Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3654c Rv3654c |
- |
hypothetical protein | Contains Tad (PF13400.12) domain(s); putative function inferred from the domain architecture. | Tad |
Family assigned |
| Rv3655c Rv3655c |
mtbc0_003873 |
hypothetical protein | Apoptosis inhibitor. | Resolved | |
| Rv3656c Rv3656c |
mtbc0_003874 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4244. Function unknown. | DUF4244 |
Still unknown |
| Rv3657c Rv3657c |
- |
membrane protein | Membrane protein. Pfam: T2SSF (PF00482.29). | T2SSF |
Family assigned |
| Rv3658c Rv3658c |
mtbc0_003876 |
transmembrane protein | Type II secretion system F family protein. Pfam: T2SSF (PF00482.29). | T2SSF |
Family assigned |
| Rv3659c Rv3659c |
- |
conjugal transfer protein | Conjugal transfer protein. Pfam: T2SSE (PF00437.27). | T2SSE |
Resolved |
| ssd Rv3660c |
mtbc0_003878 |
hypothetical protein | Septum site-determining protein Ssd. Pfam: Rv3660c_N (PF26563.1). | Rv3660c_N |
Resolved |
| Rv3661 Rv3661 |
mtbc0_003879 |
hypothetical protein | HAD-IB family hydrolase. Pfam: Hydrolase (PF00702.33), HAD (PF12710.14). | Hydrolase HAD |
Family assigned |
| Rv3662c Rv3662c |
mtbc0_003880 |
hypothetical protein | Oxidoreductase. | Resolved | |
| dppD Rv3663c |
mtbc0_003881 |
dipeptide ABC transporter ATP-binding protein DppD | ABC transporter ATP-binding protein. Pfam: oligo_HPY (PF08352.18), ABC_tran (PF00005.34). | oligo_HPY ABC_tran |
Family assigned |
| dppC Rv3664c |
- |
dipeptide ABC transporter permease DppC | Dipeptide ABC transporter permease DppC. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| dppB Rv3665c |
mtbc0_003883 |
dipeptide ABC transporter permease DppB | ABC transporter permease. Pfam: BPD_transp_1_N (PF19300.5), BPD_transp_1 (PF00528.28). | BPD_transp_1_N BPD_transp_1 |
Family assigned |
| dppA Rv3666c |
mtbc0_003884 |
dipeptide ABC transporter substrate-binding lipoprotein DppA | ABC transporter substrate-binding protein. Pfam: SBP_bac_5 (PF00496.28). | SBP_bac_5 |
Family assigned |
| acs Rv3667 |
mtbc0_003886 |
acetyl-CoAsynthetase | Acetate--CoA ligase. Pfam: ACAS_N (PF16177.12), AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | ACAS_N AMP-binding AMP-binding_C |
Resolved |
| Rv3668c Rv3668c |
mtbc0_003887 |
protease | Serine protease. Characterised on the M. tuberculosis protein itself: Rv3668c modulates the host-pathogen interaction through the Erk / NF-kappaB axis, with differential cytokine expression (Zhang et al. 2014). Concordant supports: UniProt 'possible protease', eggNOG 'endopeptidase activity', and structural matches to alpha-lytic-protease-type structures (TM 0.80/0.79, PDB 1p09/3lpr). The catalytic residues have not been verified against M-CSA here; the activity is reported by the primary literature, not by this pipeline. | Resolved | |
| Rv3669 Rv3669 |
mtbc0_003888 |
transmembrane protein | Phage holin family protein. Pfam: Phage_holin_3_6 (PF07332.17). | Phage_holin_3_6 |
Family assigned |
| ephE Rv3670 |
mtbc0_003889 |
epoxide hydrolase EphE | Alpha/beta hydrolase. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| marP Rv3671c |
mtbc0_003890 |
serine protease | Acid resistance serine protease MarP. Pfam: Colicin_V (PF02674.23), Trypsin_2 (PF13365.13), Trypsin (PF00089.33). | Colicin_V Trypsin_2 Trypsin |
Resolved |
| Rv3672c Rv3672c |
mtbc0_003891 |
hypothetical protein | CoA pyrophosphatase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| Rv3673c Rv3673c |
- |
membrane-anchored thioredoxin-like protein | Membrane-anchored thioredoxin-like protein. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28), Thioredoxin_8 (PF13905.13). | Redoxin AhpC-TSA Thioredoxin_8 |
Family assigned |
| nth Rv3674c |
mtbc0_003893 |
endonuclease III | Endonuclease III. Pfam: HhH-GPD (PF00730.32), HHH (PF00633.30), EndIII_4Fe-2S (PF10576.15). | HhH-GPD HHH EndIII_4Fe-2S |
Resolved |
| Rv3675 Rv3675 |
mtbc0_003894 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| crp Rv3676 |
mtbc0_003895 |
cAMP receptor protein | CAMP-activated global transcriptional regulator CRP. Pfam: cNMP_binding (PF00027.36), HTH_Crp_2 (PF13545.13), Crp (PF00325.27). | cNMP_binding HTH_Crp_2 Crp |
Family assigned |
| Rv3677c Rv3677c |
mtbc0_003896 |
beta lactamase | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14), WHD_BLACT (PF17778.8). | Lactamase_B Lactamase_B_2 WHD_BLACT |
Resolved |
| Rv3678A Rv3678A |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8i0t-assembly1_C The cryo-EM structure of human Bact-III complex (prob 1.00, TM 0.82). Structure-based, putative. | Family assigned | |
| Rv3678c Rv3678c |
mtbc0_003897 |
hypothetical protein | RidA family protein. Pfam: YjgF_endoribonc (PF14588.12), Ribonuc_L-PSP (PF01042.27). | YjgF_endoribonc Ribonuc_L-PSP |
Family assigned |
| Rv3679 Rv3679 |
mtbc0_003899 |
anion transporter ATPase | ArsA family ATPase. Pfam: ArsA_ATPase (PF02374.22), CbiA (PF01656.30). | ArsA_ATPase CbiA |
Family assigned |
| Rv3680 Rv3680 |
mtbc0_003900 |
anion transporter ATPase | ArsA family ATPase. Pfam: ArsA_ATPase (PF02374.22), CbiA (PF01656.30), AAA_31 (PF13614.13). | ArsA_ATPase CbiA AAA_31 |
Family assigned |
| whiB4 Rv3681c |
mtbc0_003901 |
transcriptional regulator WhiB4 | Transcriptional regulator WhiB4. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| ponA2 Rv3682 |
- |
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase | Bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase. Pfam: Transgly (PF00912.29), Transpeptidase (PF00905.28), PASTA (PF03793.25). | Transgly Transpeptidase PASTA |
Resolved |
| Rv3683 Rv3683 |
mtbc0_003903 |
hypothetical protein | Metallophosphoesterase. Pfam: Metallophos (PF00149.34), Metallophos_2 (PF12850.13). | Metallophos Metallophos_2 |
Resolved |
| Rv3684 Rv3684 |
- |
lyase | Lyase. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| cyp137 Rv3685c |
mtbc0_003906 |
cytochrome P450 Cyp137 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv3686c Rv3686c |
mtbc0_003907 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| rsfB Rv3687c |
mtbc0_003908 |
anti-anti-sigma factor RsfB | STAS domain-containing protein. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Family assigned |
| Rv3688c Rv3688c |
mtbc0_003909 |
hypothetical protein | GatB/YqeY domain-containing protein. Pfam: YqeY (PF09424.16). | YqeY |
Family assigned |
| Rv3689 Rv3689 |
- |
transmembrane protein | Transmembrane protein. | DUF7847 |
Resolved |
| Rv3690 Rv3690 |
mtbc0_003911 |
membrane protein | Candidate lipid-transport/handling protein of the Repeating-Beta-Groove (RBG) superfamily (Bridge-Like Lipid Transfer Proteins / VPS13-ATG2-AsmA-TamB), based on a significant but ISOLATED HHpred hit. DUF4129 single-pass membrane protein, perfectly conserved (pN/pS 0), in a membrane operon (Rv3689-3695) with the MoxR2 AAA+ assembly ATPase. The single isolated hit and the assembly-ATPase operon context leave the precise role uncertain. RefSeq leaves this locus uncharacterised. | DUF4129 |
Family assigned |
| Rv3691 Rv3691 |
- |
hypothetical protein | DUF4350 protein of the IFT52 / OST48-WBP1 / ThuA-like Rossmann-fold superfamily (significant HHpred). This is a functionally diverse superfamily (membrane oligosaccharyltransferase non-catalytic subunits, intraflagellar/transport proteins, trehalose-utilization ThuA, GATase1-like), so the precise molecular function is undetermined. Genomic context: in the Rv3689-3695 membrane operon together with moxR2 (AAA+ assembly ATPase) and Rv3690 (the RBG/BLTP lipid-transport candidate, STRING-linked) -> likely a membrane-associated component of this module. RefSeq leaves this locus uncharacterised. | DUF4350 |
Family assigned |
| moxR2 Rv3692 |
mtbc0_003913 |
methanol dehydrogenase transcriptional regulator MoxR | MoxR family ATPase. Pfam: bpMoxR (PF20030.6), MCM (PF00493.30), AAA_3 (PF07726.18), AAA_5 (PF07728.21), AAA (PF00004.36), AAA_lid_2 (PF17863.8). | bpMoxR MCM AAA_3 AAA_5 AAA AAA_lid_2 |
Family assigned |
| Rv3693 Rv3693 |
mtbc0_003914 |
membrane protein | Sec-translocon-associated membrane protein (translocon-associated protein TRAP-beta-like fold). RefSeq leaves it 'hypothetical protein'. | DUF58 |
Family assigned |
| Rv3694c Rv3694c |
mtbc0_003915 |
transmembrane protein | Stage II sporulation protein M. Pfam: DUF8413 (PF28475.1), SpoIIM (PF01944.23). | DUF8413 SpoIIM |
Resolved |
| Rv3695 Rv3695 |
mtbc0_003916 |
membrane protein | RDD family protein. Pfam: RDD (PF06271.19). | RDD |
Family assigned |
| glpK Rv3696c |
mtbc0_003917 |
glycerol kinase | Glycerol kinase GlpK. Pfam: FGGY_N (PF00370.28), FGGY_C (PF02782.23). | FGGY_N FGGY_C |
Resolved |
| vapB48 Rv3697A |
- |
antitoxin VapB48 | Antitoxin VapB48. | Resolved | |
| vapC48 Rv3697c |
mtbc0_003918 |
ribonuclease VapC48 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv3698 Rv3698 |
- |
hypothetical protein | Contains GCS2 (PF04107.19) domain(s); putative function inferred from the domain architecture. | GCS2 |
Family assigned |
| Rv3699 Rv3699 |
mtbc0_003921 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: TPMT (PF05724.18), Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | TPMT Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| egtE Rv3700c |
mtbc0_003922 |
pyridoxal-phosphate-dependent protein EgtE | Ergothioneine biosynthesis PLP-dependent enzyme EgtE. Pfam: Aminotran_5 (PF00266.26). | Aminotran_5 |
Resolved |
| egtD Rv3701c |
mtbc0_003923 |
histidine-specific methyltransferase EtgD | L-histidine N(alpha)-methyltransferase. Pfam: Methyltransf_33 (PF10017.16). | Methyltransf_33 |
Resolved |