Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| nat Rv3566c |
- |
arylamine N-acetyltransferase | Arylamine N-acetyltransferase. Pfam: Acetyltransf_2 (PF00797.24). | Acetyltransf_2 |
Resolved |
| hsaB Rv3567c |
mtbc0_003786 |
flavin-dependent monooxygenase reductase subunit HsaB | Flavin-dependent monooxygenase reductase subunit HsaB. Pfam: Flavin_Reduct (PF01613.25). | Flavin_Reduct |
Family assigned |
| hsaC Rv3568c |
mtbc0_003787 |
extradiol dioxygenase | Iron-dependent extradiol dioxygenase HsaC. Pfam: BphC_D1 (PF22632.3), Glyoxalase (PF00903.32). | BphC_D1 Glyoxalase |
Resolved |
| hsaD Rv3569c |
mtbc0_003788 |
4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | Alpha/beta fold hydrolase. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Resolved |
| hsaA Rv3570c |
mtbc0_003789 |
flavin-dependent monooxygenase oxygenase subunit HsaA | Flavin-dependent monooxygenase oxygenase subunit HsaA. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_2 |
Family assigned |
| kshB Rv3571 |
mtbc0_003790 |
3-ketosteroid-9-alpha-hydroxylase reductase subunit | 3-ketosteroid-9-alpha-hydroxylase reductase subunit. Pfam: FAD_binding_6 (PF00970.31), NAD_binding_1 (PF00175.27), Fer2 (PF00111.33). | FAD_binding_6 NAD_binding_1 Fer2 |
Family assigned |
| Rv3572 Rv3572 |
mtbc0_003791 |
hypothetical protein | Candidate accessory component of the cholesterol-catabolism module, coupled to the 3-ketosteroid 9alpha-hydroxylase sub-module (KshB, Rv3571). Rv3572 is the immediate genomic neighbour of kshB on H37Rv and is phylogenetically and contextually associated (STRING context-driven, text-mining excluded) with kshB and the ring-degradation core (hsaB, hsaD, hsaC, hsaA). It is under purifying selection on 145,209 MTBC genomes (3 synonymous / 4 missense segregating sites; a real, conserved gene). No dedicated functional study of Rv3572 exists in the published TB literature. The association to the cholesterol module is strong; the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Still unknown | |
| fadE34 Rv3573c |
mtbc0_003792 |
acyl-CoA dehydrogenase FadE34 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_M (PF02770.25). | Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_M |
Resolved |
| kstR Rv3574 |
mtbc0_003793 |
HTH-type transcriptional regulator KstR | Cholesterol catabolism transcriptional regulator KstR. Pfam: TetR_N (PF00440.30), TetR_C_20 (PF17925.7). | TetR_N TetR_C_20 |
Family assigned |
| Rv3575c Rv3575c |
mtbc0_003794 |
LacI family transcriptional regulator | LacI family DNA-binding transcriptional regulator. Pfam: Peripla_BP_1 (PF00532.28), Peripla_BP_3 (PF13377.13). | Peripla_BP_1 Peripla_BP_3 |
Family assigned |
| lppH Rv3576 |
- |
lipoprotein LppH | Lipoprotein LppH. Pfam: PknH_C (PF14032.13). | PknH_C |
Resolved |
| Rv3577 Rv3577 |
- |
hypothetical protein | Binuclear metallo-beta-lactamase (MBL)-fold metallo-hydrolase of the UPF0173/UlaG family (InterPro IPR050114), substrate unassigned. RefSeq leaves it 'hypothetical protein'. The MBL HxHxDH motif (His74-His76-Asp78-His79) was confirmed as a genuine two-metal centre by co-folding the chain with two metal ions on AlphaFold Server (independent Zn and Fe jobs, top model iPTM 0.98): the ions bind a single bridged binuclear site 3.2-3.4 A apart, partitioned into a three-histidine metal (His74/His76/His137) and an aspartate-plus-two-histidine metal (Asp78/His79/His235), with identical geometry for Zn or Fe. HHpred top hits (>=99.8%) are UPF0173/UlaG metal-dependent hydrolases (UlaG 2wyl; COG2220). The fold-paralogue safeguard withholds the RNase Z (held by Rv2407) and glyoxalase II (Rv0634c/Rv2581c) labels: only the fold-level family is claimed. The six metal ligands are effectively invariant across ~250,724 genomes (most frequent non-synonymous ligand variant 0.0032%). A structural prediction, not a biochemical assay. | Resolved | |
| arsB2 Rv3578 |
mtbc0_003797 |
arsenic transport integral membrane protein ArsB | Arsenic transport integral membrane protein ArsB. Pfam: ArsB (PF02040.21), CitMHS (PF03600.23). | ArsB CitMHS |
Resolved |
| rlmB Rv3579c |
mtbc0_003798 |
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB. Pfam: SpoU_sub_bind (PF08032.18), SpoU_methylase (PF00588.25). | SpoU_sub_bind SpoU_methylase |
Resolved |
| cysS1 Rv3580c |
- |
cysteine--tRNA ligase | Cysteine--tRNA ligase. Pfam: tRNA-synt_1e (PF01406.26), tRNA-synt_1g (PF09334.18), DALR_2 (PF09190.18). | tRNA-synt_1e tRNA-synt_1g DALR_2 |
Resolved |
| ispF Rv3581c |
mtbc0_003800 |
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase. Pfam: YgbB (PF02542.22). | YgbB |
Resolved |
| ispD Rv3582c |
mtbc0_003801 |
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. Pfam: IspD (PF01128.26), CTP_transf_3 (PF02348.26), NTP_transf_3 (PF12804.14). | IspD CTP_transf_3 NTP_transf_3 |
Resolved |
| carD Rv3583c |
mtbc0_003802 |
RNA polymerase-binding transcription factor CarD | RNA polymerase-binding transcription factor CarD. Pfam: CarD_TRCF_RID (PF02559.23), CarD_C (PF21095.4). | CarD_TRCF_RID CarD_C |
Resolved |
| lpqE Rv3584 |
mtbc0_003803 |
lipoprotein LpqE | Contains LpqE-like (PF04314.19) domain(s); putative function inferred from the domain architecture. | LpqE-like |
Family assigned |
| radA Rv3585 |
mtbc0_003804 |
DNA repair protein RadA | DNA repair protein RadA. Pfam: Zn_ribbon_LapB (PF18073.8), ATPase (PF06745.20), DUF7125 (PF23442.2), DnaB_C (PF03796.22), AAA_25 (PF13481.13), AAA (PF00004.36), Lon_C (PF05362.20), ChlI (PF13541.13). | Zn_ribbon_LapB ATPase DUF7125 DnaB_C AAA_25 AAA Lon_C ChlI |
Resolved |
| disA Rv3586 |
mtbc0_003805 |
DNA integrity scanning protein DisA | DNA integrity scanning diadenylate cyclase DisA. Pfam: DAC (PF02457.22), DisA-linker (PF10635.15). | DAC DisA-linker |
Resolved |
| Rv3587c Rv3587c |
mtbc0_003806 |
membrane protein | Membrane/surface protein; its high-activity binding peptides bind alveolar epithelial (A549) and monocyte (U937) cells and inhibit M. tuberculosis invasion, implicating it in host-cell adhesion/invasion. Molecular function unfixed. | Family assigned | |
| canB Rv3588c |
mtbc0_003807 |
carbonic anhydrase | Beta-carbonic anhydrase CanB. Pfam: Pro_CA (PF00484.25). | Pro_CA |
Resolved |
| mutY Rv3589 |
mtbc0_003808 |
A/G-specific adenine glycosylase | A/G-specific adenine glycosylase. Pfam: HhH-GPD (PF00730.32), HHH (PF00633.30). | HhH-GPD HHH |
Resolved |
| PE_PGRS58 Rv3590c |
- |
PE-PGRS family protein PE_PGRS58 | PE-PGRS family protein PE_PGRS58. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv3591c Rv3591c |
mtbc0_003810 |
hydrolase | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| mhuD Rv3592 |
mtbc0_003811 |
heme-degrading monooxygenase | Mycobilin-forming heme oxygenase MhuD. Pfam: ABM (PF03992.23). | ABM |
Resolved |
| lpqF Rv3593 |
mtbc0_003812 |
lipoprotein LpqF | Serine hydrolase. Pfam: ORF_12_N (PF18042.8), Beta-lactamase2 (PF13354.13). | ORF_12_N Beta-lactamase2 |
Resolved |
| Rv3594 Rv3594 |
mtbc0_003813 |
hypothetical protein | N-acetylmuramoyl-L-alanine amidase. Pfam: Amidase_2 (PF01510.31), Rv3766_C (PF27131.1). | Amidase_2 Rv3766_C |
Resolved |
| PE_PGRS59 Rv3595c |
- |
PE-PGRS family protein PE_PGRS59 | PE-PGRS family protein PE_PGRS59. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| clpC1 Rv3596c |
- |
ATP-dependent protease ATP-binding subunit ClpC | ATP-dependent protease ATP-binding subunit ClpC. Pfam: Clp_N (PF02861.26), NBD_SMAX1 (PF23569.2), TniB (PF05621.18), AAA (PF00004.36), AAA_lid_9 (PF17871.8), UVR (PF02151.26), Sigma54_activat (PF00158.33), AAA_2 (PF07724.21), AAA_5 (PF07728.21), ClpB_D2-small (PF10431.16). | Clp_N NBD_SMAX1 TniB AAA AAA_lid_9 UVR Sigma54_activat AAA_2 AAA_5 ClpB_D2-small |
Family assigned |
| lsr2 Rv3597c |
mtbc0_003816 |
iron-regulated H-NS-like protein | Histone-like nucleoid-structuring protein Lsr2. Pfam: Lsr2 (PF11774.15), Lsr2_DNA-bd (PF23359.2). | Lsr2 Lsr2_DNA-bd |
Resolved |
| lysS Rv3598c |
mtbc0_003817 |
lysine--tRNA ligase | Lysine--tRNA ligase. Pfam: tRNA_anti-codon (PF01336.32), tRNA-synt_2 (PF00152.26). | tRNA_anti-codon tRNA-synt_2 |
Resolved |
| Rv3600c Rv3600c |
mtbc0_003818 |
type III pantothenate kinase | Type III pantothenate kinase. Pfam: Pan_kinase (PF03309.21). | Pan_kinase |
Resolved |
| panD Rv3601c |
mtbc0_003819 |
aspartate 1-decarboxylase | Aspartate 1-decarboxylase. Pfam: Asp_decarbox (PF02261.23). | Asp_decarbox |
Resolved |
| panC Rv3602c |
mtbc0_003820 |
pantothenate synthetase | Pantoate--beta-alanine ligase. Pfam: Pantoate_ligase (PF02569.22). | Pantoate_ligase |
Resolved |
| Rv3603c Rv3603c |
mtbc0_003821 |
hypothetical protein | Rossmann-like and DUF2520 domain-containing protein. Pfam: Rossmann-like (PF10727.16), F420_oxidored (PF03807.24), DUF2520 (PF10728.15). | Rossmann-like F420_oxidored DUF2520 |
Family assigned |
| Rv3604c Rv3604c |
mtbc0_003822 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF6779. Function unknown. | DUF6779 |
Still unknown |
| Rv3605c Rv3605c |
mtbc0_003823 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3180 |
Family assigned |
| folK Rv3606c |
mtbc0_003824 |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. Pfam: HPPK (PF01288.26). | HPPK |
Resolved |
| folB Rv3607c |
- |
dihydroneopterin aldolase | Dihydroneopterin aldolase. Pfam: FolB (PF02152.24). | FolB |
Resolved |
| folP1 Rv3608c |
- |
dihydropteroate synthase | Dihydropteroate synthase. Pfam: Pterin_bind (PF00809.29). | Pterin_bind |
Resolved |
| folE Rv3609c |
mtbc0_003827 |
GTP cyclohydrolase I | GTP cyclohydrolase I FolE. Pfam: GTP_cyclohydroI (PF01227.28). | GTP_cyclohydroI |
Resolved |
| ftsH Rv3610c |
mtbc0_003828 |
zinc metalloprotease FtsH | ATP-dependent zinc metalloprotease FtsH. Pfam: FtsH_ext (PF06480.21), AAA_5 (PF07728.21), AAA (PF00004.36), AAA_lid_3 (PF17862.8), Peptidase_M41 (PF01434.25). | FtsH_ext AAA_5 AAA AAA_lid_3 Peptidase_M41 |
Resolved |
| Rv3612c Rv3612c |
mtbc0_000273 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3j6b-assembly1_T Structure of the yeast mitochondrial large ribosomal (prob 0.11, TM 0.30). | Still unknown | |
| Rv3613c Rv3613c |
mtbc0_003830 |
hypothetical protein | Member of the espACD-Rv3613c-Rv3612c operon required for virulence-critical ESX-1 secretion. RefSeq leaves it of unknown function. This five-gene operon, positively regulated by EspR through a distal enhancer (the espA activating region), is essential for ESX-1 secretion and virulence (Hunt 2012). Molecular function of Rv3613c unfixed but tied to the ESX-1 secretion apparatus. | Family assigned | |
| espD Rv3614c |
mtbc0_003831 |
ESX-1 secretion-associated protein EspD | Type VII secretion system ESX-1 target EspD. | Resolved | |
| espC Rv3615c |
mtbc0_003832 |
ESX-1 secretion-associated protein EspC | Type VII secretion system ESX-1 filament-forming target EspC. Pfam: T7SS_ESX_EspC (PF10824.15). | T7SS_ESX_EspC |
Resolved |
| espA Rv3616c |
mtbc0_003833 |
ESX-1 secretion-associated protein EspA | Type VII secretion system ESX-1 target EspA. Pfam: EspA_EspE (PF18879.7). | EspA_EspE |
Resolved |
| ephA Rv3617 |
mtbc0_003834 |
epoxide hydrolase EphA | Epoxide hydrolase EphA. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 |
Resolved |