Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1139c Rv1139c |
mtbc0_001224 |
hypothetical protein | Isoprenylcysteine carboxyl methyltransferase family protein. Pfam: ICMT (PF04140.20), PEMT (PF04191.19). | ICMT PEMT |
Family assigned |
| Rv1147 Rv1147 |
mtbc0_001232 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Family assigned |
| Rv1148c Rv1148c |
- |
hypothetical protein | Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. | DUF222 HNH |
Family assigned |
| Rv1154c Rv1154c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 2hiy-assembly1_B The structure of conserved bacterial protein SP0830 from Strept (prob 1.00, TM 0.79). Structure-based, putative. | DUF1697 |
Family assigned |
| Rv1155a Rv1155a |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5302. Function unknown. | DUF5302 |
Still unknown |
| Rv1156 Rv1156 |
mtbc0_001243 |
hypothetical protein | HhH-GPD-type base excision DNA repair protein. Pfam: HhH-GPD (PF00730.32). | HhH-GPD |
Resolved |
| Rv1157c Rv1157c |
mtbc0_001245 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8glv-assembly1_Gs 96-nm repeat unit of doublet microtubules from Chlam (prob 0.04, TM 0.08). | Still unknown | |
| Rv1158c Rv1158c |
mtbc0_001246 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1171 Rv1171 |
mtbc0_001260 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv1176c Rv1176c |
mtbc0_001265 |
hypothetical protein | PadR family transcriptional regulator. Pfam: PadR (PF03551.21), Vir_act_alpha_C (PF10400.16). | PadR Vir_act_alpha_C |
Family assigned |
| Rv1179c Rv1179c |
mtbc0_001268 |
hypothetical protein | DEAD/DEAH box helicase family protein. Pfam: ResIII (PF04851.22). | ResIII |
Family assigned |
| chp2 Rv1184c |
mtbc0_001272 |
hypothetical protein | Diacyltrehalose acyltransferase Chp2. Pfam: PE-PPE (PF08237.18). | PE-PPE |
Resolved |
| Rv1186c Rv1186c |
mtbc0_001274 |
hypothetical protein | PucR family transcriptional regulator. Pfam: HTH_30 (PF13556.13). | HTH_30 |
Family assigned |
| Rv1190 Rv1190 |
mtbc0_001278 |
hypothetical protein | Alpha/beta fold hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv1191 Rv1191 |
mtbc0_001279 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv1192 Rv1192 |
mtbc0_001280 |
hypothetical protein | Alpha/beta hydrolase. | Family assigned | |
| Rv1194c Rv1194c |
mtbc0_001282 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| Rv1203c Rv1203c |
- |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: weak fold echo only (HEAT-repeat alpha-solenoid); function unknown. | Still unknown | |
| Rv1204c Rv1204c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1205 Rv1205 |
mtbc0_001293 |
hypothetical protein | TIGR00730 family Rossman fold protein. Pfam: LDcluster4 (PF18306.7), Lysine_decarbox (PF03641.20). | LDcluster4 Lysine_decarbox |
Family assigned |
| Rv1209 Rv1209 |
mtbc0_001297 |
hypothetical protein | DivIVA domain-containing protein. | Family assigned | |
| Rv1211 Rv1211 |
- |
hypothetical protein | Natively unfolded (intrinsically disordered) protein required for growth and pathogenesis; binds the calmodulin antagonist trifluoperazine (Kd 41 uM) in its C-terminal region while remaining unfolded. An earlier 'calmodulin-like Ca2+-binding protein (CAMLP)' assignment is CONTESTED: the structural study shows it does not bind Ca2+. A drug-interaction target of unfixed molecular function. | DUF3117 |
Family assigned |
| Rv1215c Rv1215c |
mtbc0_001303 |
hypothetical protein | CocE/NonD family hydrolase. Pfam: Peptidase_S15 (PF02129.25), Peptidase_S9 (PF00326.28), PepX_C (PF08530.17). | Peptidase_S15 Peptidase_S9 PepX_C |
Family assigned |
| Rv1225c Rv1225c |
mtbc0_001313 |
hypothetical protein | HAD-IIA family hydrolase. Pfam: Hydrolase_6 (PF13344.13), Hydrolase (PF00702.33), HAD_2 (PF13419.13), Hydrolase_like (PF13242.13). | Hydrolase_6 Hydrolase HAD_2 Hydrolase_like |
Family assigned |
| Rv1228a Rv1228a |
- |
hypothetical protein | Conserved hypothetical; no reliable functional assignment. A Foldseek hit resembles 6jqy-assembly1_A Crystal structure of N-terminal domain, but that function is encoded elsewhere in the genome (vapb46 = Rv3385c) -- treated as a paralogue-of-fold artefact, not propagated. | Still unknown | |
| Rv1232c Rv1232c |
mtbc0_001321 |
hypothetical protein | Magnesium transporter. Pfam: SH3_actinomycetes (PF26205.1), MgtE_N (PF03448.23), CBS (PF00571.34). | SH3_actinomycetes MgtE_N CBS |
Resolved |
| Rv1233c Rv1233c |
mtbc0_001322 |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF4190 |
Family assigned |
| Rv1251c Rv1251c |
mtbc0_001340 |
hypothetical protein | TM0106 family RecB-like putative nuclease. Pfam: PDDEXK_1 (PF12705.14), RNase_H_2 (PF13482.13), AAA_19 (PF13245.13), AAA_30 (PF13604.13), NAT10_TcmA_helicase (PF05127.22), AAA_12 (PF13087.13). | PDDEXK_1 RNase_H_2 AAA_19 AAA_30 NAT10_TcmA_helicase AAA_12 |
Family assigned |
| Rv1261c Rv1261c |
mtbc0_001350 |
hypothetical protein | F420H(2)-dependent quinone reductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| Rv1262c Rv1262c |
mtbc0_001351 |
hypothetical protein | HIT family protein. Pfam: DcpS_C (PF11969.14), HIT (PF01230.30). | DcpS_C HIT |
Family assigned |
| Rv1265 Rv1265 |
- |
hypothetical protein | Contains Rv1265_N (PF27105.1), Mb1296_C (PF27540.1) domain(s); putative function inferred from the domain architecture. | Rv1265_N Mb1296_C |
Family assigned |
| Rv1268c Rv1268c |
mtbc0_001358 |
hypothetical protein | C39 family peptidase. Pfam: Peptidase_C39_2 (PF13529.14). | Peptidase_C39_2 |
Family assigned |
| Rv1269c Rv1269c |
mtbc0_001359 |
hypothetical protein | DUF4189; same fold as Rv1813c (PDB 7NHZ); secreted DUF4189-family protein. | DUF4189 |
Family assigned |
| Rv1271c Rv1271c |
mtbc0_001361 |
hypothetical protein | Secreted protein recognised as an antigen (antibody responses during active TB). Pfam DUF732 (a mycobacterial domain of unknown function). Molecular function unfixed. | DUF732 |
Family assigned |
| Rv1276c Rv1276c |
- |
hypothetical protein | Contains His_Phos_1 (PF00300.28) domain(s); putative function inferred from the domain architecture. | His_Phos_1 |
Family assigned |
| Rv1277 Rv1277 |
- |
hypothetical protein | Contains Metallophos (PF00149.34) domain(s); putative function inferred from the domain architecture. | Metallophos |
Family assigned |
| Rv1278 Rv1278 |
mtbc0_001368 |
hypothetical protein | AAA family ATPase. Pfam: AAA_15 (PF13175.13), AAA_27 (PF13514.13), AAA_23 (PF13476.13). | AAA_15 AAA_27 AAA_23 |
Family assigned |
| Rv1288 Rv1288 |
mtbc0_001378 |
hypothetical protein | Esterase. Pfam: Phage_tail_X (PF05489.19), LysM (PF01476.27), Esterase (PF00756.27). | Phage_tail_X LysM Esterase |
Resolved |
| Rv1289 Rv1289 |
mtbc0_001379 |
hypothetical protein | Contains Rv1289 (PF27329.1) domain(s); putative function inferred from the domain architecture. | Rv1289 |
Family assigned |
| Rv1290A Rv1290A |
- |
hypothetical protein | Leucine carboxyl methyltransferase-family enzyme (eggNOG COG3315, secondary-metabolism COG category Q): a SAM-dependent protein-carboxyl methyltransferase. RefSeq leaves it 'hypothetical protein'. The methyl-acceptor substrate is undetermined. | Family assigned | |
| Rv1290c Rv1290c |
mtbc0_001380 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2254 |
Family assigned |
| Rv1291c Rv1291c |
mtbc0_001382 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF732. Function unknown. Foldseek best (non-significant) hit: 3j9x-assembly1_A A Virus that Infects a Hyperthermophile Encapsidates (prob 0.47, TM 0.55). | DUF732 |
Still unknown |
| Rv1303 Rv1303 |
mtbc0_001395 |
hypothetical protein | ATP synthase subunit I. Pfam: ATP-synt_I (PF03899.22). | ATP-synt_I |
Family assigned |
| Rv1312 Rv1312 |
mtbc0_001404 |
hypothetical protein | DUF2550; Foldseek best hit (PH domain, TM 0.46) not conclusive. Function unknown. | DUF2550 |
Still unknown |
| Rv1322 Rv1322 |
mtbc0_001418 |
hypothetical protein | Contains Rv1322 (PF27609.1) domain(s); putative function inferred from the domain architecture. | Rv1322 |
Family assigned |
| Rv1322A Rv1322A |
- |
hypothetical protein | Contains Glyoxalase (PF00903.32), Glyoxalase_3 (PF13468.13), Glyoxalase_4 (PF13669.13) domain(s); putative function inferred from the domain architecture. | Glyoxalase Glyoxalase_3 Glyoxalase_4 |
Family assigned |
| Rv1339 Rv1339 |
- |
hypothetical protein | Contains Anti-Pycsar_Apyc1 (PF23023.2), Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14) domain(s); putative function inferred from the domain architecture. | Anti-Pycsar_Apyc1 Lactamase_B Lactamase_B_2 |
Family assigned |
| Rv1342c Rv1342c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3817 |
Family assigned |
| Rv1351 Rv1351 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1352 Rv1352 |
mtbc0_001452 |
hypothetical protein | Contains Rv1352 (PF27111.1) domain(s); putative function inferred from the domain architecture. | Rv1352 |
Family assigned |