Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| gpm1 Rv0489 |
- |
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Resolved |
| senX3 Rv0490 |
mtbc0_000515 |
two component sensor histidine kinase SenX3 | Two-component system sensor histidine kinase SenX3. Pfam: HisKA (PF00512.32), HATPase_c (PF02518.32). | HisKA HATPase_c |
Resolved |
| regX3 Rv0491 |
- |
two component sensory transduction protein RegX | Two component sensory transduction protein RegX. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Resolved |
| Rv0492A Rv0492A |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv0492c Rv0492c |
mtbc0_000517 |
GMC-type oxidoreductase | GMC family oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), FAD_binding_2 (PF00890.31), NAD_binding_8 (PF13450.13), GMC_oxred_N (PF00732.26), GMC_oxred_C (PF05199.20). | FAD_binding_3 FAD_binding_2 NAD_binding_8 GMC_oxred_N GMC_oxred_C |
Family assigned |
| Rv0493c Rv0493c |
- |
hypothetical protein | Contains Tocopherol_cycl (PF14249.13) domain(s); putative function inferred from the domain architecture. | Tocopherol_cycl |
Family assigned |
| Rv0494 Rv0494 |
- |
HTH-type transcriptional regulator | HTH-type transcriptional regulator. Pfam: GntR (PF00392.28), HTH_Crp_2 (PF13545.13), FCD (PF07729.18). | GntR HTH_Crp_2 FCD |
Family assigned |
| Rv0495c Rv0495c |
- |
hypothetical protein | Contains Rv0495c (PF11307.14) domain(s); putative function inferred from the domain architecture. | Rv0495c |
Family assigned |
| Rv0496 Rv0496 |
- |
hypothetical protein | Contains Ppx-GppA (PF02541.23) domain(s); putative function inferred from the domain architecture. | Ppx-GppA |
Family assigned |
| Rv0497 Rv0497 |
mtbc0_000523 |
transmembrane protein | Contains Rv0497_C (PF27548.1) domain(s); putative function inferred from the domain architecture. | Rv0497_C |
Family assigned |
| Rv0498 Rv0498 |
mtbc0_000524 |
hypothetical protein | Sugar phosphate isomerase/epimerase. Pfam: AP_endonuc_2 (PF01261.31). | AP_endonuc_2 |
Resolved |
| Rv0499 Rv0499 |
mtbc0_000525 |
hypothetical protein | Thioesterase family protein. Pfam: 4HBT_3 (PF13622.13), 4HBT_3C (PF20789.4). | 4HBT_3 4HBT_3C |
Family assigned |
| proC Rv0500 |
- |
pyrroline-5-carboxylate reductase | Pyrroline-5-carboxylate reductase. Pfam: F420_oxidored (PF03807.24), NAD_binding_2 (PF03446.22), P5CR_dimer (PF14748.12). | F420_oxidored NAD_binding_2 P5CR_dimer |
Resolved |
| Rv0500A Rv0500A |
- |
DNA-binding protein | DNA-binding protein. Pfam: HTH_17 (PF12728.14). | HTH_17 |
Family assigned |
| Rv0500B Rv0500B |
|
Conserved hypothetical protein | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds rRNA | COX24_C |
Family assigned |
| galE2 Rv0501 |
mtbc0_000529 |
UDP-glucose 4-epimerase GalE | SDR family oxidoreductase. Pfam: Epimerase (PF01370.28), GDP_Man_Dehyd (PF16363.12), 3Beta_HSD (PF01073.26). | Epimerase GDP_Man_Dehyd 3Beta_HSD |
Family assigned |
| Rv0502 Rv0502 |
mtbc0_000530 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| cmaA2 Rv0503c |
mtbc0_000531 |
cyclopropane mycolic acid synthase | Cyclopropane mycolic acid synthase CmaA2. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_12 (PF08242.19), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_12 Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv0504c Rv0504c |
mtbc0_000532 |
hypothetical protein | MaoC family dehydratase N-terminal domain-containing protein. Pfam: FAS1_DH_region (PF13452.12). | FAS1_DH_region |
Family assigned |
| serB1 Rv0505c |
- |
phosphoserine phosphatase SerB | Phosphoserine phosphatase SerB. Pfam: Hydrolase (PF00702.33), HAD (PF12710.14), Hydrolase_3 (PF08282.19). | Hydrolase HAD Hydrolase_3 |
Resolved |
| mmpS2 Rv0506 |
mtbc0_000534 |
membrane protein MmpS2 | MmpS family protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| mmpL2 Rv0507 |
mtbc0_000535 |
transmembrane transport protein MmpL2 | RND transporter MmpL2. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv0508 Rv0508 |
mtbc0_000536 |
hypothetical protein | Glutaredoxin family protein. Pfam: Glrx-like (PF05768.21). | Glrx-like |
Family assigned |
| hemA Rv0509 |
mtbc0_000537 |
glutamyl-tRNA reductase | Glutamyl-tRNA reductase. Pfam: GlutR_N (PF05201.21), Shikimate_DH (PF01488.27), GlutR_dimer (PF00745.26). | GlutR_N Shikimate_DH GlutR_dimer |
Resolved |
| hemC Rv0510 |
mtbc0_000538 |
porphobilinogen deaminase | Hydroxymethylbilane synthase. Pfam: Porphobil_deam (PF01379.26), Porphobil_deamC (PF03900.21). | Porphobil_deam Porphobil_deamC |
Resolved |
| hemD Rv0511 |
- |
uroporphyrin-III C-methyltransferase | Uroporphyrin-III C-methyltransferase. Pfam: TP_methylase (PF00590.26), HEM4 (PF02602.21). | TP_methylase HEM4 |
Resolved |
| hemB Rv0512 |
mtbc0_000540 |
delta-aminolevulinic acid dehydratase | Porphobilinogen synthase. Pfam: ALAD (PF00490.28). | ALAD |
Resolved |
| Rv0513 Rv0513 |
mtbc0_000541 |
transmembrane protein | DUF3093 domain-containing protein. Pfam: UCP026610 (PF27726.1). | UCP026610 |
Family assigned |
| Rv0514 Rv0514 |
mtbc0_000542 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0515 Rv0515 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat protein family (eggNOG COG1403, defense COG category V). RefSeq leaves it 'hypothetical protein'. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| oprA Rv0516c |
mtbc0_000544 |
anti-anti-sigma factor | Osmosensory protein OprA. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Resolved |
| Rv0517 Rv0517 |
- |
acyltransferase | Acyltransferase. Pfam: Acyl_transf_3 (PF01757.29). | Acyl_transf_3 |
Resolved |
| Rv0518 Rv0518 |
mtbc0_000546 |
hypothetical protein | SGNH/GDSL hydrolase family protein. Pfam: Lipase_GDSL (PF00657.29), Lipase_GDSL_2 (PF13472.13). | Lipase_GDSL Lipase_GDSL_2 |
Family assigned |
| Rv0519c Rv0519c |
- |
membrane protein | Membrane protein. Pfam: Esterase (PF00756.27). | Esterase |
Family assigned |
| gabP Rv0522 |
- |
GABA permease GabP | GABA permease GabP. Pfam: AA_permease (PF00324.28), AA_permease_2 (PF13520.13), Spore_permease (PF03845.20). | AA_permease AA_permease_2 Spore_permease |
Resolved |
| Rv0523c Rv0523c |
mtbc0_000551 |
hypothetical protein | Nitroreductase family deazaflavin-dependent oxidoreductase. | Family assigned | |
| hemL Rv0524 |
mtbc0_000552 |
glutamate-1-semialdehyde 2,1-aminomutase | Glutamate-1-semialdehyde 2%2C1-aminomutase. Pfam: Aminotran_3 (PF00202.28). | Aminotran_3 |
Resolved |
| Rv0525 Rv0525 |
mtbc0_000553 |
hypothetical protein | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| Rv0526 Rv0526 |
- |
thioredoxin | Thioredoxin. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28), Thioredoxin (PF00085.27). | Redoxin AhpC-TSA Thioredoxin |
Resolved |
| ccdA Rv0527 |
- |
cytochrome C-type biogenesis protein CcdA | Cytochrome C-type biogenesis protein CcdA. | Resolved | |
| Rv0528 Rv0528 |
mtbc0_000556 |
transmembrane protein | Cytochrome c biogenesis protein ResB. Pfam: ResB (PF05140.20). | ResB |
Resolved |
| ccsA Rv0529 |
mtbc0_000557 |
cytochrome C-type biogenesis protein CcsA | C-type cytochrome biogenesis protein CcsB. Pfam: Cytochrom_C_asm (PF01578.26). | Cytochrom_C_asm |
Resolved |
| Rv0530 Rv0530 |
mtbc0_000558 |
hypothetical protein | MinD/ParA family protein. Pfam: CbiA (PF01656.30), AAA_31 (PF13614.13), CBP_BcsQ (PF06564.19). | CbiA AAA_31 CBP_BcsQ |
Family assigned |
| Rv0530A Rv0530A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0531 Rv0531 |
mtbc0_000560 |
membrane protein | Candidate accessory component of the cell-wall arabinan / arabinogalactan biosynthesis machinery (Emb/Aft arabinofuranosyltransferases), coupled to the AftC arabinofuranosyltransferase (alpha1->3 arabinan branching). Rv0531 is a STRING context partner by phylogenetic cooccurrence (not a genomic neighbour) of Rv3668c:765;Rv3346c:733;aftC:721;Rv3802c:692;lpqB:653;Rv1476:632 (context-driven, text-mining excluded). It is under purifying selection on 145,209 MTBC genomes (3 segregating sites). No dedicated functional study of Rv0531 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | DUF4229 |
Family assigned |
| PE_PGRS6 Rv0532 |
- |
PE-PGRS family protein PE_PGRS6 | PE-PGRS family protein PE_PGRS6. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| fabH Rv0533c |
mtbc0_000562 |
3-oxoacyl-ACP synthase III | Beta-ketoacyl-ACP synthase III. Pfam: Thiolase_N (PF00108.30), ACP_syn_III (PF08545.17), ACP_syn_III_C (PF08541.17). | Thiolase_N ACP_syn_III ACP_syn_III_C |
Resolved |
| menA Rv0534c |
mtbc0_000563 |
1,4-dihydroxy-2-naphthoate octaprenyltransferase | 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase. Pfam: UbiA (PF01040.24). | UbiA |
Resolved |
| Rv0535 Rv0535 |
- |
5'-methylthioadenosine phosphorylase | 5'-methylthioadenosine phosphorylase. Pfam: PNP_UDP_1 (PF01048.27). | PNP_UDP_1 |
Resolved |
| galE3 Rv0536 |
- |
UDP-glucose 4-epimerase GalE | UDP-glucose 4-epimerase GalE. Pfam: GDP_Man_Dehyd (PF16363.12), Epimerase (PF01370.28). | GDP_Man_Dehyd Epimerase |
Resolved |