Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0203 Rv0203 |
mtbc0_000217 |
hypothetical protein | Secreted heme-binding hemophore (Pfam MHB PF16525). Captures host-derived heme and delivers it across the cell envelope for iron acquisition, a component of the mycobacterial heme-uptake system important for growth on heme as an iron source. | MHB |
Resolved |
| Rv0207c Rv0207c |
mtbc0_000221 |
hypothetical protein | NYN-domain ribonuclease (Pfam NYN PF01936), of the PIN/NYN metal-dependent RNase superfamily. Putative ribonuclease. | NYN |
Family assigned |
| Rv0209 Rv0209 |
mtbc0_000223 |
hypothetical protein | IniC/dynamin-like protein (isoniazid-induced, iniBAC-family large GTPase-like). RefSeq leaves it 'hypothetical protein'. Distinct locus from iniC/Rv0342. | Family assigned | |
| Rv0210 Rv0210 |
mtbc0_000224 |
hypothetical protein | Conserved hypothetical protein; no Pfam domain above threshold. Foldseek gives only a low-TM (0.21) partial match to Mtb IniA, not conclusive. Uncharacterised. | Still unknown | |
| Rv0225 Rv0225 |
mtbc0_000239 |
hypothetical protein | Glycosyltransferase family 4 (GT-B fold) protein (Pfam Glycos_transf_1 PF00534 with GT4 domains). Transfers a sugar moiety to an acceptor; the specific donor/acceptor is not established. | Glyco_transf_4 Glyco_trans_4_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Family assigned |
| Rv0229c Rv0229c |
mtbc0_000243 |
hypothetical protein | PIN-domain ribonuclease, VapC-family toxin (Pfam PIN PF01850): the toxin of a VapBC-type toxin-antitoxin module, a metal-dependent mRNA interferase that cleaves RNA. | PIN |
Family assigned |
| Rv0236A Rv0236A |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2613. Function unknown. | DUF2613 |
Still unknown |
| Rv0250c Rv0250c |
mtbc0_000266 |
hypothetical protein | No Pfam domain above threshold, but Foldseek strongly matches a sensor / HD-domain fold (CpxA-like, prob 0.95, TM=0.88): a putative signal-transduction / sensor-associated module. Structure-based. | Family assigned | |
| Rv0257 Rv0257 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0258c Rv0258c |
mtbc0_000274 |
hypothetical protein | TetR/AcrR-family transcriptional regulator (Pfam TetR_C_16 PF17920). PGAP left it 'hypothetical', but the TetR C-terminal ligand-binding/regulatory domain identifies it as a one-component transcriptional regulator. | TetR_C_16 |
Resolved |
| Rv0259c Rv0259c |
mtbc0_000275 |
hypothetical protein | Sirohydrochlorin chelatase (CbiX family, Pfam CbiX PF01903): inserts cobalt or ferrous iron into sirohydrochlorin during siroheme / cobalamin (vitamin B12) cofactor biosynthesis. | CbiX |
Family assigned |
| Rv0263c Rv0263c |
mtbc0_000279 |
hypothetical protein | Carboxyltransferase / 5-oxoprolinase (A/B) subunit (Pfam CT_A_B PF02626; PGAP 5-oxoprolinase/urea-amidolyase family). Putative ATP-dependent amide-bond-hydrolysing subunit, partnering Rv0264c. | CT_A_B |
Family assigned |
| Rv0264c Rv0264c |
mtbc0_000280 |
hypothetical protein | Allophanate hydrolase / 5-oxoprolinase (C/D) subunit (Pfam CT_C_D PF02682). With Rv0263c forms a urea-amidolyase / 5-oxoprolinase-type complex that hydrolyses amide bonds (e.g. allophanate or 5-oxoproline). | CT_C_D |
Family assigned |
| Rv0268c Rv0268c |
- |
hypothetical protein | Contains PhdYeFM_antitox (PF02604.27) domain(s); putative function inferred from the domain architecture. | PhdYeFM_antitox |
Family assigned |
| Rv0269c Rv0269c |
mtbc0_000286 |
hypothetical protein | LigD-type primase-polymerase (Pfam LigD_Prim-Pol PF21686 + DNA_primase_S PF01896): the polymerase/primase (PolDom) module of the bacterial non-homologous end-joining (NHEJ) DNA double-strand-break repair pathway. | LigD_Prim-Pol DNA_primase_S |
Resolved |
| Rv0272c Rv0272c |
mtbc0_000289 |
hypothetical protein | Alpha/beta-hydrolase-fold enzyme (PGAP; Foldseek significant match to a cold-adapted esterase fold, E=7e-6, TM=0.65). Putative esterase/hydrolase; specific substrate not established. | Family assigned | |
| Rv0274 Rv0274 |
mtbc0_000291 |
hypothetical protein | VOC (vicinal-oxygen-chelate) / glyoxalase-bleomycin-resistance superfamily protein (Pfam Glyoxalase PF00903). Putative metalloenzyme (glyoxalase / dioxygenase-type chemistry); specific substrate not established. | Glyoxalase Glyoxalase_4 |
Family assigned |
| Rv0276 Rv0276 |
mtbc0_000293 |
hypothetical protein | Oxygenase MpaB family protein. Pfam: MPAB_Lcp_cat (PF09995.16). | MPAB_Lcp_cat |
Family assigned |
| Rv0293c Rv0293c |
mtbc0_000312 |
hypothetical protein | Alpha/beta fold hydrolase. Pfam: Abhydrolase_1 (PF00561.27). | Abhydrolase_1 |
Resolved |
| Rv0295c Rv0295c |
mtbc0_000314 |
hypothetical protein | Stf0 family sulfotransferase. Pfam: Sulphotransf (PF09037.17). | Sulphotransf |
Family assigned |
| Rv0307c Rv0307c |
mtbc0_000327 |
hypothetical protein | PH/GRAM-superfamily fold (pleckstrin-homology-like beta-sandwich, typically lipid/membrane-binding); specific function undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv0309 Rv0309 |
mtbc0_000329 |
hypothetical protein | L%2CD-transpeptidase. Pfam: YkuD (PF03734.20). | YkuD |
Resolved |
| Rv0310c Rv0310c |
mtbc0_000330 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_4 (PF13577.13). | SnoaL_4 |
Family assigned |
| Rv0311 Rv0311 |
mtbc0_000331 |
hypothetical protein | Longin-like / alpha-beta-plait sensor (ligand-binding) domain; structural homology to DmpR/MopR aromatic-sensing transcriptional regulators, H-NOX gas sensors, and TRAPPC3; specific ligand undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv0312 Rv0312 |
mtbc0_000332 |
hypothetical protein | Hsp70 family protein. Pfam: HSP70 (PF00012.27). | HSP70 |
Family assigned |
| Rv0313 Rv0313 |
mtbc0_000333 |
hypothetical protein | Contains Rv0313_N (PF27179.1) domain(s); putative function inferred from the domain architecture. | Rv0313_N |
Family assigned |
| Rv0320 Rv0320 |
mtbc0_000341 |
hypothetical protein | Contains VldE (PF26571.1) domain(s); putative function inferred from the domain architecture. | VldE |
Family assigned |
| Rv0323c Rv0323c |
mtbc0_000344 |
hypothetical protein | PIG-L deacetylase family protein. Pfam: PIG-L (PF02585.23). | PIG-L |
Family assigned |
| Rv0325 Rv0325 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5u0p-assembly1_V Cryo-EM structure of the transcriptional Mediator (prob 0.02, TM 0.31). | Still unknown | |
| Rv0326 Rv0326 |
- |
hypothetical protein | Contains Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19) domain(s); putative function inferred from the domain architecture. | Methyltransf_25 Methyltransf_11 |
Family assigned |
| Rv0329c Rv0329c |
mtbc0_000349 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_31 Ubie_methyltran Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| Rv0330c Rv0330c |
mtbc0_000350 |
hypothetical protein | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv0332 Rv0332 |
- |
hypothetical protein | Contains MDMPI_N (PF11716.14), MDMPI_C (PF07398.17) domain(s); putative function inferred from the domain architecture. | MDMPI_N MDMPI_C |
Family assigned |
| Rv0333 Rv0333 |
mtbc0_000353 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_2 (PF12680.14). | SnoaL_2 |
Family assigned |
| Rv0336 Rv0336 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| Rv0340 Rv0340 |
mtbc0_000360 |
hypothetical protein | Rv0340 family IniB-related protein. Pfam: IniB (PF27122.1). | IniB |
Family assigned |
| Rv0345 Rv0345 |
- |
hypothetical protein | Contains NTP_transf_3 (PF12804.14) domain(s); putative function inferred from the domain architecture. | NTP_transf_3 |
Family assigned |
| Rv0349 Rv0349 |
- |
hypothetical protein | MazF/PemK-family ribonuclease fold (candidate toxin of a type II toxin-antitoxin system). RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on MazF (PDB 9g2g; Foldseek prob 1.0, TM 0.72). A distinct locus from the named M. tuberculosis MazF paralogues. Fold-level TA-toxin assignment; the cognate antitoxin and cleavage specificity are undemonstrated. | Family assigned | |
| Rv0356c Rv0356c |
mtbc0_000376 |
hypothetical protein | PaaI family thioesterase. Pfam: 4HBT (PF03061.29). | 4HBT |
Family assigned |
| Rv0358 Rv0358 |
mtbc0_000378 |
hypothetical protein | Peptidase M50. | Resolved | |
| Rv0360c Rv0360c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3151. Function unknown. Foldseek best (non-significant) hit: 8ump-assembly1_A T33-ml35 - Designed Tetrahedral Protein Cage Using Ma (prob 1.00, TM 0.56). | DUF3151 |
Still unknown |
| Rv0365c Rv0365c |
mtbc0_000385 |
hypothetical protein | Glycoside hydrolase family 76 protein. Pfam: Glyco_hydro_76 (PF03663.21). | Glyco_hydro_76 |
Family assigned |
| Rv0366c Rv0366c |
mtbc0_000386 |
hypothetical protein | Zeta toxin family protein. Pfam: Zeta_toxin (PF06414.19), AAA_33 (PF13671.13). | Zeta_toxin AAA_33 |
Family assigned |
| Rv0367c Rv0367c |
mtbc0_000387 |
hypothetical protein | Contains ParD_like (PF11903.15) domain(s); putative function inferred from the domain architecture. | ParD_like |
Family assigned |
| Rv0368c Rv0368c |
mtbc0_000388 |
hypothetical protein | VWA domain-containing protein. Pfam: VWA_CoxE (PF05762.21). | VWA_CoxE |
Family assigned |
| Rv0371c Rv0371c |
mtbc0_000391 |
hypothetical protein | NTP transferase domain-containing protein. Pfam: NTP_transf_3 (PF12804.14). | NTP_transf_3 |
Family assigned |
| Rv0372c Rv0372c |
mtbc0_000392 |
hypothetical protein | XdhC family protein. Pfam: XdhC_CoxI (PF02625.22), XdhC_C (PF13478.13). | XdhC_CoxI XdhC_C |
Family assigned |
| Rv0376c Rv0376c |
- |
hypothetical protein | Contains XdhC_CoxI (PF02625.22), XdhC_C (PF13478.13) domain(s); putative function inferred from the domain architecture. | XdhC_CoxI XdhC_C |
Family assigned |
| Rv0378 Rv0378 |
mtbc0_000398 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2pne-assembly1_A Crystal Structure of the Snow Flea Antifreeze Protein (prob 0.06, TM 0.35). | Still unknown | |
| Rv0381c Rv0381c |
mtbc0_000401 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4j51-assembly2_B Cyrstal structure of protein tyrosine phosphatase Lyp (prob 0.33, TM 0.63). | Still unknown |