Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| PE_PGRS13 Rv0833 |
- |
PE-PGRS family protein PE_PGRS13 | PE-PGRS family protein PE_PGRS13. | Family assigned | |
| PE_PGRS14 Rv0834c |
- |
PE-PGRS family protein PE_PGRS14 | PE-PGRS family protein PE_PGRS14. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| lpqQ Rv0835 |
mtbc0_000889 |
lipoprotein LpqQ | Sensor domain-containing protein. Pfam: PknH_C (PF14032.13). | PknH_C |
Family assigned |
| Rv0836c Rv0836c |
- |
hypothetical protein | MenT2 (MenAT2 system), a DUF1814 nucleotidyltransferase toxin of the MenAT family. RefSeq leaves this locus 'hypothetical protein'; the toxin identity is established in the literature (Cai 2020). Paralogue-of-fold caution: the ESMFold model matches a MenAT1 complex (Foldseek 8an5) by paralogy - the locus is MenT2, not MenT1; the assignment rests on genomic context, not the fold name. | Resolved | |
| Rv0837c Rv0837c |
mtbc0_000892 |
hypothetical protein | MenA2, the type IV antitoxin of the MenAT2 module (AbiEi family, Pfam AbiEi_2). RefSeq names only 'type IV TA AbiEi family antitoxin'; the MenA2 identity and autoregulation are established (Cai 2020; Beck 2020). | AbiEi_2 |
Resolved |
| lpqR Rv0838 |
mtbc0_000893 |
lipoprotein LpqR | M15 family metallopeptidase. Pfam: Peptidase_M15 (PF01427.23). | Peptidase_M15 |
Family assigned |
| Rv0839 Rv0839 |
mtbc0_000894 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), PCMT (PF01135.26), MetW (PF07021.19), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), MTS (PF05175.21), NodS (PF05401.17), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 PCMT MetW Methyltransf_31 Ubie_methyltran MTS NodS Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Family assigned |
| pip Rv0840c |
mtbc0_000895 |
proline iminopeptidase | Proline-specific peptidase family protein. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| Rv0841 Rv0841 |
- |
transmembrane protein | Transmembrane protein. | Resolved | |
| Rv0842 Rv0842 |
mtbc0_000897 |
integral membrane protein | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv0843 Rv0843 |
mtbc0_000898 |
dehydrogenase | Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha. Pfam: E1_dh (PF00676.26). | E1_dh |
Family assigned |
| narL Rv0844c |
mtbc0_000899 |
nitrate/nitrite response transcriptional regulator NarL | Two-component system response regulator NarL. Pfam: Response_reg (PF00072.31), GerE (PF00196.26). | Response_reg GerE |
Resolved |
| Rv0845 Rv0845 |
- |
sensor histidine kinase NarS | Sensor histidine kinase NarS. Pfam: HATPase_c (PF02518.32). | HATPase_c |
Resolved |
| mmcO Rv0846c |
mtbc0_000901 |
oxidase | Multicopper oxidase MmcO. Pfam: Cu-oxidase_3 (PF07732.22), Cu-oxidase (PF00394.29), Cu-oxidase_2 (PF07731.21). | Cu-oxidase_3 Cu-oxidase Cu-oxidase_2 |
Resolved |
| lpqS Rv0847 |
mtbc0_000902 |
lipoprotein LpqS | Lipoprotein LpqS. Pfam: LpqS (PF26327.1). | LpqS |
Resolved |
| cysK2 Rv0848 |
- |
cysteine synthase CysK | Cysteine synthase CysK. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| Rv0849 Rv0849 |
mtbc0_000904 |
MFS-type transporter | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv0851c Rv0851c |
mtbc0_000906 |
short-chain type dehydrogenase/reductase | SDR family NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv0852 Rv0852 |
mtbc0_000907 |
hypothetical protein | Possible fatty-acid--CoA ligase FadD16 (UniProt: 'possible', unreviewed name; eggNOG preferred name fadD16). CAVEAT — our own structural layer does not corroborate a ligase: the best AlphaFold-model matches are an anthrone-oxidase-like protein (TM 0.66) and a putative monooxygenase (TM 0.55), not an adenylate-forming enzyme. The assignment rests on the legacy FadD16 naming alone; no publication mentions this locus. | Resolved | |
| pdc Rv0853c |
mtbc0_000908 |
alpha-keto-acid decarboxylase | Alpha-keto-acid decarboxylase. Pfam: TPP_enzyme_N (PF02776.24), TPP_enzyme_M (PF00205.29), TPP_enzyme_C (PF02775.27). | TPP_enzyme_N TPP_enzyme_M TPP_enzyme_C |
Resolved |
| Rv0854 Rv0854 |
mtbc0_000909 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| far Rv0855 |
mtbc0_000910 |
fatty-acid-CoA racemase | Fatty-acid-CoA racemase. Pfam: CoA_transf_3 (PF02515.23). | CoA_transf_3 |
Resolved |
| Rv0856 Rv0856 |
- |
hypothetical protein | Contains Polyketide_cyc (PF03364.26) domain(s); putative function inferred from the domain architecture. | Polyketide_cyc |
Family assigned |
| Rv0857 Rv0857 |
- |
hypothetical protein | Contains Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26) domain(s); putative function inferred from the domain architecture. | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| dapC Rv0858c |
mtbc0_000913 |
N-succinyldiaminopimelate aminotransferase DapC | Pyridoxal phosphate-dependent aminotransferase. Pfam: Aminotran_1_2 (PF00155.28), Aminotran_5 (PF00266.26). | Aminotran_1_2 Aminotran_5 |
Resolved |
| fadA Rv0859 |
mtbc0_000914 |
acyltransferase | Acetyl-CoA C-acetyltransferase. Pfam: Thiolase_N (PF00108.30), ketoacyl-synt (PF00109.33), Thiolase_C (PF02803.25). | Thiolase_N ketoacyl-synt Thiolase_C |
Resolved |
| fadB Rv0860 |
mtbc0_000915 |
fatty oxidation protein FadB | Fatty oxidation protein FadB. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11), 3HCDH_N (PF02737.25), 3HCDH (PF00725.28). | ECH_1 ECH_2 3HCDH_N 3HCDH |
Resolved |
| ercc3 Rv0861c |
- |
DNA helicase Ercc3 | DNA helicase Ercc3. Pfam: Helicase_C_3 (PF13625.12), ResIII (PF04851.22), DEAD (PF00270.36), ERCC3_RAD25_C (PF16203.12), Helicase_C (PF00271.38). | Helicase_C_3 ResIII DEAD ERCC3_RAD25_C Helicase_C |
Resolved |
| Rv0862c Rv0862c |
mtbc0_000917 |
hypothetical protein | Helicase-associated domain-containing protein. Pfam: Helicase_C_3 (PF13625.12). | Helicase_C_3 |
Family assigned |
| Rv0863 Rv0863 |
mtbc0_000918 |
hypothetical protein | Candidate component of molybdopterin (Moco) cofactor biosynthesis: first gene of the operon Rv0863-moaC2-mog-moaE2 (co-transcribed with the molybdopterin-synthesis genes moaC2/mog/moaE2), so contextually associated with Moco biosynthesis. Its precise molecular role is not established. NOTE: a strong STRING experimental interaction with the cytochrome-oxidase subunit ctaD (score 987) is discounted as a likely bacterial-two-hybrid false positive, as ctaD is a hub and the interaction contradicts the molybdopterin operon context (P7.7 guard: an experimental PPI that conflicts with the operon is treated as an artefact). | Family assigned | |
| moaC2 Rv0864 |
mtbc0_000919 |
cyclic pyranopterin monophosphate synthase accessory protein | Cyclic pyranopterin monophosphate synthase MoaC. Pfam: MoaC (PF01967.28). | MoaC |
Resolved |
| mog Rv0865 |
mtbc0_000920 |
molybdopterin biosynthesis protein | MogA/MoaB family molybdenum cofactor biosynthesis protein. Pfam: MoCF_biosynth (PF00994.30). | MoCF_biosynth |
Family assigned |
| moaE2 Rv0866 |
mtbc0_000921 |
molybdopterin synthase catalytic subunit 2 | Molybdopterin synthase subunit MoaE2. Pfam: MoaE (PF02391.23). | MoaE |
Family assigned |
| rpfA Rv0867c |
mtbc0_000922 |
resuscitation-promoting factor RpfA | Resuscitation-promoting factor protein RpfA. Pfam: Transglycosylas (PF06737.20). | Transglycosylas |
Resolved |
| moaD2 Rv0868c |
mtbc0_000923 |
cyclic pyranopterin monophosphate synthase | Molybdopterin synthase subunit MoaD2. Pfam: ThiS (PF02597.27). | ThiS |
Family assigned |
| moaA2 Rv0869c |
mtbc0_000924 |
molybdenum cofactor biosynthesis protein MoaA | GTP 3'%2C8-cyclase MoaA. Pfam: Radical_SAM (PF04055.28), Mob_synth_C (PF06463.19). | Radical_SAM Mob_synth_C |
Resolved |
| Rv0870c Rv0870c |
mtbc0_000925 |
integral membrane protein | YccF domain-containing protein. Pfam: YccF (PF03733.19). | YccF |
Family assigned |
| cspB Rv0871 |
mtbc0_000926 |
cold shock-like protein CspB | Cold-shock protein. Pfam: CSD (PF00313.29). | CSD |
Resolved |
| PE_PGRS15 Rv0872c |
- |
PE-PGRS family protein PE_PGRS15 | PE-PGRS family protein PE_PGRS15. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| fadE10 Rv0873 |
mtbc0_000928 |
acyl-CoA dehydrogenase | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| Rv0874c Rv0874c |
mtbc0_000929 |
hypothetical protein | FIST C-terminal domain-containing protein. Pfam: FIST (PF08495.16), FIST_C (PF10442.15). | FIST FIST_C |
Family assigned |
| Rv0875c Rv0875c |
mtbc0_000930 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2771. Function unknown. Foldseek best (non-significant) hit: 6d0k-assembly1_D Crystal structure of a CLC-type fluoride/proton antip (prob 0.60, TM 0.45). | DUF2771 |
Still unknown |
| Rv0876c Rv0876c |
mtbc0_000931 |
transmembrane protein | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| Rv0877 Rv0877 |
mtbc0_000932 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3027. Function unknown. Foldseek best (non-significant) hit: 5kuy-assembly1_G Influenza hemagglutinin H3 A/Hong Kong/1/1968 in comp (prob 0.66, TM 0.50). | DUF3027 |
Still unknown |
| PPE13 Rv0878c |
- |
PPE family protein PPE13 | PPE family protein PPE13. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv0879c Rv0879c |
mtbc0_000934 |
transmembrane protein | Small integral membrane protein (DUF2530) under strong purifying selection; its fold resembles actinobacterial respiratory-supercomplex accessory membrane subunits (HHpred 7Q21 Cgl2017 ~92% E0.24). CAVEAT: fold resemblance ONLY, no genomic/co-expression/structural corroboration that it is a subunit; not part of a validated functional module. | DUF2530 |
Family assigned |
| Rv0880 Rv0880 |
mtbc0_000935 |
HTH-type transcriptional regulator | MarR family transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29). | MarR_2 MarR |
Family assigned |
| Rv0881 Rv0881 |
mtbc0_000936 |
tRNA/rRNA methyltransferase | RNA methyltransferase. Pfam: SpoU_methylase (PF00588.25). | SpoU_methylase |
Resolved |
| Rv0882 Rv0882 |
mtbc0_000937 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF2537. Function unknown. | DUF2537 |
Still unknown |
| sepH Rv0883c |
mtbc0_000938 |
hypothetical protein | Septation protein SepH. | DUF3071 |
Resolved |