MTBC Gene Atlas

Genes

1086 genes matched.

GeneMTBC0Legacy (H37Rv)MTBC0 PGAP / revisedPfamVerdict
Rv2478c
Rv2478c		 - hypothetical protein Contains SSB (PF00436.32) domain(s); putative function inferred from the domain architecture. SSB Family assigned
Rv2481c
Rv2481c		 mtbc0_002641 hypothetical protein Conserved protein co-transcribed with plsB2 (glycerol-3-phosphate acyltransferase) and plsC (1-acylglycerol-3-phosphate acyltransferase) in a phospholipid-biosynthesis operon, under purifying selection. Contextual candidate: associated with phospholipid / phosphatidic-acid biosynthesis. Its molecular role is not established. Family assigned
Rv2489c
Rv2489c		 mtbc0_002650 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv2490a
Rv2490a		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv2491
Rv2491		 mtbc0_002653 hypothetical protein TIGR00725 family protein. Pfam: LDcluster4 (PF18306.7). LDcluster4 Family assigned
Rv2492
Rv2492		 mtbc0_002654 hypothetical protein Thymidylate-synthase (TS)-superfamily (hydroxymethyl)transferase acting on a deoxyuridylate-type nucleotide, a distinct non-essential locus separate from the essential thymidylate synthases ThyA/ThyX. RefSeq leaves it 'hypothetical protein'. The model superposes on MilA (a CMP hydroxymethyltransferase, PDB 5b6d) with a complete catalytic constellation at the nucleotide (nucleophile Cys151, phosphate-binding Arg175, base-reading Asp178, ribose-binding His222/Tyr224); HHpred places it 100% in the thymidylate-synthase / dCMP-hydroxymethylase superfamily. The specificity residues reassign the substrate away from the template's cytidylate: Asn186 (vs MilA Asp186) and Ser176 (deoxy-type) point to a (deoxy)uridylate (dUMP-type) substrate with one-carbon chemistry on the pyrimidine C5. Vertically conserved through the human and animal MTBC and M. canettii (an earlier anti-phage-defence hypothesis is rejected). A structural prediction; substrate narrowed, not fixed. Resolved
Rv2507
Rv2507		 mtbc0_002669 hypothetical protein MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). Mycobact_memb Family assigned
Rv2510c
Rv2510c		 mtbc0_002672 hypothetical protein DUF853 domain-containing protein. Pfam: HerA_C (PF05872.19), DUF87 (PF01935.24), TrwB_AAD_bind (PF10412.16). HerA_C DUF87 TrwB_AAD_bind Family assigned
Rv2512a
Rv2512a		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7jt2-assembly1_q 70S ribosome stalled on long mRNA with ArfB bound in (prob 0.03, TM 0.26). Still unknown
Rv2513
Rv2513		 mtbc0_002676 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv2514c
Rv2514c		 mtbc0_002677 hypothetical protein DUF4411 family protein. DUF4411 Family assigned
Rv2515c
Rv2515c		 mtbc0_002678 hypothetical protein XRE family transcriptional regulator. Pfam: HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20). HTH_3 Peptidase_M78 Family assigned
Rv2516c
Rv2516c		 mtbc0_002679 hypothetical protein Conserved hypothetical protein; no Pfam-A domain above the gathering threshold. Function unknown. Two NON-SIGNIFICANT and mutually contradictory structural leads, neither sufficient to assign a function. (i) DNA-binding lead, supported by four independent layers: a sub-threshold Pfam hit to Sigma70_r4 (PF04545, residues 98-121, i-E 8.4e-4), a canonical helix-turn-helix motif in the sequence at exactly those positions (MSAAEIADELGVSRQRVHQLRSTA), the UniProt name 'Helix-turn-helix domain-containing protein' (I6YDM0), and MerR-family regulators bound to promoter DNA among the Foldseek hits on the AlphaFold model (3hh0 TM 0.686, 5d8c TM 0.708, 5d90 TM 0.683). (ii) RNA-binding lead, supported by one layer: the best-by-E-value Foldseek hits are circular permutants of ribosomal protein S6 (7b90, 7bff, 7bfd; TM 0.617-0.664), i.e. LOWER TM-scores than the MerR hits. All structural hits are flagged non-significant. To be settled by profile-profile HHpred. Still unknown
Rv2517c
Rv2517c		 mtbc0_002680 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7ax2-assembly1_A Crystal structure of the computationally designed Sco (prob 0.51, TM 0.79). Still unknown
Rv2522c
Rv2522c		 mtbc0_002686 hypothetical protein Dipeptidase. Pfam: Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20). Peptidase_M20 M20_dimer Resolved
Rv2525c
Rv2525c		 mtbc0_002689 hypothetical protein DUF1906 domain-containing protein. Pfam: Rv2525c_GlyHyd-like (PF08924.18). Rv2525c_GlyHyd-like Family assigned
Rv2529
Rv2529		 - hypothetical protein Contains ERCC4 (PF02732.22), Lsr2_DNA-bd (PF23359.2) domain(s); putative function inferred from the domain architecture. ERCC4 Lsr2_DNA-bd Family assigned
Rv2532c
Rv2532c		 mtbc0_002698 hypothetical protein Antitermination protein NusB. Resolved
Rv2541
Rv2541		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3zbh-assembly1_B Geobacillus thermodenitrificans EsxA crystal form I (prob 1.00, TM 0.78). Still unknown
Rv2542
Rv2542		 mtbc0_002708 hypothetical protein Alpha/beta hydrolase family protein. Pfam: Abhydrolase_8 (PF06259.19). Abhydrolase_8 Family assigned
Rv2548A
Rv2548A		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv2551c
Rv2551c		 mtbc0_002719 hypothetical protein A24 family peptidase. Pfam: Peptidase_A24 (PF01478.24). Peptidase_A24 Family assigned
Rv2556c
Rv2556c		 mtbc0_002724 hypothetical protein Secondary thiamine-phosphate synthase enzyme YjbQ. Pfam: YjbQ (PF01894.23). YjbQ Resolved
Rv2557
Rv2557		 - hypothetical protein Contains ABM (PF03992.23) domain(s); putative function inferred from the domain architecture. ABM Family assigned
Rv2558
Rv2558		 - hypothetical protein Cofactor-independent ABM (antibiotic-biosynthesis-monooxygenase) of the quinone-monooxygenase family (ActVA-Orf6/SnoaB/YgiN), substrate unknown (weaker candidate). RefSeq leaves it 'hypothetical protein'. Tandem-ABM protein (paralogue Rv2557, 69% identity); only the C-terminal lobe forms a competent pocket, centred on His124 and lined by Phe168/Tyr154 - the signature of a cofactorless ABM site where an aromatic substrate replaces flavin. A heme-oxygenase assignment is excluded structurally (geometry not heme-compatible; IsdG/MhuD catalytic determinants absent) and by the fold-paralogue safeguard (heme degradation in M. tuberculosis is already carried by MhuD/Rv3592). HHpred top hits (>=99.9%) are cofactorless ActVA-Orf6/YgiN-family monooxygenases; the IsdG/MhuD heme-oxygenase subfamily is absent. The C-terminal site residues are near-invariant across ~250,724 genomes. Fold and sub-type are well supported; substrate and activity remain undemonstrated. Family assigned
Rv2559c
Rv2559c		 mtbc0_002727 hypothetical protein Replication-associated recombination protein A. Pfam: RuvB_N (PF05496.19), Sigma54_activ_2 (PF14532.13), AAA (PF00004.36), AAA_5 (PF07728.21), AAA_assoc_2 (PF16193.12), MgsA_C (PF12002.14). RuvB_N Sigma54_activ_2 AAA AAA_5 AAA_assoc_2 MgsA_C Resolved
Rv2560
Rv2560		 mtbc0_002728 hypothetical protein Membrane protein (33 kDa) localised to the mycobacterial membrane (immuno-EM); its high-activity binding peptides bind alveolar epithelial (A549) and monocyte (U937) cells and inhibit host-cell invasion, implicating it in adhesion/invasion of monocytes and epithelial cells. Molecular function unfixed. Family assigned
Rv2561
Rv2561		 Conserved hypothetical protein Pfam Adenylate and Guanylate cyclase catalytic domain Family assigned
Rv2562
Rv2562		 Conserved hypothetical protein Protein of unknown function (DUF2652) Family assigned
Rv2566
Rv2566		 - hypothetical protein Contains Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26), DUF2126 (PF09899.15) domain(s); putative function inferred from the domain architecture. Bact_transglu_N Transglut_core DUF2126 Family assigned
Rv2567
Rv2567		 mtbc0_002734 hypothetical protein Circularly permuted type 2 ATP-grasp protein. Pfam: CP_ATPgrasp_1 (PF04174.19), CP_ATPgrasp_2 (PF14403.12), Alpha-E (PF04168.18). CP_ATPgrasp_1 CP_ATPgrasp_2 Alpha-E Resolved
Rv2568c
Rv2568c		 mtbc0_002735 hypothetical protein Putative zinc-binding metallopeptidase. Pfam: Zn_ribbon_DZR_6 (PF10005.15), Peptidase_Mx (PF15887.12). Zn_ribbon_DZR_6 Peptidase_Mx Family assigned
Rv2569c
Rv2569c		 mtbc0_002736 hypothetical protein Transglutaminase family protein. Pfam: Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26). Bact_transglu_N Transglut_core Family assigned
Rv2570
Rv2570		 mtbc0_002737 hypothetical protein MmcQ/YjbR family DNA-binding protein. Pfam: YjbR (PF04237.19). YjbR Family assigned
Rv2574
Rv2574		 mtbc0_002741 hypothetical protein SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16). Polyketide_cyc2 Family assigned
Rv2577
Rv2577		 mtbc0_002744 hypothetical protein Metallophosphoesterase family protein. Pfam: Pur_ac_phosph_N (PF16656.12), Metallophos (PF00149.34). Pur_ac_phosph_N Metallophos Family assigned
Rv2578c
Rv2578c		 mtbc0_002745 hypothetical protein Rv2578c family radical SAM protein. Pfam: Radical_SAM (PF04055.28). Radical_SAM Family assigned
Rv2598
Rv2598		 mtbc0_002765 hypothetical protein DUF2617 family protein. DUF2617 Family assigned
Rv2614A
Rv2614A		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv2616
Rv2616		 mtbc0_002785 hypothetical protein DUF1990 family protein. DUF1990 Family assigned
Rv2618
Rv2618		 - hypothetical protein No Pfam domain above threshold; Foldseek indicates a fold similar to 6cmv-assembly3_F Crystal structure of Archaeal Biofilm Regulator (AbfR2) from Su (prob 1.00, TM 0.57). Structure-based, putative. Family assigned
Rv2619c
Rv2619c		 mtbc0_002788 hypothetical protein Cupin domain-containing protein. Family assigned
Rv2627c
Rv2627c		 mtbc0_002796 hypothetical protein Alpha/beta-hydrolase-FOLD protein: the AlphaFold model matches a hypothetical protein (TM 0.70, PDB 4z8z) and a thermostable esterase-like variant (TM 0.61). Putative hydrolase, fold-level only — no Pfam domain, no verified catalytic triad. NOTE: Rv2627c is otherwise a much-studied protein (9 TB papers) but exclusively as a DORMANCY (DosR) REGULON ANTIGEN — immunogenicity, TLR agonist, serodiagnosis of latent infection. An antigen status is not a molecular function, and no publication addresses what this protein does. Family assigned
Rv2628
Rv2628		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7xzi-assembly1_F Cryo-EM structure of TOC-TIC supercomplex from Chlamy (prob 0.10, TM 0.32). Still unknown
Rv2629
Rv2629		 mtbc0_002798 hypothetical protein Contains baeRF_family10 (PF18854.7), baeRF_family2 (PF18844.7) domain(s); putative function inferred from the domain architecture. baeRF_family10 baeRF_family2 Family assigned
Rv2630
Rv2630		 mtbc0_002799 hypothetical protein Archease. Pfam: Archease (PF01951.22). Archease Resolved
Rv2632c
Rv2632c		 mtbc0_002801 hypothetical protein DUF1876 domain-containing protein. Pfam: Rv2632c-like (PF08962.17). Rv2632c-like Family assigned
Rv2633c
Rv2633c		 mtbc0_002802 hypothetical protein Non-heme di-iron catalase. Pfam: Hemerythrin (PF01814.29). Hemerythrin Resolved
Rv2635
Rv2635		 mtbc0_002805 hypothetical protein Nucleoid-associated protein (NAP); a small intrinsically disordered protein (IDP) that undergoes liquid-liquid phase separation. RefSeq leaves this locus 'hypothetical protein'. By in-silico analysis and circular dichroism Rv2635 is established as an IDP; GFP-tagged Rv2635 phase-separates into reversible condensates (FRAP); it binds DNA sequence-independently (EMSA) and, when over-expressed in E. coli, causes nucleoid compaction and co-localises with the condensed nucleoid. Its unstructured regions are required for phase separation and its C-terminus for DNA binding, indicating a phase-separating NAP role in mycobacteria (Chandra 2025). Experimentally characterised. Resolved
Rv2638
Rv2638		 mtbc0_002808 hypothetical protein Anti-sigma factor antagonist. Pfam: STAS_2 (PF13466.13), STAS (PF01740.27). STAS_2 STAS Resolved