Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| adnA Rv3202c |
mtbc0_003406 |
ATP-dependent DNA helicase | ATP-dependent DNA helicase AdnA. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), PDDEXK_1 (PF12705.14). | UvrD-helicase AAA_19 UvrD_C PDDEXK_1 |
Resolved |
| lipV Rv3203 |
- |
lipase LipV | Lipase LipV. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14), Abhydrolase_1 (PF00561.27), Ser_hydrolase (PF06821.20), Thioesterase (PF00975.27). | Hydrolase_4 Abhydrolase_6 Abhydrolase_1 Ser_hydrolase Thioesterase |
Resolved |
| Rv3204 Rv3204 |
mtbc0_003409 |
DNA-methyltransferase | MGMT family protein. Pfam: DNA_binding_1 (PF01035.27). | DNA_binding_1 |
Family assigned |
| Rv3205c Rv3205c |
- |
hypothetical protein | Protein-kinase-like (APH/ePK) fold whose active site is NOT retained. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on an aminoglycoside 3',5"-phosphotransferase (PDB 1l8t = M-CSA entry 640, EC 2.7.1.95), but the M-CSA active-site check shows the 4 catalytic residues are all ALIGNED yet SUBSTITUTED (0/4 conserved) -> same fold, active site not retained. A worked negative control: the kinase fold is present but the gene is NOT an active aminoglycoside phosphotransferase. | Family assigned | |
| moeB1 Rv3206c |
- |
adenylyltransferase/sulfurtransferase MoeZ | Adenylyltransferase/sulfurtransferase MoeZ. Pfam: ThiF (PF00899.28), Rhodanese (PF00581.26). | ThiF Rhodanese |
Resolved |
| Rv3207c Rv3207c |
- |
hypothetical protein | Zinc-dependent metalloprotease (eggNOG COG5479, cell-envelope COG category M; DUF3152). RefSeq leaves it 'hypothetical protein'. Metallopeptidase fold; substrate undetermined. | DUF3152 |
Family assigned |
| Rv3208 Rv3208 |
mtbc0_003413 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_46 (PF21943.2). | TetR_N TetR_C_46 |
Family assigned |
| TB9.4 Rv3208A |
- |
hypothetical protein | Structurally characterized DUF3107 protein (Pfam) of unknown biochemical function. RefSeq leaves it 'hypothetical protein'. A crystal structure of the hexadecameric form of this family was solved (PDB 7rur; Foldseek prob 1.0, E 3e-11, TM 0.95). STRING context links it to the cytochrome bcc subunit qcrC (Rv2194). Family/structure assigned; molecular function unfixed. | DUF3107 |
Family assigned |
| Rv3209 Rv3209 |
mtbc0_003415 |
hypothetical protein | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv3210c Rv3210c |
mtbc0_003416 |
hypothetical protein | Ferritin-like fold-containing protein. Pfam: Ferritin_fold-like (PF13794.13). | Ferritin_fold-like |
Family assigned |
| rhlE Rv3211 |
mtbc0_003417 |
ATP-dependent RNA helicase RhlE | DEAD/DEAH box helicase. Pfam: DEAD (PF00270.36), Helicase_C (PF00271.38). | DEAD Helicase_C |
Resolved |
| Rv3212 Rv3212 |
mtbc0_003418 |
hypothetical protein | Beta-propeller protein of the BamB/quinoprotein-like family (eggNOG COG1520). A WD40/PQQ-type beta-propeller scaffold; specific partner/role in M. tuberculosis undetermined. | Family assigned | |
| Rv3213c Rv3213c |
mtbc0_003419 |
SOJ/ParA-like protein | AAA family ATPase. Pfam: AAA_31 (PF13614.13), ParA (PF10609.16), CBP_BcsQ (PF06564.19), CbiA (PF01656.30), ArsA_ATPase (PF02374.22), Fer4_NifH (PF00142.25). | AAA_31 ParA CBP_BcsQ CbiA ArsA_ATPase Fer4_NifH |
Family assigned |
| gpm2 Rv3214 |
- |
phosphoglycerate mutase | Phosphoglycerate mutase. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Resolved |
| entC Rv3215 |
mtbc0_003421 |
isochorismate synthase | Isochorismate synthase. Pfam: Chorismate_bind (PF00425.25). | Chorismate_bind |
Resolved |
| Rv3217c Rv3217c |
mtbc0_003423 |
integral membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3218 Rv3218 |
mtbc0_003424 |
hypothetical protein | Diacylglycerol kinase family lipid kinase. Pfam: DAGK_cat (PF00781.30). | DAGK_cat |
Family assigned |
| whiB1 Rv3219 |
- |
transcriptional regulator WhiB1 | Transcriptional regulator WhiB1. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| Rv3220c Rv3220c |
mtbc0_003426 |
two component sensor kinase | Histidine kinase N-terminal domain-containing protein. Pfam: GAF_PdtaS (PF12282.16), HisKA_2 (PF07568.19), HWE_HK (PF07536.21), HATPase_c_2 (PF13581.13), HATPase_c (PF02518.32). | GAF_PdtaS HisKA_2 HWE_HK HATPase_c_2 HATPase_c |
Family assigned |
| rshA Rv3221A |
- |
anti-sigma factor RshA | Anti-sigma factor RshA. Pfam: zf-HC2 (PF13490.12). | zf-HC2 |
Resolved |
| TB7.3 Rv3221c |
mtbc0_003427 |
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit | Biotin/lipoyl-binding carrier protein. Pfam: BSH_RND (PF25917.1), Biotin_lipoyl (PF00364.29). | BSH_RND Biotin_lipoyl |
Resolved |
| Rv3222c Rv3222c |
mtbc0_003429 |
hypothetical protein | Essential (Tn-seq ES) and HIGHLY VULNERABLE (CRISPRi vulnerability index -15.5, the most vulnerable of the atlas hypotheticals) conserved protein (strong purifying selection) encoded WITHIN the sigH stress-response operon: it overlaps (-4 bp on both sides) the alternative sigma factor SigH (Rv3223c) and its cognate anti-sigma factor RshA (Rv3221A), is transcriptionally activated by SigH, and its top STRING partner is RshA (score 979). This places it as a candidate essential component of the SigH-RshA oxidative/heat-stress regulatory module (a co-regulated factor or a modulator of the sigma / anti-sigma switch). Its molecular function is not established; the low-complexity, poorly-ordered sequence (183 aa, G/A/V-rich, pLDDT 40, no Pfam or Foldseek hit) limits structural inference. NOT previously characterised in the literature (WebSearch + tbmonitor negative) - a novel, essential, highly vulnerable, uncharacterised drug-target candidate. HHpred profile-profile gives NO confident hit (best is DUF7993 / Pfam PF25956 at only 9.5% probability, E-value 1300 = noise), consistent with the low-complexity, poorly-ordered sequence; the SigH-RshA contextual hypothesis remains the sole functional handle. | Family assigned | |
| sigH Rv3223c |
mtbc0_003430 |
ECF RNA polymerase sigma factor SigH | Sigma-70 family RNA polymerase sigma factor SigH. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Family assigned |
| Rv3224 Rv3224 |
mtbc0_003431 |
iron-regulated short-chain dehydrogenase/reductase | NAD(P)-dependent oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short KR adh_short_C2 |
Resolved |
| Rv3224A Rv3224A |
|
Conserved hypothetical protein | Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily | Family assigned | |
| Rv3224B Rv3224B |
|
Conserved hypothetical protein | Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily | Family assigned | |
| Rv3225c Rv3225c |
mtbc0_003434 |
GCN5-like N-acetyltransferase | Bifunctional GNAT family N-acetyltransferase/aminoglycoside 3'-phosphotransferase/choline kinase family protein. Pfam: Acetyltransf_3 (PF13302.14), Acetyltransf_1 (PF00583.32), APH (PF01636.30). | Acetyltransf_3 Acetyltransf_1 APH |
Family assigned |
| Rv3226c Rv3226c |
mtbc0_003435 |
hypothetical protein | SOS response-associated peptidase. Pfam: SRAP (PF02586.20). | SRAP |
Resolved |
| aroA Rv3227 |
mtbc0_003436 |
3-phosphoshikimate 1-carboxyvinyltransferase | 3-phosphoshikimate 1-carboxyvinyltransferase. Pfam: EPSP_synthase (PF00275.26). | EPSP_synthase |
Resolved |
| rsgA Rv3228 |
mtbc0_003437 |
hypothetical protein | Ribosome small subunit-dependent GTPase A. Pfam: RsgA_GTPase (PF03193.23), MMR_HSR1 (PF01926.30). | RsgA_GTPase MMR_HSR1 |
Family assigned |
| desA3 Rv3229c |
- |
stearoyl-CoA 9-desaturase | Stearoyl-CoA 9-desaturase. Pfam: FA_desaturase (PF00487.31). | FA_desaturase |
Resolved |
| Rv3230c Rv3230c |
mtbc0_003439 |
stearoyl-CoA 9-desaturase electron transfer protein | NADPH oxidoreductase. Pfam: FAD_binding_6 (PF00970.31), NAD_binding_1 (PF00175.27), Fer2 (PF00111.33). | FAD_binding_6 NAD_binding_1 Fer2 |
Resolved |
| Rv3231c Rv3231c |
mtbc0_003440 |
hypothetical protein | Conserved cytoplasmic protein co-transcribed with ppk2 (polyphosphate kinase 2, Rv3232c) as a two-gene operon, under strong purifying selection and required for in-vivo fitness. The genomic context (operon with ppk2) points to a candidate role associated with polyphosphate metabolism, a persistence- and stress-linked pathway; the specific molecular function is not established. | DUF6912 |
Family assigned |
| ppk2 Rv3232c |
- |
polyphosphate kinase | Polyphosphate kinase. Pfam: PPK2 (PF03976.21). | PPK2 |
Resolved |
| Rv3233c Rv3233c |
|
Possible triacylglycerol synthase (diacylglycerol acyltransferase) | May be involved in synthesis of triacylglycerol | WS_DGAT_C |
Family assigned |
| tgs3 Rv3234c |
- |
diacyglycerol O-acyltransferase | Diacyglycerol O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22). | WS_DGAT_cat |
Resolved |
| Rv3235 Rv3235 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF6459. Function unknown. Foldseek best (non-significant) hit: 8j07-assembly1_k1 96nm repeat of human respiratory doublet microtubule (prob 0.01, TM 0.10). | DUF6459 |
Still unknown |
| Rv3236c Rv3236c |
- |
integral membrane transport protein | Integral membrane transport protein. Pfam: Na_H_Exchanger (PF00999.27). | Na_H_Exchanger |
Resolved |
| Rv3237c Rv3237c |
mtbc0_003445 |
hypothetical protein | Cation:proton antiporter regulatory subunit. Pfam: KhtT_N (PF25991.1), TrkA_C (PF02080.27). | KhtT_N TrkA_C |
Family assigned |
| Rv3238c Rv3238c |
mtbc0_003446 |
integral membrane protein | Isoprenylcysteine carboxylmethyltransferase family protein. | Family assigned | |
| Rv3239c Rv3239c |
mtbc0_003447 |
transmembrane transport protein | MFS transporter. Pfam: MFS_1 (PF07690.22), MFS_3 (PF05977.20), cNMP_binding (PF00027.36), Patatin (PF01734.28). | MFS_1 MFS_3 cNMP_binding Patatin |
Resolved |
| secA1 Rv3240c |
- |
protein translocase subunit SecA | Protein translocase subunit SecA. Pfam: SecA_DEAD (PF07517.21), SecA_PP_bind (PF01043.27), P-loop_SecA (PF21090.4), SecA_SW (PF07516.19). | SecA_DEAD SecA_PP_bind P-loop_SecA SecA_SW |
Family assigned |
| raiA Rv3241c |
mtbc0_003449 |
hypothetical protein | Ribosome-associated translation inhibitor RaiA. Pfam: Ribosomal_S30AE (PF02482.26), Ribosom_S30AE_C (PF16321.11). | Ribosomal_S30AE Ribosom_S30AE_C |
Resolved |
| Rv3242c Rv3242c |
mtbc0_003450 |
hypothetical protein | ComF family protein. | Family assigned | |
| Rv3243c Rv3243c |
mtbc0_003451 |
hypothetical protein | LmeA family phospholipid-binding protein. | Family assigned | |
| lpqB Rv3244c |
mtbc0_003452 |
lipoprotein LpqB | MtrAB system accessory lipoprotein LpqB. Pfam: LpqB_N (PF25976.1), Germane (PF10646.15), Gmad1 (PF10647.16). | LpqB_N Germane Gmad1 |
Resolved |
| mtrB Rv3245c |
mtbc0_003453 |
two component sensory histidine kinase MtrB | Two-component system sensor histidine kinase MtrB. Pfam: HAMP (PF00672.31), HisKA (PF00512.32), HATPase_c_2 (PF13581.13), HATPase_c (PF02518.32). | HAMP HisKA HATPase_c_2 HATPase_c |
Resolved |
| mtrA Rv3246c |
mtbc0_003454 |
two component DNA-binding response regulator MtrA | Two-component system response regulator MtrA. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Resolved |
| tmk Rv3247c |
mtbc0_003455 |
thymidylate kinase | DTMP kinase. Pfam: Thymidylate_kin (PF02223.24). | Thymidylate_kin |
Resolved |
| sahH Rv3248c |
mtbc0_003456 |
adenosylhomocysteinase | Adenosylhomocysteinase. Pfam: AdoHcyase (PF05221.24), AdoHcyase_NAD (PF00670.28), 2-Hacid_dh_C (PF02826.26), KARI_N (PF07991.19). | AdoHcyase AdoHcyase_NAD 2-Hacid_dh_C KARI_N |
Resolved |