Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| fcoT Rv0098 |
mtbc0_000107 |
fatty acyl CoA thioesterase FcoT | Fatty acyl CoA thioesterase FcoT. Pfam: FcoT (PF10862.15). | FcoT |
Resolved |
| fadD10 Rv0099 |
- |
fatty-acid--CoA ligase FadD10 | Fatty-acid--CoA ligase FadD10. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| Rv0100 Rv0100 |
mtbc0_000109 |
hypothetical protein | Acyl carrier protein (ACP). Pfam PP-binding (PF00550) is the phosphopantetheine-attachment site: the protein carries acyl intermediates as a 4'-phosphopantetheine thioester for fatty-acid / polyketide biosynthesis. A standalone ACP, likely partnering a biosynthetic cluster in this genomic region. | PP-binding |
Resolved |
| nrp Rv0101 |
mtbc0_000110 |
peptide synthetase Nrp | Non-ribosomal peptide synthetase Nrp. Pfam: Condensation (PF00668.26), AMP-binding (PF00501.35), AMP-binding_C (PF13193.13), PP-binding (PF00550.32), Epimerase (PF01370.28), NAD_binding_4 (PF07993.19). | Condensation AMP-binding AMP-binding_C PP-binding Epimerase NAD_binding_4 |
Resolved |
| Rv0102 Rv0102 |
mtbc0_000111 |
integral membrane protein | Cytochrome c oxidase assembly protein. Pfam: Caa3_CtaG (PF09678.16). | Caa3_CtaG |
Resolved |
| ctpB Rv0103c |
mtbc0_000112 |
cation-transporter P-type ATPase B | Cation-translocating P-type ATPase. Pfam: HMA (PF00403.33), E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | HMA E1-E2_ATPase Hydrolase |
Resolved |
| Rv0104 Rv0104 |
mtbc0_000113 |
hypothetical protein | Cyclic-nucleotide-binding (cNMP) domain protein (Pfam cNMP_binding PF00027). A large (504 aa) protein carrying a cNMP regulatory module, likely a cyclic-nucleotide-responsive regulator/effector; the precise function is not established. | cNMP_binding |
Family assigned |
| rpmB1 Rv0105c |
- |
50S ribosomal protein L28 | 50S ribosomal protein L28. Pfam: Ribosomal_L28 (PF00830.25). | Ribosomal_L28 |
Resolved |
| Rv0106 Rv0106 |
mtbc0_000116 |
hypothetical protein | CobW/P47K-family nucleotide- and metal-binding protein (Pfam cobW PF02492 + CobW_C PF07683), of the COG0523 subfamily of putative metallochaperones (often involved in zinc/cobalt homeostasis). The specific metal and role are not established. | cobW CobW_C |
Family assigned |
| ctpI Rv0107c |
- |
cation-transporter ATPase I | Cation-transporter ATPase I. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33), Cation_ATPase (PF13246.13), Cation_ATPase_C (PF00689.27). | E1-E2_ATPase Hydrolase Cation_ATPase Cation_ATPase_C |
Resolved |
| Rv0108c Rv0108c |
- |
hypothetical protein | Small OB-fold / twisted beta-sandwich protein; ambiguous fold-level match (phage head-to-tail joining gpFII-like and/or EF-P/eIF5A OB-fold); function undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| PE_PGRS1 Rv0109 |
- |
PE-PGRS family protein PE_PGRS1 | PE-PGRS family protein PE_PGRS1. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv0110 Rv0110 |
- |
integral membrane protein | Integral membrane protein. Pfam: Rhomboid (PF01694.29). | Rhomboid |
Family assigned |
| Rv0111 Rv0111 |
mtbc0_000121 |
acyltransferase | Acyltransferase family protein. Pfam: Acyl_transf_3 (PF01757.29), SGNH (PF19040.7), DUF459 (PF04311.21). | Acyl_transf_3 SGNH DUF459 |
Family assigned |
| gca Rv0112 |
mtbc0_000122 |
GDP-mannose 4,6-dehydratase | GDP-mannose 4%2C6-dehydratase. Pfam: RmlD_sub_bind (PF04321.24), Epimerase (PF01370.28), GDP_Man_Dehyd (PF16363.12). | RmlD_sub_bind Epimerase GDP_Man_Dehyd |
Resolved |
| gmhA Rv0113 |
mtbc0_000123 |
phosphoheptose isomerase | D-sedoheptulose 7-phosphate isomerase. Pfam: SIS_2 (PF13580.12), SIS (PF01380.28). | SIS_2 SIS |
Resolved |
| gmhB Rv0114 |
mtbc0_000124 |
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase | D-glycero-alpha-D-manno-heptose-1%2C7-bisphosphate 7-phosphatase. | Resolved | |
| hddA Rv0115 |
mtbc0_000125 |
D-alpha-D-heptose-7-phosphate kinase HddA | D-alpha-D-heptose-7-phosphate kinase HddA. Pfam: GHMP_kinases_N (PF00288.33), GHMP_kinases_C (PF08544.19). | GHMP_kinases_N GHMP_kinases_C |
Resolved |
| Rv0115a Rv0115a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| ldtA Rv0116c |
mtbc0_000127 |
L,D-transpeptidase LdtA | L%2CD-transpeptidase LdtMt1. Pfam: Big_10 (PF17964.8), YkuD (PF03734.20). | Big_10 YkuD |
Resolved |
| oxyS Rv0117 |
mtbc0_000128 |
oxidative stress response regulatory protein OxyS | LysR family transcriptional regulator OxyS. Pfam: HTH_1 (PF00126.34), LysR_substrate (PF03466.26). | HTH_1 LysR_substrate |
Family assigned |
| oxcA Rv0118c |
mtbc0_000129 |
oxalyl-CoA decarboxylase OxcA | Oxalyl-CoA decarboxylase. Pfam: TPP_enzyme_N (PF02776.24), TPP_enzyme_M (PF00205.29), TPP_enzyme_C (PF02775.27). | TPP_enzyme_N TPP_enzyme_M TPP_enzyme_C |
Resolved |
| fadD7 Rv0119 |
mtbc0_000130 |
fatty-acid--CoA ligase FadD7 | FadD7 family fatty acid--CoA ligase. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Family assigned |
| fusA2 Rv0120c |
mtbc0_000131 |
elongation factor G | Elongation factor G-like protein EF-G2. Pfam: GTP_EFTU (PF00009.34), MMR_HSR1 (PF01926.30), EF-G_D2 (PF22042.3), GTP_EFTU_D2 (PF03144.32), EFG_III (PF14492.13), EFG_IV (PF03764.25), EFG_C (PF00679.31). | GTP_EFTU MMR_HSR1 EF-G_D2 GTP_EFTU_D2 EFG_III EFG_IV EFG_C |
Family assigned |
| Rv0121c Rv0121c |
mtbc0_000132 |
hypothetical protein | F420-dependent / PNPOx-class oxidoreductase (Pfam PNPOx_N PF01243; PGAP TIGR03668 PPOX-class F420-dependent oxidoreductase). Putative deazaflavin (F420)-dependent oxidoreductase, a redox chemistry characteristic of mycobacteria. | PNPOx_N |
Family assigned |
| Rv0122 Rv0122 |
mtbc0_000133 |
hypothetical protein | Conserved hypothetical protein; no Pfam domain above threshold. Foldseek gives a suggestive but non-significant fold similarity to a ribonuclease (prob 0.98, E=5e-2, TM=0.61) with weaker hits to HigBA-type toxin-antitoxin RNases: a possible RNase/toxin-like fold, not conclusive. | Still unknown | |
| Rv0123 Rv0123 |
mtbc0_000134 |
hypothetical protein | Putative DNA-binding protein. No Pfam domain above threshold, but Foldseek matches antitoxin DNA-binding domains strongly and consistently (CopASO antitoxin prob 0.99 / TM 0.83; ParDE antitoxin; PutA HTH), pointing to a ribbon-helix-helix / antitoxin-type DNA-binding fold. Structure-based, consistent with the PGAP 'DNA-binding protein' call. | Family assigned | |
| PE_PGRS2 Rv0124 |
- |
PE-PGRS family protein PE_PGRS2 | PE-PGRS family protein PE_PGRS2. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| pepA Rv0125 |
mtbc0_000136 |
serine protease PepA | S1C family serine protease. Pfam: Trypsin_2 (PF13365.13), Trypsin (PF00089.33), PDZ (PF00595.30), PDZ_2 (PF13180.13). | Trypsin_2 Trypsin PDZ PDZ_2 |
Family assigned |
| treS Rv0126 |
mtbc0_000137 |
trehalose synthase/amylase TreS | Maltose alpha-D-glucosyltransferase. Pfam: Alpha-amylase (PF00128.32), Malt_amylase_C (PF16657.12). | Alpha-amylase Malt_amylase_C |
Resolved |
| mak Rv0127 |
mtbc0_000138 |
maltokinase | Maltokinase. Pfam: Mak_N_cap (PF18085.7). | Mak_N_cap |
Resolved |
| Rv0128 Rv0128 |
mtbc0_000139 |
transmembrane protein | YoaK family protein. | DUF1275 |
Family assigned |
| fbpC Rv0129c |
- |
diacylglycerol acyltransferase/mycolyltransferase Ag85C | Diacylglycerol acyltransferase/mycolyltransferase Ag85C. Pfam: Esterase (PF00756.27). | Esterase |
Resolved |
| htdZ Rv0130 |
mtbc0_000141 |
3-hydroxyl-thioester dehydratase | 3-hydroxyacyl-thioester dehydratase HtdZ. Pfam: MaoC_dehydratas (PF01575.26), FAS1_DH_region (PF13452.12). | MaoC_dehydratas FAS1_DH_region |
Resolved |
| fadE1 Rv0131c |
- |
acyl-CoA dehydrogenase FadE1 | Acyl-CoA dehydrogenase FadE1. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Resolved |
| fgd2 Rv0132c |
mtbc0_000143 |
F420-dependent glucose-6-phosphate dehydrogenase | F420-dependent hydroxymycolic acid dehydrogenase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv0133 Rv0133 |
mtbc0_000144 |
GCN5-like N-acetyltransferase | GNAT family N-acetyltransferase. Pfam: Acetyltransf_1 (PF00583.32), Acetyltransf_10 (PF13673.14). | Acetyltransf_1 Acetyltransf_10 |
Family assigned |
| ephF Rv0134 |
mtbc0_000145 |
epoxide hydrolase EphF | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 |
Family assigned |
| Rv0135c Rv0135c |
mtbc0_000146 |
transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| cyp138 Rv0136 |
mtbc0_000147 |
cytochrome P450 Cyp138 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| msrA Rv0137c |
mtbc0_000148 |
peptide methionine sulfoxide reductase MsrA | Peptide-methionine (S)-S-oxide reductase MsrA. Pfam: PMSR (PF01625.29). | PMSR |
Resolved |
| Rv0138 Rv0138 |
mtbc0_000149 |
hypothetical protein | NTF2-like / SnoaL-like superfamily protein (Pfam SnoaL_4 PF13577 + SnoaL_2 PF12680). A cone fold often acting as a polyketide cyclase or hydrophobic-ligand-binding domain; the specific role is not established. | SnoaL_4 SnoaL_2 |
Family assigned |
| Rv0139 Rv0139 |
mtbc0_000150 |
oxidoreductase | NAD-dependent epimerase/dehydratase family protein. Pfam: Epimerase (PF01370.28), 3Beta_HSD (PF01073.26), GDP_Man_Dehyd (PF16363.12), NmrA (PF05368.20), NAD_binding_10 (PF13460.13), NAD_binding_4 (PF07993.19). | Epimerase 3Beta_HSD GDP_Man_Dehyd NmrA NAD_binding_10 NAD_binding_4 |
Family assigned |
| Rv0140 Rv0140 |
mtbc0_000151 |
hypothetical protein | Putative nucleotidyltransferase (Pfam NTP_transf_9 PF04248; the family formerly named DUF427). A minimal nucleotidyltransferase fold; the substrate is not established. | NTP_transf_9 |
Family assigned |
| Rv0141c Rv0141c |
mtbc0_000152 |
hypothetical protein | NTF2-like / SnoaL-like superfamily protein (Pfam SnoaL_2 PF12680), as for Rv0138. Cone-fold ligand-binding / cyclase-like domain; specific role not established. | SnoaL_2 |
Family assigned |
| Rv0142 Rv0142 |
mtbc0_000153 |
hypothetical protein | DNA-3-methyladenine glycosylase: a base-excision-repair enzyme that removes alkylated bases (e.g. 3-methyladenine) from DNA, initiating their repair. Assigned by RefSeq/PGAP homology (no Pfam domain above the gathering threshold). | Resolved | |
| Rv0143c Rv0143c |
mtbc0_000154 |
transmembrane protein | Chloride channel protein. Pfam: Voltage_CLC (PF00654.26). | Voltage_CLC |
Resolved |
| Rv0144 Rv0144 |
- |
transcriptional regulator | Transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_13 (PF16925.11). | TetR_N TetR_C_13 |
Family assigned |
| Rv0145 Rv0145 |
mtbc0_000156 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv0146 Rv0146 |
mtbc0_000157 |
S-adenosylmethionine-dependent methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |