Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| mce2F Rv0594 |
mtbc0_000624 |
Mce family protein Mce2F | MlaD family protein. Pfam: MlaD (PF02470.26), Mce4_CUP1 (PF11887.14). | MlaD Mce4_CUP1 |
Family assigned |
| vapC4 Rv0595c |
mtbc0_000625 |
ribonuclease VapC4 | Type II toxin-antitoxin system toxin ribonuclease C4. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| vapB4 Rv0596c |
mtbc0_000626 |
antitoxin VapB4 | Type II toxin-antitoxin system antitoxin VapB4. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| Rv0597c Rv0597c |
mtbc0_000627 |
hypothetical protein | ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). | AAA_14 DUF4143 |
Family assigned |
| vapC27 Rv0598c |
mtbc0_000628 |
ribonuclease VapC27 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB27 Rv0599c |
mtbc0_000629 |
antitoxin VapB27 | Type II toxin-antitoxin system antitoxin VapB27. Pfam: MazE_antitoxin (PF04014.24). | MazE_antitoxin |
Resolved |
| Rv0600c Rv0600c |
- |
two component sensor kinase HK1 | Two component sensor kinase HK1. Pfam: HATPase_c (PF02518.32). | HATPase_c |
Resolved |
| Rv0601c Rv0601c |
- |
two component sensor kinase HK2 | Two component sensor kinase HK2. Pfam: HAMP (PF00672.31). | HAMP |
Resolved |
| tcrA Rv0602c |
- |
two component DNA binding transcriptional regulator TcrA | Two component DNA binding transcriptional regulator TcrA. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Family assigned |
| Rv0603 Rv0603 |
mtbc0_000633 |
hypothetical protein | Secreted protein with a solved NMR structure (PDB 2LRA, Rv0603); fold characterised, function not established. | Family assigned | |
| lpqO Rv0604 |
mtbc0_000634 |
lipoprotein LpqO | Conserved hypothetical protein; DUF domain(s) DUF1529. Function unknown. | DUF1529 |
Still unknown |
| Rv0605 Rv0605 |
mtbc0_000635 |
IS1536 family serine type transposase | IS607-like element IS1536 family transposase. Pfam: Resolvase (PF00239.27). | Resolvase |
Family assigned |
| Rv0607 Rv0607 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6j9r-assembly1_A Coiled-coil Domain of Drosophila TRIM Protein Brat (prob 0.02, TM 0.20). | Still unknown | |
| vapB28 Rv0608 |
mtbc0_000638 |
antitoxin VapB28 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Family assigned |
| vapC28 Rv0609 |
mtbc0_000639 |
ribonuclease VapC28 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0609A Rv0609A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6teo-assembly2_D Crystal structure of a yeast Snu114-Prp8 complex (prob 0.01, TM 0.28). | Still unknown | |
| Rv0610c Rv0610c |
mtbc0_000642 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2z0r-assembly7_B Crystal structure of hypothetical protein TTHA0547 (prob 1.00, TM 0.70). | Still unknown | |
| Rv0611c Rv0611c |
mtbc0_000643 |
hypothetical protein | Conserved hypothetical; function unknown. Structure-based hint rejected: weak fold echo (SH3 beta-barrel, eukaryotic); function unknown. | DUF4926 |
Still unknown |
| Rv0612 Rv0612 |
mtbc0_000644 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 6lja-assembly1_A Crystal Structure of exoHep from Bacteroides intestin (prob 0.23, TM 0.31). | Still unknown | |
| Rv0613c Rv0613c |
mtbc0_000645 |
hypothetical protein | SEC-C domain-containing protein. Pfam: SEC-C (PF02810.22). | SEC-C |
Family assigned |
| Rv0614 Rv0614 |
mtbc0_000646 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3wbn-assembly1_A Crystal structure of MATE in complex with MaL6 (prob 0.03, TM 0.32). | Still unknown | |
| Rv0615 Rv0615 |
mtbc0_000647 |
integral membrane protein | Small integral membrane protein associated with the mycobacterial respiratory (cytochrome bcc-aa3) supercomplex RefSeq leaves this locus uncharacterised. | Family assigned | |
| vapB29 Rv0616A |
- |
antitoxin VapB29 | Antitoxin VapB29. | Resolved | |
| vapC29 Rv0617 |
mtbc0_000650 |
ribonuclease VapC29 | Type II toxin-antitoxin system ribonuclease VapC29. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| galK Rv0620 |
mtbc0_000653 |
galactokinase | Galactokinase. Pfam: GalKase_gal_bdg (PF10509.16), GHMP_kinases_N (PF00288.33), GHMP_kinases_C (PF08544.19). | GalKase_gal_bdg GHMP_kinases_N GHMP_kinases_C |
Resolved |
| Rv0621 Rv0621 |
- |
membrane protein | Membrane protein. | Family assigned | |
| Rv0622 Rv0622 |
mtbc0_000655 |
membrane protein | Conserved hypothetical protein; DUF domain(s) DUF732. Function unknown. | DUF732 |
Still unknown |
| vapB30 Rv0623 |
mtbc0_000656 |
antitoxin VapB30 | Type II toxin-antitoxin system antitoxin VapB30. Pfam: PSK_trans_fac (PF07704.18). | PSK_trans_fac |
Resolved |
| vapC30 Rv0624 |
mtbc0_000657 |
ribonuclease VapC30 | Type II toxin-antitoxin system toxin ribonuclease C30. Pfam: PIN (PF01850.28). | PIN |
Resolved |
| Rv0625c Rv0625c |
mtbc0_000658 |
transmembrane protein | TVP38/TMEM64 family protein. Pfam: VTT_dom (PF09335.17). | VTT_dom |
Family assigned |
| vapB5 Rv0626 |
mtbc0_000659 |
antitoxin VapB5 | Type II toxin-antitoxin system Phd/YefM family antitoxin. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Family assigned |
| vapC5 Rv0627 |
mtbc0_000651 |
ribonuclease VapC5 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0628c Rv0628c |
mtbc0_000661 |
hypothetical protein | FIST N-terminal domain-containing protein. Pfam: FIST (PF08495.16), FIST_C (PF10442.15). | FIST FIST_C |
Family assigned |
| recD Rv0629c |
mtbc0_000662 |
exonuclease V subunit alpha RecD | Exodeoxyribonuclease V subunit alpha. Pfam: RecD_N (PF21185.4), AAA_30 (PF13604.13), AAA_11 (PF13086.13), UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), AAA_22 (PF13401.13), NAT10_TcmA_helicase (PF05127.22), Viral_helicase1 (PF01443.25), UvrD_C_2 (PF13538.13). | RecD_N AAA_30 AAA_11 UvrD-helicase AAA_19 AAA_22 NAT10_TcmA_helicase Viral_helicase1 UvrD_C_2 |
Family assigned |
| recB Rv0630c |
mtbc0_000663 |
exonuclease V subunit beta RecB | Exodeoxyribonuclease V subunit beta. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), PDDEXK_1 (PF12705.14). | UvrD-helicase AAA_19 UvrD_C PDDEXK_1 |
Family assigned |
| recC Rv0631c |
mtbc0_000664 |
exonuclease V subunit gamma RecC | Exodeoxyribonuclease V subunit gamma. Pfam: Exonuc_V_gamma (PF04257.21), RecC_4th (PF27451.1), RecC_C (PF17946.8). | Exonuc_V_gamma RecC_4th RecC_C |
Family assigned |
| echA3 Rv0632c |
mtbc0_000665 |
enoyl-CoA hydratase EchA3 | Crotonase/enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| Rv0633c Rv0633c |
mtbc0_000666 |
hypothetical protein | Conserved hypothetical; Foldseek best hit (KirBac channel, TM 0.43, 4.1A) not conclusive. Function unknown. | Still unknown | |
| Rv0634A Rv0634A |
- |
hypothetical protein | Contains VapB_antitoxin (PF09957.16) domain(s); putative function inferred from the domain architecture. | VapB_antitoxin |
Family assigned |
| rpmG2 Rv0634B |
- |
50S ribosomal protein L33 | 50S ribosomal protein L33. Pfam: Ribosomal_L33 (PF00471.27). | Ribosomal_L33 |
Resolved |
| Rv0634c Rv0634c |
mtbc0_000667 |
glyoxalase II | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| hadA Rv0635 |
mtbc0_000672 |
(3R)-hydroxyacyl-ACP dehydratase subunit HadA | (3R)-hydroxyacyl-ACP dehydratase subunit HadA. Pfam: FAS1_DH_region (PF13452.12). | FAS1_DH_region |
Family assigned |
| hadB Rv0636 |
mtbc0_000673 |
(3R)-hydroxyacyl-ACP dehydratase subunit HadB | (3R)-hydroxyacyl-ACP dehydratase subunit HadB. Pfam: MaoC_dehydratas (PF01575.26). | MaoC_dehydratas |
Family assigned |
| hadC Rv0637 |
mtbc0_000674 |
(3R)-hydroxyacyl-ACP dehydratase subunit HadC | (3R)-hydroxyacyl-ACP dehydratase subunit HadC. Pfam: FAS1_DH_region (PF13452.12). | FAS1_DH_region |
Family assigned |
| secE1 Rv0638 |
- |
preprotein translocase SecE | Preprotein translocase SecE. Pfam: SecE (PF00584.26). | SecE |
Resolved |
| nusG Rv0639 |
mtbc0_000677 |
transcription termination/antitermination protein NusG | Transcription termination/antitermination protein NusG. Pfam: NusG (PF02357.25). | NusG |
Resolved |
| rplK Rv0640 |
mtbc0_000678 |
50S ribosomal protein L11 | 50S ribosomal protein L11. Pfam: Ribosomal_L11_N (PF03946.20), Ribosomal_L11 (PF00298.25). | Ribosomal_L11_N Ribosomal_L11 |
Resolved |
| rplA Rv0641 |
mtbc0_000679 |
50S ribosomal protein L1 | 50S ribosomal protein L1. Pfam: Ribosomal_L1 (PF00687.27). | Ribosomal_L1 |
Resolved |
| mmaA4 Rv0642c |
mtbc0_000680 |
hydroxymycolate synthase MmaA4 | Hydroxymycolate synthase MmaA4. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| mmaA3 Rv0643c |
mtbc0_000681 |
methoxy mycolic acid synthase MmaA3 | Methoxy mycolic acid synthase MmaA3. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_11 |
Resolved |