Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| atsB Rv3299c |
mtbc0_003507 |
arylsulfatase AtsB | Arylsulfatase AtsB. Pfam: DUF1269 (PF06897.18), Sulfatase (PF00884.29). | DUF1269 Sulfatase |
Resolved |
| Rv3300c Rv3300c |
mtbc0_003508 |
hypothetical protein | RluA family pseudouridine synthase. Pfam: PseudoU_synth_2 (PF00849.28). | PseudoU_synth_2 |
Family assigned |
| phoY1 Rv3301c |
mtbc0_003509 |
phosphate transport system transcriptional regulator PhoY | Phosphate signaling complex protein PhoU. Pfam: PhoU (PF01895.25). | PhoU |
Resolved |
| glpD2 Rv3302c |
mtbc0_003510 |
glycerol-3-phosphate dehydrogenase | Glycerol-3-phosphate dehydrogenase/oxidase. Pfam: FAD_binding_3 (PF01494.26), DAO (PF01266.31), FAD_oxidored (PF12831.14), FAD_binding_2 (PF00890.31), DAO_C (PF16901.11). | FAD_binding_3 DAO FAD_oxidored FAD_binding_2 DAO_C |
Resolved |
| lpdA Rv3303c |
mtbc0_003511 |
NAD(P)H quinone reductase LpdA | NAD(P)H-quinone dehydrogenase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox (PF00070.34), Pyr_redox_dim (PF02852.29). | Pyr_redox_2 Pyr_redox Pyr_redox_dim |
Resolved |
| Rv3304 Rv3304 |
mtbc0_003512 |
hypothetical protein | Gamma-glutamylcyclotransferase. Pfam: GGACT (PF06094.18), AIG2_2 (PF13772.12). | GGACT AIG2_2 |
Resolved |
| amiA1 Rv3305c |
- |
N-acyl-L-amino acid amidohydrolase AmiA | N-acyl-L-amino acid amidohydrolase AmiA. Pfam: Peptidase_M20 (PF01546.34). | Peptidase_M20 |
Resolved |
| amiB1 Rv3306c |
- |
amidase AmiB | Amidase AmiB. Pfam: Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20). | Peptidase_M20 M20_dimer |
Resolved |
| deoD Rv3307 |
mtbc0_003515 |
purine nucleoside phosphorylase | Purine-nucleoside phosphorylase. Pfam: PNP_UDP_1 (PF01048.27). | PNP_UDP_1 |
Resolved |
| pmmB Rv3308 |
mtbc0_003516 |
phosphomannomutase PmmB | Phospho-sugar mutase. Pfam: PGM_PMM_I (PF02878.23), PGM_PMM_II (PF02879.23), PGM_PMM_III (PF02880.23). | PGM_PMM_I PGM_PMM_II PGM_PMM_III |
Resolved |
| upp Rv3309c |
mtbc0_003517 |
uracil phosphoribosyltransferase | Uracil phosphoribosyltransferase. Pfam: UPRTase (PF14681.13), Pribosyltran (PF00156.34). | UPRTase Pribosyltran |
Resolved |
| sapM Rv3310 |
mtbc0_003518 |
acid phosphatase | Phosphatidylinositol-3-phosphatase. Pfam: Phosphoesterase (PF04185.20). | Phosphoesterase |
Resolved |
| Rv3311 Rv3311 |
mtbc0_003519 |
hypothetical protein | Primosomal protein. | Family assigned | |
| Rv3312A Rv3312A |
- |
pilin | Pilin. Pfam: Pilin_Mycobact (PF26380.2). | Pilin_Mycobact |
Resolved |
| Rv3312b Rv3312b |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3312c Rv3312c |
mtbc0_003520 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| add Rv3313c |
mtbc0_003523 |
adenosine deaminase | Adenosine deaminase. Pfam: A_deaminase (PF00962.29). | A_deaminase |
Resolved |
| deoA Rv3314c |
mtbc0_003524 |
thymidine phosphorylase | Thymidine phosphorylase. Pfam: Glycos_trans_3N (PF02885.23), Glycos_transf_3 (PF00591.28), PYNP_C (PF07831.20). | Glycos_trans_3N Glycos_transf_3 PYNP_C |
Resolved |
| cdd Rv3315c |
mtbc0_003525 |
cytidine deaminase | Cytidine deaminase. Pfam: dCMP_cyt_deam_2 (PF08211.19), dCMP_cyt_deam_1 (PF00383.30). | dCMP_cyt_deam_2 dCMP_cyt_deam_1 |
Resolved |
| sdhC Rv3316 |
mtbc0_003526 |
succinate dehydrogenase cytochrome B-556 subunit | Succinate dehydrogenase%2C cytochrome b556 subunit. Pfam: Sdh_cyt (PF01127.28). | Sdh_cyt |
Family assigned |
| sdhD Rv3317 |
mtbc0_003527 |
succinate dehydrogenase hydrophobic membrane anchor subunit | Succinate dehydrogenase hydrophobic membrane anchor subunit. Pfam: Sdh_cyt (PF01127.28). | Sdh_cyt |
Family assigned |
| sdhA Rv3318 |
mtbc0_003528 |
succinate dehydrogenase flavoprotein subunit | Succinate dehydrogenase flavoprotein subunit. Pfam: FAD_binding_2 (PF00890.31), Succ_DH_flav_C (PF02910.26). | FAD_binding_2 Succ_DH_flav_C |
Family assigned |
| sdhB Rv3319 |
mtbc0_003529 |
succinate dehydrogenase iron-sulphur protein subunit | Succinate dehydrogenase iron-sulfur subunit. Pfam: Fer2_3 (PF13085.12), Fer4_10 (PF13237.12), Fer4_8 (PF13183.12), Fer4_17 (PF13534.12). | Fer2_3 Fer4_10 Fer4_8 Fer4_17 |
Family assigned |
| vapC44 Rv3320c |
mtbc0_003530 |
ribonuclease VapC44 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB44 Rv3321c |
mtbc0_003531 |
antitoxin VapB44 | CopG family transcriptional regulator. | Family assigned | |
| Rv3322c Rv3322c |
- |
methyltransferase | Methyltransferase. Pfam: Methyltransf_25 (PF13649.13). | Methyltransf_25 |
Resolved |
| moaX Rv3323c |
- |
MoaD-MoaE fusion protein MoaX | MoaD-MoaE fusion protein MoaX. Pfam: ThiS (PF02597.27), MoaE (PF02391.23). | ThiS MoaE |
Resolved |
| moaC3 Rv3324c |
mtbc0_003534 |
cyclic pyranopterin monophosphate synthase accessory protein | Cyclic pyranopterin monophosphate synthase MoaC. Pfam: MoaC (PF01967.28). | MoaC |
Resolved |
| Rv3327 Rv3327 |
mtbc0_003540 |
transposase fusion protein | IS110 family transposase. Pfam: DEDD_Tnp_IS110 (PF01548.24), Transposase_20 (PF02371.23). | DEDD_Tnp_IS110 Transposase_20 |
Family assigned |
| sigJ Rv3328c |
mtbc0_003541 |
ECF RNA polymerase sigma factor SigJ | Sigma-70 family RNA polymerase sigma factor SigJ. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), SnoaL_2 (PF12680.14). | Sigma70_r2 Sigma70_r4_2 SnoaL_2 |
Family assigned |
| Rv3329 Rv3329 |
- |
aminotransferase | Aminotransferase. Pfam: Aminotran_3 (PF00202.28). | Aminotran_3 |
Resolved |
| dacB1 Rv3330 |
mtbc0_003543 |
penicillin-binding protein DacB | D-alanyl-D-alanine carboxypeptidase DacB1. Pfam: Peptidase_S11 (PF00768.26), Beta-lactamase2 (PF13354.13). | Peptidase_S11 Beta-lactamase2 |
Resolved |
| sugI Rv3331 |
- |
sugar-transport integral membrane protein SugI | Sugar-transport integral membrane protein SugI. Pfam: Sugar_tr (PF00083.31), MFS_1 (PF07690.22). | Sugar_tr MFS_1 |
Resolved |
| nagA Rv3332 |
mtbc0_003545 |
N-acetylglucosamine-6-phosphate deacetylase NagA | N-acetylglucosamine-6-phosphate deacetylase. Pfam: Amidohydro_1 (PF01979.27). | Amidohydro_1 |
Resolved |
| prp1 Rv3333c |
mtbc0_003546 |
hypothetical protein | PDZ-interacting protease regulator Ppr1. | DUF732 |
Resolved |
| Rv3334 Rv3334 |
mtbc0_003547 |
MerR family transcriptional regulator | Hypoxia response transcriptional regulator. Pfam: MerR_1 (PF13411.13), MerR (PF00376.30), MerR-DNA-bind (PF09278.18). | MerR_1 MerR MerR-DNA-bind |
Family assigned |
| yhjD Rv3335c |
mtbc0_003548 |
integral membrane protein | Inner membrane protein YhjD. Pfam: Virul_fac_BrkB (PF03631.21). | Virul_fac_BrkB |
Resolved |
| trpS Rv3336c |
mtbc0_003549 |
tryptophan--tRNA ligase | Tryptophan--tRNA ligase. Pfam: tRNA-synt_1b (PF00579.32). | tRNA-synt_1b |
Resolved |
| Rv3337 Rv3337 |
|
Conserved hypothetical protein | Putative esterase: the AlphaFold model matches solved carboxylesterases (TM 0.85 to a Bacillus stearothermophilus carboxylesterase, TM 0.82 to esterase D of Lactobacillus rhamnosus). The previous wording was the raw eggNOG/GO term 'hydrolase activity, acting on ester bonds'. Fold-level only — no Pfam domain, no verified catalytic triad, no publication. | Family assigned | |
| Rv3338 Rv3338 |
|
Conserved hypothetical protein | Catalyzes the hydrolysis of epoxide-containing substrates (PubMed:36777032). In vitro, catalyzes the hydrolysis of the synthetic compounds PHOME and styrene oxide (PubMed:36777032). Plays an essential role in subverting phagosomal acidification (PubMed:36777032). Plays a major role in the survival of M.tuberculosis (Mtb) during in vitro acidic stress and protects Mtb in response to phagosomal acidification inside macrophages (PubMed:36777032). Also supports Mtb growth under the nutrient-deprived condition at pH 7.0 (PubMed:36777032) | Abhydrolase_6 |
Family assigned |
| icd1 Rv3339c |
mtbc0_003551 |
isocitrate dehydrogenase | NADP-dependent isocitrate dehydrogenase. Pfam: Iso_dh (PF00180.26). | Iso_dh |
Resolved |
| metC Rv3340 |
mtbc0_003552 |
O-acetylhomoserine sulfhydrylase | Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase. Pfam: Cys_Met_Meta_PP (PF01053.27). | Cys_Met_Meta_PP |
Resolved |
| metA Rv3341 |
mtbc0_003553 |
homoserine O-acetyltransferase | Homoserine O-acetyltransferase. Pfam: Abhydrolase_1 (PF00561.27). | Abhydrolase_1 |
Resolved |
| Rv3342 Rv3342 |
mtbc0_003554 |
methyltransferase | Class I SAM-dependent methyltransferase. Pfam: Methyltransf_23 (PF13489.13), Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Ubie_methyltran Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| PPE54 Rv3343c |
- |
PPE family protein PPE54 | PPE family protein PPE54. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| PE_PGRS49 Rv3344c |
- |
PE-PGRS family protein PE_PGRS49 | PE-PGRS family protein PE_PGRS49. | Family assigned | |
| PE_PGRS50 Rv3345c |
- |
PE-PGRS family protein PE_PGRS50 | PE-PGRS family protein PE_PGRS50. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv3346c Rv3346c |
mtbc0_003558 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF3017. Function unknown. | DUF3017 |
Still unknown |
| PPE55 Rv3347c |
- |
PPE family protein PPE55 | PPE family protein PPE55. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3348 Rv3348 |
- |
transposase | Transposase. Pfam: DEDD_Tnp_IS110 (PF01548.24). | DEDD_Tnp_IS110 |
Resolved |