Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv0052 Rv0052 |
- |
hypothetical protein | Contains DJ-1_PfpI (PF01965.31) domain(s); putative function inferred from the domain architecture. | DJ-1_PfpI |
Family assigned |
| rpsF Rv0053 |
mtbc0_000058 |
30S ribosomal protein S6 | 30S ribosomal protein S6. Pfam: Ribosomal_S6 (PF01250.23). | Ribosomal_S6 |
Resolved |
| ssb Rv0054 |
mtbc0_000059 |
single-strand DNA-binding protein | Single-stranded DNA-binding protein. Pfam: SSB (PF00436.32). | SSB |
Family assigned |
| rpsR1 Rv0055 |
- |
30S ribosomal protein S18 | 30S ribosomal protein S18. Pfam: Ribosomal_S18 (PF01084.27). | Ribosomal_S18 |
Resolved |
| rplI Rv0056 |
mtbc0_000061 |
50S ribosomal protein L9 | 50S ribosomal protein L9. Pfam: Ribosomal_L9_N (PF01281.26), Ribosomal_L9_C (PF03948.20). | Ribosomal_L9_N Ribosomal_L9_C |
Resolved |
| Rv0057 Rv0057 |
mtbc0_000062 |
hypothetical protein | Conserved hypothetical protein. No Pfam-A domain above the gathering threshold and no Foldseek structural hit on the ESMFold model: genuinely uncharacterised at both the sequence and the structure level. | Still unknown | |
| dnaB Rv0058 |
mtbc0_000063 |
replicative DNA helicase | Replicative DNA helicase. Pfam: DnaB (PF00772.27), DnaB_C (PF03796.22), AAA_25 (PF13481.13), Intein_splicing (PF14890.12), LAGLIDADG_3 (PF14528.12). | DnaB DnaB_C AAA_25 Intein_splicing LAGLIDADG_3 |
Resolved |
| darT Rv0059 |
mtbc0_000064 |
hypothetical protein | DarT (DarT_Mtb), toxin of the DarTG toxin-antitoxin system: a DNA ADP-ribosyltransferase that sequence-specifically modifies thymidines on single-stranded DNA. Unchecked it blocks replication and is bactericidal; it is neutralised and reversed by the cognate antitoxin DarG (Rv0060). The toxin is dispensable for viability. | DarT |
Resolved |
| darG Rv0060 |
mtbc0_000065 |
hypothetical protein | DarG (DarG_Mtb), antitoxin of the DarTG system: a macrodomain DNA ADP-ribosyl-glycohydrolase that removes the ADP-ribose mark deposited on DNA by the toxin DarT (Rv0059) and binds/neutralises it. In M. tuberculosis DarG is essential; its depletion triggers the DNA-damage response and cell death. | Macro |
Resolved |
| Rv0061c Rv0061c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5oun-assembly1_A NMR solution structure of the external DII domain of (prob 0.15, TM 0.64). | Still unknown | |
| celA1 Rv0062 |
- |
cellulase CelA | Cellulase CelA. Pfam: Glyco_hydro_6 (PF01341.24). | Glyco_hydro_6 |
Resolved |
| Rv0063 Rv0063 |
mtbc0_000068 |
oxidoreductase | FAD-binding oxidoreductase. Pfam: FAD_binding_4 (PF01565.29), BBE (PF08031.18). | FAD_binding_4 BBE |
Resolved |
| Rv0063a Rv0063a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0064 Rv0064 |
mtbc0_000070 |
transmembrane protein | UPF0182 family protein. | UPF0182 |
Family assigned |
| vapB1 Rv0064A |
- |
antitoxin VapB1 | Antitoxin VapB1. Pfam: FitA-like_RHH (PF22513.3). | FitA-like_RHH |
Resolved |
| vapC1 Rv0065 |
mtbc0_000072 |
ribonuclease VapC1 | Type II toxin-antitoxin system ribonuclease VapC1. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| icd2 Rv0066c |
mtbc0_000073 |
isocitrate dehydrogenase | NADP-dependent isocitrate dehydrogenase. Pfam: IDH (PF03971.20). | IDH |
Resolved |
| Rv0067c Rv0067c |
mtbc0_000074 |
transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30), TetR_C_43 (PF21597.3). | TetR_N TetR_C_43 |
Family assigned |
| Rv0068 Rv0068 |
mtbc0_000075 |
oxidoreductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| sdaA Rv0069c |
mtbc0_000076 |
L-serine dehydratase | L-serine ammonia-lyase. Pfam: SDH_beta (PF03315.22), SDH_alpha (PF03313.22). | SDH_beta SDH_alpha |
Resolved |
| glyA2 Rv0070c |
mtbc0_000077 |
serine hydroxymethyltransferase | Serine hydroxymethyltransferase. Pfam: SHMT (PF00464.26), Aminotran_1_2 (PF00155.28), DegT_DnrJ_EryC1 (PF01041.24). | SHMT Aminotran_1_2 DegT_DnrJ_EryC1 |
Resolved |
| Rv0071 Rv0071 |
mtbc0_000078 |
maturase | Reverse transcriptase domain-containing protein. Pfam: RVT_1 (PF00078.33). | RVT_1 |
Family assigned |
| Rv0072 Rv0072 |
mtbc0_000080 |
glutamine ABC transporter permease | FtsX-like permease family protein. Pfam: MacB_PCD (PF12704.15), FtsX (PF02687.28). | MacB_PCD FtsX |
Family assigned |
| Rv0073 Rv0073 |
mtbc0_000081 |
glutamine ABC transporter ATP-binding protein | ATP-binding cassette domain-containing protein. Pfam: ABC_tran (PF00005.34), cNMP_binding (PF00027.36). | ABC_tran cNMP_binding |
Family assigned |
| Rv0074 Rv0074 |
mtbc0_000082 |
hypothetical protein | Amidohydrolase-superfamily metalloenzyme (Pfam Amidohydro_1 PF01979 + Amidohydro_3). A TIM-barrel metal-dependent hydrolase; the specific substrate in M. tuberculosis is not established. | Amidohydro_1 Amidohydro_3 |
Family assigned |
| Rv0075 Rv0075 |
mtbc0_000083 |
aminotransferase | MalY/PatB family protein. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Family assigned |
| Rv0076c Rv0076c |
- |
membrane protein | Membrane protein. | Family assigned | |
| Rv0077c Rv0077c |
mtbc0_000085 |
oxidoreductase | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| Rv0078 Rv0078 |
mtbc0_000086 |
transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_41 (PF21351.3). | TetR_N TetR_C_41 |
Family assigned |
| Rv0078A Rv0078A |
- |
hypothetical protein | Contains AbiEii (PF08843.18) domain(s); putative function inferred from the domain architecture. | AbiEii |
Family assigned |
| Rv0078B Rv0078B |
- |
hypothetical protein | Contains Rv0078B (PF18993.7) domain(s); putative function inferred from the domain architecture. | Rv0078B |
Family assigned |
| Rv0079 Rv0079 |
mtbc0_000089 |
hypothetical protein | DATIN (Dormancy-Associated Translation Inhibitor), a DosR-regulon protein. Pfam Ribosom_S30AE_C (PF16321) places it in the ribosome-associated / hibernation-factor family; it is proposed to bind the 30S/70S ribosomal subunits and inhibit or stabilise translation during dormancy. The activity remains a (well-argued) prediction. | Ribosom_S30AE_C |
Resolved |
| Rv0080 Rv0080 |
mtbc0_000090 |
hypothetical protein | Pyridoxamine-5'-phosphate-oxidase (PNPOx) family protein / FMN-binding split-barrel (Pfam Pyridox_ox_2 PF12900). Putative FMN-dependent oxidoreductase; specific reaction not established. | Pyridox_ox_2 |
Family assigned |
| Rv0081 Rv0081 |
mtbc0_000091 |
HTH-type transcriptional regulator | Lsr2/espR transcriptional regulator. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27). | HTH_20 HTH_5 |
Family assigned |
| Rv0082 Rv0082 |
mtbc0_000092 |
oxidoreductase | NADH-quinone oxidoreductase subunit B family protein. Pfam: Oxidored_q6 (PF01058.30). | Oxidored_q6 |
Family assigned |
| Rv0083 Rv0083 |
mtbc0_000093 |
oxidoreductase | Oxidoreductase. Pfam: Proton_antipo_M (PF00361.26). | Proton_antipo_M |
Resolved |
| hycD Rv0084 |
mtbc0_000094 |
formate hydrogenlyase HycD | Respiratory chain complex I subunit 1 family protein. Pfam: NADHdh (PF00146.27). | NADHdh |
Family assigned |
| hycP Rv0085 |
mtbc0_000095 |
hydrogenase HycP | Polytopic integral membrane protein with 7 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hydrogenase HycP'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned | |
| hycQ Rv0086 |
mtbc0_000096 |
hydrogenase HycQ | Hydrogenase HycQ. Pfam: Proton_antipo_M (PF00361.26). | Proton_antipo_M |
Resolved |
| hycE Rv0087 |
mtbc0_000097 |
formate hydrogenase HycE | NADH-quinone oxidoreductase subunit C. Pfam: Complex1_30kDa (PF00329.26), NiFeSe_Hases (PF00374.25), Complex1_49kDa (PF00346.25). | Complex1_30kDa NiFeSe_Hases Complex1_49kDa |
Family assigned |
| Rv0088 Rv0088 |
- |
polyketide cyclase/dehydrase | Polyketide cyclase/dehydrase. Pfam: Polyketide_cyc2 (PF10604.16). | Polyketide_cyc2 |
Resolved |
| Rv0089 Rv0089 |
- |
methyltransferase | Methyltransferase. Pfam: Methyltransf_9 (PF08003.18), RrnaAD (PF00398.27), Methyltransf_2 (PF00891.25), MTS (PF05175.21), Ubie_methyltran (PF01209.25), PrmA (PF06325.20), Methyltransf_23 (PF13489.13), NodS (PF05401.17), Methyltransf_25 (PF13649.13), Methyltransf_31 (PF13847.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_9 RrnaAD Methyltransf_2 MTS Ubie_methyltran PrmA Methyltransf_23 NodS Methyltransf_25 Methyltransf_31 Methyltransf_11 Methyltransf_12 |
Resolved |
| Rv0090 Rv0090 |
mtbc0_000100 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF2127. Function unknown. | DUF2127 |
Still unknown |
| mtn Rv0091 |
mtbc0_000101 |
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase. Pfam: PNP_UDP_1 (PF01048.27). | PNP_UDP_1 |
Resolved |
| ctpA Rv0092 |
mtbc0_000102 |
cation transporter ATPase A | Heavy metal translocating P-type ATPase. Pfam: HMA (PF00403.33), E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | HMA E1-E2_ATPase Hydrolase |
Resolved |
| Rv0093c Rv0093c |
- |
membrane protein | Membrane protein. Pfam: zf-HC2 (PF13490.12). | zf-HC2 |
Family assigned |
| Rv0094c Rv0094c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| Rv0095c Rv0095c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| PPE1 Rv0096 |
- |
PPE family protein PPE1 | PPE family protein PPE1. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| Rv0097 Rv0097 |
mtbc0_000106 |
oxidoreductase | TauD/TfdA family dioxygenase. Pfam: TauD (PF02668.23). | TauD |
Family assigned |