Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3099c Rv3099c |
mtbc0_003295 |
hypothetical protein | Maleylpyruvate isomerase family mycothiol-dependent enzyme. Pfam: MDMPI_N (PF11716.14), DinB_2 (PF12867.13), MDMPI_C (PF07398.17). | MDMPI_N DinB_2 MDMPI_C |
Family assigned |
| Rv3103c Rv3103c |
mtbc0_003299 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3108 Rv3108 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6qc3-assembly1_B5 Ovine respiratory supercomplex I+III2 open class 1 (prob 0.02, TM 0.19). | Still unknown | |
| Rv3114 Rv3114 |
mtbc0_003310 |
hypothetical protein | Nucleoside deaminase. Pfam: dCMP_cyt_deam_1 (PF00383.30), MafB19-deam (PF14437.13). | dCMP_cyt_deam_1 MafB19-deam |
Resolved |
| Rv3118 Rv3118 |
- |
hypothetical protein | Contains DUF1416 (PF07210.19), CarboxypepD_reg (PF13620.13) domain(s); putative function inferred from the domain architecture. | DUF1416 CarboxypepD_reg |
Family assigned |
| Rv3120 Rv3120 |
mtbc0_003316 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv3122 Rv3122 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF6788. Function unknown. Foldseek best (non-significant) hit: 2w9j-assembly1_A The crystal structure of SRP14 from the Schizosacchar (prob 0.41, TM 0.31). | DUF6788 |
Still unknown |
| Rv3123 Rv3123 |
mtbc0_003320 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8tqc-assembly1_C Structure of the human CDK8 kinase module (prob 0.02, TM 0.18). | Still unknown | |
| Rv3126c Rv3126c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3127 Rv3127 |
mtbc0_003323 |
hypothetical protein | NAD(P)H nitroreductase. | Resolved | |
| Rv3136A Rv3136A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7d8r-assembly2_C MITF HLHLZ structure (prob 0.41, TM 0.32). | Still unknown | |
| Rv3142c Rv3142c |
mtbc0_003340 |
hypothetical protein | DUF6188 family protein. | DUF6188 |
Family assigned |
| Rv3163c Rv3163c |
mtbc0_003362 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF58. Function unknown. | DUF58 |
Still unknown |
| Rv3165c Rv3165c |
mtbc0_003364 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3166c Rv3166c |
mtbc0_003365 |
hypothetical protein | Cell-surface protein (immuno-EM); its high-activity binding peptides bind A549 and U937 cells and inhibit mycobacterial invasion (by up to 94%), implicating it in host-cell adhesion/invasion. Pfam DUF4129. Molecular function unfixed. | DUF4129 |
Family assigned |
| Rv3169 Rv3169 |
mtbc0_003368 |
hypothetical protein | NTF2-like / SnoaL-like superfamily enzyme (polyketide cyclase / steroid-lyase / [4+2]-Diels-Alderase fold). RefSeq leaves it 'hypothetical protein'. Strongest match to 25-phosphosteroid lyase (steroid/cholesterol degradation); a candidate steroid/lipid-processing lyase-cyclase, though the precise substrate within this functionally diverse superfamily is undetermined. RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3172c Rv3172c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7s5n-assembly2_D Crystal Structure of a Putative uncharacterized prote (prob 1.00, TM 0.93). | Still unknown | |
| Rv3178a Rv3178a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4jo7-assembly1_C Crystal structure of the human Nup49CCS2+3* Nup57CCS3 (prob 0.06, TM 0.41). | Still unknown | |
| Rv3179 Rv3179 |
mtbc0_003380 |
hypothetical protein | ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). | AAA_14 DUF4143 |
Family assigned |
| Rv3182 Rv3182 |
mtbc0_003383 |
hypothetical protein | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: Gp49 (PF05973.21). | Gp49 |
Family assigned |
| Rv3188 Rv3188 |
mtbc0_003385 |
hypothetical protein | Antitoxin Xre/MbcA/ParS toxin-binding domain-containing protein. | Family assigned | |
| Rv3189 Rv3189 |
mtbc0_003386 |
hypothetical protein | RES family NAD+ phosphorylase. Pfam: RES (PF08808.18). | RES |
Family assigned |
| Rv3190A Rv3190A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7tzb-assembly1_B Crystal structure of the human mitochondrial seryl-tR (prob 0.06, TM 0.52). | Still unknown | |
| Rv3190c Rv3190c |
mtbc0_003387 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3192 Rv3192 |
- |
hypothetical protein | Contains Bac_luciferase (PF00296.27) domain(s); putative function inferred from the domain architecture. | Bac_luciferase |
Family assigned |
| Rv3194c Rv3194c |
mtbc0_003395 |
hypothetical protein | PDZ domain-containing protein. Pfam: PDZ_2 (PF13180.13), Lon_C (PF05362.20). | PDZ_2 Lon_C |
Family assigned |
| Rv3195 Rv3195 |
mtbc0_003396 |
hypothetical protein | Zinc-dependent metalloprotease. Pfam: Zincin_2 (PF10103.16). | Zincin_2 |
Resolved |
| Rv3196 Rv3196 |
- |
hypothetical protein | Probable ThiF/MoeB/E1-family adenylyltransferase of undetermined substrate; NOT a YcaO heterocyclase. RefSeq leaves it 'hypothetical protein'. A strong Foldseek hit to the cyanobactin heterocyclase TruD (4bs9, query-normalised TM-score 0.72) is a normalised-TM-score artefact: the alignment covers only the N-terminal scaffold (TruD residues 3-321), stops before the YcaO catalytic domain, and the target-normalised TM-score is 0.33 (~38% coverage); none of the YcaO catalytic residues lies in the aligned region. HHpred re-routes it (>=99.9%) to standalone adenylyltransferases (MccB, PaaA) and the ThiF/MoeB/E1-like adenylation superfamily, within which the CxxC pair (C208/C211) matches the MoeB-type zinc motif. A RiPP role is independently improbable (no precursor-peptide cassette, maturation protease, or TfuA in H37Rv). A worked example of the normalised-TM-score trap. | Family assigned | |
| Rv3196A Rv3196A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4jq5-assembly2_H Crystal structure of the human Nup49CCS2+3* coiled-co (prob 0.66, TM 0.87). | Still unknown | |
| Rv3202a Rv3202a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3205c Rv3205c |
- |
hypothetical protein | Protein-kinase-like (APH/ePK) fold whose active site is NOT retained. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on an aminoglycoside 3',5"-phosphotransferase (PDB 1l8t = M-CSA entry 640, EC 2.7.1.95), but the M-CSA active-site check shows the 4 catalytic residues are all ALIGNED yet SUBSTITUTED (0/4 conserved) -> same fold, active site not retained. A worked negative control: the kinase fold is present but the gene is NOT an active aminoglycoside phosphotransferase. | Family assigned | |
| Rv3207c Rv3207c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3152. Function unknown. Foldseek best (non-significant) hit: 6n8l-assembly1_T Cryo-EM structure of early cytoplasmic-late (ECL) pre (prob 0.09, TM 0.41). | DUF3152 |
Still unknown |
| TB9.4 Rv3208A |
- |
hypothetical protein | Structurally characterized DUF3107 protein (Pfam) of unknown biochemical function. RefSeq leaves it 'hypothetical protein'. A crystal structure of the hexadecameric form of this family was solved (PDB 7rur; Foldseek prob 1.0, E 3e-11, TM 0.95). STRING context links it to the cytochrome bcc subunit qcrC (Rv2194). Family/structure assigned; molecular function unfixed. | DUF3107 |
Family assigned |
| Rv3209 Rv3209 |
mtbc0_003415 |
hypothetical protein | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv3210c Rv3210c |
mtbc0_003416 |
hypothetical protein | Ferritin-like fold-containing protein. Pfam: Ferritin_fold-like (PF13794.13). | Ferritin_fold-like |
Family assigned |
| Rv3212 Rv3212 |
mtbc0_003418 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3218 Rv3218 |
mtbc0_003424 |
hypothetical protein | Diacylglycerol kinase family lipid kinase. Pfam: DAGK_cat (PF00781.30). | DAGK_cat |
Family assigned |
| Rv3222c Rv3222c |
mtbc0_002141 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3226c Rv3226c |
mtbc0_003435 |
hypothetical protein | SOS response-associated peptidase. Pfam: SRAP (PF02586.20). | SRAP |
Resolved |
| rsgA Rv3228 |
mtbc0_003437 |
hypothetical protein | Ribosome small subunit-dependent GTPase A. Pfam: RsgA_GTPase (PF03193.23), MMR_HSR1 (PF01926.30). | RsgA_GTPase MMR_HSR1 |
Family assigned |
| Rv3231c Rv3231c |
mtbc0_003440 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF6912. Function unknown. Foldseek best (non-significant) hit: 8zm3-assembly1_C Cryo-EM strcuture of Cas5-HNH Cascade,apo-Conf2 (prob 0.03, TM 0.35). | DUF6912 |
Still unknown |
| Rv3235 Rv3235 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF6459. Function unknown. Foldseek best (non-significant) hit: 8j07-assembly1_k1 96nm repeat of human respiratory doublet microtubule (prob 0.01, TM 0.10). | DUF6459 |
Still unknown |
| Rv3237c Rv3237c |
mtbc0_003445 |
hypothetical protein | Cation:proton antiporter regulatory subunit. Pfam: KhtT_N (PF25991.1), TrkA_C (PF02080.27). | KhtT_N TrkA_C |
Family assigned |
| raiA Rv3241c |
mtbc0_003449 |
hypothetical protein | Ribosome-associated translation inhibitor RaiA. Pfam: Ribosomal_S30AE (PF02482.26), Ribosom_S30AE_C (PF16321.11). | Ribosomal_S30AE Ribosom_S30AE_C |
Resolved |
| Rv3242c Rv3242c |
mtbc0_003450 |
hypothetical protein | ComF family protein. | Family assigned | |
| Rv3243c Rv3243c |
mtbc0_003451 |
hypothetical protein | LmeA family phospholipid-binding protein. | Family assigned | |
| Rv3254 Rv3254 |
mtbc0_003462 |
hypothetical protein | Oxidoreductase. | Resolved | |
| Rv3256c Rv3256c |
mtbc0_003464 |
hypothetical protein | TobH protein. | Resolved | |
| Rv3258c Rv3258c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3499. Function unknown. Foldseek best (non-significant) hit: 6wwa-assembly2_Y Crystal structure of human SHLD2-SHLD3-REV7 complex (prob 0.02, TM 0.13). | DUF3499 |
Still unknown |
| Rv3259 Rv3259 |
mtbc0_003467 |
hypothetical protein | Metallopeptidase family protein. Pfam: Zincin_1 (PF06262.18). | Zincin_1 |
Family assigned |