Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3517 Rv3517 |
mtbc0_003733 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| cyp142 Rv3518c |
mtbc0_003734 |
cytochrome P450 monooxygenase Cyp142 | Steroid C26-monooxygenase Cyp142. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv3519 Rv3519 |
mtbc0_003735 |
hypothetical protein | Acetoacetate decarboxylase family protein. Pfam: ADC (PF06314.17). | ADC |
Family assigned |
| Rv3520c Rv3520c |
- |
coenzyme F420-dependent oxidoreductase | Coenzyme F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv3521 Rv3521 |
- |
hypothetical protein | Contains OB_ChsH2_C (PF01796.24) domain(s); putative function inferred from the domain architecture. | OB_ChsH2_C |
Family assigned |
| ltp4 Rv3522 |
mtbc0_003738 |
lipid transfer protein | Thiolase domain-containing protein. | Family assigned | |
| ltp3 Rv3523 |
mtbc0_003739 |
lipid carrier protein | Thiolase domain-containing protein. Pfam: Thiolase_C_1 (PF22691.3). | Thiolase_C_1 |
Family assigned |
| Rv3524 Rv3524 |
mtbc0_003740 |
membrane protein | NHL repeat-containing protein. Pfam: NHL (PF01436.28). | NHL |
Family assigned |
| Rv3525c Rv3525c |
mtbc0_003741 |
siderophore-binding protein | Gamma carbonic anhydrase family protein. | Family assigned | |
| kshA Rv3526 |
mtbc0_003742 |
3-ketosteroid-9-alpha-monooxygenase oxygenase subunit | 3-ketosteroid-9-alpha-hydroxylase subunit KshA. Pfam: Rieske (PF00355.33), KshA_C (PF19298.6). | Rieske KshA_C |
Family assigned |
| Rv3527 Rv3527 |
mtbc0_003743 |
hypothetical protein | Candidate accessory component of the cholesterol-catabolism module, coupled to the 3-ketosteroid 9alpha-hydroxylase sub-module (KshA, Rv3526). Rv3527 is the immediate genomic neighbour of kshA on H37Rv and is phylogenetically and contextually associated (STRING context-driven, text-mining excluded) with kshA and the ring-degradation core (hsaC, hsaD, hsaA, chsH1, chsH2) and the regulon repressor KstR (Rv3574). It is under purifying selection on 145,209 MTBC genomes (3 synonymous / 3 missense segregating sites; a real, conserved gene, not an ORF artefact). No dedicated functional study of Rv3527 exists in the published TB literature. The association to the cholesterol module is strong; the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Still unknown | |
| Rv3528c Rv3528c |
mtbc0_003744 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 7pga-assembly2_D Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions (prob 1.00, TM 0.55). Structure-based, putative. | Family assigned | |
| Rv3529c Rv3529c |
mtbc0_003746 |
hypothetical protein | TLR2-mediated response inhibitor. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| Rv3530c Rv3530c |
mtbc0_003747 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv3531c Rv3531c |
mtbc0_003748 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3u07-assembly2_B Crystal Structure of the VPA0106 protein from Vibrio parahaemol (prob 1.00, TM 0.41). Structure-based, putative. | Family assigned | |
| PPE61 Rv3532 |
- |
PPE family protein PPE61 | PPE family protein PPE61. Pfam: PPE (PF00823.26), PPE-SVP (PF12484.14). | PPE PPE-SVP |
Family assigned |
| PPE62 Rv3533c |
- |
PPE family protein PPE62 | PPE family protein PPE62. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| hsaF Rv3534c |
mtbc0_003751 |
4-hydroxy-2-oxovalerate aldolase | 4-hydroxy-2-oxovalerate aldolase. Pfam: HMGL-like (PF00682.26), DmpG_comm (PF07836.17). | HMGL-like DmpG_comm |
Resolved |
| hsaG Rv3535c |
mtbc0_003752 |
acetaldehyde dehydrogenase | Acetaldehyde dehydrogenase (acetylating). Pfam: AcetDehyd-dimer (PF09290.17). | AcetDehyd-dimer |
Resolved |
| hsaE Rv3536c |
mtbc0_003753 |
hydratase | 2-keto-4-pentenoate hydratase. Pfam: FAA_hydrolase (PF01557.24). | FAA_hydrolase |
Resolved |
| kstD Rv3537 |
mtbc0_003754 |
3-oxosteroid 1-dehydrogenase | 3-oxosteroid 1-dehydrogenase. Pfam: FAD_binding_3 (PF01494.26), FAD_binding_2 (PF00890.31), FAD_oxidored (PF12831.14), DAO (PF01266.31), NAD_binding_8 (PF13450.13). | FAD_binding_3 FAD_binding_2 FAD_oxidored DAO NAD_binding_8 |
Resolved |
| Rv3538 Rv3538 |
- |
dehydrogenase | Dehydrogenase. Pfam: MFE-2_hydrat-2_N (PF22622.3), MaoC_dehydratas (PF01575.26). | MFE-2_hydrat-2_N MaoC_dehydratas |
Resolved |
| PPE63 Rv3539 |
- |
PPE family protein PPE63 | PPE family protein PPE63. Pfam: PPE (PF00823.26), PE-PPE (PF08237.18). | PPE PE-PPE |
Family assigned |
| ltp2 Rv3540c |
mtbc0_003757 |
lipid transfer protein | Lipid-transfer protein. Pfam: Thiolase_N (PF00108.30), Thiolase_C_1 (PF22691.3). | Thiolase_N Thiolase_C_1 |
Resolved |
| chsH1 Rv3541c |
mtbc0_003758 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit beta ChsH1. | Family assigned | |
| chsH2 Rv3542c |
mtbc0_003759 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit alpha ChsH2. Pfam: FAS1_DH_region (PF13452.12), OB_ChsH2_C (PF01796.24). | FAS1_DH_region OB_ChsH2_C |
Family assigned |
| fadE29 Rv3543c |
mtbc0_003760 |
acyl-CoA dehydrogenase FadE29 | Acyl-CoA dehydrogenase FadE29. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Resolved |
| fadE28 Rv3544c |
mtbc0_003761 |
acyl-CoA dehydrogenase FadE28 | Acyl-CoA dehydrogenase FadE28. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_1 |
Resolved |
| cyp125 Rv3545c |
- |
steroid C26-monooxygenase | Steroid C26-monooxygenase. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| fadA5 Rv3546 |
mtbc0_003763 |
acetyl-CoA acetyltransferase FadA | Steroid 3-ketoacyl-CoA thiolase. Pfam: Thiolase_N (PF00108.30), Thiolase_C (PF02803.25). | Thiolase_N Thiolase_C |
Resolved |
| ddn Rv3547 |
mtbc0_003764 |
deazaflavin-dependent nitroreductase | Deazaflavin-dependent nitroreductase Ddn. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| Rv3548c Rv3548c |
mtbc0_003765 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| Rv3549c Rv3549c |
mtbc0_003766 |
short-chain type dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13), SDR (PF23441.1). | adh_short KR Epimerase adh_short_C2 SDR |
Family assigned |
| echA20 Rv3550 |
mtbc0_003767 |
enoyl-CoA hydratase EchA20 | Enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv3551 Rv3551 |
mtbc0_003768 |
CoA-transferase subunit alpha | CoA transferase subunit A. Pfam: CoA_trans (PF01144.30). | CoA_trans |
Family assigned |
| Rv3552 Rv3552 |
mtbc0_003769 |
CoA-transferase subunit beta | CoA-transferase subunit beta. | Family assigned | |
| Rv3553 Rv3553 |
mtbc0_003770 |
oxidoreductase | Nitronate monooxygenase. Pfam: IMPDH (PF00478.32), NMO (PF03060.22), FMN_dh (PF01070.25). | IMPDH NMO FMN_dh |
Resolved |
| fdxB Rv3554 |
mtbc0_003771 |
electron transfer protein FdxB | Fatty acid desaturase. Pfam: FA_desaturase (PF00487.31), FAD_binding_6 (PF00970.31), NAD_binding_1 (PF00175.27), Fer2 (PF00111.33). | FA_desaturase FAD_binding_6 NAD_binding_1 Fer2 |
Resolved |
| Rv3555c Rv3555c |
mtbc0_003772 |
hypothetical protein | DUF559 domain-containing protein. Pfam: AbiEi_1 (PF09407.17), DUF559 (PF04480.19). | AbiEi_1 DUF559 |
Family assigned |
| fadA6 Rv3556c |
mtbc0_003773 |
acetyl-CoA acetyltransferase FadA | Acetyl-CoA C-acetyltransferase. Pfam: Thiolase_N (PF00108.30), ketoacyl-synt (PF00109.33), Thiolase_C (PF02803.25). | Thiolase_N ketoacyl-synt Thiolase_C |
Resolved |
| kstR2 Rv3557c |
mtbc0_003774 |
HTH-type transcriptional regulator KstR2 | TetR family transcriptional regulator KstR2. Pfam: TetR_N (PF00440.30), TetR_C_24 (PF17932.7). | TetR_N TetR_C_24 |
Family assigned |
| PPE64 Rv3558 |
- |
PPE family protein PPE64 | PPE family protein PPE64. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3559c Rv3559c |
mtbc0_003776 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Family assigned |
| fadE30 Rv3560c |
mtbc0_003777 |
acyl-CoA dehydrogenase FadE30 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Family assigned |
| fadD3 Rv3561 |
mtbc0_003778 |
fatty-acid--CoA ligase FadD3 | 3-((3aS%2C4S%2C7aS)-7a-methyl-1%2C5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase FadD3. Pfam: AMP-binding (PF00501.35), AMP-binding_C (PF13193.13). | AMP-binding AMP-binding_C |
Resolved |
| fadE31 Rv3562 |
mtbc0_003779 |
acyl-CoA dehydrogenase FadE31 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 |
Family assigned |
| fadE32 Rv3563 |
mtbc0_003780 |
acyl-CoA dehydrogenase FadE32 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30). | Acyl-CoA_dh_N Acyl-CoA_dh_1 |
Family assigned |
| fadE33 Rv3564 |
mtbc0_003781 |
acyl-CoA dehydrogenase FadE33 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| aspB Rv3565 |
mtbc0_003782 |
aspartate aminotransferase AspB | Pyridoxal phosphate-dependent aminotransferase. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Resolved |
| Rv3566A Rv3566A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8xt2-assembly1_Lg Cryo-EM structure of the human 55S mitoribosome with (prob 0.01, TM 0.22). | Still unknown |