Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3349c Rv3349c |
- |
transposase | Transposase. Pfam: DDE_Tnp_ISL3 (PF01610.24). | DDE_Tnp_ISL3 |
Resolved |
| PPE56 Rv3350c |
- |
PPE family protein PPE56 | PPE family protein PPE56. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3351c Rv3351c |
- |
hypothetical protein | Contains BBE (PF08031.18) domain(s); putative function inferred from the domain architecture. | BBE |
Family assigned |
| Rv3352c Rv3352c |
- |
oxidoreductase | Oxidoreductase. Pfam: FAD_binding_4 (PF01565.29). | FAD_binding_4 |
Resolved |
| Rv3353c Rv3353c |
mtbc0_003568 |
hypothetical protein | Oxidoreductase. | Resolved | |
| Rv3354 Rv3354 |
mtbc0_003569 |
hypothetical protein | Secreted protein kinase effector that targets the host COP9 signalosome to suppress apoptosis. RefSeq leaves it 'hypothetical'. Rv3354 is secreted into mononuclear phagocytes and is required for virulence; it targets the JAMM metalloprotease domain of COP9-signalosome subunit 5 (CSN5), destabilising cullin-RING ubiquitin-ligase activity and suppressing apoptosis (Danelishvili 2014). A secreted protein with a signal sequence conserved in M. leprae. | DUF732 |
Resolved |
| Rv3355c Rv3355c |
mtbc0_003570 |
integral membrane protein | Conserved hypothetical protein; DUF domain(s) DUF3017. Function unknown. | DUF3017 |
Still unknown |
| folD Rv3356c |
- |
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase. Pfam: THF_DHG_CYH (PF00763.29), THF_DHG_CYH_C (PF02882.26). | THF_DHG_CYH THF_DHG_CYH_C |
Resolved |
| relJ Rv3357 |
mtbc0_003572 |
antitoxin RelJ | Type II toxin-antitoxin system antitoxin RelJ. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| relK Rv3358 |
mtbc0_003573 |
toxin RelK | Txe/YoeB family addiction module toxin. Pfam: YoeB_toxin (PF06769.21). | YoeB_toxin |
Family assigned |
| Rv3359 Rv3359 |
mtbc0_003574 |
oxidoreductase | NADH:flavin oxidoreductase. Pfam: Oxidored_FMN (PF00724.27). | Oxidored_FMN |
Resolved |
| Rv3360 Rv3360 |
mtbc0_003575 |
hypothetical protein | FHA domain-containing protein. Pfam: FHA (PF00498.32). | FHA |
Family assigned |
| mfpA Rv3361c |
mtbc0_003576 |
hypothetical protein | Pentapeptide repeat protein MfpA. Pfam: Pentapeptide_3 (PF13576.13), Pentapeptide (PF00805.29). | Pentapeptide_3 Pentapeptide |
Resolved |
| Rv3362c Rv3362c |
mtbc0_003577 |
ATP/GTP-binding protein | ATP/GTP-binding protein. Pfam: ATP_bind_1 (PF03029.24). | ATP_bind_1 |
Family assigned |
| Rv3363c Rv3363c |
mtbc0_003578 |
hypothetical protein | MarR-family DNA-binding transcriptional regulator (eggNOG COG1846, transcription COG category K). A winged-HTH transcriptional regulator; regulon undetermined. | DUF742 |
Family assigned |
| Rv3364c Rv3364c |
mtbc0_003579 |
hypothetical protein | Serine protease inhibitor. Pfam: Robl_LC7 (PF03259.24). | Robl_LC7 |
Resolved |
| Rv3365c Rv3365c |
mtbc0_003580 |
hypothetical protein | Sensor histidine kinase. Pfam: DUF8316 (PF26990.1), HATPase_c (PF02518.32). | DUF8316 HATPase_c |
Resolved |
| spoU Rv3366 |
mtbc0_003581 |
tRNA/rRNA methylase SpoU | TRNA (cytidine(34)-2'-O)-methyltransferase. Pfam: SpoU_methylase (PF00588.25). | SpoU_methylase |
Resolved |
| PE_PGRS51 Rv3367 |
- |
PE-PGRS family protein PE_PGRS51 | PE-PGRS family protein PE_PGRS51. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv3368c Rv3368c |
mtbc0_003583 |
oxidoreductase | Nitroreductase family protein. Pfam: Nitroreductase (PF00881.30). | Nitroreductase |
Family assigned |
| Rv3369 Rv3369 |
- |
hypothetical protein | Contains PNPOx_N (PF01243.28) domain(s); putative function inferred from the domain architecture. | PNPOx_N |
Family assigned |
| dnaE2 Rv3370c |
- |
error-prone DNA polymerase | Error-prone DNA polymerase. Pfam: PHP (PF02811.27), DNA_pol3_alpha (PF07733.19), DNA_pol3_finger (PF17657.7), HHH_6 (PF14579.13), tRNA_anti-codon (PF01336.32). | PHP DNA_pol3_alpha DNA_pol3_finger HHH_6 tRNA_anti-codon |
Resolved |
| Rv3371 Rv3371 |
mtbc0_003586 |
diacyglycerol O-acyltransferase | Diacylglycerol O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Resolved |
| otsB2 Rv3372 |
mtbc0_003587 |
trehalose 6-phosphate phosphatase | Trehalose-phosphatase. Pfam: Trehalose_PPase (PF02358.23). | Trehalose_PPase |
Resolved |
| echA18 Rv3373 |
- |
enoyl-CoA hydratase | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| amiD Rv3375 |
mtbc0_003590 |
amidase | Amidase. Pfam: Amidase (PF01425.27). | Amidase |
Resolved |
| Rv3376 Rv3376 |
mtbc0_003591 |
phosphatase | HAD family phosphatase. Pfam: Hydrolase (PF00702.33), HAD_2 (PF13419.13), Hydrolase_like (PF13242.13). | Hydrolase HAD_2 Hydrolase_like |
Family assigned |
| Rv3377c Rv3377c |
mtbc0_003592 |
type B diterpene cyclase | Type B diterpene cyclase. Pfam: SQHop_cyclase_C (PF13243.13). | SQHop_cyclase_C |
Resolved |
| Rv3378c Rv3378c |
mtbc0_003593 |
diterpene synthase | Diterpene synthase. | Resolved | |
| dxs2 Rv3379c |
- |
1-deoxy-D-xylulose-5-phosphate synthase | 1-deoxy-D-xylulose-5-phosphate synthase. Pfam: DXP_synthase_N (PF13292.12), Transket_pyr (PF02779.30), Transketolase_C (PF02780.26). | DXP_synthase_N Transket_pyr Transketolase_C |
Resolved |
| Rv3382c Rv3382c |
- |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. Pfam: LYTB (PF02401.24). | LYTB |
Resolved |
| idsB Rv3383c |
mtbc0_003596 |
polyprenyl synthetase IdsB | Polyprenyl synthetase family protein. Pfam: polyprenyl_synt (PF00348.23). | polyprenyl_synt |
Family assigned |
| vapC46 Rv3384c |
mtbc0_003597 |
ribonuclease VapC46 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| vapB46 Rv3385c |
- |
antitoxin VapB46 | Antitoxin VapB46. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| Rv3386 Rv3386 |
- |
transposase | Transposase. | DUF772 |
Resolved |
| Rv3387 Rv3387 |
- |
transposase | Transposase. Pfam: DDE_Tnp_1 (PF01609.28). | DDE_Tnp_1 |
Resolved |
| PE_PGRS52 Rv3388 |
- |
PE-PGRS family protein PE_PGRS52 | PE-PGRS family protein PE_PGRS52. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| htdY Rv3389c |
mtbc0_003601 |
3-hydroxyacyl-thioester dehydratase HtdY | 3-hydroxyacyl-thioester dehydratase HtdY. Pfam: MFE-2_hydrat-2_N (PF22622.3), MaoC_dehydratas (PF01575.26). | MFE-2_hydrat-2_N MaoC_dehydratas |
Resolved |
| lpqD Rv3390 |
mtbc0_003602 |
lipoprotein LpqD | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| acrA1 Rv3391 |
mtbc0_003603 |
acyl-CoA-reductase AcrA | SDR family oxidoreductase. Pfam: Epimerase (PF01370.28), NAD_binding_4 (PF07993.19), GDP_Man_Dehyd (PF16363.12), NAD_binding_10 (PF13460.13), adh_short (PF00106.32), KR (PF08659.17), adh_short_C2 (PF13561.13). | Epimerase NAD_binding_4 GDP_Man_Dehyd NAD_binding_10 adh_short KR adh_short_C2 |
Family assigned |
| cmaA1 Rv3392c |
mtbc0_003604 |
cyclopropane mycolic acid synthase CmaA | Cyclopropane mycolic acid synthase CmaA1. Pfam: CMAS (PF02353.27), Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | CMAS Methyltransf_23 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| iunH Rv3393 |
mtbc0_003605 |
nucleoside hydrolase | Nucleoside hydrolase IunH. Pfam: IU_nuc_hydro (PF01156.25). | IU_nuc_hydro |
Resolved |
| Rv3394c Rv3394c |
mtbc0_003606 |
hypothetical protein | DNA polymerase Y family protein. Pfam: IMS (PF00817.26). | IMS |
Family assigned |
| Rv3395A Rv3395A |
- |
membrane protein | Membrane protein. | Family assigned | |
| Rv3395c Rv3395c |
mtbc0_003607 |
hypothetical protein | Contains MT3502_N (PF27531.1), Rv3395c_C (PF27314.1) domain(s); putative function inferred from the domain architecture. | MT3502_N Rv3395c_C |
Family assigned |
| guaA Rv3396c |
mtbc0_003609 |
GMP synthase | Glutamine-hydrolyzing GMP synthase. Pfam: GATase (PF00117.35), Peptidase_C26 (PF07722.20), NAD_synthase (PF02540.24), GMP_synt_C (PF00958.28). | GATase Peptidase_C26 NAD_synthase GMP_synt_C |
Resolved |
| phyA Rv3397c |
mtbc0_003610 |
phytoene synthase | Presqualene diphosphate synthase HpnD. Pfam: SQS_PSY (PF00494.25). | SQS_PSY |
Resolved |
| idsA1 Rv3398c |
- |
multifunctional dimethylallyltransferase/geranyltranstransferase/farnesyltranstransferase | Multifunctional dimethylallyltransferase/geranyltranstransferase/farnesyltranstransferase. Pfam: polyprenyl_synt (PF00348.23). | polyprenyl_synt |
Resolved |
| Rv3399 Rv3399 |
- |
S-adenosylmethionine-dependent methyltransferase | S-adenosylmethionine-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv3400 Rv3400 |
mtbc0_003613 |
hydrolase | Beta-phosphoglucomutase family hydrolase. Pfam: Hydrolase (PF00702.33), HAD_2 (PF13419.13). | Hydrolase HAD_2 |
Family assigned |