Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2164c Rv2164c |
mtbc0_002300 |
hypothetical protein | Cell-division / septum-associated membrane protein (eggNOG COG2919, 'essential cell division protein FtsB-like'; COG category D). RefSeq leaves it 'hypothetical protein'. Division-machinery role at orthology level. | Family assigned | |
| Rv2172c Rv2172c |
mtbc0_002306 |
hypothetical protein | Mycobacterial-type methylenetetrahydrofolate reductase. Pfam: MTHFR_2 (PF19345.6). | MTHFR_2 |
Resolved |
| Rv2183c Rv2183c |
mtbc0_002318 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2184c Rv2184c |
- |
hypothetical protein | Contains ArsA_ATPase (PF02374.22), ArsA_HSP20 (PF17886.8) domain(s); putative function inferred from the domain architecture. | ArsA_ATPase ArsA_HSP20 |
Family assigned |
| TB16.3 Rv2185c |
mtbc0_002320 |
hypothetical protein | SRPBCC family protein. Pfam: Polyketide_cyc2 (PF10604.16), Polyketide_cyc (PF03364.26). | Polyketide_cyc2 Polyketide_cyc |
Family assigned |
| Rv2186c Rv2186c |
mtbc0_002321 |
hypothetical protein | Polyketide cyclase / dehydrase and lipid transport. | Resolved | |
| Rv2189c Rv2189c |
mtbc0_002324 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: the real M1 alanyl-aminopeptidase PepN is Rv2467 (paralogue-of-fold). | Still unknown | |
| Rv2191 Rv2191 |
- |
hypothetical protein | Contains RNase_T (PF00929.32), UvrC_M (PF27096.1) domain(s); putative function inferred from the domain architecture. | RNase_T UvrC_M |
Family assigned |
| Rv2204c Rv2204c |
mtbc0_002340 |
hypothetical protein | Iron-sulfur cluster assembly accessory protein. Pfam: Fe-S_biosyn (PF01521.27). | Fe-S_biosyn |
Resolved |
| Rv2205c Rv2205c |
mtbc0_002341 |
hypothetical protein | Glycerate kinase. Pfam: Gly_kinase (PF02595.21). | Gly_kinase |
Resolved |
| Rv2224d Rv2224d |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2226 Rv2226 |
mtbc0_002364 |
hypothetical protein | CYTH and CHAD domain-containing protein. Pfam: CYTH (PF01928.27), CHAD (PF05235.20). | CYTH CHAD |
Family assigned |
| Rv2227 Rv2227 |
- |
hypothetical protein | Contains Oxygenase-NA (PF09859.16) domain(s); putative function inferred from the domain architecture. | Oxygenase-NA |
Family assigned |
| Rv2229c Rv2229c |
mtbc0_002368 |
hypothetical protein | Zinc ribbon domain-containing protein. Pfam: CT398_CC (PF24481.3), Zn_ribbon_9 (PF02591.21). | CT398_CC Zn_ribbon_9 |
Family assigned |
| Rv2237 Rv2237 |
- |
hypothetical protein | Contains MPAB_Lcp_cat (PF09995.16) domain(s); putative function inferred from the domain architecture. | MPAB_Lcp_cat |
Family assigned |
| Rv2237A Rv2237A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2239c Rv2239c |
- |
hypothetical protein | S-adenosyl-methionine (SAM)-dependent methyltransferase fold. RefSeq leaves it 'hypothetical protein' (Pfam DUF3052). The AlphaFold model superposes on an O-methyltransferase bound to the product SAH (PDB 8bif; Foldseek prob 1.0, E 2e-5, TM 0.55). STRING context: peroxiredoxin ahpE (Rv2238c). A SAM-MTase fold assignment; the acceptor substrate is not determined. | DUF3052 |
Family assigned |
| Rv2240c Rv2240c |
mtbc0_002382 |
hypothetical protein | Contains Rv2240c (PF27150.1) domain(s); putative function inferred from the domain architecture. | Rv2240c |
Family assigned |
| Rv2242 Rv2242 |
mtbc0_002384 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| Rv2248 Rv2248 |
- |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| Rv2253 Rv2253 |
mtbc0_002395 |
hypothetical protein | Membrane protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard). Same sensor fold as Rv3491. | Family assigned | |
| Rv2255c Rv2255c |
|
Hypothetical protein | — | Still unknown | |
| Rv2256a Rv2256a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2256c Rv2256c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3145. Function unknown. Foldseek best (non-significant) hit: 6bwo-assembly1_A LarC2, the C-terminal domain of a cyclometallase invo (prob 0.77, TM 0.32). | DUF3145 |
Still unknown |
| Rv2257c Rv2257c |
mtbc0_002400 |
hypothetical protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| Rv2260 Rv2260 |
mtbc0_002403 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| Rv2261c Rv2261c |
|
Conserved hypothetical protein | Transfers the fatty acyl group on membrane lipoproteins | CN_hydrolase |
Family assigned |
| Rv2262c Rv2262c |
|
Conserved hypothetical protein | Transfers the fatty acyl group on membrane lipoproteins | LNT_N |
Family assigned |
| Rv2264c Rv2264c |
mtbc0_002406 |
hypothetical protein | Hsp70 family protein. Pfam: HSP70 (PF00012.27). | HSP70 |
Family assigned |
| Rv2267c Rv2267c |
mtbc0_002409 |
hypothetical protein | Sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| Rv2269c Rv2269c |
mtbc0_002411 |
hypothetical protein | Gene of the sulfomenaquinone (SMK) biosynthetic operon. RefSeq leaves it of unknown function. Rv2269c is part of the operon (with the sulfotransferase stf3 and the cytochrome P450 cyp128) producing SMK, an MTBC-specific virulence-modulating menaquinone derivative; rv2269c shows promoter activity, while cyp128 and stf3 are sufficient for SMK biosynthesis (Sogi 2016). Specific role unfixed. | Family assigned | |
| Rv2271 Rv2271 |
mtbc0_002413 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2695. Function unknown. Foldseek best (non-significant) hit: 7kuw-assembly1_A High-throughput design and refinement of stable prote (prob 0.04, TM 0.37). | DUF2695 |
Still unknown |
| Rv2283 Rv2283 |
mtbc0_002424 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2286c Rv2286c |
mtbc0_002427 |
hypothetical protein | DsbA family protein. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| Rv2288 Rv2288 |
mtbc0_002429 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2292c Rv2292c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2293c Rv2293c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2295 Rv2295 |
mtbc0_002435 |
hypothetical protein | CbrC family protein. | UPF0167 |
Family assigned |
| Rv2297 Rv2297 |
mtbc0_002437 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2302 Rv2302 |
mtbc0_002442 |
hypothetical protein | Conserved hypothetical protein with an NMR-determined solution structure: a five-strand antiparallel beta-sheet core with one C-terminal alpha-helix, with no high structural similarity to known proteins (a possible novel fold). Up-regulated under starvation and heat-shock; structural homolog of Rv0569. Biochemical function unknown. | DUF1918 |
Family assigned |
| Rv2304c Rv2304c |
mtbc0_002444 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2305 Rv2305 |
mtbc0_002445 |
hypothetical protein | Condensation/epimerization-domain-like fold of the non-ribosomal peptide synthetase (NRPS) superfamily. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes strongly on an NRPS epimerization domain (PDB 6ta8; Foldseek prob 1.0, E 3e-21, TM 0.67), and eggNOG places it near D-alanyl carrier / D-Ala-D-Ala chemistry (COG Q, secondary metabolism). Fold/family assignment; the catalysed step and substrate are undemonstrated. | Family assigned | |
| Rv2307A Rv2307A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7nhl-assembly1_2 VgaA-LC, an antibiotic resistance ABCF, in complex wi (prob 0.03, TM 0.37). | Still unknown | |
| Rv2307B Rv2307B |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2mf6-assembly1_C Solution NMR structure of Chimeric Avidin, ChiAVD(I11 (prob 0.28, TM 0.63). | Still unknown | |
| Rv2307D Rv2307D |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2307c Rv2307c |
mtbc0_002447 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv2308 Rv2308 |
mtbc0_002452 |
hypothetical protein | Putative antitoxin (DUF433 + HTH) and a certain paralogue of the validated antitoxin Rv2018; proposed antitoxin half of an ancient Rv2308-Rv2308a operon. The operon is conserved beyond the MTBC to the M. canettii outgroup, with the antitoxin (96% identity) more conserved than its faster-evolving putative toxin partner Rv2308a (45%), the canonical asymmetry of a genuine TA pair. The toxin-antitoxin pairing nonetheless remains a hypothesis: AlphaFold3 predicts no Rv2308-Rv2308a complex (inter-chain ipTM ~0.11). | DUF433 |
Family assigned |
| Rv2308a Rv2308a |
- |
hypothetical protein | Putative VapC/PIN-like ribonuclease toxin, proposed partner of the antitoxin Rv2308 in an ancient operon. Dark to Foldseek/ESMFold; HHpred matches ribonuclease/PIN-like toxin profiles (probability ~99%), i.e. distant family-level homology. Conserved to the M. canettii outgroup (45% identity, full length, 44 bp downstream of Rv2308) and present at 100% identity in M. bovis although unannotated there, so not an H37Rv annotation artefact. The pairing is tentative: AlphaFold3 yields neither a confident monomer fold (pTM ~0.20) nor a Rv2308-Rv2308a complex (ipTM ~0.11); presented as an unconfirmed hypothesis. | Family assigned | |
| Rv2309A Rv2309A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8by2-assembly1_B Structure of the K+/H+ exchanger KefC with GSH. (prob 0.06, TM 0.58). | Still unknown | |
| Rv2311 Rv2311 |
- |
hypothetical protein | Contains SH3_Rv2311 (PF27170.1) domain(s); putative function inferred from the domain architecture. | SH3_Rv2311 |
Family assigned |