Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| yrbE2A Rv0587 |
mtbc0_000617 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| Rv0588 Rv0588 |
mtbc0_000618 |
hypothetical protein | ABC transporter permease. Pfam: MlaE (PF02405.22). | MlaE |
Family assigned |
| mce2A Rv0589 |
- |
Mce family protein Mce2A | Mce family protein Mce2A. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce2B Rv0590 |
|
Mce-family protein Mce2B | Mce-family protein Mce2B | Mce4_CUP1 MlaD |
Family assigned |
| Rv0590A Rv0590A |
|
Mce-family related protein | Mce-family related protein | Family assigned | |
| mce2C Rv0591 |
mtbc0_000621 |
Mce family protein Mce2C | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce2D Rv0592 |
mtbc0_000622 |
Mce family protein Mce2D | Virulence factor Mce family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| lprL Rv0593 |
- |
Mce family lipoprotein LprL | Mce family lipoprotein LprL. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| mce2F Rv0594 |
mtbc0_000624 |
Mce family protein Mce2F | MlaD family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| vapC4 Rv0595c |
mtbc0_000625 |
ribonuclease VapC4 | Type II toxin-antitoxin system toxin ribonuclease C4. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| vapB4 Rv0596c |
mtbc0_000626 |
antitoxin VapB4 | Type II toxin-antitoxin system antitoxin VapB4. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| Rv0597c Rv0597c |
mtbc0_000627 |
hypothetical protein | ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). | AAA_14 DUF4143 |
Family assigned |
| vapC27 Rv0598c |
mtbc0_000628 |
ribonuclease VapC27 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB27 Rv0599c |
mtbc0_000629 |
antitoxin VapB27 | Type II toxin-antitoxin system antitoxin VapB27. Pfam: MazE_antitoxin (PF04014.24). | MazE_antitoxin |
Resolved |
| Rv0600c Rv0600c |
- |
two component sensor kinase HK1 | Two component sensor kinase HK1. Pfam: HATPase_c (PF02518.32). | HATPase_c |
Resolved |
| Rv0601c Rv0601c |
- |
two component sensor kinase HK2 | Two component sensor kinase HK2. Pfam: HAMP (PF00672.31). | HAMP |
Resolved |
| tcrA Rv0602c |
- |
two component DNA binding transcriptional regulator TcrA | Two component DNA binding transcriptional regulator TcrA. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Family assigned |
| Rv0603 Rv0603 |
mtbc0_000633 |
hypothetical protein | Secreted protein with a solved NMR structure (PDB 2LRA, Rv0603); fold characterised, function not established. | Family assigned | |
| lpqO Rv0604 |
mtbc0_000634 |
lipoprotein LpqO | LysM-repeat peptidoglycan-binding protein (eggNOG COG1388, cell-envelope COG category M). LysM domain binds peptidoglycan; the full cell-wall role is undetermined. | DUF1529 |
Family assigned |
| Rv0605 Rv0605 |
mtbc0_000635 |
IS1536 family serine type transposase | IS607-like element IS1536 family transposase. Pfam: Resolvase (PF00239.27). | Resolvase |
Family assigned |
| Rv0607 Rv0607 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6j9r-assembly1_A Coiled-coil Domain of Drosophila TRIM Protein Brat (prob 0.02, TM 0.20). | Still unknown | |
| vapB28 Rv0608 |
mtbc0_000638 |
antitoxin VapB28 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Family assigned |
| vapC28 Rv0609 |
mtbc0_000639 |
ribonuclease VapC28 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0609A Rv0609A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6teo-assembly2_D Crystal structure of a yeast Snu114-Prp8 complex (prob 0.01, TM 0.28). | Still unknown | |
| Rv0610c Rv0610c |
mtbc0_000642 |
hypothetical protein | N-terminal region matches the SseB N-terminal domain family (Pfam PF07179, HHpred probability ~96%, E=0.09), with converging hits to DUF3234 (PF11572) and the structural-genomics protein TTHA0547 (PDB 2Z0R). A domain/fold is assigned by profile-profile search (HHpred), but both families are poorly characterised, so the precise function in M. tuberculosis remains undefined. (The lower VbhA/Fic-antitoxin hits are high-E-value noise.) | Family assigned | |
| Rv0611c Rv0611c |
mtbc0_000643 |
hypothetical protein | Small SH3-like / beta-barrel domain protein (SH3-like superfamily protein-protein/peptide interaction module): HHpred top hit YorP SH3-like fold 97.68% E0.0013 (borderline significant), with convergence on SH3-like beta-barrels (PetP cytochrome-b6f SH3 subunit, L24 ribosomal-protein SH3-barrel, Tudor domain, ydhK/DUF1541). SH3-like domains mediate protein-protein/peptide interactions; the specific binding partner is undetermined. RefSeq leaves this locus uncharacterised. | DUF4926 |
Family assigned |
| Rv0612 Rv0612 |
mtbc0_000644 |
hypothetical protein | Belongs to the DUF6155 family (Pfam PF19652, HHpred 96.6%, near full-length), with a converging hit to DUF6880 (PF21810, 96%) and to the nuclear proteasome-tether protein Cut8 (Pfam PF08559 / PDB 3Q5W, ~94%, E~4). A domain is assigned; the Cut8 match is a suggestive lead toward a proteasome-associated role (plausible given the Mtb Pup-proteasome), but at moderate E-value it is not asserted, and the DUF families are uncharacterised, so the precise function remains undefined. (The many ribosomal-S20 / TPR hits below ~85% with E>>1 are noise.) | Family assigned | |
| Rv0613c Rv0613c |
mtbc0_000645 |
hypothetical protein | SEC-C domain-containing protein. Pfam: SEC-C (PF02810.22). | SEC-C |
Family assigned |
| Rv0614 Rv0614 |
mtbc0_000646 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3wbn-assembly1_A Crystal structure of MATE in complex with MaL6 (prob 0.03, TM 0.32). | Still unknown | |
| Rv0615 Rv0615 |
mtbc0_000647 |
integral membrane protein | Small integral membrane protein, candidate accessory subunit of the mycobacterial respiratory cytochrome bcc:aa3 supercomplex: its fold matches actinobacterial supercomplex membrane subunits (HHpred, the strongest of this set: 7Q21 Cgl2017 / 7E1V, E~0.24) and it is quasi-invariant across 145,209 genomes (3 segregating sites; the pN/pS of 0.2 rests on too few sites to be tested). CAVEAT: structural-fold candidacy ONLY; no genomic, co-expression or structural-modelling corroboration that it is a bona fide subunit. | Family assigned | |
| vapB29 Rv0616A |
- |
antitoxin VapB29 | Antitoxin VapB29. | Resolved | |
| Rv0616c Rv0616c |
|
Hypothetical protein | — | Still unknown | |
| vapC29 Rv0617 |
mtbc0_000650 |
ribonuclease VapC29 | Type II toxin-antitoxin system ribonuclease VapC29. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| galTa Rv0618 |
|
Probable galactose-1-phosphate uridylyltransferase GalTa [first part] | Involved in galactose metabolism (leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]. | GalP_UDP_transf |
Family assigned |
| galTb Rv0619 |
|
Probable galactose-1-phosphate uridylyltransferase GalTb [second part] | Involved in galactose metabolism (leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]. | GalP_UDP_tr_C |
Family assigned |
| galK Rv0620 |
mtbc0_000653 |
galactokinase | Galactokinase. Pfam: GalKase_gal_bdg (PF10509.16), GHMP_kinases_N (PF00288.33), GHMP_kinases_C (PF08544.19). | GalKase_gal_bdg GHMP_kinases_N GHMP_kinases_C |
Resolved |
| Rv0621 Rv0621 |
- |
membrane protein | Membrane protein. | Family assigned | |
| Rv0622 Rv0622 |
mtbc0_000655 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF732. Function unknown. | DUF732 |
Still unknown |
| vapB30 Rv0623 |
mtbc0_000656 |
antitoxin VapB30 | Type II toxin-antitoxin system antitoxin VapB30. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Resolved |
| vapC30 Rv0624 |
mtbc0_000657 |
ribonuclease VapC30 | Type II toxin-antitoxin system toxin ribonuclease C30. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| Rv0625c Rv0625c |
mtbc0_000658 |
transmembrane protein | TVP38/TMEM64 family protein. Pfam: VTT_dom (PF09335.17). | VTT_dom |
Family assigned |
| vapB5 Rv0626 |
mtbc0_000659 |
antitoxin VapB5 | Type II toxin-antitoxin system Phd/YefM family antitoxin. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Family assigned |
| vapC5 Rv0627 |
mtbc0_000660 |
ribonuclease VapC5 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0628c Rv0628c |
mtbc0_000661 |
hypothetical protein | FIST N-terminal domain-containing protein. Pfam: FIST (PF08495.16), FIST_C (PF10442.15). | FIST FIST_C |
Family assigned |
| recD Rv0629c |
mtbc0_000662 |
exonuclease V subunit alpha RecD | Exodeoxyribonuclease V subunit alpha. Pfam: RecD_N (PF21185.4), AAA_30 (PF13604.13), AAA_11 (PF13086.13), UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), AAA_22 (PF13401.13), NAT10_TcmA_helicase (PF05127.22), Viral_helicase1 (PF01443.25), UvrD_C_2 (PF13538.13). | RecD_N AAA_30 AAA_11 UvrD-helicase AAA_19 AAA_22 NAT10_TcmA_helicase Viral_helicase1 UvrD_C_2 |
Family assigned |
| recB Rv0630c |
mtbc0_000663 |
exonuclease V subunit beta RecB | Exodeoxyribonuclease V subunit beta. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), PDDEXK_1 (PF12705.14). | UvrD-helicase AAA_19 UvrD_C PDDEXK_1 |
Family assigned |
| recC Rv0631c |
mtbc0_000664 |
exonuclease V subunit gamma RecC | Exodeoxyribonuclease V subunit gamma. Pfam: Exonuc_V_gamma (PF04257.21), RecC_4th (PF27451.1), RecC_C (PF17946.8). | Exonuc_V_gamma RecC_4th RecC_C |
Family assigned |
| echA3 Rv0632c |
mtbc0_000665 |
enoyl-CoA hydratase EchA3 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv0633c Rv0633c |
mtbc0_000666 |
hypothetical protein | Membrane protein co-transcribed with echA3 (enoyl-CoA hydratase, fatty-acid beta-oxidation), under purifying selection. Contextual candidate: associated with fatty-acid / lipid beta-oxidation metabolism. Its molecular role is not established. | Family assigned | |
| Rv0634A Rv0634A |
- |
hypothetical protein | Predicted VapB-type antitoxin (Pfam VapB_antitoxin PF09957). RefSeq leaves it 'hypothetical protein'; antitoxin architecture predicted (TASmania, Akarsu 2019). | VapB_antitoxin |
Family assigned |