Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2061c Rv2061c |
mtbc0_002194 |
hypothetical protein | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv2067c Rv2067c |
mtbc0_002201 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_9 (PF08003.18), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19), Methyltransf_23 (PF13489.13). | Methyltransf_9 Methyltransf_25 Methyltransf_31 Methyltransf_12 Methyltransf_11 Methyltransf_23 |
Resolved |
| Rv2075c Rv2075c |
mtbc0_002209 |
hypothetical protein | Contains PI-PLC_cat (PF26178.1) domain(s); putative function inferred from the domain architecture. | PI-PLC_cat |
Family assigned |
| Rv2076c Rv2076c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| Rv2077A Rv2077A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6uuj-assembly2_E Structure of PE5-PPE4-EspG3 complex from the type VII (prob 0.90, TM 0.69). | Still unknown | |
| Rv2078 Rv2078 |
mtbc0_002212 |
hypothetical protein | DUF2563 family protein. | DUF2563 |
Family assigned |
| Rv2079 Rv2079 |
mtbc0_002213 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Hydro_N_hd (PF22905.3), Abhydrolase_8 (PF06259.19). | Hydro_N_hd Abhydrolase_8 |
Family assigned |
| Rv2082 Rv2082 |
mtbc0_002215 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5632, DUF5631. Function unknown. | DUF5632 DUF5631 |
Still unknown |
| Rv2083 Rv2083 |
mtbc0_002219 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2084 Rv2084 |
mtbc0_002220 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 1l7c-assembly1_A alpha-catenin fragment, residues 385-651 (prob 0.21, TM 0.26). | Still unknown | |
| Rv2085 Rv2085 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2086 Rv2086 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8i0p-assembly1_u The cryo-EM structure of human pre-Bact complex (prob 0.01, TM 0.14). | Still unknown | |
| Rv2100 Rv2100 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| Rv2102 Rv2102 |
- |
hypothetical protein | Contains SWIM (PF04434.23) domain(s); putative function inferred from the domain architecture. | SWIM |
Family assigned |
| Rv2104a Rv2104a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2114 Rv2114 |
mtbc0_002246 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8b6h-assembly1_ES Cryo-EM structure of cytochrome c oxidase dimer (com (prob 0.08, TM 0.34). | Still unknown | |
| Rv2117 Rv2117 |
mtbc0_002249 |
hypothetical protein | DUF503 domain-containing protein. | DUF503 |
Family assigned |
| Rv2119 Rv2119 |
mtbc0_002251 |
hypothetical protein | RecB family exonuclease. Pfam: PDDEXK_1 (PF12705.14). | PDDEXK_1 |
Family assigned |
| Rv2125 Rv2125 |
mtbc0_002257 |
hypothetical protein | PAC2 family protein. Pfam: PAC2 (PF09754.16). | PAC2 |
Family assigned |
| Rv2132 Rv2132 |
mtbc0_002265 |
hypothetical protein | Ribbon-helix-helix protein%2C CopG family. Pfam: RHH_1 (PF01402.28). | RHH_1 |
Family assigned |
| Rv2133c Rv2133c |
mtbc0_002266 |
hypothetical protein | SCO1664 family protein. | Family assigned | |
| Rv2134c Rv2134c |
- |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: weak fold hit (DUF3090); function unknown. | DUF3090 |
Still unknown |
| Rv2135c Rv2135c |
mtbc0_002268 |
hypothetical protein | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| Rv2137c Rv2137c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6hhm-assembly1_A Crystal structure of the family S1_7 ulvan-specific s (prob 0.63, TM 0.66). | Still unknown | |
| TB18.6 Rv2140c |
mtbc0_002274 |
hypothetical protein | YbhB/YbcL family Raf kinase inhibitor-like protein. Pfam: PBP (PF01161.26). | PBP |
Family assigned |
| Rv2141c Rv2141c |
- |
hypothetical protein | Contains Peptidase_M28 (PF04389.23), Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20) domain(s); putative function inferred from the domain architecture. | Peptidase_M28 Peptidase_M20 M20_dimer |
Family assigned |
| Rv2143 Rv2143 |
mtbc0_002279 |
hypothetical protein | Phosphoribosyltransferase family protein. Pfam: Pribosyltran (PF00156.34). | Pribosyltran |
Family assigned |
| Rv2148c Rv2148c |
mtbc0_002284 |
hypothetical protein | YggS family pyridoxal phosphate-dependent enzyme. Pfam: Ala_racemase_N (PF01168.27). | Ala_racemase_N |
Family assigned |
| Rv2159c Rv2159c |
mtbc0_002295 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. Pfam: CMD (PF02627.26). | CMD |
Family assigned |
| Rv2161c Rv2161c |
mtbc0_002297 |
hypothetical protein | TIGR03619 family F420-dependent LLM class oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Family assigned |
| Rv2164c Rv2164c |
mtbc0_002300 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8j07-assembly1_c2 96nm repeat of human respiratory doublet microtubule (prob 0.04, TM 0.14). | Still unknown | |
| Rv2172c Rv2172c |
mtbc0_002306 |
hypothetical protein | Mycobacterial-type methylenetetrahydrofolate reductase. Pfam: MTHFR_2 (PF19345.6). | MTHFR_2 |
Resolved |
| Rv2183c Rv2183c |
mtbc0_002318 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2184c Rv2184c |
- |
hypothetical protein | Contains ArsA_ATPase (PF02374.22), ArsA_HSP20 (PF17886.8) domain(s); putative function inferred from the domain architecture. | ArsA_ATPase ArsA_HSP20 |
Family assigned |
| TB16.3 Rv2185c |
mtbc0_002320 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv2186c Rv2186c |
mtbc0_002321 |
hypothetical protein | Polyketide cyclase / dehydrase and lipid transport. | Resolved | |
| Rv2189c Rv2189c |
mtbc0_002324 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real M1 alanyl-aminopeptidase PepN is Rv2467 (paralogue-of-fold). | Still unknown | |
| Rv2191 Rv2191 |
- |
hypothetical protein | Contains RNase_T (PF00929.32), UvrC_M (PF27096.1) domain(s); putative function inferred from the domain architecture. | RNase_T UvrC_M |
Family assigned |
| Rv2204c Rv2204c |
mtbc0_002340 |
hypothetical protein | Iron-sulfur cluster assembly accessory protein. Pfam: Fe-S_biosyn (PF01521.27). | Fe-S_biosyn |
Resolved |
| Rv2205c Rv2205c |
mtbc0_002341 |
hypothetical protein | Glycerate kinase. Pfam: Gly_kinase (PF02595.21). | Gly_kinase |
Resolved |
| Rv2224d Rv2224d |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2226 Rv2226 |
mtbc0_002364 |
hypothetical protein | CYTH and CHAD domain-containing protein. Pfam: CYTH (PF01928.27), CHAD (PF05235.20). | CYTH CHAD |
Family assigned |
| Rv2227 Rv2227 |
- |
hypothetical protein | Contains Oxygenase-NA (PF09859.16) domain(s); putative function inferred from the domain architecture. | Oxygenase-NA |
Family assigned |
| Rv2229c Rv2229c |
mtbc0_002368 |
hypothetical protein | Zinc ribbon domain-containing protein. Pfam: CT398_CC (PF24481.3), Zn_ribbon_9 (PF02591.21). | CT398_CC Zn_ribbon_9 |
Family assigned |
| Rv2237 Rv2237 |
- |
hypothetical protein | Contains MPAB_Lcp_cat (PF09995.16) domain(s); putative function inferred from the domain architecture. | MPAB_Lcp_cat |
Family assigned |
| Rv2237A Rv2237A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2239c Rv2239c |
- |
hypothetical protein | S-adenosyl-methionine (SAM)-dependent methyltransferase fold. RefSeq leaves it 'hypothetical protein' (Pfam DUF3052). The AlphaFold model superposes on an O-methyltransferase bound to the product SAH (PDB 8bif; Foldseek prob 1.0, E 2e-5, TM 0.55). STRING context: peroxiredoxin ahpE (Rv2238c). A SAM-MTase fold assignment; the acceptor substrate is not determined. | DUF3052 |
Family assigned |
| Rv2240c Rv2240c |
mtbc0_002382 |
hypothetical protein | Contains Rv2240c (PF27150.1) domain(s); putative function inferred from the domain architecture. | Rv2240c |
Family assigned |
| Rv2242 Rv2242 |
mtbc0_002384 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| Rv2248 Rv2248 |
- |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |