Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| lcp1 Rv3267 |
mtbc0_003475 |
hypothetical protein | Phosphotransferase Lcp1. Pfam: LytR_cpsA_psr (PF03816.20), LytR_C (PF13399.12). | LytR_cpsA_psr LytR_C |
Resolved |
| Rv3268 Rv3268 |
- |
hypothetical protein | TIGR03089-family protein, uncharacterised. NOTE: the acetyl-CoA-synthetase fold is shared, but the genuine Mtb acetyl-CoA synthetase is Rv3667 (acsA), a different gene. | Family assigned | |
| Rv3269 Rv3269 |
mtbc0_003477 |
hypothetical protein | DUF1490 family protein. | DUF1490 |
Family assigned |
| Rv3272 Rv3272 |
mtbc0_003480 |
hypothetical protein | CoA transferase. Pfam: CoA_transf_3 (PF02515.23). | CoA_transf_3 |
Resolved |
| Rv3282 Rv3282 |
mtbc0_003490 |
hypothetical protein | Nucleoside triphosphate pyrophosphatase. Pfam: Maf (PF02545.20). | Maf |
Resolved |
| Rv3284 Rv3284 |
mtbc0_003492 |
hypothetical protein | SufE family protein. Pfam: SufE (PF02657.21). | SufE |
Family assigned |
| usfY Rv3288c |
- |
hypothetical protein | UsfY, an open reading frame of the sigF gene cluster, located immediately upstream of usfX-sigF (the stress/stationary-phase sigma factor and its anti-sigma factor). UsfY has no significant homologues and may not be co-transcribed with usfX-sigF; molecular function unknown but its genomic context ties it to the SigF stress-response locus. | Family assigned | |
| Rv3292 Rv3292 |
mtbc0_003500 |
hypothetical protein | VOC family protein. Pfam: HGLS (PF07063.20). | HGLS |
Family assigned |
| Rv3294c Rv3294c |
- |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: mismatch endonuclease NucS/EndoMS is Rv1321; this gene is a DUF4143 protein (paralogue-of-fold). | DUF4143 |
Still unknown |
| Rv3300c Rv3300c |
mtbc0_003508 |
hypothetical protein | RluA family pseudouridine synthase. Pfam: PseudoU_synth_2 (PF00849.28). | PseudoU_synth_2 |
Family assigned |
| Rv3304 Rv3304 |
mtbc0_003512 |
hypothetical protein | Gamma-glutamylcyclotransferase. Pfam: GGACT (PF06094.18), AIG2_2 (PF13772.12). | GGACT AIG2_2 |
Resolved |
| Rv3311 Rv3311 |
mtbc0_003519 |
hypothetical protein | Primosomal protein. | Family assigned | |
| Rv3312b Rv3312b |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3312c Rv3312c |
mtbc0_003520 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| prp1 Rv3333c |
mtbc0_003546 |
hypothetical protein | PDZ-interacting protease regulator Ppr1. | DUF732 |
Resolved |
| Rv3351c Rv3351c |
- |
hypothetical protein | Contains BBE (PF08031.18) domain(s); putative function inferred from the domain architecture. | BBE |
Family assigned |
| Rv3353c Rv3353c |
mtbc0_003568 |
hypothetical protein | Oxidoreductase. | Resolved | |
| Rv3354 Rv3354 |
mtbc0_003569 |
hypothetical protein | Secreted protein kinase effector that targets the host COP9 signalosome to suppress apoptosis. RefSeq leaves it 'hypothetical'. Rv3354 is secreted into mononuclear phagocytes and is required for virulence; it targets the JAMM metalloprotease domain of COP9-signalosome subunit 5 (CSN5), destabilising cullin-RING ubiquitin-ligase activity and suppressing apoptosis (Danelishvili 2014). A secreted protein with a signal sequence conserved in M. leprae. | DUF732 |
Resolved |
| Rv3360 Rv3360 |
mtbc0_003575 |
hypothetical protein | FHA domain-containing protein. Pfam: FHA (PF00498.32). | FHA |
Family assigned |
| mfpA Rv3361c |
mtbc0_003576 |
hypothetical protein | Pentapeptide repeat protein MfpA. Pfam: Pentapeptide_3 (PF13576.13), Pentapeptide (PF00805.29). | Pentapeptide_3 Pentapeptide |
Resolved |
| Rv3363c Rv3363c |
mtbc0_003578 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: non-transferable cross-kingdom fold (human FAM91A1/TBC1D23 Golgi trafficking); function unknown. | DUF742 |
Still unknown |
| Rv3364c Rv3364c |
mtbc0_003579 |
hypothetical protein | Serine protease inhibitor. Pfam: Robl_LC7 (PF03259.24). | Robl_LC7 |
Resolved |
| Rv3365c Rv3365c |
mtbc0_003580 |
hypothetical protein | Sensor histidine kinase. Pfam: DUF8316 (PF26990.1), HATPase_c (PF02518.32). | DUF8316 HATPase_c |
Resolved |
| Rv3369 Rv3369 |
- |
hypothetical protein | Contains PNPOx_N (PF01243.28) domain(s); putative function inferred from the domain architecture. | PNPOx_N |
Family assigned |
| Rv3394c Rv3394c |
mtbc0_003606 |
hypothetical protein | DNA polymerase Y family protein. Pfam: IMS (PF00817.26). | IMS |
Family assigned |
| Rv3395c Rv3395c |
mtbc0_003607 |
hypothetical protein | Contains MT3502_N (PF27531.1), Rv3395c_C (PF27314.1) domain(s); putative function inferred from the domain architecture. | MT3502_N Rv3395c_C |
Family assigned |
| Rv3402c Rv3402c |
mtbc0_001626 |
hypothetical protein | DegT/DnrJ/EryC1/StrS family aminotransferase. Pfam: DegT_DnrJ_EryC1 (PF01041.24). | DegT_DnrJ_EryC1 |
Family assigned |
| Rv3403c Rv3403c |
mtbc0_003617 |
hypothetical protein | FAD/NAD(P)-binding protein. Pfam: NAD_binding_9 (PF13454.13). | NAD_binding_9 |
Family assigned |
| Rv3404c Rv3404c |
mtbc0_003618 |
hypothetical protein | DTDP-4-amino-4%2C6-dideoxyglucose formyltransferase. Pfam: Formyl_trans_N (PF00551.25), N_formyltrans_C (PF18216.7). | Formyl_trans_N N_formyltrans_C |
Resolved |
| Rv3412 Rv3412 |
mtbc0_003626 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5319. Function unknown. | DUF5319 |
Still unknown |
| Rv3415c Rv3415c |
mtbc0_003629 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rsv-assembly1_A Rap from bacteriophage Phi3T in presence of pheromone RRGHTAS (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| tsaB Rv3421c |
mtbc0_003635 |
hypothetical protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB. Pfam: TsaD (PF00814.32). | TsaD |
Family assigned |
| Rv3424c Rv3424c |
mtbc0_003639 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3430a Rv3430a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3438 Rv3438 |
mtbc0_003657 |
hypothetical protein | Alpha/beta hydrolase. | Family assigned | |
| Rv3439c Rv3439c |
mtbc0_003658 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-PE-PPE superfamily protein associated with the Type VII (ESX) secretion system; conserved four-helical-bundle/WXG domain within a large (467 aa) protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3440c Rv3440c |
mtbc0_003659 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5los-assembly1_A Piriformospora indica PIIN_05872 (prob 0.96, TM 0.86). Structure-based, putative. | Family assigned | |
| Rv3446c Rv3446c |
mtbc0_003665 |
hypothetical protein | Type VII secretion-associated protein. | Family assigned | |
| Rv3463 Rv3463 |
mtbc0_003681 |
hypothetical protein | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv3466 Rv3466 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. | DUF222 |
Still unknown |
| Rv3467 Rv3467 |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF222. Function unknown. Foldseek best (non-significant) hit: 4h9d-assembly1_C Crystal Structure of Mn-dependent Gme HNH nicking end (prob 0.25, TM 0.74). | DUF222 |
Still unknown |
| Rv3471c Rv3471c |
- |
hypothetical protein | Contains Cupin_2 (PF07883.18) domain(s); putative function inferred from the domain architecture. | Cupin_2 |
Family assigned |
| Rv3472 Rv3472 |
mtbc0_003689 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_4 (PF13577.13), DUF4440 (PF14534.13). | SnoaL_4 DUF4440 |
Family assigned |
| Rv3483c Rv3483c |
mtbc0_003698 |
hypothetical protein | LppP/LprE family lipoprotein. Pfam: Lipoprotein_21 (PF14041.12). | Lipoprotein_21 |
Family assigned |
| cpsA Rv3484 |
mtbc0_003699 |
hypothetical protein | LCP family protein. Pfam: LytR_cpsA_psr (PF03816.20), LytR_C (PF13399.12). | LytR_cpsA_psr LytR_C |
Family assigned |
| Rv3486 Rv3486 |
mtbc0_003701 |
hypothetical protein | DoxX family protein. Pfam: DoxX (PF07681.18). | DoxX |
Family assigned |
| Rv3488 Rv3488 |
mtbc0_003703 |
hypothetical protein | PadR family transcriptional regulator. Pfam: PadR (PF03551.21). | PadR |
Family assigned |
| Rv3489 Rv3489 |
mtbc0_003704 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3daq-assembly2_D Crystal structure of dihydrodipicolinate synthase fro (prob 0.06, TM 0.44). | Still unknown | |
| Rv3491 Rv3491 |
mtbc0_003706 |
hypothetical protein | Membrane-anchored protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard); ligand/partner undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3510c Rv3510c |
mtbc0_003725 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |