Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pepD Rv0983 |
mtbc0_001054 |
serine protease PepD | Serine protease PepD. Pfam: Trypsin (PF00089.33), Trypsin_2 (PF13365.13), PDZ (PF00595.30), PDZ_2 (PF13180.13). | Trypsin Trypsin_2 PDZ PDZ_2 |
Resolved |
| moaB2 Rv0984 |
mtbc0_001055 |
pterin-4-alpha-carbinolamine dehydratase | MogA/MoaB family molybdenum cofactor biosynthesis protein. Pfam: MoCF_biosynth (PF00994.30). | MoCF_biosynth |
Family assigned |
| mscL Rv0985c |
mtbc0_001056 |
large-conductance ion mechanosensitive channel | Large-conductance mechanosensitive channel protein MscL. Pfam: MscL (PF01741.24). | MscL |
Resolved |
| Rv0986 Rv0986 |
mtbc0_001057 |
adhesion component ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Family assigned |
| Rv0987 Rv0987 |
mtbc0_001058 |
adhesion component ABC transporter permease | FtsX-like permease family protein. Pfam: MacB_PCD (PF12704.15), FtsX (PF02687.28). | MacB_PCD FtsX |
Family assigned |
| Rv0988 Rv0988 |
mtbc0_001059 |
hypothetical protein | Lipocalin-like domain-containing protein. Pfam: CrtC (PF07143.18), Lipocalin_9 (PF17186.11). | CrtC Lipocalin_9 |
Family assigned |
| grcC2 Rv0989c |
mtbc0_001060 |
polyprenyl-diphosphate synthase GrcC | Polyprenyl-diphosphate synthase GrcC. Pfam: polyprenyl_synt (PF00348.23). | polyprenyl_synt |
Resolved |
| Rv0990c Rv0990c |
mtbc0_001061 |
hypothetical protein | SAF domain-containing protein. Pfam: SAF (PF08666.18), ChapFlgA (PF13144.12). | SAF ChapFlgA |
Family assigned |
| Rv0991c Rv0991c |
mtbc0_001062 |
hypothetical protein | FmdB family zinc ribbon protein. Pfam: Zn_ribbon_8 (PF09723.16). | Zn_ribbon_8 |
Family assigned |
| Rv0992c Rv0992c |
mtbc0_001063 |
5-formyltetrahydrofolate cyclo-ligase | 5-formyltetrahydrofolate cyclo-ligase. Pfam: 5-FTHF_cyc-lig (PF01812.27). | 5-FTHF_cyc-lig |
Resolved |
| galU Rv0993 |
mtbc0_001064 |
UTP--glucose-1-phosphate uridylyltransferase | UTP--glucose-1-phosphate uridylyltransferase. Pfam: NTP_transferase (PF00483.30). | NTP_transferase |
Resolved |
| moeA1 Rv0994 |
- |
molybdopterin molybdenumtransferase 1 | Molybdopterin molybdenumtransferase 1. Pfam: MoeA_N (PF03453.23), MoCF_biosynth (PF00994.30), MoeA_C (PF03454.21). | MoeA_N MoCF_biosynth MoeA_C |
Resolved |
| rimJ Rv0995 |
- |
ribosomal-protein-alanine acetyltransferase RimJ | Ribosomal-protein-alanine acetyltransferase RimJ. Pfam: Acetyltransf_3 (PF13302.14), Acetyltransf_1 (PF00583.32). | Acetyltransf_3 Acetyltransf_1 |
Resolved |
| Rv0996 Rv0996 |
mtbc0_001067 |
transmembrane protein | Contains GlpR (PF28211.1) domain(s); putative function inferred from the domain architecture. | GlpR |
Family assigned |
| Rv0997 Rv0997 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0997a Rv0997a |
- |
hypothetical protein | N-terminal (KOW-like / SH3-barrel) domain of a translation elongation factor P (EF-P) / eIF-5A family protein (Pfam EFP_N, HHpred 96.5%, E=0.15, with a large confident cascade of EF-P / eIF-5A hits at 90-96%). Confident fold assignment: an EF-P-type ribosome-associated translation factor domain (EF-P assists translation of polyproline motifs). Likely a standalone EF-P N-terminal-domain protein / paralogue. | Resolved | |
| Rv0998 Rv0998 |
mtbc0_001072 |
acetyltransferase Pat | GNAT family N-acetyltransferase. Pfam: cNMP_binding (PF00027.36), Acetyltransf_3 (PF13302.14), Acetyltransf_1 (PF00583.32). | cNMP_binding Acetyltransf_3 Acetyltransf_1 |
Family assigned |
| Rv0999 Rv0999 |
- |
hypothetical protein | Lipoprotein / outer-membrane-associated protein (lipoprotein-like beta fold); structurally solved but functionally uncharacterised fold RefSeq leaves this locus uncharacterised. | DUF5642 |
Family assigned |
| Rv1000c Rv1000c |
- |
hypothetical protein | Contains 2OG-FeII_Oxy_2 (PF13532.13) domain(s); putative function inferred from the domain architecture. | 2OG-FeII_Oxy_2 |
Family assigned |
| arcA Rv1001 |
mtbc0_001076 |
arginine deiminase | Arginine deiminase. Pfam: ADI (PF02274.23). | ADI |
Resolved |
| Rv1002c Rv1002c |
mtbc0_001077 |
dolichyl-phosphate-mannose--protein mannosyltransferase | Dolichyl-phosphate-mannose--protein mannosyltransferase. Pfam: PMT_2 (PF13231.13), PMT (PF02366.25), PMT_4TMC (PF16192.11). | PMT_2 PMT PMT_4TMC |
Resolved |
| rsmI Rv1003 |
mtbc0_001078 |
rRNA small subunit methyltransferase I | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase. Pfam: TP_methylase (PF00590.26). | TP_methylase |
Resolved |
| Rv1004c Rv1004c |
mtbc0_001079 |
membrane protein | Signal-peptide protein with a strong STRING experimental association (score 829) to ftsY, the signal-recognition-particle receptor of the co-translational protein-targeting/insertion machinery. Contextual candidate: associated with protein targeting / secretion. Guilt-by-association, not an established function. | Family assigned | |
| Rv1005c Rv1005c |
- |
para-aminobenzoate synthase component I | Para-aminobenzoate synthase component I. Pfam: Chorismate_bind (PF00425.25). | Chorismate_bind |
Resolved |
| Rv1006 Rv1006 |
mtbc0_001081 |
hypothetical protein | Glycoside-hydrolase-like fold (GH2, PDB 5T99); putative glycosidase. | Family assigned | |
| metS Rv1007c |
mtbc0_001082 |
methionine--tRNA ligase | Methionine--tRNA ligase. Pfam: tRNA-synt_1g (PF09334.18), tRNA-synt_1 (PF00133.29), Anticodon_3 (PF19303.6). | tRNA-synt_1g tRNA-synt_1 Anticodon_3 |
Resolved |
| tatD Rv1008 |
- |
deoxyribonuclease TatD | Deoxyribonuclease TatD. Pfam: TatD_DNase (PF01026.28). | TatD_DNase |
Resolved |
| rpfB Rv1009 |
- |
resuscitation-promoting factor RpfB | Resuscitation-promoting factor RpfB. Pfam: DUF348 (PF03990.21), G5 (PF07501.18), Transglycosylas (PF06737.20). | DUF348 G5 Transglycosylas |
Resolved |
| ksgA Rv1010 |
mtbc0_001085 |
rRNA small subunit methyltransferase A | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA. Pfam: RrnaAD (PF00398.27). | RrnaAD |
Resolved |
| ispE Rv1011 |
- |
4-diphosphocytidyl-2C-methyl-D-erythritol kinase | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Pfam: GHMP_kinases_N (PF00288.33), GHMP_kinases_C (PF08544.19). | GHMP_kinases_N GHMP_kinases_C |
Resolved |
| Rv1012 Rv1012 |
mtbc0_001087 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| pks16 Rv1013 |
mtbc0_001088 |
polyketide synthase | Fatty acyl-AMP ligase. Pfam: AMP-binding (PF00501.35). | AMP-binding |
Resolved |
| pth Rv1014c |
mtbc0_001089 |
peptidyl-tRNA hydrolase | Aminoacyl-tRNA hydrolase. Pfam: Pept_tRNA_hydro (PF01195.26). | Pept_tRNA_hydro |
Resolved |
| rplY Rv1015c |
mtbc0_001090 |
50S ribosomal protein L25/general stress protein Ctc | 50S ribosomal protein L25/general stress protein Ctc. Pfam: Ribosomal_L25p (PF01386.25), Ribosomal_TL5_C (PF14693.12). | Ribosomal_L25p Ribosomal_TL5_C |
Resolved |
| lpqT Rv1016c |
- |
lipoprotein LpqT | Lipoprotein LpqT. Pfam: Lpp-LpqN (PF10738.16). | Lpp-LpqN |
Resolved |
| prsA Rv1017c |
mtbc0_001092 |
ribose-phosphate pyrophosphokinase | Ribose-phosphate diphosphokinase. Pfam: Pribosyltran_N (PF13793.13), Pribosyltran (PF00156.34), Pribosyl_synth (PF14572.13). | Pribosyltran_N Pribosyltran Pribosyl_synth |
Resolved |
| glmU Rv1018c |
mtbc0_001093 |
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase | Bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU. Pfam: IspD (PF01128.26), NTP_transf_3 (PF12804.14), NTP_transferase (PF00483.30), Hexapep (PF00132.31). | IspD NTP_transf_3 NTP_transferase Hexapep |
Resolved |
| Rv1019 Rv1019 |
mtbc0_001095 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_46 (PF21943.2). | TetR_N TetR_C_46 |
Family assigned |
| mfd Rv1020 |
mtbc0_001096 |
transcription-repair coupling factor | Transcription-repair coupling factor. Pfam: UvrB_inter (PF17757.7), CarD_TRCF_RID (PF02559.23), DEAD (PF00270.36), ResIII (PF04851.22), Helicase_C (PF00271.38), TRCF (PF03461.21). | UvrB_inter CarD_TRCF_RID DEAD ResIII Helicase_C TRCF |
Resolved |
| Rv1021 Rv1021 |
mtbc0_001097 |
nucleoside triphosphate pyrophosphohydrolase | Nucleoside triphosphate pyrophosphohydrolase. Pfam: MazG_N (PF27510.1), MazG (PF03819.23). | MazG_N MazG |
Resolved |
| lpqU Rv1022 |
mtbc0_001098 |
lipoprotein LpqU | Lytic murein transglycosylase. Pfam: SLT_2 (PF13406.12). | SLT_2 |
Resolved |
| eno Rv1023 |
mtbc0_001099 |
enolase | Phosphopyruvate hydratase. Pfam: Enolase_N (PF03952.22), Enolase_C (PF00113.29), MR_MLE_C (PF13378.13). | Enolase_N Enolase_C MR_MLE_C |
Resolved |
| Rv1024 Rv1024 |
mtbc0_001100 |
membrane protein | Septum formation initiator family protein. Pfam: DivIC (PF04977.21). | DivIC |
Family assigned |
| Rv1025 Rv1025 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF501 (PF04417). Function unknown. No structural homologue (Foldseek vs pdb100 + afdb-swissprot + cath50) and no profile homologue (HHpred): the fold is new and the function is not nameable by homology. Carries an invariant Cys113-His115-Glu59 candidate metal site (supported, not confirmed -- see the functional site layer), which makes DUF501 a candidate metalloprotein. | DUF501 |
Still unknown |
| ppx2 Rv1026 |
mtbc0_001102 |
hypothetical protein | Exopolyphosphatase Ppx2. Pfam: Ppx-GppA (PF02541.23). | Ppx-GppA |
Resolved |
| kdpE Rv1027c |
mtbc0_001104 |
transcriptional regulator KdpE | Two-component system response regulator KdpE. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Resolved |
| kdpF Rv1028A |
- |
membrane protein KdpF | Membrane protein KdpF. Pfam: Potass_KdpF (PF09604.16). | Potass_KdpF |
Resolved |
| kdpD Rv1028c |
mtbc0_001105 |
sensor protein KdpD | Sensor histidine kinase KdpD. Pfam: KdpD (PF02702.24), Usp (PF00582.33), DUF4118 (PF13493.12), HisKA (PF00512.32), HATPase_c (PF02518.32). | KdpD Usp DUF4118 HisKA HATPase_c |
Resolved |
| kdpA Rv1029 |
mtbc0_001108 |
potassium-transporting ATPase subunit A | Potassium-transporting ATPase subunit KdpA. Pfam: KdpA (PF03814.22). | KdpA |
Family assigned |
| kdpB Rv1030 |
mtbc0_001109 |
potassium-transporting ATPase subunit B | Potassium-transporting ATPase subunit KdpB. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Family assigned |