Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3611 Rv3611 |
|
Hypothetical arginine and proline rich protein | — | Still unknown | |
| Rv3612c Rv3612c |
mtbc0_003829 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3j6b-assembly1_T Structure of the yeast mitochondrial large ribosomal (prob 0.11, TM 0.30). | Still unknown | |
| Rv3613c Rv3613c |
mtbc0_003830 |
hypothetical protein | Member of the espACD-Rv3613c-Rv3612c operon required for virulence-critical ESX-1 secretion. RefSeq leaves it of unknown function. This five-gene operon, positively regulated by EspR through a distal enhancer (the espA activating region), is essential for ESX-1 secretion and virulence (Hunt 2012). Molecular function of Rv3613c unfixed but tied to the ESX-1 secretion apparatus. | Family assigned | |
| Rv3626c Rv3626c |
mtbc0_003843 |
hypothetical protein | Zinc-dependent metalloprotease. Pfam: Zincin_2 (PF10103.16). | Zincin_2 |
Resolved |
| dacB Rv3627c |
mtbc0_003844 |
hypothetical protein | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase. Pfam: Rv3627c_N (PF23714.2), Peptidase_S13 (PF02113.21). | Rv3627c_N Peptidase_S13 |
Resolved |
| Rv3633 Rv3633 |
mtbc0_003850 |
hypothetical protein | Phytanoyl-CoA dioxygenase family protein. Pfam: PhyH (PF05721.20). | PhyH |
Family assigned |
| Rv3639c Rv3639c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8vdu-assembly1_E Crystal structure of hybrid insulin peptide (InsC8-15 (prob 0.01, TM 0.17). | Still unknown | |
| Rv3642c Rv3642c |
mtbc0_003857 |
hypothetical protein | VbhA/FicA-family antitoxin (Pfam VbhA PF18495) of a FicTA module. RefSeq names only 'VbhA family protein'; the FicTA pairing was characterised by Tandon 2019. | VbhA |
Resolved |
| Rv3643 Rv3643 |
mtbc0_003859 |
hypothetical protein | Tyrosine-recombinase / integrase-family fold (small, 63 aa); candidate site-specific recombination / mobile-element-associated protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3647c Rv3647c |
mtbc0_003864 |
hypothetical protein | WhiA-like cell-division / homeostasis protein (LAGLIDADG-derived DNA-binding fold). RefSeq leaves it 'hypothetical protein'. Distinct from whiA/Rv3641c. | Family assigned | |
| Rv3651 Rv3651 |
mtbc0_003868 |
hypothetical protein | DUF5628 domain-containing protein. Pfam: Rv3651-like_N (PF18007.8), Rv3651-like_middle (PF18621.8), Rv3651-like_C (PF21043.4). | Rv3651-like_N Rv3651-like_middle Rv3651-like_C |
Family assigned |
| Rv3654c Rv3654c |
- |
hypothetical protein | Contains Tad (PF13400.12) domain(s); putative function inferred from the domain architecture. | Tad |
Family assigned |
| Rv3655c Rv3655c |
mtbc0_003873 |
hypothetical protein | Apoptosis inhibitor. | Resolved | |
| Rv3656c Rv3656c |
mtbc0_003874 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF4244. Function unknown. | DUF4244 |
Still unknown |
| ssd Rv3660c |
mtbc0_003878 |
hypothetical protein | Septum site-determining protein Ssd. Pfam: Rv3660c_N (PF26563.1). | Rv3660c_N |
Resolved |
| Rv3661 Rv3661 |
mtbc0_003879 |
hypothetical protein | HAD-IB family hydrolase. Pfam: Hydrolase (PF00702.33), HAD (PF12710.14). | Hydrolase HAD |
Family assigned |
| Rv3662c Rv3662c |
mtbc0_003880 |
hypothetical protein | Oxidoreductase. | Resolved | |
| Rv3672c Rv3672c |
mtbc0_003891 |
hypothetical protein | CoA pyrophosphatase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| Rv3678A Rv3678A |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8i0t-assembly1_C The cryo-EM structure of human Bact-III complex (prob 1.00, TM 0.82). Structure-based, putative. | Family assigned | |
| Rv3678c Rv3678c |
mtbc0_003897 |
hypothetical protein | RidA family protein. Pfam: YjgF_endoribonc (PF14588.12), Ribonuc_L-PSP (PF01042.27). | YjgF_endoribonc Ribonuc_L-PSP |
Family assigned |
| Rv3683 Rv3683 |
mtbc0_003903 |
hypothetical protein | Metallophosphoesterase. Pfam: Metallophos (PF00149.34), Metallophos_2 (PF12850.13). | Metallophos Metallophos_2 |
Resolved |
| Rv3686c Rv3686c |
mtbc0_003907 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3688c Rv3688c |
mtbc0_003909 |
hypothetical protein | GatB/YqeY domain-containing protein. Pfam: YqeY (PF09424.16). | YqeY |
Family assigned |
| Rv3691 Rv3691 |
- |
hypothetical protein | DUF4350 protein of the IFT52 / OST48-WBP1 / ThuA-like Rossmann-fold superfamily (significant HHpred). This is a functionally diverse superfamily (membrane oligosaccharyltransferase non-catalytic subunits, intraflagellar/transport proteins, trehalose-utilization ThuA, GATase1-like), so the precise molecular function is undetermined. Genomic context: in the Rv3689-3695 membrane operon together with moxR2 (AAA+ assembly ATPase) and Rv3690 (the RBG/BLTP lipid-transport candidate, STRING-linked) -> likely a membrane-associated component of this module. RefSeq leaves this locus uncharacterised. | DUF4350 |
Family assigned |
| Rv3698 Rv3698 |
- |
hypothetical protein | Contains GCS2 (PF04107.19) domain(s); putative function inferred from the domain architecture. | GCS2 |
Family assigned |
| Rv3699 Rv3699 |
mtbc0_003921 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: TPMT (PF05724.18), Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | TPMT Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| Rv3705A Rv3705A |
- |
hypothetical protein | Acid-stress / persistence-associated protein; member of the TcrXY (acid-sensing two-component) regulon required for persistent infection (Stupar 2024). Precise molecular role undefined. | Family assigned | |
| Rv3705c Rv3705c |
mtbc0_003927 |
hypothetical protein | Sensor domain-containing protein. Pfam: PknH_C (PF14032.13). | PknH_C |
Family assigned |
| Rv3706c Rv3706c |
mtbc0_003929 |
hypothetical protein | Effector of the TcrXY acid-sensing two-component system regulon, required for persistent infection. RefSeq leaves it of unknown function. Rv3706c, with Rv3705A, is a characterised member of the TcrXY regulon implicated in Mtb survival in vivo by mitigating redox stress at acidic pH (Stupar 2024). Molecular function unfixed. | Family assigned | |
| Rv3707c Rv3707c |
- |
hypothetical protein | AraH2: endo-D-arabinofuranase, founding member (with AraH1/Rv1754c) of glycoside hydrolase family GH183 (Pfam DUF4185). Cleaves the D-arabinan core of arabinogalactan / lipoarabinomannan, i.e. mycobacterial cell-wall remodelling/degradation. NOTE: RefSeq/PGAP still annotate this gene as a hypothetical protein; it was characterised experimentally by Behrens et al. 2023. | DUF4185 |
Resolved |
| Rv3714c Rv3714c |
mtbc0_003937 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| Rv3716c Rv3716c |
mtbc0_003939 |
hypothetical protein | YbaB/EbfC family nucleoid-associated protein. Pfam: YbaB_DNA_bd (PF02575.22). M. tuberculosis carries a second YbaB/EbfC paralog, Rv0030 (this re-annotation campaign), so the two form a YbaB/EbfC nucleoid-associated-protein pair. | YbaB_DNA_bd |
Family assigned |
| Rv3717 Rv3717 |
- |
hypothetical protein | Contains Amidase_3 (PF01520.24) domain(s); putative function inferred from the domain architecture. | Amidase_3 |
Family assigned |
| Rv3718c Rv3718c |
mtbc0_003941 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16). | Polyketide_cyc2 |
Family assigned |
| Rv3719 Rv3719 |
- |
hypothetical protein | Contains FAD_binding_4 (PF01565.29) domain(s); putative function inferred from the domain architecture. | FAD_binding_4 |
Family assigned |
| Rv3722c Rv3722c |
mtbc0_003945 |
hypothetical protein | Aminotransferase. Pfam: Asp_aminotransf (PF12897.14). | Asp_aminotransf |
Resolved |
| ligD Rv3730c |
mtbc0_003955 |
hypothetical protein | Non-homologous end-joining DNA ligase. Pfam: LigD_Prim-Pol (PF21686.4), DNA_primase_S (PF01896.26). | LigD_Prim-Pol DNA_primase_S |
Resolved |
| Rv3732 Rv3732 |
mtbc0_003957 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2330. Function unknown. Foldseek best (non-significant) hit: 6oiu-assembly3_C X-ray crystal structure of the ectodomain of the Toxo (prob 0.14, TM 0.24). | DUF2330 |
Still unknown |
| Rv3733c Rv3733c |
mtbc0_003958 |
hypothetical protein | NUDIX domain-containing protein. Pfam: NUDIX (PF00293.35). | NUDIX |
Family assigned |
| Rv3735 Rv3735 |
mtbc0_003960 |
hypothetical protein | Adenosine-specific kinase. Pfam: Adenosine_kin (PF04008.20). | Adenosine_kin |
Resolved |
| Rv3745c Rv3745c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2237. Function unknown. | DUF2237 |
Still unknown |
| Rv3747 Rv3747 |
mtbc0_003970 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real Wzm/Wzt galactan-export ABC transporter is Rv3781/Rv3783 (paralogue-of-fold). | Still unknown | |
| Rv3748 Rv3748 |
mtbc0_003971 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1qvy-assembly3_C Crystal structure of RhoGDI K(199,200)R double mutant (prob 1.00, TM 0.60). Structure-based, putative. | Family assigned | |
| Rv3749c Rv3749c |
- |
hypothetical protein | VapC50, a PIN-domain ribonuclease toxin of a VapBC type II module (Pfam VapC50_C PF26343). RefSeq leaves it 'hypothetical protein'; toxin activity was characterised by Kim 2016. | VapC50_C |
Resolved |
| Rv3753c Rv3753c |
- |
hypothetical protein | Contains Rv3753c (PF27101.1) domain(s); putative function inferred from the domain architecture. | Rv3753c |
Family assigned |
| Rv3755c Rv3755c |
mtbc0_003979 |
hypothetical protein | Putative glycolipid-binding domain-containing protein. Pfam: Glycolipid_bind (PF06475.19). | Glycolipid_bind |
Family assigned |
| Rv3766 Rv3766 |
- |
hypothetical protein | Contains Rv3766_C (PF27131.1) domain(s); putative function inferred from the domain architecture. | Rv3766_C |
Family assigned |
| Rv3768 Rv3768 |
mtbc0_003992 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_2 (PF12680.14). | SnoaL_2 |
Family assigned |
| Rv3769 Rv3769 |
mtbc0_003993 |
hypothetical protein | Conserved protein with a strong STRING experimental association (score 788) to scpA (a segregation-and-condensation protein of the chromosome-segregation machinery). Contextual candidate: associated with chromosome segregation / condensation. Guilt-by-association, not an established function. | Family assigned | |
| Rv3770c Rv3770c |
mtbc0_003994 |
hypothetical protein | Polytopic integral membrane protein with 5 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | Family assigned |