MTBC Gene Atlas

Genes

1086 genes matched.

GeneMTBC0Legacy (H37Rv)MTBC0 PGAP / revisedPfamVerdict
Rv3005c
Rv3005c		 mtbc0_003194 hypothetical protein DoxX family protein. Pfam: DoxX (PF07681.18), MauE (PF07291.17). DoxX MauE Family assigned
Rv3008
Rv3008		 mtbc0_003197 hypothetical protein MgtC/SapB family protein. Family assigned
Rv3013
Rv3013		 mtbc0_003202 hypothetical protein RelA/SpoT-homolog (RSH) family protein (eggNOG COG0317, signal-transduction COG category KT): a (p)ppGpp-metabolism / small-alarmone-synthetase-domain protein. The auto-curation mislabelled it "amino acid-binding protein"; the COG0317 orthology specifically places it in the RelA/SpoT (p)ppGpp synthetase/hydrolase family. At 218 aa it is distinct from the two characterised M. tuberculosis bifunctional synthetases Rel (Rv2583c, 790 aa) and RelZ (RNase-HII-fused, ~500 aa); a candidate additional (p)ppGpp-metabolism enzyme / SAS, role (synthetase vs hydrolase) undetermined. Family assigned
Rv3015c
Rv3015c		 mtbc0_003204 hypothetical protein Methionine synthase. Pfam: Meth_synt_2 (PF01717.25). Meth_synt_2 Resolved
Rv3026c
Rv3026c		 mtbc0_003217 hypothetical protein Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). Acyltransferase Family assigned
Rv3032A
Rv3032A		 - hypothetical protein Conserved protein, invariant over 145,209 strains (2 segregating sites; pN/pS unpowered) — an invariance that argues for a real, constrained gene rather than a spurious ORF — adopting a defined fold shared with Rv1914c (a small intra-MTBC structural family, Foldseek TM-score 0.78). The fold is only remotely reminiscent of the YxkI family; Rv3032A LACKS the HExxH zinc-metalloprotease catalytic motif and is predicted cytoplasmic (globular, no transmembrane helix). The previously proposed 'membrane metalloprotease-like' assignment is therefore NOT supported and is withdrawn. Molecular function remains undetermined. Family assigned
Rv3033
Rv3033		 mtbc0_003225 hypothetical protein Secreted anti-apoptotic virulence factor. RefSeq leaves it 'hypothetical'. Rv3033 represses the intrinsic (caspase-9-mediated) but not the extrinsic apoptotic pathway in infected macrophages, blocking both mitochondrial cytochrome-c release and ER-stress (PERK) activation, thereby promoting bacillary survival (Zhang 2018). DUF4333 Resolved
Rv3035
Rv3035		 - hypothetical protein Contains PQQ_2 (PF13360.14) domain(s); putative function inferred from the domain architecture. PQQ_2 Family assigned
TB22.2
Rv3036c		 mtbc0_003228 hypothetical protein RsiV family protein. DUF3298 Family assigned
Rv3038c
Rv3038c		 mtbc0_003230 hypothetical protein Methyltransferase domain-containing protein. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_23 (PF13489.13), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). Ubie_methyltran Methyltransf_31 Methyltransf_23 Methyltransf_11 Methyltransf_25 Methyltransf_12 Family assigned
Rv3040c
Rv3040c		 mtbc0_003232 hypothetical protein Nudix-hydrolase-family protein (eggNOG 'Nudix hydrolase'; the AlphaFold model matches a solved Nudix hydrolase at TM 0.83 and MutT at TM 0.79). Putative — the Nudix box is a broad signature whose members hydrolyse different nucleoside-diphosphate-X substrates; the substrate of Rv3040c is undetermined and no catalytic site is verified. Context: mycobacterial Nudix hydrolases with CoA / acyl-CoA pyrophosphatase activity have been characterised in M. smegmatis (Kumar et al. 2019), not on this locus. Resolved
Rv3046c
Rv3046c		 mtbc0_003238 hypothetical protein Member of the DUF3349 (PF11829) protein superfamily, predominant in Mycobacterium and Rhodococcus. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on the solved DUF3349 structure MSMEG_1053 (PDB 2lky; Foldseek prob 1.0, E 2e-4), a five-alpha-helix bundle; same superfamily as Rv0543c (already curated). Genus-restricted fold of unknown biochemical function. DUF3349 Family assigned
Rv3047c
Rv3047c		 mtbc0_003239 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5y5z-assembly1_Y V/A-type ATPase/synthase from Thermus thermophilus, r (prob 0.06, TM 0.40). Still unknown
Rv3054c
Rv3054c		 mtbc0_003246 hypothetical protein NADPH-dependent FMN reductase. Pfam: FMN_red (PF03358.21), Flavodoxin_2 (PF02525.23). FMN_red Flavodoxin_2 Resolved
Rv3067
Rv3067		 - hypothetical protein Secreted protein of the mycobacterial DUF732 family. All-vs-all structural clustering (Foldseek on ESMFold models, phase36) places it in a tight fold family (median TM-score 0.67) that includes the characterised host-directed effectors Rv1804c (sequesters host IkappaB-alpha) and Rv3354 (targets the host COP9 signalosome), plus the secreted antigen Rv1271c. It shares the family's N-terminal signal peptide (DeepTMHMM) and the ~110-aa secreted fold. A host-interaction / secreted-effector role is therefore plausible, but the specific molecular target of THIS member is not experimentally established (the DUF732 family is functionally heterogeneous). DUF732 Family assigned
Rv3071
Rv3071		 mtbc0_003264 hypothetical protein DUF190 domain-containing protein. DUF190 Family assigned
Rv3072c
Rv3072c		 - hypothetical protein Contains Bac_luciferase (PF00296.27) domain(s); putative function inferred from the domain architecture. Bac_luciferase Family assigned
Rv3073c
Rv3073c		 mtbc0_003267 hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF488-N3i, DUF488-N3a, DUF488. Function unknown. Foldseek best (non-significant) hit: 3ijd-assembly2_B-2 Uncharacterized protein Cthe_2304 from Clostridium (prob 0.04, TM 0.37). DUF488-N3i DUF488-N3a DUF488 Still unknown
Rv3074
Rv3074		 mtbc0_003268 hypothetical protein HNH endonuclease / nuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). RefSeq leaves it 'hypothetical protein'. HNH active-site motif; target undetermined. DUF222 Family assigned
Rv3075c
Rv3075c		 mtbc0_003269 hypothetical protein CoA ester lyase. Pfam: HpcH_HpaI (PF03328.21). HpcH_HpaI Resolved
Rv3076
Rv3076		 mtbc0_003270 hypothetical protein SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). Polyketide_cyc2 Polyketide_cyc Family assigned
Rv3079c
Rv3079c		 mtbc0_003273 hypothetical protein LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). Bac_luciferase Resolved
Rv3081
Rv3081		 mtbc0_003275 hypothetical protein Nucleotidyltransferase. DUF2204 Resolved
Rv3090
Rv3090		 mtbc0_003284 hypothetical protein SPFH domain-containing protein. Pfam: Band_7 (PF01145.32). Band_7 Family assigned
Rv3091
Rv3091		 mtbc0_003285 hypothetical protein Patatin-like phospholipase family protein. Pfam: Patatin (PF01734.28). Patatin Family assigned
Rv3094c
Rv3094c		 mtbc0_003288 hypothetical protein Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_2 Family assigned
Rv3096
Rv3096		 mtbc0_003290 hypothetical protein 1%2C4-beta-xylanase. Resolved
Rv3098c
Rv3098c		 mtbc0_003292 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6xr2-assembly2_E Computationally designed right-handed alpha/alpha hom (prob 0.66, TM 0.57). Still unknown
Rv3099c
Rv3099c		 mtbc0_003295 hypothetical protein Maleylpyruvate isomerase family mycothiol-dependent enzyme. Pfam: MDMPI_N (PF11716.14), DinB_2 (PF12867.13), MDMPI_C (PF07398.17). MDMPI_N DinB_2 MDMPI_C Family assigned
Rv3103c
Rv3103c		 mtbc0_003299 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv3108
Rv3108		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6qc3-assembly1_B5 Ovine respiratory supercomplex I+III2 open class 1 (prob 0.02, TM 0.19). Still unknown
Rv3114
Rv3114		 mtbc0_003310 hypothetical protein Nucleoside deaminase. Pfam: dCMP_cyt_deam_1 (PF00383.30), MafB19-deam (PF14437.13). dCMP_cyt_deam_1 MafB19-deam Resolved
Rv3118
Rv3118		 - hypothetical protein Contains DUF1416 (PF07210.19), CarboxypepD_reg (PF13620.13) domain(s); putative function inferred from the domain architecture. DUF1416 CarboxypepD_reg Family assigned
Rv3120
Rv3120		 mtbc0_003316 hypothetical protein Class I SAM-dependent methyltransferase. Pfam: Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). Methyltransf_25 Methyltransf_11 Resolved
Rv3122
Rv3122		 - hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF6788. Function unknown. Foldseek best (non-significant) hit: 2w9j-assembly1_A The crystal structure of SRP14 from the Schizosacchar (prob 0.41, TM 0.31). DUF6788 Still unknown
Rv3123
Rv3123		 mtbc0_003320 hypothetical protein Transposase of an insertion sequence / mobile element (eggNOG COG3464). A mobile-element function, not a host-metabolic gene. Family assigned
Rv3126c
Rv3126c		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv3127
Rv3127		 mtbc0_003323 hypothetical protein NAD(P)H nitroreductase. Resolved
Rv3129
Rv3129		 Conserved hypothetical protein Pyridoxamine 5-phosphate Pyridox_ox_2 Family assigned
Rv3136A
Rv3136A		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7d8r-assembly2_C MITF HLHLZ structure (prob 0.41, TM 0.32). Still unknown
Rv3142c
Rv3142c		 mtbc0_003340 hypothetical protein DUF6188 family protein. DUF6188 Family assigned
Rv3163c
Rv3163c		 mtbc0_003362 hypothetical protein Conserved hypothetical protein; DUF domain(s) DUF58. Function unknown. DUF58 Still unknown
Rv3165c
Rv3165c		 mtbc0_003364 hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Still unknown
Rv3166c
Rv3166c		 mtbc0_003365 hypothetical protein Cell-surface protein (immuno-EM); its high-activity binding peptides bind A549 and U937 cells and inhibit mycobacterial invasion (by up to 94%), implicating it in host-cell adhesion/invasion. Pfam DUF4129. Molecular function unfixed. DUF4129 Family assigned
Rv3169
Rv3169		 mtbc0_003368 hypothetical protein NTF2-like / SnoaL-like superfamily enzyme (polyketide cyclase / steroid-lyase / [4+2]-Diels-Alderase fold). RefSeq leaves it 'hypothetical protein'. Strongest match to 25-phosphosteroid lyase (steroid/cholesterol degradation); a candidate steroid/lipid-processing lyase-cyclase, though the precise substrate within this functionally diverse superfamily is undetermined. RefSeq leaves this locus uncharacterised. Family assigned
Rv3172c
Rv3172c		 - hypothetical protein Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7s5n-assembly2_D Crystal Structure of a Putative uncharacterized prote (prob 1.00, TM 0.93). Still unknown
Rv3178a
Rv3178a		 - hypothetical protein Minimal nucleotidyltransferase of the polymerase-beta-like superfamily (HHpred COG1669 95.7%, E=0.16, with strongly converging hits to putative/minimal nucleotidyltransferases and to MntA-type nucleotidyltransferase antitoxins). Confident fold assignment. Genomic context does NOT support a toxin-antitoxin antitoxin role (Rv3178a is a singleton flanked by a nitroreductase and an AAA ATPase at 239/287 bp, no adjacent toxin), so most likely a standalone nucleotidyltransferase; the precise substrate/acceptor remains undefined. Resolved
Rv3179
Rv3179		 mtbc0_003380 hypothetical protein ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). AAA_14 DUF4143 Family assigned
Rv3182
Rv3182		 mtbc0_003383 hypothetical protein Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: Gp49 (PF05973.21). Gp49 Family assigned
Rv3188
Rv3188		 mtbc0_003385 hypothetical protein Predicted Xre/MbcA/ParS-type antitoxin, proposed antitoxin of a RES-Xre pair Rv3188-Rv3189. RefSeq names only the toxin-binding-domain protein; the pairing is a structural prediction awaiting experimental confirmation. Family assigned