Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| oppD Rv1281c |
mtbc0_001371 |
oligopeptide ABC transporter ATP-binding protein OppD | ABC transporter ATP-binding protein. Pfam: oligo_HPY (PF08352.18), ABC_tran (PF00005.34). | oligo_HPY ABC_tran |
Family assigned |
| oppC Rv1282c |
mtbc0_001372 |
oligopeptide ABC transporter permease OppC | ABC transporter permease. Pfam: OppC_N (PF12911.13), BPD_transp_1 (PF00528.28). | OppC_N BPD_transp_1 |
Family assigned |
| oppB Rv1283c |
mtbc0_001373 |
oligopeptide ABC transporter permease OppB | ABC transporter permease. Pfam: BPD_transp_1_N (PF19300.5), BPD_transp_1 (PF00528.28). | BPD_transp_1_N BPD_transp_1 |
Family assigned |
| canA Rv1284 |
mtbc0_001374 |
beta-carbonic anhydrase | Beta-carbonic anhydrase CanA. Pfam: Pro_CA (PF00484.25). | Pro_CA |
Resolved |
| cysD Rv1285 |
mtbc0_001375 |
sulfate adenylyltransferase subunit 2 | Sulfate adenylyltransferase subunit CysD. Pfam: PAPS_reduct (PF01507.26). | PAPS_reduct |
Family assigned |
| cysC Rv1286 |
mtbc0_001376 |
adenylyl-sulfate kinase | Adenylyl-sulfate kinase. Pfam: GTP_EFTU (PF00009.34), GTP-eEF1A_C (PF22594.3), APS_kinase (PF01583.27), AAA_33 (PF13671.13). | GTP_EFTU GTP-eEF1A_C APS_kinase AAA_33 |
Resolved |
| Rv1287 Rv1287 |
mtbc0_001377 |
HTH-type transcriptional regulator | RrF2 family transcriptional regulator. Pfam: Rrf2 (PF02082.27). | Rrf2 |
Family assigned |
| Rv1288 Rv1288 |
mtbc0_001378 |
hypothetical protein | Esterase. Pfam: Phage_tail_X (PF05489.19), LysM (PF01476.27), Esterase (PF00756.27). | Phage_tail_X LysM Esterase |
Resolved |
| Rv1289 Rv1289 |
mtbc0_001379 |
hypothetical protein | Contains Rv1289 (PF27329.1) domain(s); putative function inferred from the domain architecture. | Rv1289 |
Family assigned |
| Rv1290A Rv1290A |
- |
hypothetical protein | Leucine carboxyl methyltransferase-family enzyme (eggNOG COG3315, secondary-metabolism COG category Q): a SAM-dependent protein-carboxyl methyltransferase. RefSeq leaves it 'hypothetical protein'. The methyl-acceptor substrate is undetermined. | Family assigned | |
| Rv1290c Rv1290c |
mtbc0_001380 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2254 |
Family assigned |
| Rv1291c Rv1291c |
mtbc0_001382 |
hypothetical protein | Secreted protein of the mycobacterial DUF732 family. All-vs-all structural clustering (Foldseek on ESMFold models, phase36) places it in a tight fold family (median TM-score 0.67) that includes the characterised host-directed effectors Rv1804c (sequesters host IkappaB-alpha) and Rv3354 (targets the host COP9 signalosome), plus the secreted antigen Rv1271c. It shares the family's N-terminal signal peptide (DeepTMHMM) and the ~110-aa secreted fold. A host-interaction / secreted-effector role is therefore plausible, but the specific molecular target of THIS member is not experimentally established (the DUF732 family is functionally heterogeneous). | DUF732 |
Family assigned |
| argS Rv1292 |
mtbc0_001384 |
arginine--tRNA ligase | Arginine--tRNA ligase. Pfam: Arg_tRNA_synt_N (PF03485.22), tRNA-synt_1d (PF00750.26), tRNA-synt_1 (PF00133.29), DALR_1 (PF05746.22). | Arg_tRNA_synt_N tRNA-synt_1d tRNA-synt_1 DALR_1 |
Resolved |
| lysA Rv1293 |
mtbc0_001385 |
diaminopimelate decarboxylase | Diaminopimelate decarboxylase. Pfam: Orn_Arg_deC_N (PF02784.23), Orn_DAP_Arg_deC (PF00278.29). | Orn_Arg_deC_N Orn_DAP_Arg_deC |
Resolved |
| thrA Rv1294 |
mtbc0_001386 |
homoserine dehydrogenase | Homoserine dehydrogenase. Pfam: NAD_binding_3 (PF03447.23), Homoserine_dh (PF00742.25), ACT (PF01842.32). | NAD_binding_3 Homoserine_dh ACT |
Resolved |
| thrC Rv1295 |
mtbc0_001387 |
threonine synthase | Threonine synthase. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| thrB Rv1296 |
mtbc0_001388 |
homoserine kinase | Homoserine kinase. Pfam: GHMP_kinases_N (PF00288.33), GHMP_kinases_C (PF08544.19). | GHMP_kinases_N GHMP_kinases_C |
Resolved |
| rho Rv1297 |
mtbc0_001389 |
transcription termination factor Rho | Transcription termination factor Rho. Pfam: Rho_N (PF07498.19), Rho_RNA_bind (PF07497.19), ATP-synt_ab (PF00006.32). | Rho_N Rho_RNA_bind ATP-synt_ab |
Resolved |
| rpmE Rv1298 |
mtbc0_001390 |
50S ribosomal protein L31 | 50S ribosomal protein L31. Pfam: Ribosomal_L31 (PF01197.24). | Ribosomal_L31 |
Resolved |
| prfA Rv1299 |
mtbc0_001391 |
peptide chain release factor PrfA | Peptide chain release factor 1. Pfam: PCRF (PF03462.24), RF-1 (PF00472.27). | PCRF RF-1 |
Resolved |
| hemK Rv1300 |
mtbc0_001392 |
release factor glutamine methyltransferase | Peptide chain release factor N(5)-glutamine methyltransferase. Pfam: PrmC_N (PF17827.7), MTS (PF05175.21), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_11 (PF08241.19). | PrmC_N MTS Methyltransf_25 Methyltransf_31 Methyltransf_11 |
Resolved |
| Rv1301 Rv1301 |
mtbc0_001393 |
threonylcarbamoyl-AMP synthase | L-threonylcarbamoyladenylate synthase. Pfam: Sua5_yciO_yrdC (PF01300.25). | Sua5_yciO_yrdC |
Resolved |
| rfe Rv1302 |
mtbc0_001394 |
decaprenyl-phosphate N-acetylglucosaminephosphotransferase | UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase. Pfam: Glycos_transf_4 (PF00953.27). | Glycos_transf_4 |
Resolved |
| Rv1303 Rv1303 |
mtbc0_001395 |
hypothetical protein | ATP synthase subunit I. Pfam: ATP-synt_I (PF03899.22). | ATP-synt_I |
Family assigned |
| atpB Rv1304 |
mtbc0_001396 |
ATP synthase subunit A | F0F1 ATP synthase subunit A. Pfam: ATP-synt_A (PF00119.26). | ATP-synt_A |
Family assigned |
| atpE Rv1305 |
mtbc0_001397 |
ATP synthase subunit C | F0F1 ATP synthase subunit C. Pfam: ATP-synt_C (PF00137.27). | ATP-synt_C |
Family assigned |
| atpF Rv1306 |
mtbc0_001398 |
ATP synthase subunit B | F0F1 ATP synthase subunit B. Pfam: ATP-synt_B (PF00430.24). | ATP-synt_B |
Family assigned |
| atpH Rv1307 |
mtbc0_001399 |
ATP synthase subunit b/delta | F0F1 ATP synthase subunit B/delta. Pfam: ATP-synt_B (PF00430.24), OSCP (PF00213.24). | ATP-synt_B OSCP |
Family assigned |
| atpA Rv1308 |
mtbc0_001400 |
ATP synthase subunit alpha | F0F1 ATP synthase subunit alpha. Pfam: ATP-synt_ab_N (PF02874.30), ATP-synt_ab (PF00006.32), ATP-synt_ab_C (PF00306.33). | ATP-synt_ab_N ATP-synt_ab ATP-synt_ab_C |
Family assigned |
| atpG Rv1309 |
mtbc0_001401 |
ATP synthase subunit gamma | F0F1 ATP synthase subunit gamma. Pfam: ATP-synt (PF00231.25). | ATP-synt |
Family assigned |
| atpD Rv1310 |
mtbc0_001402 |
ATP synthase subunit beta | F0F1 ATP synthase subunit beta. Pfam: ATP-synt_ab_N (PF02874.30), ATP-synt_ab (PF00006.32), ATP-synt_VA_C (PF22919.2). | ATP-synt_ab_N ATP-synt_ab ATP-synt_VA_C |
Family assigned |
| atpC Rv1311 |
mtbc0_001403 |
ATP synthase subunit epsilon | F0F1 ATP synthase subunit epsilon. Pfam: ATP-synt_DE_N (PF02823.22). | ATP-synt_DE_N |
Family assigned |
| Rv1312 Rv1312 |
mtbc0_001404 |
hypothetical protein | Membrane protein encoded as the terminal gene of the F1F0-ATP synthase operon (Rv1303-atpBEFGHDC-Rv1312; operon structure established in the published M. tuberculosis oxidative-phosphorylation literature), co-transcribed with the atp genes and under strong purifying selection. The convergent context — co-transcription within the ATP-synthase operon, predicted membrane localisation, and an in-vivo fitness requirement (Tn-seq) — makes it a candidate accessory / associated component of the mycobacterial ATP synthase (oxidative phosphorylation). Whether it is a structural subunit, an assembly factor, or a co-regulated membrane protein is not established. RefSeq leaves it 'hypothetical protein'. | DUF2550 |
Family assigned |
| Rv1313c Rv1313c |
mtbc0_004026 |
insertion sequence element IS1557 transposase | ISL3-like element IS1557 family transposase. Pfam: Zn_ribbon_ISL3 (PF14690.12), HTH_Tnp_ISL3 (PF13542.13), DDE_Tnp_ISL3 (PF01610.24). | Zn_ribbon_ISL3 HTH_Tnp_ISL3 DDE_Tnp_ISL3 |
Family assigned |
| Rv1314c Rv1314c |
mtbc0_001406 |
cob(I)yrinic acid a,c-diamide adenosyltransferase | Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase. Pfam: Cob_adeno_trans (PF01923.24). | Cob_adeno_trans |
Resolved |
| murA Rv1315 |
mtbc0_001407 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine 1-carboxyvinyltransferase. Pfam: EPSP_synthase (PF00275.26). | EPSP_synthase |
Resolved |
| ogt Rv1316c |
mtbc0_001411 |
methylated-DNA--protein-cysteine methyltransferase | Methylated-DNA--protein-cysteine methyltransferase. Pfam: Methyltransf_1N (PF02870.22), DNA_binding_1 (PF01035.27). | Methyltransf_1N DNA_binding_1 |
Resolved |
| alkA Rv1317c |
mtbc0_001412 |
bifunctional regulatory protein/DNA repair enzyme AlkA | Bifunctional regulatory protein/DNA repair enzyme AlkA. Pfam: Ada_Zn_binding (PF02805.22), HTH_18 (PF12833.14), AlkA_N (PF06029.18), HhH-GPD (PF00730.32). | Ada_Zn_binding HTH_18 AlkA_N HhH-GPD |
Family assigned |
| Rv1318c Rv1318c |
mtbc0_001413 |
adenylate cyclase | Adenylate/guanylate cyclase domain-containing protein. Pfam: HAMP (PF00672.31), Guanylate_cyc (PF00211.26). | HAMP Guanylate_cyc |
Family assigned |
| Rv1319c Rv1319c |
- |
adenylate cyclase | Adenylate cyclase. Pfam: HAMP (PF00672.31), Guanylate_cyc (PF00211.26). | HAMP Guanylate_cyc |
Resolved |
| Rv1320c Rv1320c |
mtbc0_001416 |
adenylate cyclase | Adenylate/guanylate cyclase domain-containing protein. Pfam: HAMP (PF00672.31), Guanylate_cyc (PF00211.26). | HAMP Guanylate_cyc |
Family assigned |
| Rv1321 Rv1321 |
- |
endonuclease NucS | Endonuclease NucS. Pfam: NucS_N (PF21003.3), NucS_C (PF01939.22). | NucS_N NucS_C |
Resolved |
| Rv1322 Rv1322 |
mtbc0_001418 |
hypothetical protein | Contains Rv1322 (PF27609.1) domain(s); putative function inferred from the domain architecture. | Rv1322 |
Family assigned |
| Rv1322A Rv1322A |
- |
hypothetical protein | Contains Glyoxalase (PF00903.32), Glyoxalase_3 (PF13468.13), Glyoxalase_4 (PF13669.13) domain(s); putative function inferred from the domain architecture. | Glyoxalase Glyoxalase_3 Glyoxalase_4 |
Family assigned |
| fadA4 Rv1323 |
- |
acetyl-CoA acetyltransferase | Acetyl-CoA acetyltransferase. Pfam: Thiolase_N (PF00108.30), ketoacyl-synt (PF00109.33), Thiolase_C (PF02803.25). | Thiolase_N ketoacyl-synt Thiolase_C |
Resolved |
| Rv1324 Rv1324 |
mtbc0_001421 |
thioredoxin | Co-chaperone YbbN. Pfam: Thioredoxin (PF00085.27), TPR_20 (PF14561.13). | Thioredoxin TPR_20 |
Resolved |
| PE_PGRS24 Rv1325c |
- |
PE-PGRS family protein PE_PGRS24 | PE-PGRS family protein PE_PGRS24. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| glgB Rv1326c |
mtbc0_001423 |
1,4-alpha-glucan branching protein | 1%2C4-alpha-glucan branching protein GlgB. Pfam: GlgB_N (PF22019.3), CBM_48 (PF02922.25), Alpha-amylase (PF00128.32), Alpha-amylase_C (PF02806.25). | GlgB_N CBM_48 Alpha-amylase Alpha-amylase_C |
Resolved |
| glgE Rv1327c |
- |
alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase | Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase. Pfam: GlgE_dom_N_S (PF11896.15), GLGE_C (PF21702.4). | GlgE_dom_N_S GLGE_C |
Resolved |
| glgP Rv1328 |
mtbc0_001425 |
glycogen phosphorylase | Glycosyltransferase family 1 protein. Pfam: DUF3417 (PF11897.14), Phosphorylase (PF00343.27), GlgP_C (PF28476.1). | DUF3417 Phosphorylase GlgP_C |
Family assigned |