv3633 |
mtbc0_003850 |
hypothetical protein | Phytanoyl-CoA dioxygenase family protein. Pfam: PhyH (PF05721.20). | PhyH |
Family assigned |
| galE1 Rv3634c |
mtbc0_003851 |
UDP-glucose 4-epimerase | UDP-glucose 4-epimerase. Pfam: RmlD_sub_bind (PF04321.24), Epimerase (PF01370.28), GDP_Man_Dehyd (PF16363.12), 3Beta_HSD (PF01073.26), Polysacc_synt_2 (PF02719.22), NAD_binding_10 (PF13460.13), NAD_binding_4 (PF07993.19). | RmlD_sub_bind Epimerase GDP_Man_Dehyd 3Beta_HSD Polysacc_synt_2 NAD_binding_10 NAD_binding_4 |
Resolved |
| Rv3635 Rv3635 |
mtbc0_003852 |
transmembrane protein | Apolipoprotein-N-acyltransferase-family membrane enzyme (eggNOG COG0815, cell-envelope COG category M): transfers a fatty-acyl group onto membrane lipoproteins (lipoprotein N-acylation / maturation). RefSeq leaves it a 'conserved transmembrane protein'. Family/activity-level; not asserted as the sole M. tuberculosis Lnt. | Family assigned | |
| Rv3638 Rv3638 |
mtbc0_003854 |
transposase | ATP-binding protein. Pfam: IstB_IS21 (PF01695.24). | IstB_IS21 |
Family assigned |
| Rv3639c Rv3639c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8vdu-assembly1_E Crystal structure of hybrid insulin peptide (InsC8-15 (prob 0.01, TM 0.17). | Still unknown | |
| Rv3640c Rv3640c |
mtbc0_003855 |
transposase | IS256-like element IS1553 family transposase. Pfam: Transposase_mut (PF00872.25). | Transposase_mut |
Family assigned |
| fic Rv3641c |
mtbc0_003856 |
cell filamentation protein Fic | Fic/DOC family protein. Pfam: Fic (PF02661.24). | Fic |
Family assigned |
| Rv3642c Rv3642c |
mtbc0_003857 |
hypothetical protein | Antitoxin VbhA family protein. Pfam: VbhA (PF18495.7). | VbhA |
Family assigned |
| Rv3643 Rv3643 |
mtbc0_003859 |
hypothetical protein | Tyrosine-recombinase / integrase-family fold (small, 63 aa); candidate site-specific recombination / mobile-element-associated protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3644c Rv3644c |
mtbc0_003861 |
DNA polymerase | DNA polymerase III subunit delta'. Pfam: DNA_pol3_delta2 (PF13177.13), AAA (PF00004.36), DNApol3-delta_C (PF09115.16). | DNA_pol3_delta2 AAA DNApol3-delta_C |
Family assigned |
| Rv3645 Rv3645 |
mtbc0_003862 |
transmembrane protein | Adenylate/guanylate cyclase domain-containing protein. Pfam: HAMP (PF00672.31), Guanylate_cyc (PF00211.26). | HAMP Guanylate_cyc |
Family assigned |
| topA Rv3646c |
mtbc0_003863 |
DNA topoisomerase I | Type I DNA topoisomerase. Pfam: Toprim (PF01751.29), Topoisom_bac (PF01131.26), Toprim_C_rpt (PF13368.12). | Toprim Topoisom_bac Toprim_C_rpt |
Resolved |
| Rv3647c Rv3647c |
mtbc0_003864 |
hypothetical protein | WhiA-like cell-division / homeostasis protein (LAGLIDADG-derived DNA-binding fold). RefSeq leaves it 'hypothetical protein'. Distinct from whiA/Rv3641c. | Family assigned | |
| cspA Rv3648c |
mtbc0_003865 |
cold shock protein A | Cold shock protein CspA. Pfam: CSD (PF00313.29). | CSD |
Resolved |
| Rv3649 Rv3649 |
mtbc0_000791 |
helicase | DEAD/DEAH box helicase. Pfam: DEAD (PF00270.36), Helicase_C (PF00271.38), WHD_HRQ1 (PF22982.4), MZB (PF09369.16). | DEAD Helicase_C WHD_HRQ1 MZB |
Resolved |
| PE33 Rv3650 |
- |
PE family protein PE33 | PE family protein PE33. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv3651 Rv3651 |
mtbc0_003868 |
hypothetical protein | DUF5628 domain-containing protein. Pfam: Rv3651-like_N (PF18007.8), Rv3651-like_middle (PF18621.8), Rv3651-like_C (PF21043.4). | Rv3651-like_N Rv3651-like_middle Rv3651-like_C |
Family assigned |
| PE_PGRS60 Rv3652 |
- |
PE-PGRS family-related protein PE_PGRS60 | PE-PGRS family-related protein PE_PGRS60. Pfam: PE (PF00934.26). | PE |
Family assigned |
| PE_PGRS61 Rv3653 |
- |
PE-PGRS family-related protein PE_PGRS61 | PE-PGRS family-related protein PE_PGRS61. Pfam: PGRS (PF21526.3). | PGRS |
Family assigned |
| Rv3654c Rv3654c |
- |
hypothetical protein | Contains Tad (PF13400.12) domain(s); putative function inferred from the domain architecture. | Tad |
Family assigned |
| Rv3655c Rv3655c |
mtbc0_003873 |
hypothetical protein | Apoptosis inhibitor. | Resolved | |
| Rv3656c Rv3656c |
mtbc0_003874 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4244. Function unknown. | DUF4244 |
Still unknown |
| Rv3657c Rv3657c |
- |
membrane protein | Membrane protein. Pfam: T2SSF (PF00482.29). | T2SSF |
Family assigned |
| Rv3658c Rv3658c |
mtbc0_003876 |
transmembrane protein | Type II secretion system F family protein. Pfam: T2SSF (PF00482.29). | T2SSF |
Family assigned |
| Rv3659c Rv3659c |
- |
conjugal transfer protein | Conjugal transfer protein. Pfam: T2SSE (PF00437.27). | T2SSE |
Resolved |
| ssd Rv3660c |
mtbc0_003878 |
hypothetical protein | Septum site-determining protein Ssd. Pfam: Rv3660c_N (PF26563.1). | Rv3660c_N |
Resolved |
| Rv3661 Rv3661 |
mtbc0_003879 |
hypothetical protein | HAD-IB family hydrolase. Pfam: Hydrolase (PF00702.33), HAD (PF12710.14). | Hydrolase HAD |
Family assigned |
| Rv3662c Rv3662c |
mtbc0_003880 |
hypothetical protein | Oxidoreductase. | Resolved | |
| dppD Rv3663c |
mtbc0_003881 |
dipeptide ABC transporter ATP-binding protein DppD | ABC transporter ATP-binding protein. Pfam: oligo_HPY (PF08352.18), ABC_tran (PF00005.34). | oligo_HPY ABC_tran |
Family assigned |
| dppC Rv3664c |
- |
dipeptide ABC transporter permease DppC | Dipeptide ABC transporter permease DppC. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| dppB Rv3665c |
mtbc0_003883 |
dipeptide ABC transporter permease DppB | ABC transporter permease. Pfam: BPD_transp_1_N (PF19300.5), BPD_transp_1 (PF00528.28). | BPD_transp_1_N BPD_transp_1 |
Family assigned |
| dppA Rv3666c |
mtbc0_003884 |
dipeptide ABC transporter substrate-binding lipoprotein DppA | ABC transporter substrate-binding protein. Pfam: SBP_bac_5 (PF00496.28). | SBP_bac_5 |
Family assigned |
| acs Rv3667 |
mtbc0_003886 |
acetyl-CoAsynthetase | Acetate--CoA ligase. Pfam: ACAS_N (PF16177.12), AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | ACAS_N AMP-binding AMP-binding_C |
Resolved |
| Rv3668c Rv3668c |
mtbc0_003887 |
protease | Protease. | Resolved | |
| Rv3669 Rv3669 |
mtbc0_003888 |
transmembrane protein | Phage holin family protein. Pfam: Phage_holin_3_6 (PF07332.17). | Phage_holin_3_6 |
Family assigned |