Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| clpP1 Rv2461c |
- |
ATP-dependent CLP protease proteolytic subunit 1 | ATP-dependent CLP protease proteolytic subunit 1. Pfam: CLP_protease (PF00574.29). | CLP_protease |
Family assigned |
| tig Rv2462c |
mtbc0_002621 |
trigger factor | Trigger factor. Pfam: Trigger_N (PF05697.19), FKBP_C (PF00254.35), Trigger_C (PF05698.20). | Trigger_N FKBP_C Trigger_C |
Resolved |
| lipP Rv2463 |
mtbc0_002624 |
esterase/lipase LipP | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| Rv2464c Rv2464c |
mtbc0_002625 |
DNA glycosylase | Fpg/Nei family DNA glycosylase. Pfam: Fapy_DNA_glyco (PF01149.30), H2TH (PF06831.20), zf-FPG_IleRS (PF06827.21). | Fapy_DNA_glyco H2TH zf-FPG_IleRS |
Family assigned |
| rpiB Rv2465c |
- |
ribose-5-phosphate isomerase B | Ribose-5-phosphate isomerase B. Pfam: LacAB_rpiB (PF02502.24). | LacAB_rpiB |
Resolved |
| Rv2466c Rv2466c |
mtbc0_002627 |
hypothetical protein | Rv2466c family mycothiol-dependent reductase. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| pepN Rv2467 |
- |
aminopeptidase PepN | Aminopeptidase PepN. Pfam: Peptidase_M1_N (PF17900.7), Peptidase_M1 (PF01433.27), ERAP1_C (PF11838.15). | Peptidase_M1_N Peptidase_M1 ERAP1_C |
Resolved |
| Rv2468A Rv2468A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2468c Rv2468c |
- |
hypothetical protein | Immunomodulatory / T-cell costimulatory protein: binds integrin VLA-5 (alpha5beta1) via an RGD motif and costimulates T cells. NOTE: a Foldseek hit to the cytochrome bcc:aa3 fold is a FALSE POSITIVE (the Mtb cytochrome bcc is qcrCAB, not this gene). | DUF5130 |
Resolved |
| Rv2469c Rv2469c |
mtbc0_002631 |
hypothetical protein | HNH endonuclease. Pfam: HNH (PF01844.30), HNH_5 (PF14279.13). | HNH HNH_5 |
Resolved |
| glbO Rv2470 |
mtbc0_002632 |
hemoglobin GlbO | Group 2 truncated hemoglobin GlbO. Pfam: Bac_globin (PF01152.28). | Bac_globin |
Resolved |
| aglA Rv2471 |
mtbc0_002633 |
alpha-glucosidase AglA | Glycoside hydrolase family 13 protein. Pfam: Alpha-amylase (PF00128.32). | Alpha-amylase |
Family assigned |
| Rv2472 Rv2472 |
mtbc0_002634 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7n51-assembly1_A Structure of a bacterial gasdermin from Vitiosangium (prob 0.03, TM 0.46). | Still unknown | |
| Rv2473 Rv2473 |
mtbc0_002635 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5xsj-assembly1_L XylFII-LytSN complex (prob 0.97, TM 0.45). | Still unknown | |
| Rv2474c Rv2474c |
mtbc0_002636 |
hypothetical protein | DnaN/beta-sliding-clamp-like fold; distinct from the genuine DNA polymerase III beta clamp dnaN/Rv0002 (fold-paralogue safeguard). Function of this paralogue undetermined. | DUF8010 DUF8185 |
Family assigned |
| Rv2475c Rv2475c |
mtbc0_002637 |
hypothetical protein | Thioesterase family protein. Pfam: Acyl-ACP_TE_C (PF20791.4), 4HBT_2 (PF13279.13). | Acyl-ACP_TE_C 4HBT_2 |
Family assigned |
| gdh Rv2476c |
mtbc0_002638 |
NAD-dependent glutamate dehydrogenase | NAD-glutamate dehydrogenase. Pfam: GDH_ACT1 (PF21075.4), GDH_HM1 (PF21073.3), GDH_ACT2 (PF21076.4), GDH_HM2 (PF21079.3), GDH_ACT3 (PF21077.4), GDH_HM3 (PF21078.3), Bac_GDH_CD (PF05088.19), GDH_C (PF21074.3). | GDH_ACT1 GDH_HM1 GDH_ACT2 GDH_HM2 GDH_ACT3 GDH_HM3 Bac_GDH_CD GDH_C |
Resolved |
| ettA Rv2477c |
mtbc0_002639 |
macrolide ABC transporter ATP-binding protein | Energy-dependent translational throttle protein EttA. Pfam: ABC_tran (PF00005.34), ABC_tran_Xtn (PF12848.14). | ABC_tran ABC_tran_Xtn |
Resolved |
| Rv2478c Rv2478c |
- |
hypothetical protein | Contains SSB (PF00436.32) domain(s); putative function inferred from the domain architecture. | SSB |
Family assigned |
| Rv2481c Rv2481c |
mtbc0_002641 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| plsB2 Rv2482c |
mtbc0_002642 |
glycerol-3-phosphate acyltransferase | Glycerol-3-phosphate 1-O-acyltransferase. Pfam: Acyltransferase (PF01553.27), GPAT_C (PF19277.5). | Acyltransferase GPAT_C |
Resolved |
| plsC Rv2483c |
mtbc0_002643 |
bifunctional L-3-phosphoserine phosphatase/1-acyl-sn-glycerol-3-phosphate acyltransferase | HAD-IB family hydrolase. Pfam: HAD (PF12710.14), Hydrolase (PF00702.33), Acyltransferase (PF01553.27). | HAD Hydrolase Acyltransferase |
Family assigned |
| Rv2484c Rv2484c |
mtbc0_002644 |
diacyglycerol O-acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| lipQ Rv2485c |
mtbc0_002645 |
carboxylesterase LipQ | Alpha/beta hydrolase. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), Peptidase_S9 (PF00326.28). | COesterase BD-FAE Abhydrolase_3 Peptidase_S9 |
Family assigned |
| echA14 Rv2486 |
mtbc0_002647 |
enoyl-CoA hydratase EchA14 | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| PE_PGRS42 Rv2487c |
- |
PE-PGRS family protein PE_PGRS42 | PE-PGRS family protein PE_PGRS42. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv2488c Rv2488c |
- |
LuxR family transcriptional regulator | LuxR family transcriptional regulator. Pfam: HTH_77 (PF25872.1), GerE (PF00196.26). | HTH_77 GerE |
Family assigned |
| Rv2489c Rv2489c |
mtbc0_002650 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2490a Rv2490a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PE_PGRS43 Rv2490c |
- |
PE-PGRS family protein PE_PGRS43 | PE-PGRS family protein PE_PGRS43. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv2491 Rv2491 |
mtbc0_002653 |
hypothetical protein | TIGR00725 family protein. Pfam: LDcluster4 (PF18306.7). | LDcluster4 |
Family assigned |
| Rv2492 Rv2492 |
mtbc0_002654 |
hypothetical protein | Thymidylate-synthase (TS)-superfamily (hydroxymethyl)transferase acting on a deoxyuridylate-type nucleotide, a distinct non-essential locus separate from the essential thymidylate synthases ThyA/ThyX. RefSeq leaves it 'hypothetical protein'. The model superposes on MilA (a CMP hydroxymethyltransferase, PDB 5b6d) with a complete catalytic constellation at the nucleotide (nucleophile Cys151, phosphate-binding Arg175, base-reading Asp178, ribose-binding His222/Tyr224); HHpred places it 100% in the thymidylate-synthase / dCMP-hydroxymethylase superfamily. The specificity residues reassign the substrate away from the template's cytidylate: Asn186 (vs MilA Asp186) and Ser176 (deoxy-type) point to a (deoxy)uridylate (dUMP-type) substrate with one-carbon chemistry on the pyrimidine C5. Vertically conserved through the human and animal MTBC and M. canettii (an earlier anti-phage-defence hypothesis is rejected). A structural prediction; substrate narrowed, not fixed. | Resolved | |
| vapB38 Rv2493 |
mtbc0_002655 |
antitoxin VapB38 | Antitoxin. | Resolved | |
| vapC38 Rv2494 |
mtbc0_002656 |
ribonuclease VapC38 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| bkdC Rv2495c |
mtbc0_002657 |
branched-chain keto acid dehydrogenase E2 component | Dihydrolipoamide acetyltransferase family protein. Pfam: Biotin_lipoyl (PF00364.29), E3_binding (PF02817.23), 2-oxoacid_dh (PF00198.29). | Biotin_lipoyl E3_binding 2-oxoacid_dh |
Family assigned |
| bkdB Rv2496c |
mtbc0_002658 |
3-methyl-2-oxobutanoate dehydrogenase subunit beta | 3-methyl-2-oxobutanoate dehydrogenase subunit beta. Pfam: Transket_pyr (PF02779.30), Transketolase_C (PF02780.26). | Transket_pyr Transketolase_C |
Family assigned |
| bkdA Rv2497c |
mtbc0_002659 |
3-methyl-2-oxobutanoate dehydrogenase subunit alpha | Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha. Pfam: E1_dh (PF00676.26), DXP_synthase_N (PF13292.12). | E1_dh DXP_synthase_N |
Family assigned |
| citE Rv2498c |
mtbc0_002660 |
citrate (pro-3S)-lyase subunit beta | Citrate (pro-3S)-lyase subunit beta. Pfam: HpcH_HpaI (PF03328.21), C-C_Bond_Lyase (PF15617.13). | HpcH_HpaI C-C_Bond_Lyase |
Family assigned |
| Rv2499c Rv2499c |
mtbc0_002661 |
oxidase regulatory-like protein | MaoC family dehydratase. Pfam: MC_hydratase (PF19315.6), MaoC_dehydratas (PF01575.26). | MC_hydratase MaoC_dehydratas |
Family assigned |
| fadE19 Rv2500c |
mtbc0_002662 |
acyl-CoA dehydrogenase FadE19 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| accA1 Rv2501c |
mtbc0_002663 |
acetyl/propionyl-CoA carboxylase subuit alpha | Acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha. Pfam: Biotin_carb_N (PF00289.29), CPSase_L_D2 (PF02786.23), Dala_Dala_lig_C (PF07478.19), Biotin_carb_C (PF02785.26), BT_MCC_alpha (PF21139.4), Biotin_lipoyl (PF00364.29). | Biotin_carb_N CPSase_L_D2 Dala_Dala_lig_C Biotin_carb_C BT_MCC_alpha Biotin_lipoyl |
Family assigned |
| accD1 Rv2502c |
mtbc0_002664 |
acetyl-/propionyl-CoA carboxylase subunit beta | Acetyl-/propionyl-CoA carboxylase subunit beta. Pfam: Carboxyl_trans (PF01039.28), ACCA (PF03255.20). | Carboxyl_trans ACCA |
Family assigned |
| scoB Rv2503c |
mtbc0_002665 |
succinyl-CoA:3-ketoacid-CoA transferase subunit B | Succinyl-CoA--3-ketoacid CoA transferase subunit B. Pfam: CoA_trans (PF01144.30), AcetylCoA_hyd_C (PF13336.13). | CoA_trans AcetylCoA_hyd_C |
Family assigned |
| scoA Rv2504c |
mtbc0_002666 |
succinyl-CoA:3-ketoacid-CoA transferase subunit A | Succinyl-CoA--3-ketoacid CoA transferase subunit A. Pfam: CoA_trans (PF01144.30). | CoA_trans |
Family assigned |
| fadD35 Rv2505c |
mtbc0_002667 |
fatty-acid--CoA ligase FadD35 | AMP-binding protein. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Family assigned |
| Rv2506 Rv2506 |
mtbc0_002668 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_24 (PF17932.7). | TetR_N TetR_C_24 |
Family assigned |
| Rv2507 Rv2507 |
mtbc0_002669 |
hypothetical protein | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv2508c Rv2508c |
mtbc0_002670 |
integral membrane protein | MFS transporter. Pfam: MFS_1 (PF07690.22), ATG22 (PF11700.15). | MFS_1 ATG22 |
Resolved |
| cmrA Rv2509 |
mtbc0_002671 |
short-chain type dehydrogenase/reductase | Mycolate reductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Resolved |
| Rv2510c Rv2510c |
mtbc0_002672 |
hypothetical protein | DUF853 domain-containing protein. Pfam: HerA_C (PF05872.19), DUF87 (PF01935.24), TrwB_AAD_bind (PF10412.16). | HerA_C DUF87 TrwB_AAD_bind |
Family assigned |