Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| ephE Rv3670 |
mtbc0_003889 |
epoxide hydrolase EphE | Alpha/beta hydrolase. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Family assigned |
| marP Rv3671c |
mtbc0_003890 |
serine protease | Acid resistance serine protease MarP. Pfam: Colicin_V (PF02674.23), Trypsin_2 (PF13365.13), Trypsin (PF00089.33). | Colicin_V Trypsin_2 Trypsin |
Resolved |
| Rv3672c Rv3672c |
mtbc0_003891 |
hypothetical protein | CoA pyrophosphatase. Pfam: NUDIX (PF00293.35). | NUDIX |
Resolved |
| Rv3673c Rv3673c |
- |
membrane-anchored thioredoxin-like protein | Membrane-anchored thioredoxin-like protein. Pfam: Redoxin (PF08534.17), AhpC-TSA (PF00578.28), Thioredoxin_8 (PF13905.13). | Redoxin AhpC-TSA Thioredoxin_8 |
Family assigned |
| nth Rv3674c |
mtbc0_003893 |
endonuclease III | Endonuclease III. Pfam: HhH-GPD (PF00730.32), HHH (PF00633.30), EndIII_4Fe-2S (PF10576.15). | HhH-GPD HHH EndIII_4Fe-2S |
Resolved |
| Rv3675 Rv3675 |
mtbc0_003894 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| crp Rv3676 |
mtbc0_003895 |
cAMP receptor protein | CAMP-activated global transcriptional regulator CRP. Pfam: cNMP_binding (PF00027.36), HTH_Crp_2 (PF13545.13), Crp (PF00325.27). | cNMP_binding HTH_Crp_2 Crp |
Family assigned |
| Rv3677c Rv3677c |
mtbc0_003896 |
beta lactamase | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34), Lactamase_B_2 (PF12706.14), WHD_BLACT (PF17778.8). | Lactamase_B Lactamase_B_2 WHD_BLACT |
Resolved |
| Rv3678A Rv3678A |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8i0t-assembly1_C The cryo-EM structure of human Bact-III complex (prob 1.00, TM 0.82). Structure-based, putative. | Family assigned | |
| Rv3678c Rv3678c |
mtbc0_003897 |
hypothetical protein | RidA family protein. Pfam: YjgF_endoribonc (PF14588.12), Ribonuc_L-PSP (PF01042.27). | YjgF_endoribonc Ribonuc_L-PSP |
Family assigned |
| Rv3679 Rv3679 |
mtbc0_003899 |
anion transporter ATPase | ArsA family ATPase. Pfam: ArsA_ATPase (PF02374.22), CbiA (PF01656.30). | ArsA_ATPase CbiA |
Family assigned |
| Rv3680 Rv3680 |
mtbc0_003900 |
anion transporter ATPase | ArsA family ATPase. Pfam: ArsA_ATPase (PF02374.22), CbiA (PF01656.30), AAA_31 (PF13614.13). | ArsA_ATPase CbiA AAA_31 |
Family assigned |
| whiB4 Rv3681c |
mtbc0_003901 |
transcriptional regulator WhiB4 | Transcriptional regulator WhiB4. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| ponA2 Rv3682 |
- |
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase | Bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase. Pfam: Transgly (PF00912.29), Transpeptidase (PF00905.28), PASTA (PF03793.25). | Transgly Transpeptidase PASTA |
Resolved |
| Rv3683 Rv3683 |
mtbc0_003903 |
hypothetical protein | Metallophosphoesterase. Pfam: Metallophos (PF00149.34), Metallophos_2 (PF12850.13). | Metallophos Metallophos_2 |
Resolved |
| Rv3684 Rv3684 |
- |
lyase | Lyase. Pfam: PALP (PF00291.32). | PALP |
Resolved |
| cyp137 Rv3685c |
mtbc0_003906 |
cytochrome P450 Cyp137 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv3686c Rv3686c |
mtbc0_003907 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| rsfB Rv3687c |
mtbc0_003908 |
anti-anti-sigma factor RsfB | STAS domain-containing protein. Pfam: STAS (PF01740.27), STAS_2 (PF13466.13). | STAS STAS_2 |
Family assigned |
| Rv3688c Rv3688c |
mtbc0_003909 |
hypothetical protein | GatB/YqeY domain-containing protein. Pfam: YqeY (PF09424.16). | YqeY |
Family assigned |
| Rv3689 Rv3689 |
- |
transmembrane protein | Transmembrane protein. | DUF7847 |
Resolved |
| Rv3690 Rv3690 |
mtbc0_003911 |
membrane protein | Candidate lipid-transport/handling protein of the Repeating-Beta-Groove (RBG) superfamily (Bridge-Like Lipid Transfer Proteins / VPS13-ATG2-AsmA-TamB), based on a significant but ISOLATED HHpred hit. DUF4129 single-pass membrane protein, perfectly conserved (pN/pS 0), in a membrane operon (Rv3689-3695) with the MoxR2 AAA+ assembly ATPase. The single isolated hit and the assembly-ATPase operon context leave the precise role uncertain. RefSeq leaves this locus uncharacterised. | DUF4129 |
Family assigned |
| Rv3691 Rv3691 |
- |
hypothetical protein | DUF4350 protein of the IFT52 / OST48-WBP1 / ThuA-like Rossmann-fold superfamily (significant HHpred). This is a functionally diverse superfamily (membrane oligosaccharyltransferase non-catalytic subunits, intraflagellar/transport proteins, trehalose-utilization ThuA, GATase1-like), so the precise molecular function is undetermined. Genomic context: in the Rv3689-3695 membrane operon together with moxR2 (AAA+ assembly ATPase) and Rv3690 (the RBG/BLTP lipid-transport candidate, STRING-linked) -> likely a membrane-associated component of this module. RefSeq leaves this locus uncharacterised. | DUF4350 |
Family assigned |
| moxR2 Rv3692 |
mtbc0_003913 |
methanol dehydrogenase transcriptional regulator MoxR | MoxR family ATPase. Pfam: bpMoxR (PF20030.6), MCM (PF00493.30), AAA_3 (PF07726.18), AAA_5 (PF07728.21), AAA (PF00004.36), AAA_lid_2 (PF17863.8). | bpMoxR MCM AAA_3 AAA_5 AAA AAA_lid_2 |
Family assigned |
| Rv3693 Rv3693 |
mtbc0_003914 |
membrane protein | Sec-translocon-associated membrane protein (translocon-associated protein TRAP-beta-like fold). RefSeq leaves it 'hypothetical protein'. | DUF58 |
Family assigned |
| Rv3694c Rv3694c |
mtbc0_003915 |
transmembrane protein | Stage II sporulation protein M. Pfam: DUF8413 (PF28475.1), SpoIIM (PF01944.23). | DUF8413 SpoIIM |
Resolved |
| Rv3695 Rv3695 |
mtbc0_003916 |
membrane protein | RDD family protein. Pfam: RDD (PF06271.19). | RDD |
Family assigned |
| glpK Rv3696c |
mtbc0_003917 |
glycerol kinase | Glycerol kinase GlpK. Pfam: FGGY_N (PF00370.28), FGGY_C (PF02782.23). | FGGY_N FGGY_C |
Resolved |
| vapB48 Rv3697A |
- |
antitoxin VapB48 | Antitoxin VapB48. | Resolved | |
| vapC48 Rv3697c |
mtbc0_003918 |
ribonuclease VapC48 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv3698 Rv3698 |
- |
hypothetical protein | Contains GCS2 (PF04107.19) domain(s); putative function inferred from the domain architecture. | GCS2 |
Family assigned |
| Rv3699 Rv3699 |
mtbc0_003921 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: TPMT (PF05724.18), Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | TPMT Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Resolved |
| egtE Rv3700c |
mtbc0_003922 |
pyridoxal-phosphate-dependent protein EgtE | Ergothioneine biosynthesis PLP-dependent enzyme EgtE. Pfam: Aminotran_5 (PF00266.26). | Aminotran_5 |
Resolved |
| egtD Rv3701c |
mtbc0_003923 |
histidine-specific methyltransferase EtgD | L-histidine N(alpha)-methyltransferase. Pfam: Methyltransf_33 (PF10017.16). | Methyltransf_33 |
Resolved |
| egtC Rv3702c |
mtbc0_003924 |
amidohydrolase EgtC | Ergothioneine biosynthesis protein EgtC. Pfam: GATase_4 (PF13230.12). | GATase_4 |
Resolved |
| etgB Rv3703c |
mtbc0_003925 |
iron(II)-dependent oxidoreductase EgtB | Ergothioneine biosynthesis protein EgtB. Pfam: DinB_2 (PF12867.13), FGE-sulfatase (PF03781.23). | DinB_2 FGE-sulfatase |
Resolved |
| gshA Rv3704c |
mtbc0_003926 |
glutamate--cysteine ligase | Ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Pfam: GCS2 (PF04107.19). | GCS2 |
Resolved |
| Rv3705A Rv3705A |
- |
hypothetical protein | Effector of the TcrXY acid-sensing two-component system regulon, required for persistent infection. RefSeq leaves it of unknown function. Rv3705A is one of two characterised members of the ~70-gene TcrXY regulon implicated as a key determinant of Mtb survival in vivo by mitigating redox stress at acidic pH (Stupar 2024). Molecular function unfixed. | Family assigned | |
| Rv3705c Rv3705c |
mtbc0_003927 |
hypothetical protein | Sensor domain-containing protein. Pfam: PknH_C (PF14032.13). | PknH_C |
Family assigned |
| Rv3706c Rv3706c |
mtbc0_003929 |
hypothetical protein | Effector of the TcrXY acid-sensing two-component system regulon, required for persistent infection. RefSeq leaves it of unknown function. Rv3706c, with Rv3705A, is a characterised member of the TcrXY regulon implicated in Mtb survival in vivo by mitigating redox stress at acidic pH (Stupar 2024). Molecular function unfixed. | Family assigned | |
| Rv3707c Rv3707c |
- |
hypothetical protein | AraH2: endo-D-arabinofuranase, founding member (with AraH1/Rv1754c) of glycoside hydrolase family GH183 (Pfam DUF4185). Cleaves the D-arabinan core of arabinogalactan / lipoarabinomannan, i.e. mycobacterial cell-wall remodelling/degradation. NOTE: RefSeq/PGAP still annotate this gene as a hypothetical protein; it was characterised experimentally by Behrens et al. 2023. | DUF4185 |
Resolved |
| asd Rv3708c |
mtbc0_003931 |
aspartate-semialdehyde dehydrogenase | Aspartate-semialdehyde dehydrogenase. Pfam: Semialdhyde_dh (PF01118.31), Semialdhyde_dhC (PF02774.24). | Semialdhyde_dh Semialdhyde_dhC |
Resolved |
| ask Rv3709c |
mtbc0_003932 |
aspartokinase | Aspartate kinase. Pfam: AA_kinase (PF00696.34), ACT (PF01842.32), ACT_7 (PF13840.13), ACT_9 (PF22468.3). | AA_kinase ACT ACT_7 ACT_9 |
Resolved |
| leuA Rv3710 |
mtbc0_003933 |
2-isopropylmalate synthase | 2-isopropylmalate synthase. Pfam: HMGL-like (PF00682.26), IPMS_D2 (PF22615.2), LeuA_dimer (PF08502.16). | HMGL-like IPMS_D2 LeuA_dimer |
Resolved |
| dnaQ Rv3711c |
mtbc0_003934 |
DNA polymerase III subunit epsilon | DEDDh family exonuclease. Pfam: RNase_T (PF00929.32). | RNase_T |
Family assigned |
| Rv3712 Rv3712 |
mtbc0_003935 |
ligase | Mur ligase family protein. Pfam: Mur_ligase_M (PF08245.19), MurT_C (PF08353.16). | Mur_ligase_M MurT_C |
Family assigned |
| cobQ2 Rv3713 |
mtbc0_003936 |
cobyric acid synthase CobQ | Type 1 glutamine amidotransferase. Pfam: GATase_3 (PF07685.21). | GATase_3 |
Resolved |
| Rv3714c Rv3714c |
mtbc0_003937 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| recR Rv3715c |
mtbc0_003938 |
recombination protein RecR | Recombination mediator RecR. Pfam: RecR_HhH (PF21176.4), RecR_ZnF (PF02132.22), Toprim_4 (PF13662.13), Toprim (PF01751.29), RecR_C (PF21175.3). | RecR_HhH RecR_ZnF Toprim_4 Toprim RecR_C |
Resolved |
| Rv3716c Rv3716c |
mtbc0_003939 |
hypothetical protein | YbaB/EbfC family nucleoid-associated protein. Pfam: YbaB_DNA_bd (PF02575.22). M. tuberculosis carries a second YbaB/EbfC paralog, Rv0030 (this re-annotation campaign), so the two form a YbaB/EbfC nucleoid-associated-protein pair. | YbaB_DNA_bd |
Family assigned |