Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3258c Rv3258c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3499. Function unknown. Foldseek best (non-significant) hit: 6wwa-assembly2_Y Crystal structure of human SHLD2-SHLD3-REV7 complex (prob 0.02, TM 0.13). | DUF3499 |
Still unknown |
| Rv3259 Rv3259 |
mtbc0_003467 |
hypothetical protein | Metallopeptidase family protein. Pfam: Zincin_1 (PF06262.18). | Zincin_1 |
Family assigned |
| whiB2 Rv3260c |
- |
transcriptional regulator WhiB2 | Transcriptional regulator WhiB2. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| fbiA Rv3261 |
mtbc0_003469 |
2-phospho-L-lactate transferase | 2-phospho-L-lactate transferase. Pfam: CofD (PF01933.24). | CofD |
Resolved |
| fbiB Rv3262 |
mtbc0_003470 |
coenzyme F420:L-glutamate ligase | Coenzyme F420-0:L-glutamate ligase. Pfam: F420_ligase (PF01996.22), Nitroreductase (PF00881.30). | F420_ligase Nitroreductase |
Resolved |
| Rv3263 Rv3263 |
mtbc0_003471 |
DNA methylase | Class I SAM-dependent methyltransferase. Pfam: N6_Mtase (PF02384.23), Eco57I (PF07669.18), M_Eco57I_C (PF22837.2). | N6_Mtase Eco57I M_Eco57I_C |
Resolved |
| manB Rv3264c |
- |
D-alpha-D-mannose-1-phosphate guanylyltransferase ManB | D-alpha-D-mannose-1-phosphate guanylyltransferase ManB. Pfam: NTP_transferase (PF00483.30), NTP_transf_3 (PF12804.14), GMPPB_C (PF25087.2). | NTP_transferase NTP_transf_3 GMPPB_C |
Resolved |
| wbbL1 Rv3265c |
- |
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase | N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase. Pfam: Glycos_transf_2 (PF00535.33), Glyco_tranf_2_3 (PF13641.13), Glyco_trans_2_3 (PF13632.13). | Glycos_transf_2 Glyco_tranf_2_3 Glyco_trans_2_3 |
Resolved |
| rmlD Rv3266c |
mtbc0_003474 |
dTDP-4-dehydrorhamnose reductase | DTDP-4-dehydrorhamnose reductase. Pfam: RmlD_sub_bind (PF04321.24), Epimerase (PF01370.28), GDP_Man_Dehyd (PF16363.12), 3Beta_HSD (PF01073.26), Polysacc_synt_2 (PF02719.22), NAD_binding_4 (PF07993.19). | RmlD_sub_bind Epimerase GDP_Man_Dehyd 3Beta_HSD Polysacc_synt_2 NAD_binding_4 |
Resolved |
| lcp1 Rv3267 |
mtbc0_003475 |
hypothetical protein | Phosphotransferase Lcp1. Pfam: LytR_cpsA_psr (PF03816.20), LytR_C (PF13399.12). | LytR_cpsA_psr LytR_C |
Resolved |
| Rv3268 Rv3268 |
- |
hypothetical protein | TIGR03089-family protein, uncharacterised. NOTE: the acetyl-CoA-synthetase fold is shared, but the genuine Mtb acetyl-CoA synthetase is Rv3667 (acsA), a different gene. | Family assigned | |
| Rv3269 Rv3269 |
mtbc0_003477 |
hypothetical protein | DUF1490 family protein. | DUF1490 |
Family assigned |
| ctpC Rv3270 |
mtbc0_003478 |
manganese/zinc-exporting P-type ATPase | Manganese-exporting P-type ATPase CtpC. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Resolved |
| Rv3271c Rv3271c |
mtbc0_003479 |
integral membrane protein | Cation transporter. Pfam: Cation_efflux (PF01545.27). | Cation_efflux |
Resolved |
| Rv3272 Rv3272 |
mtbc0_003480 |
hypothetical protein | CoA transferase. Pfam: CoA_transf_3 (PF02515.23). | CoA_transf_3 |
Resolved |
| Rv3273 Rv3273 |
- |
transmembrane carbonic anhydrase | Transmembrane carbonic anhydrase. Pfam: Sulfate_transp (PF00916.27), Pro_CA (PF00484.25). | Sulfate_transp Pro_CA |
Resolved |
| fadE25 Rv3274c |
mtbc0_003482 |
acyl-CoA dehydrogenase | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17), ACOX_C_alpha1 (PF22924.2). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 ACOX_C_alpha1 |
Resolved |
| purE Rv3275c |
mtbc0_003483 |
5-(carboxyamino)imidazole ribonucleotide mutase | 5-(carboxyamino)imidazole ribonucleotide mutase. Pfam: AIRC (PF00731.27). | AIRC |
Resolved |
| purK Rv3276c |
mtbc0_003484 |
5-(carboxyamino)imidazole ribonucleotide synthase | 5-(carboxyamino)imidazole ribonucleotide synthase. Pfam: RS_preATP-grasp-like (PF22660.3), CPSase_L_D2 (PF02786.23), ATP-grasp (PF02222.28), PurK_C (PF17769.8). | RS_preATP-grasp-like CPSase_L_D2 ATP-grasp PurK_C |
Resolved |
| Rv3277 Rv3277 |
- |
transmembrane protein | Transmembrane protein. Pfam: GtrA_DPMS_TM (PF04138.21). | GtrA_DPMS_TM |
Resolved |
| Rv3278c Rv3278c |
mtbc0_003486 |
transmembrane protein | PH domain-containing protein. Pfam: bPH_2 (PF03703.21). | bPH_2 |
Family assigned |
| birA Rv3279c |
mtbc0_003487 |
bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase | Biotin--[acetyl-CoA-carboxylase] ligase. Pfam: BPL_LplA_LipB (PF03099.25), BPL_C (PF02237.24). | BPL_LplA_LipB BPL_C |
Resolved |
| accD5 Rv3280 |
mtbc0_003488 |
propionyl-CoA carboxylase subunit beta | Acyl-CoA carboxylase subunit beta. Pfam: Carboxyl_trans (PF01039.28), ACCA (PF03255.20). | Carboxyl_trans ACCA |
Family assigned |
| accE5 Rv3281 |
mtbc0_003489 |
bifunctional protein acetyl-/propionyl-CoAcarboxylase subunit epsilon AccE | Acyl-CoA carboxylase subunit epsilon. Pfam: ACC_epsilon (PF13822.12). | ACC_epsilon |
Family assigned |
| Rv3282 Rv3282 |
mtbc0_003490 |
hypothetical protein | Nucleoside triphosphate pyrophosphatase. Pfam: Maf (PF02545.20). | Maf |
Resolved |
| sseA Rv3283 |
mtbc0_003491 |
thiosulfate sulfurtransferase SseA | Sulfurtransferase. Pfam: Rhodanese (PF00581.26). | Rhodanese |
Resolved |
| Rv3284 Rv3284 |
mtbc0_003492 |
hypothetical protein | SufE family protein. Pfam: SufE (PF02657.21). | SufE |
Family assigned |
| accA3 Rv3285 |
mtbc0_003493 |
bifunctional protein acetyl-/propionyl-CoA carboxylase subunit alpha AccA | Acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha. Pfam: Biotin_carb_N (PF00289.29), CPSase_L_D2 (PF02786.23), ATP-grasp (PF02222.28), Dala_Dala_lig_C (PF07478.19), Biotin_carb_C (PF02785.26), Biotin_lipoyl (PF00364.29). | Biotin_carb_N CPSase_L_D2 ATP-grasp Dala_Dala_lig_C Biotin_carb_C Biotin_lipoyl |
Family assigned |
| sigF Rv3286c |
mtbc0_003494 |
RNA polymerase sigma factor SigF | RNA polymerase sigma factor SigF. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r3 (PF04539.23), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r3 Sigma70_r4_2 Sigma70_r4 |
Resolved |
| rsbW Rv3287c |
mtbc0_003495 |
anti-sigma factor RsbW | Anti-sigma B factor RsbW. | Resolved | |
| usfY Rv3288c |
- |
hypothetical protein | UsfY, an open reading frame of the sigF gene cluster, located immediately upstream of usfX-sigF (the stress/stationary-phase sigma factor and its anti-sigma factor). UsfY has no significant homologues and may not be co-transcribed with usfX-sigF; molecular function unknown but its genomic context ties it to the SigF stress-response locus. | Family assigned | |
| Rv3289c Rv3289c |
mtbc0_003497 |
transmembrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| lat Rv3290c |
mtbc0_003498 |
L-lysine-epsilon aminotransferase | L-lysine 6-transaminase. Pfam: Aminotran_3 (PF00202.28). | Aminotran_3 |
Resolved |
| lrpA Rv3291c |
mtbc0_003499 |
transcriptional regulator LrpA | Transcriptional regulator LrpA. Pfam: HTH_24 (PF13412.13), HTH_AsnC-type (PF13404.13), AsnC_trans_reg (PF01037.29). | HTH_24 HTH_AsnC-type AsnC_trans_reg |
Family assigned |
| Rv3292 Rv3292 |
mtbc0_003500 |
hypothetical protein | VOC family protein. Pfam: HGLS (PF07063.20). | HGLS |
Family assigned |
| pcd Rv3293 |
- |
piperideine-6-carboxylic acid dehydrogenase | Piperideine-6-carboxylic acid dehydrogenase. Pfam: Aldedh (PF00171.28). | Aldedh |
Resolved |
| Rv3294c Rv3294c |
- |
hypothetical protein | Predicted AAA+-superfamily ATPase (eggNOG COG1373, COG category J). AAA+ ATPase fold at orthology level; role undetermined. | DUF4143 |
Family assigned |
| Rv3295 Rv3295 |
mtbc0_003503 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| lhr Rv3296 |
mtbc0_003504 |
ATP-dependent helicase | ATP-dependent helicase. Pfam: DEAD (PF00270.36), ResIII (PF04851.22), Helicase_C (PF00271.38), WHD_Lhr (PF19306.6), DEAD_assoc (PF08494.17), WHD_2nd_Lhr (PF23236.2), WHD_3rd_Lhr (PF23235.2), WHD_4th_Lhr (PF23234.2). | DEAD ResIII Helicase_C WHD_Lhr DEAD_assoc WHD_2nd_Lhr WHD_3rd_Lhr WHD_4th_Lhr |
Resolved |
| nei Rv3297 |
mtbc0_003505 |
endonuclease VIII | Endonuclease VIII Nei2. Pfam: Fapy_DNA_glyco (PF01149.30), H2TH (PF06831.20). | Fapy_DNA_glyco H2TH |
Resolved |
| lpqC Rv3298c |
mtbc0_003506 |
esterase LpqC | PHB depolymerase family esterase. Pfam: Peptidase_S9 (PF00326.28). | Peptidase_S9 |
Family assigned |
| atsB Rv3299c |
mtbc0_003507 |
arylsulfatase AtsB | Arylsulfatase AtsB. Pfam: DUF1269 (PF06897.18), Sulfatase (PF00884.29). | DUF1269 Sulfatase |
Resolved |
| Rv3300c Rv3300c |
mtbc0_003508 |
hypothetical protein | RluA family pseudouridine synthase. Pfam: PseudoU_synth_2 (PF00849.28). | PseudoU_synth_2 |
Family assigned |
| phoY1 Rv3301c |
mtbc0_003509 |
phosphate transport system transcriptional regulator PhoY | Phosphate signaling complex protein PhoU. Pfam: PhoU (PF01895.25). | PhoU |
Resolved |
| glpD2 Rv3302c |
mtbc0_003510 |
glycerol-3-phosphate dehydrogenase | Glycerol-3-phosphate dehydrogenase/oxidase. Pfam: FAD_binding_3 (PF01494.26), DAO (PF01266.31), FAD_oxidored (PF12831.14), FAD_binding_2 (PF00890.31), DAO_C (PF16901.11). | FAD_binding_3 DAO FAD_oxidored FAD_binding_2 DAO_C |
Resolved |
| lpdA Rv3303c |
mtbc0_003511 |
NAD(P)H quinone reductase LpdA | NAD(P)H-quinone dehydrogenase. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox (PF00070.34), Pyr_redox_dim (PF02852.29). | Pyr_redox_2 Pyr_redox Pyr_redox_dim |
Resolved |
| Rv3304 Rv3304 |
mtbc0_003512 |
hypothetical protein | Gamma-glutamylcyclotransferase. Pfam: GGACT (PF06094.18), AIG2_2 (PF13772.12). | GGACT AIG2_2 |
Resolved |
| amiA1 Rv3305c |
- |
N-acyl-L-amino acid amidohydrolase AmiA | N-acyl-L-amino acid amidohydrolase AmiA. Pfam: Peptidase_M20 (PF01546.34). | Peptidase_M20 |
Resolved |
| amiB1 Rv3306c |
- |
amidase AmiB | Amidase AmiB. Pfam: Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20). | Peptidase_M20 M20_dimer |
Resolved |
| deoD Rv3307 |
mtbc0_003515 |
purine nucleoside phosphorylase | Purine-nucleoside phosphorylase. Pfam: PNP_UDP_1 (PF01048.27). | PNP_UDP_1 |
Resolved |