Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2557 Rv2557 |
- |
hypothetical protein | Contains ABM (PF03992.23) domain(s); putative function inferred from the domain architecture. | ABM |
Family assigned |
| Rv2558 Rv2558 |
- |
hypothetical protein | Cofactor-independent ABM (antibiotic-biosynthesis-monooxygenase) of the quinone-monooxygenase family (ActVA-Orf6/SnoaB/YgiN), substrate unknown (weaker candidate). RefSeq leaves it 'hypothetical protein'. Tandem-ABM protein (paralogue Rv2557, 69% identity); only the C-terminal lobe forms a competent pocket, centred on His124 and lined by Phe168/Tyr154 - the signature of a cofactorless ABM site where an aromatic substrate replaces flavin. A heme-oxygenase assignment is excluded structurally (geometry not heme-compatible; IsdG/MhuD catalytic determinants absent) and by the fold-paralogue safeguard (heme degradation in M. tuberculosis is already carried by MhuD/Rv3592). HHpred top hits (>=99.9%) are cofactorless ActVA-Orf6/YgiN-family monooxygenases; the IsdG/MhuD heme-oxygenase subfamily is absent. The C-terminal site residues are near-invariant across ~250,724 genomes. Fold and sub-type are well supported; substrate and activity remain undemonstrated. | Family assigned | |
| Rv2559c Rv2559c |
mtbc0_002727 |
hypothetical protein | Replication-associated recombination protein A. Pfam: RuvB_N (PF05496.19), Sigma54_activ_2 (PF14532.13), AAA (PF00004.36), AAA_5 (PF07728.21), AAA_assoc_2 (PF16193.12), MgsA_C (PF12002.14). | RuvB_N Sigma54_activ_2 AAA AAA_5 AAA_assoc_2 MgsA_C |
Resolved |
| Rv2560 Rv2560 |
mtbc0_002728 |
hypothetical protein | Membrane protein (33 kDa) localised to the mycobacterial membrane (immuno-EM); its high-activity binding peptides bind alveolar epithelial (A549) and monocyte (U937) cells and inhibit host-cell invasion, implicating it in adhesion/invasion of monocytes and epithelial cells. Molecular function unfixed. | Family assigned | |
| Rv2566 Rv2566 |
- |
hypothetical protein | Contains Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26), DUF2126 (PF09899.15) domain(s); putative function inferred from the domain architecture. | Bact_transglu_N Transglut_core DUF2126 |
Family assigned |
| Rv2567 Rv2567 |
mtbc0_002734 |
hypothetical protein | Circularly permuted type 2 ATP-grasp protein. Pfam: CP_ATPgrasp_1 (PF04174.19), CP_ATPgrasp_2 (PF14403.12), Alpha-E (PF04168.18). | CP_ATPgrasp_1 CP_ATPgrasp_2 Alpha-E |
Resolved |
| Rv2568c Rv2568c |
mtbc0_002735 |
hypothetical protein | Putative zinc-binding metallopeptidase. Pfam: Zn_ribbon_DZR_6 (PF10005.15), Peptidase_Mx (PF15887.12). | Zn_ribbon_DZR_6 Peptidase_Mx |
Family assigned |
| Rv2569c Rv2569c |
mtbc0_002736 |
hypothetical protein | Transglutaminase family protein. Pfam: Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26). | Bact_transglu_N Transglut_core |
Family assigned |
| Rv2570 Rv2570 |
mtbc0_002737 |
hypothetical protein | MmcQ/YjbR family DNA-binding protein. Pfam: YjbR (PF04237.19). | YjbR |
Family assigned |
| Rv2574 Rv2574 |
mtbc0_002741 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16). | Polyketide_cyc2 |
Family assigned |
| Rv2577 Rv2577 |
mtbc0_002744 |
hypothetical protein | Metallophosphoesterase family protein. Pfam: Pur_ac_phosph_N (PF16656.12), Metallophos (PF00149.34). | Pur_ac_phosph_N Metallophos |
Family assigned |
| Rv2578c Rv2578c |
mtbc0_002745 |
hypothetical protein | Rv2578c family radical SAM protein. Pfam: Radical_SAM (PF04055.28). | Radical_SAM |
Family assigned |
| Rv2598 Rv2598 |
mtbc0_002765 |
hypothetical protein | DUF2617 family protein. | DUF2617 |
Family assigned |
| Rv2614A Rv2614A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2616 Rv2616 |
mtbc0_002785 |
hypothetical protein | DUF1990 family protein. | DUF1990 |
Family assigned |
| Rv2618 Rv2618 |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 6cmv-assembly3_F Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Su (prob 1.00, TM 0.57). Structure-based, putative. | Family assigned | |
| Rv2619c Rv2619c |
mtbc0_002788 |
hypothetical protein | Cupin domain-containing protein. | Family assigned | |
| Rv2627c Rv2627c |
mtbc0_002796 |
hypothetical protein | Alpha/beta hydrolase. | Family assigned | |
| Rv2628 Rv2628 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7xzi-assembly1_F Cryo-EM structure of TOC-TIC supercomplex from Chlamy (prob 0.10, TM 0.32). | Still unknown | |
| Rv2629 Rv2629 |
mtbc0_002798 |
hypothetical protein | Contains baeRF_family10 (PF18854.7), baeRF_family2 (PF18844.7) domain(s); putative function inferred from the domain architecture. | baeRF_family10 baeRF_family2 |
Family assigned |
| Rv2630 Rv2630 |
mtbc0_002799 |
hypothetical protein | Archease. Pfam: Archease (PF01951.22). | Archease |
Resolved |
| Rv2632c Rv2632c |
mtbc0_002801 |
hypothetical protein | DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). | Rv2632c-like |
Family assigned |
| Rv2633c Rv2633c |
mtbc0_002802 |
hypothetical protein | Non-heme di-iron catalase. Pfam: Hemerythrin (PF01814.29). | Hemerythrin |
Resolved |
| Rv2635 Rv2635 |
mtbc0_002805 |
hypothetical protein | Nucleoid-associated protein (NAP); a small intrinsically disordered protein (IDP) that undergoes liquid-liquid phase separation. RefSeq leaves this locus 'hypothetical protein'. By in-silico analysis and circular dichroism Rv2635 is established as an IDP; GFP-tagged Rv2635 phase-separates into reversible condensates (FRAP); it binds DNA sequence-independently (EMSA) and, when over-expressed in E. coli, causes nucleoid compaction and co-localises with the condensed nucleoid. Its unstructured regions are required for phase separation and its C-terminus for DNA binding, indicating a phase-separating NAP role in mycobacteria (Chandra 2025). Experimentally characterised. | Resolved | |
| Rv2638 Rv2638 |
mtbc0_002808 |
hypothetical protein | Anti-sigma factor antagonist. Pfam: STAS_2 (PF13466.13), STAS (PF01740.27). | STAS_2 STAS |
Resolved |
| Rv2644c Rv2644c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3azo-assembly2_B Crystal structure of puromycin hydrolase (prob 0.14, TM 0.69). | Still unknown | |
| Rv2645 Rv2645 |
mtbc0_002820 |
hypothetical protein | Immunodominant T-cell antigen encoded in region-of-difference RD13 (present in M. tuberculosis, absent from BCG and M. bovis); a cell-mediated-immunity-based diagnostic/vaccine antigen. Despite this immunological characterisation, its molecular/biochemical function remains unknown (verdict kept 'dark'). | Still unknown | |
| Rv2647 Rv2647 |
- |
hypothetical protein | Secreted virulence factor that inhibits macrophage pyroptosis by promoting NLRP3 ubiquitination/degradation. RefSeq leaves it 'hypothetical'. Rv2647 binds ISG15 and competitively inhibits ISGylation of NLRP3, enhancing its ubiquitination and degradation; this inactivates NLRP3-caspase-1-GSDMD, reduces IL-1beta and promotes Mtb survival (Jin 2025). | Resolved | |
| Rv2660c Rv2660c |
mtbc0_002834 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8pui-assembly1_A human PHOX2B C-terminal domain including the polyA fr (prob 0.02, TM 0.30). | Still unknown | |
| Rv2661c Rv2661c |
mtbc0_002835 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2662 Rv2662 |
mtbc0_002836 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2663 Rv2663 |
mtbc0_002837 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 7vd7-assembly1_A Toxin - Antitoxin complex from Salmonella enterica serovar Typh (prob 1.00, TM 0.66). Structure-based, putative. | Family assigned | |
| Rv2664 Rv2664 |
mtbc0_002838 |
hypothetical protein | DNA-binding transcriptional regulator (winged-HTH / ECF-sigma-factor-like fold), structural homolog of the mycobacterial transcription factor Rv2667/CymA (ClpC2/CymA system) RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv2665 Rv2665 |
mtbc0_002839 |
hypothetical protein | Arginine RICH protein. | Resolved | |
| Rv2668 Rv2668 |
mtbc0_002842 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3cfu-assembly1_A Crystal structure of the yjhA protein from Bacillus subtilis. N (prob 1.00, TM 0.61). Structure-based, putative. | Family assigned | |
| zapE Rv2670c |
mtbc0_002844 |
hypothetical protein | Cell division protein ZapE. Pfam: AFG1_ATPase (PF03969.23). | AFG1_ATPase |
Resolved |
| Rv2675c Rv2675c |
mtbc0_002849 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| hemQ Rv2676c |
mtbc0_002850 |
hypothetical protein | Hydrogen peroxide-dependent heme synthase. Pfam: Chlor_dismutase (PF06778.19). | Chlor_dismutase |
Resolved |
| Rv2680 Rv2680 |
mtbc0_002854 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3000. Function unknown. Foldseek best (non-significant) hit: 8any-assembly1_f Human mitochondrial ribosome in complex with LRPPRC, (prob 0.44, TM 0.39). | DUF3000 |
Still unknown |
| Rv2681 Rv2681 |
mtbc0_002855 |
hypothetical protein | Ribonuclease D. Pfam: DNA_pol_A_exo1 (PF01612.27), HRDC (PF00570.29), DNA_pol_A_exoN (PF18305.7). | DNA_pol_A_exo1 HRDC DNA_pol_A_exoN |
Resolved |
| Rv2683 Rv2683 |
- |
hypothetical protein | Contains CBS (PF00571.34) domain(s); putative function inferred from the domain architecture. | CBS |
Family assigned |
| Rv2689c Rv2689c |
mtbc0_002863 |
hypothetical protein | Class I SAM-dependent RNA methyltransferase. Pfam: TRAM (PF01938.27), tRNA_U5-meth_tr (PF05958.18). | TRAM tRNA_U5-meth_tr |
Resolved |
| Rv2694c Rv2694c |
mtbc0_002868 |
hypothetical protein | OB-fold nucleic acid binding domain-containing protein. | Family assigned | |
| Rv2695 Rv2695 |
mtbc0_002869 |
hypothetical protein | Alpha/beta fold hydrolase. | Resolved | |
| Rv2696c Rv2696c |
mtbc0_002870 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3710. Function unknown. | DUF3710 |
Still unknown |
| Rv2699c Rv2699c |
mtbc0_002873 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4193. Function unknown. | DUF4193 |
Still unknown |
| cei Rv2700 |
mtbc0_002874 |
hypothetical protein | Envelope integrity protein Cei. Pfam: LytR_C (PF13399.12). | LytR_C |
Resolved |
| Rv2704 Rv2704 |
mtbc0_002878 |
hypothetical protein | RidA family protein. Pfam: Ribonuc_L-PSP (PF01042.27). | Ribonuc_L-PSP |
Family assigned |
| Rv2705c Rv2705c |
mtbc0_002879 |
hypothetical protein | DUF952 domain-containing protein. | DUF952 |
Family assigned |
| Rv2706c Rv2706c |
mtbc0_002880 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown |