Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| fdxD Rv3503c |
mtbc0_003718 |
ferredoxin FdxD | Ferredoxin. Pfam: Fer4_15 (PF13459.12), Fer4_13 (PF13370.12). | Fer4_15 Fer4_13 |
Resolved |
| fadE26 Rv3504 |
mtbc0_003719 |
acyl-CoA dehydrogenase FadE26 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Resolved |
| fadE27 Rv3505 |
mtbc0_003720 |
acyl-CoA dehydrogenase FadE27 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| fadD17 Rv3506 |
mtbc0_003721 |
long-chain-fatty-acid--CoA ligase FadD17 | Long-chain-fatty-acid--CoA ligase FadD17. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| PE_PGRS53 Rv3507 |
- |
PE-PGRS family protein PE_PGRS53 | PE-PGRS family protein PE_PGRS53. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| PE_PGRS54 Rv3508 |
- |
PE-PGRS family protein PE_PGRS54 | PE-PGRS family protein PE_PGRS54. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| ilvX Rv3509c |
mtbc0_003724 |
acetohydroxyacid synthase large subunit | Acetolactate synthase large subunit. Pfam: TPP_enzyme_N (PF02776.24), TPP_enzyme_C (PF02775.27). | TPP_enzyme_N TPP_enzyme_C |
Family assigned |
| Rv3510c Rv3510c |
mtbc0_003725 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |
| PE_PGRS55 Rv3511 |
- |
PE-PGRS family protein PE_PGRS55 | PE-PGRS family protein PE_PGRS55. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| PE_PGRS56 Rv3512 |
- |
PE-PGRS family protein PE_PGRS56 | PE-PGRS family protein PE_PGRS56. | Family assigned | |
| fadD18 Rv3513c |
- |
fatty-acid--CoA ligase FadD18 | Fatty-acid--CoA ligase FadD18. Pfam: AMP-binding_C (PF13193.13). | AMP-binding_C |
Resolved |
| PE_PGRS57 Rv3514 |
- |
PE-PGRS family protein PE_PGRS57 | PE-PGRS family protein PE_PGRS57. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| fadD19 Rv3515c |
- |
acyl-CoA synthetase | Acyl-CoA synthetase. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| echA19 Rv3516 |
mtbc0_003732 |
enoyl-CoA hydratase EchA19 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv3517 Rv3517 |
mtbc0_003733 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| cyp142 Rv3518c |
mtbc0_003734 |
cytochrome P450 monooxygenase Cyp142 | Steroid C26-monooxygenase Cyp142. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv3519 Rv3519 |
mtbc0_003735 |
hypothetical protein | Acetoacetate decarboxylase family protein. Pfam: ADC (PF06314.17). | ADC |
Family assigned |
| Rv3520c Rv3520c |
- |
coenzyme F420-dependent oxidoreductase | Coenzyme F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv3521 Rv3521 |
- |
hypothetical protein | Contains OB_ChsH2_C (PF01796.24) domain(s); putative function inferred from the domain architecture. | OB_ChsH2_C |
Family assigned |
| ltp4 Rv3522 |
mtbc0_003738 |
lipid transfer protein | Thiolase domain-containing protein. | Family assigned | |
| ltp3 Rv3523 |
mtbc0_003739 |
lipid carrier protein | Thiolase domain-containing protein. Pfam: Thiolase_C_1 (PF22691.3). | Thiolase_C_1 |
Family assigned |
| Rv3524 Rv3524 |
mtbc0_003740 |
membrane protein | NHL repeat-containing protein. Pfam: NHL (PF01436.28). | NHL |
Family assigned |
| Rv3525c Rv3525c |
mtbc0_003741 |
siderophore-binding protein | Gamma carbonic anhydrase family protein. | Family assigned | |
| kshA Rv3526 |
mtbc0_003742 |
3-ketosteroid-9-alpha-monooxygenase oxygenase subunit | 3-ketosteroid-9-alpha-hydroxylase subunit KshA. Pfam: Rieske (PF00355.33), KshA_C (PF19298.6). | Rieske KshA_C |
Family assigned |
| Rv3527 Rv3527 |
mtbc0_003743 |
hypothetical protein | Candidate accessory of the cholesterol-catabolism module and, more specifically, a candidate ferredoxin / iron-sulfur electron-transfer partner of the KshAB 3-ketosteroid 9alpha-hydroxylase. Rv3527 is the immediate genomic neighbour of kshA (Rv3526), co-occurs phylogenetically with the KstR1 ring-degradation regulon, and is under purifying selection on 145,209 MTBC genomes (6 segregating sites; a real, conserved gene). Structure-based refinement: of its 25 nearest ESM-Atlas neighbours, 11 are annotated as ferredoxins, and the protein carries a Cys78-x-x-Cys81 motif plus distal cysteines (Cys38/Cys107/Cys126) compatible with an Fe-S cluster. Because KshA is a Rieske [2Fe-2S] monooxygenase that depends on electron transfer, an electron-transfer ferredoxin role is mechanistically coherent. A guilt-by-association plus structural-homology hypothesis; the molecular function (electron transfer to KshAB) remains experimentally undemonstrated, so the verdict is kept 'dark'. Decisive test: co-folding Rv3527 with KshA/KshB (AlphaFold-multimer). | Family assigned | |
| Rv3528c Rv3528c |
mtbc0_003744 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 7pga-assembly2_D Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions (prob 1.00, TM 0.55). Structure-based, putative. | Family assigned | |
| Rv3529c Rv3529c |
mtbc0_003746 |
hypothetical protein | TLR2-mediated response inhibitor. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| Rv3530c Rv3530c |
mtbc0_003747 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv3531c Rv3531c |
mtbc0_003748 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3u07-assembly2_B Crystal Structure of the VPA0106 protein from Vibrio parahaemol (prob 1.00, TM 0.41). Structure-based, putative. | Family assigned | |
| PPE61 Rv3532 |
- |
PPE family protein PPE61 | PPE family protein PPE61. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PPE62 Rv3533c |
- |
PPE family protein PPE62 | PPE family protein PPE62. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| hsaF Rv3534c |
mtbc0_003751 |
4-hydroxy-2-oxovalerate aldolase | 4-hydroxy-2-oxovalerate aldolase. Pfam: HMGL-like (PF00682.26), DmpG_comm (PF07836.17). | HMGL-like DmpG_comm |
Resolved |
| hsaG Rv3535c |
mtbc0_003752 |
acetaldehyde dehydrogenase | Acetaldehyde dehydrogenase (acetylating). Pfam: AcetDehyd-dimer (PF09290.17). | AcetDehyd-dimer |
Resolved |
| hsaE Rv3536c |
mtbc0_003753 |
hydratase | 2-keto-4-pentenoate hydratase. Pfam: FAA_hydrolase (PF01557.24). | FAA_hydrolase |
Resolved |
| kstD Rv3537 |
mtbc0_003754 |
3-oxosteroid 1-dehydrogenase | 3-oxosteroid 1-dehydrogenase. Pfam: FAD_binding_3 (PF01494.26), FAD_binding_2 (PF00890.31), FAD_oxidored (PF12831.14), DAO (PF01266.31), NAD_binding_8 (PF13450.13). | FAD_binding_3 FAD_binding_2 FAD_oxidored DAO NAD_binding_8 |
Resolved |
| Rv3538 Rv3538 |
- |
dehydrogenase | Dehydrogenase. Pfam: MFE-2_hydrat-2_N (PF22622.3), MaoC_dehydratas (PF01575.26). | MFE-2_hydrat-2_N MaoC_dehydratas |
Resolved |
| PPE63 Rv3539 |
- |
PPE family protein PPE63 | PPE family protein PPE63. Pfam: PPE (PF00823.26), PE-PPE (PF08237.18). | PPE PE-PPE |
Family assigned |
| ltp2 Rv3540c |
mtbc0_003757 |
lipid transfer protein | Lipid-transfer protein. Pfam: Thiolase_N (PF00108.30), Thiolase_C_1 (PF22691.3). | Thiolase_N Thiolase_C_1 |
Resolved |
| chsH1 Rv3541c |
mtbc0_003758 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit beta ChsH1. | Family assigned | |
| chsH2 Rv3542c |
mtbc0_003759 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit alpha ChsH2. Pfam: FAS1_DH_region (PF13452.12), OB_ChsH2_C (PF01796.24). | FAS1_DH_region OB_ChsH2_C |
Family assigned |
| fadE29 Rv3543c |
mtbc0_003760 |
acyl-CoA dehydrogenase FadE29 | Acyl-CoA dehydrogenase FadE29. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Resolved |
| fadE28 Rv3544c |
mtbc0_003761 |
acyl-CoA dehydrogenase FadE28 | Acyl-CoA dehydrogenase FadE28. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_1 |
Resolved |
| cyp125 Rv3545c |
- |
steroid C26-monooxygenase | Steroid C26-monooxygenase. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| fadA5 Rv3546 |
mtbc0_003763 |
acetyl-CoA acetyltransferase FadA | Steroid 3-ketoacyl-CoA thiolase. Pfam: Thiolase_N (PF00108.30), Thiolase_C (PF02803.25). | Thiolase_N Thiolase_C |
Resolved |
| ddn Rv3547 |
mtbc0_003764 |
deazaflavin-dependent nitroreductase | Deazaflavin-dependent nitroreductase Ddn. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| Rv3548c Rv3548c |
mtbc0_003765 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv3549c Rv3549c |
mtbc0_003766 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13), SDR (PF23441.1). | adh_short KR Epimerase adh_short_C2 SDR |
Family assigned |
| echA20 Rv3550 |
mtbc0_003767 |
enoyl-CoA hydratase EchA20 | Enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv3551 Rv3551 |
mtbc0_003768 |
CoA-transferase subunit alpha | CoA transferase subunit A. Pfam: CoA_trans (PF01144.30). | CoA_trans |
Family assigned |
| Rv3552 Rv3552 |
mtbc0_003769 |
CoA-transferase subunit beta | IpdB — beta subunit of the IpdAB cholesterol ring-cleaving hydrolase of the steroid catabolic pathway (UniProt: 'cholesterol ring-cleaving hydrolase IpdB subunit', EC 4.1.99.-). The fold is that of a CoA-transferase beta subunit (eggNOG COG2057), which is why the earlier annotation stopped at 'CoA-transferase subunit beta' — but the characterised activity of the IpdAB complex is ring cleavage, not CoA transfer. Our own structural layer settles it: TM 0.989 on the solved M. tuberculosis IpdAB (PDB 6con) and TM 0.983 on the Rhodococcus jostii IpdAB (6co6). IpdAB was shown to be a cholesterol ring-cleaving hydrolase and a virulence factor of Mtb (Crowe et al. 2018). | Family assigned |