Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2018 Rv2018 |
mtbc0_002148 |
hypothetical protein | DUF433 domain-containing protein. Pfam: HTH_66 (PF21321.4), DUF433 (PF04255.21). | HTH_66 DUF433 |
Family assigned |
| Rv2019 Rv2019 |
mtbc0_002149 |
hypothetical protein | Contains PIN_10 (PF18478.8) domain(s); putative function inferred from the domain architecture. | PIN_10 |
Family assigned |
| Rv2020c Rv2020c |
|
Conserved hypothetical protein | site-specific DNA-methyltransferase (adenine-specific) activity | Type_ISP_C |
Family assigned |
| Rv2022c Rv2022c |
mtbc0_002152 |
hypothetical protein | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: Gp49 (PF05973.21). | Gp49 |
Family assigned |
| Rv2023c Rv2023c |
mtbc0_002153 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2024c Rv2024c |
- |
hypothetical protein | Contains Mrr_cat (PF04471.19), Mrr_cat_2 (PF13156.13), ResIII (PF04851.22), DEAD (PF00270.36) domain(s); putative function inferred from the domain architecture. | Mrr_cat Mrr_cat_2 ResIII DEAD |
Family assigned |
| Rv2030c Rv2030c |
mtbc0_002163 |
hypothetical protein | Erythromycin esterase family protein. Pfam: Pribosyltran (PF00156.34), Erythro_esteras (PF05139.20). | Pribosyltran Erythro_esteras |
Family assigned |
| Rv2033c Rv2033c |
mtbc0_002166 |
hypothetical protein | 5'-3' exoribonuclease / diribonuclease of the TrpH/YciV (RNase AM) family, a metallophosphoesterase-fold RNase (eggNOG COG0613). Named nuclease family; exact in-vivo RNA substrate undetermined. | DUF3097_N DUF3097_C |
Family assigned |
| Rv2035 Rv2035 |
mtbc0_002168 |
hypothetical protein | SRPBCC family protein. Pfam: AHSA1 (PF08327.18). | AHSA1 |
Family assigned |
| Rv2036 Rv2036 |
mtbc0_002169 |
hypothetical protein | Maleylpyruvate isomerase family mycothiol-dependent enzyme. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv2042c Rv2042c |
mtbc0_002175 |
hypothetical protein | Ketosteroid isomerase family protein. Pfam: NTF2 (PF02136.27), SnoaL_2 (PF12680.14). | NTF2 SnoaL_2 |
Family assigned |
| Rv2044c Rv2044c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2784 |
Family assigned |
| Rv2047c Rv2047c |
mtbc0_002180 |
hypothetical protein | Sugar epimerase family protein. Pfam: Epimerase (PF01370.28), 3Beta_HSD (PF01073.26), NAD_binding_10 (PF13460.13), Rph_4th (PF27448.1), PEP-utilizers (PF00391.30). | Epimerase 3Beta_HSD NAD_binding_10 Rph_4th PEP-utilizers |
Family assigned |
| Rv2049c Rv2049c |
- |
hypothetical protein | Putative FrmR/CsoR-family transcriptional regulator (ESMFold model matches a formaldehyde-responsive regulator, Foldseek 5lcy). Surfaced as a TA candidate but re-annotated here as a non-TA regulator: no cognate toxin/antitoxin partner and no TA-family domain. Excluded from the TA set. | Family assigned | |
| Rv2052c Rv2052c |
mtbc0_002185 |
hypothetical protein | Amidohydrolase. Pfam: Amidohydro_3 (PF07969.18). | Amidohydro_3 |
Resolved |
| Rv2054 Rv2054 |
mtbc0_002187 |
hypothetical protein | Dienelactone hydrolase family protein. Pfam: DLH (PF01738.25). | DLH |
Family assigned |
| Rv2059 Rv2059 |
- |
hypothetical protein | Contains ZnuA (PF01297.23) domain(s); putative function inferred from the domain architecture. | ZnuA |
Family assigned |
| Rv2061c Rv2061c |
mtbc0_002194 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv2067c Rv2067c |
mtbc0_002201 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_9 (PF08003.18), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19), Methyltransf_23 (PF13489.13). | Methyltransf_9 Methyltransf_25 Methyltransf_31 Methyltransf_12 Methyltransf_11 Methyltransf_23 |
Resolved |
| Rv2075c Rv2075c |
mtbc0_002209 |
hypothetical protein | Contains PI-PLC_cat (PF26178.1) domain(s); putative function inferred from the domain architecture. | PI-PLC_cat |
Family assigned |
| Rv2076c Rv2076c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv2077A Rv2077A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6uuj-assembly2_E Structure of PE5-PPE4-EspG3 complex from the type VII (prob 0.90, TM 0.69). | Still unknown | |
| Rv2078 Rv2078 |
mtbc0_002212 |
hypothetical protein | DUF2563 family protein. | DUF2563 |
Family assigned |
| Rv2079 Rv2079 |
mtbc0_002213 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Hydro_N_hd (PF22905.3), Abhydrolase_8 (PF06259.19). | Hydro_N_hd Abhydrolase_8 |
Family assigned |
| Rv2082 Rv2082 |
mtbc0_002218 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5632, DUF5631. Function unknown. | DUF5632 DUF5631 |
Still unknown |
| Rv2083 Rv2083 |
mtbc0_002219 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2084 Rv2084 |
mtbc0_002220 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 1l7c-assembly1_A alpha-catenin fragment, residues 385-651 (prob 0.21, TM 0.26). | Still unknown | |
| Rv2085 Rv2085 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2963, transposase; COG category L). A mobile-element function. | Family assigned | |
| Rv2086 Rv2086 |
- |
hypothetical protein | Transposase of insertion sequence IS1556 (eggNOG COG2801, DDE transposase; COG category L). A mobile-element function. | Family assigned | |
| Rv2087 Rv2087 |
|
Conserved hypothetical protein | transposition | Family assigned | |
| Rv2100 Rv2100 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). Lies in a region-of-difference (RDcap_Asia3) context. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv2102 Rv2102 |
- |
hypothetical protein | Contains SWIM (PF04434.23) domain(s); putative function inferred from the domain architecture. | SWIM |
Family assigned |
| Rv2104a Rv2104a |
- |
hypothetical protein | Proteasome-alpha-subunit-family protein, located in the M. tuberculosis proteasome gene region. HHpred: 25/25 top hits are 20S-proteasome alpha-type subunits (incl. the M.tb proteasome alpha 3MI0, 88.4%); eggNOG COG0638 (20S proteasome alpha/beta) with EC 3.4.25.1. Genomic context: immediately flanked by the proteasome core/Pup genes prcA (Rv2109c), prcB (Rv2110c) and pafA (Rv2097c); under purifying selection. At 85 aa it is a small/partial proteasome-alpha-fold protein - whether a bona fide additional subunit or a proteasome-associated protein is undetermined (the canonical alpha subunit is prcA/Rv2109c). | Family assigned | |
| Rv2114 Rv2114 |
mtbc0_002246 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8b6h-assembly1_ES Cryo-EM structure of cytochrome c oxidase dimer (com (prob 0.08, TM 0.34). | Still unknown | |
| Rv2117 Rv2117 |
mtbc0_002249 |
hypothetical protein | DUF503 domain-containing protein. | DUF503 |
Family assigned |
| Rv2119 Rv2119 |
mtbc0_002251 |
hypothetical protein | RecB family exonuclease. Pfam: PDDEXK_1 (PF12705.14). | PDDEXK_1 |
Family assigned |
| Rv2125 Rv2125 |
mtbc0_002257 |
hypothetical protein | PAC2 family protein. Pfam: PAC2 (PF09754.16). | PAC2 |
Family assigned |
| Rv2132 Rv2132 |
mtbc0_002265 |
hypothetical protein | Ribbon-helix-helix protein%2C CopG family. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Family assigned |
| Rv2133c Rv2133c |
mtbc0_002266 |
hypothetical protein | SCO1664 family protein. | Family assigned | |
| Rv2134c Rv2134c |
- |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: weak fold hit (DUF3090); function unknown. | DUF3090 |
Still unknown |
| Rv2135c Rv2135c |
mtbc0_002268 |
hypothetical protein | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| Rv2137c Rv2137c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6hhm-assembly1_A Crystal structure of the family S1_7 ulvan-specific s (prob 0.63, TM 0.66). | Still unknown | |
| TB18.6 Rv2140c |
mtbc0_002274 |
hypothetical protein | YbhB/YbcL family Raf kinase inhibitor-like protein. Pfam: PBP (PF01161.26). | PBP |
Family assigned |
| Rv2141c Rv2141c |
- |
hypothetical protein | Contains Peptidase_M28 (PF04389.23), Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20) domain(s); putative function inferred from the domain architecture. | Peptidase_M28 Peptidase_M20 M20_dimer |
Family assigned |
| Rv2143 Rv2143 |
mtbc0_002279 |
hypothetical protein | Phosphoribosyltransferase family protein. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Family assigned |
| Rv2148c Rv2148c |
mtbc0_002284 |
hypothetical protein | YggS family pyridoxal phosphate-dependent enzyme. Pfam: Ala_racemase_N (PF01168.27). | Ala_racemase_N |
Family assigned |
| Rv2159c Rv2159c |
mtbc0_002295 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| Rv2160A Rv2160A |
|
Conserved hypothetical protein | PFAM regulatory protein TetR | TetR_N |
Family assigned |
| Rv2160c Rv2160c |
|
Conserved hypothetical protein | transcriptional regulator | TetR_C_13 |
Family assigned |
| Rv2161c Rv2161c |
mtbc0_002297 |
hypothetical protein | TIGR03619 family F420-dependent LLM class oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Family assigned |