Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2253 Rv2253 |
mtbc0_002395 |
hypothetical protein | Membrane protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard). Same sensor fold as Rv3491. | Family assigned | |
| Rv2256a Rv2256a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2256c Rv2256c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3145. Function unknown. Foldseek best (non-significant) hit: 6bwo-assembly1_A LarC2, the C-terminal domain of a cyclometallase invo (prob 0.77, TM 0.32). | DUF3145 |
Still unknown |
| Rv2257c Rv2257c |
mtbc0_002400 |
hypothetical protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| Rv2260 Rv2260 |
mtbc0_002403 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| Rv2264c Rv2264c |
mtbc0_002406 |
hypothetical protein | Hsp70 family protein. Pfam: HSP70 (PF00012.27). | HSP70 |
Family assigned |
| Rv2267c Rv2267c |
mtbc0_002409 |
hypothetical protein | Sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| Rv2269c Rv2269c |
mtbc0_002411 |
hypothetical protein | Gene of the sulfomenaquinone (SMK) biosynthetic operon. RefSeq leaves it of unknown function. Rv2269c is part of the operon (with the sulfotransferase stf3 and the cytochrome P450 cyp128) producing SMK, an MTBC-specific virulence-modulating menaquinone derivative; rv2269c shows promoter activity, while cyp128 and stf3 are sufficient for SMK biosynthesis (Sogi 2016). Specific role unfixed. | Family assigned | |
| Rv2271 Rv2271 |
mtbc0_002413 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2695. Function unknown. Foldseek best (non-significant) hit: 7kuw-assembly1_A High-throughput design and refinement of stable prote (prob 0.04, TM 0.37). | DUF2695 |
Still unknown |
| Rv2283 Rv2283 |
mtbc0_002424 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2286c Rv2286c |
mtbc0_002427 |
hypothetical protein | DsbA family protein. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| Rv2288 Rv2288 |
mtbc0_002429 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2292c Rv2292c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2293c Rv2293c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2295 Rv2295 |
mtbc0_002435 |
hypothetical protein | CbrC family protein. | UPF0167 |
Family assigned |
| Rv2297 Rv2297 |
mtbc0_002437 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2302 Rv2302 |
mtbc0_002442 |
hypothetical protein | Conserved hypothetical protein with an NMR-determined solution structure: a five-strand antiparallel beta-sheet core with one C-terminal alpha-helix, with no high structural similarity to known proteins (a possible novel fold). Up-regulated under starvation and heat-shock; structural homolog of Rv0569. Biochemical function unknown. | DUF1918 |
Family assigned |
| Rv2304c Rv2304c |
mtbc0_002444 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2305 Rv2305 |
mtbc0_002445 |
hypothetical protein | Condensation/epimerization-domain-like fold of the non-ribosomal peptide synthetase (NRPS) superfamily. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes strongly on an NRPS epimerization domain (PDB 6ta8; Foldseek prob 1.0, E 3e-21, TM 0.67), and eggNOG places it near D-alanyl carrier / D-Ala-D-Ala chemistry (COG Q, secondary metabolism). Fold/family assignment; the catalysed step and substrate are undemonstrated. | Family assigned | |
| Rv2307A Rv2307A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7nhl-assembly1_2 VgaA-LC, an antibiotic resistance ABCF, in complex wi (prob 0.03, TM 0.37). | Still unknown | |
| Rv2307B Rv2307B |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2mf6-assembly1_C Solution NMR structure of Chimeric Avidin, ChiAVD(I11 (prob 0.28, TM 0.63). | Still unknown | |
| Rv2307D Rv2307D |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2307c Rv2307c |
mtbc0_002447 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv2308 Rv2308 |
mtbc0_002452 |
hypothetical protein | DUF433 domain-containing protein. | DUF433 |
Family assigned |
| Rv2308a Rv2308a |
- |
hypothetical protein | 3'-5' exonuclease of the DEDDh / RNase-T superfamily (Mut-7-like exoribonuclease fold); nuclease activity RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv2309A Rv2309A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8by2-assembly1_B Structure of the K+/H+ exchanger KefC with GSH. (prob 0.06, TM 0.58). | Still unknown | |
| Rv2311 Rv2311 |
- |
hypothetical protein | Contains SH3_Rv2311 (PF27170.1) domain(s); putative function inferred from the domain architecture. | SH3_Rv2311 |
Family assigned |
| Rv2312 Rv2312 |
mtbc0_002460 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dz1-assembly1_A Crystal structure of Dihydrodipicolinate Synthase fro (prob 0.01, TM 0.27). | Still unknown | |
| Rv2313c Rv2313c |
mtbc0_002461 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. | Family assigned | |
| Rv2314c Rv2314c |
mtbc0_002462 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_3rd |
Family assigned |
| Rv2315c Rv2315c |
mtbc0_002463 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_1st (PF01523.22), PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_1st PmbA_TldD_3rd |
Family assigned |
| Rv2323c Rv2323c |
- |
hypothetical protein | Contains DDAH_eukar (PF19420.6) domain(s); putative function inferred from the domain architecture. | DDAH_eukar |
Family assigned |
| Rv2325c Rv2325c |
mtbc0_002473 |
hypothetical protein | CbiQ family ECF transporter T component. Pfam: CbiQ (PF02361.22). | CbiQ |
Family assigned |
| Rv2327 Rv2327 |
mtbc0_002475 |
hypothetical protein | MarR family winged helix-turn-helix transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29), HTH_27 (PF13463.13). | MarR_2 MarR HTH_27 |
Family assigned |
| Rv2331 Rv2331 |
mtbc0_002480 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2331A Rv2331A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| tyzA Rv2336 |
mtbc0_002486 |
hypothetical protein | TyzA, an N-acyltransferase of the tyz (tyrazolone) gene cluster that initiates the biosynthesis of acyl-oxazolones, a novel class of M. tuberculosis lipids. RefSeq leaves this locus 'hypothetical protein'. Heterologous expression of tyzA (Rv2336), tyzB (Rv2338c) and tyzC (Rv2337c) produces C12:0-tyrazolone, also found in Mtb lipid extracts; TyzA catalyses the N-acylation of L-amino acids with highest specificity for L-Tyr/L-Phe and lauroyl-CoA (kcat/KM = 5.9e3 M-1 s-1) (Grigg 2023). The tyz cluster was previously implicated in oxidative-stress resistance and macrophage survival. Experimentally characterised enzyme. | Resolved | |
| tyzC Rv2337c |
mtbc0_002487 |
hypothetical protein | TyzC, a flavin-dependent oxidase (FDO) of the nitroreductase (NTR) superfamily acting in acyl-oxazolone biosynthesis. RefSeq leaves this locus 'hypothetical protein'. In the tyz cluster, TyzC catalyses the O2-dependent desaturation of the N-acyl-L-Tyr produced by TyzA, while TyzB (a ThiF homolog) catalyses its ATP-dependent cyclisation to the acyl-oxazolone; the substrate preferences of TyzB/TyzC set the identity of the final lipid (Grigg 2023). This work expands the NTR superfamily to a set of broadly distributed FDOs (five in Mtb) that desaturate lipid species. Experimentally characterised enzyme. | Resolved | |
| Rv2342 Rv2342 |
mtbc0_002494 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2348c Rv2348c |
mtbc0_002500 |
hypothetical protein | T-cell-stimulating antigen used (with EspC and EspF) in an ESAT-6-free IGRA; a non-synonymous variant (I101M) shows a genome-to-genome association with human PRDM15. Despite this immunological/genetic characterisation, its molecular function remains unknown (verdict kept 'dark'). | Still unknown | |
| Rv2360c Rv2360c |
mtbc0_002512 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: non-transferable fold (Deinococcus DR_1245 chaperone); function unknown. | Still unknown | |
| Rv2365c Rv2365c |
mtbc0_002517 |
hypothetical protein | Cytidine deaminase. Pfam: CDL (PF26947.1). | CDL |
Resolved |
| Rv2369c Rv2369c |
mtbc0_002521 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2370c Rv2370c |
mtbc0_002522 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| Rv2375 Rv2375 |
mtbc0_002527 |
hypothetical protein | Type II toxin-antitoxin system VapB family antitoxin. Pfam: VapB (PF23719.2). | VapB |
Family assigned |
| mbtH Rv2377c |
mtbc0_002529 |
hypothetical protein | Mycobactin NRPS accessory protein MbtH. Pfam: MbtH (PF03621.19). | MbtH |
Resolved |
| Rv2386a Rv2386a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 1y96-assembly2_D crystal structure of the Gemin6/Gemin7 heterodimer fr (prob 0.98, TM 0.69). | Still unknown | |
| Rv2387 Rv2387 |
mtbc0_002540 |
hypothetical protein | Sodium-dependent bicarbonate transport family permease. Pfam: Sbt_1 (PF05982.18). | Sbt_1 |
Family assigned |
| Rv2390c Rv2390c |
mtbc0_002543 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rta-assembly1_G Arches-protomer complex full-length structure (TrwJ/VirB8) from (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| Rv2401 Rv2401 |
mtbc0_002556 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown |