Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2008c Rv2008c |
- |
hypothetical protein | Contains AAA_14 (PF13173.13), DUF4143 (PF13635.13) domain(s); putative function inferred from the domain architecture. | AAA_14 DUF4143 |
Family assigned |
| vapB15 Rv2009 |
- |
antitoxin VapB15 | Antitoxin VapB15. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Resolved |
| vapC15 Rv2010 |
mtbc0_002138 |
ribonuclease VapC15 | PIN domain nuclease. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv2011c Rv2011c |
mtbc0_002139 |
hypothetical protein | MarR family winged helix-turn-helix transcriptional regulator. Pfam: MarR_2 (PF12802.14). | MarR_2 |
Family assigned |
| Rv2012 Rv2012 |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 2hh8-assembly1_A Solution NMR structure of the ydfO protein from Escherichia col (prob 1.00, TM 0.74). Structure-based, putative. | DUF1398 |
Family assigned |
| Rv2015c Rv2015c |
mtbc0_001879 |
hypothetical protein | HNH endonuclease signature motif containing protein. Pfam: DUF222 (PF02720.23), HNH (PF01844.30). | DUF222 HNH |
Resolved |
| Rv2016 Rv2016 |
mtbc0_002146 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2e2l-assembly1_E Helicobacter pylori formamidase AmiF contains a fine- (prob 0.13, TM 0.52). | Still unknown | |
| Rv2017 Rv2017 |
mtbc0_002147 |
transcriptional regulator | ImmA/IrrE family metallo-endopeptidase. Pfam: HTH_31 (PF13560.13), HTH_19 (PF12844.14), HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20). | HTH_31 HTH_19 HTH_3 Peptidase_M78 |
Family assigned |
| Rv2018 Rv2018 |
mtbc0_002148 |
hypothetical protein | DUF433 domain-containing protein. Pfam: HTH_66 (PF21321.4), DUF433 (PF04255.21). | HTH_66 DUF433 |
Family assigned |
| Rv2019 Rv2019 |
mtbc0_002149 |
hypothetical protein | Contains PIN_10 (PF18478.8) domain(s); putative function inferred from the domain architecture. | PIN_10 |
Family assigned |
| Rv2021c Rv2021c |
mtbc0_002151 |
transcriptional regulator | XRE family transcriptional regulator. Pfam: HTH_37 (PF13744.13), HTH_31 (PF13560.13), HTH_3 (PF01381.29). | HTH_37 HTH_31 HTH_3 |
Family assigned |
| Rv2022c Rv2022c |
mtbc0_002152 |
hypothetical protein | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: Gp49 (PF05973.21). | Gp49 |
Family assigned |
| Rv2023c Rv2023c |
mtbc0_002153 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2024c Rv2024c |
- |
hypothetical protein | Contains Mrr_cat (PF04471.19), Mrr_cat_2 (PF13156.13), ResIII (PF04851.22), DEAD (PF00270.36) domain(s); putative function inferred from the domain architecture. | Mrr_cat Mrr_cat_2 ResIII DEAD |
Family assigned |
| Rv2025c Rv2025c |
mtbc0_002158 |
cation efflux system protein | Cation diffusion facilitator family transporter. Pfam: Cation_efflux (PF01545.27), ZT_dimer (PF16916.12). | Cation_efflux ZT_dimer |
Family assigned |
| Rv2026c Rv2026c |
mtbc0_002159 |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| dosT Rv2027c |
mtbc0_002160 |
two component sensor histidine kinase DosT | Two-component system sensor histidine kinase DosT. Pfam: GAF (PF01590.33), GAF_2 (PF13185.13), GAF_3 (PF13492.13), HisKA_3 (PF07730.20), HATPase_c (PF02518.32). | GAF GAF_2 GAF_3 HisKA_3 HATPase_c |
Resolved |
| Rv2028c Rv2028c |
mtbc0_002161 |
universal stress protein | Universal stress protein. Pfam: Usp (PF00582.33). | Usp |
Resolved |
| pfkB Rv2029c |
mtbc0_002162 |
6-phosphofructokinase PfkB | 1-phosphofructokinase family hexose kinase. Pfam: PfkB (PF00294.30). | PfkB |
Family assigned |
| Rv2030c Rv2030c |
mtbc0_002163 |
hypothetical protein | Erythromycin esterase family protein. Pfam: Pribosyltran (PF00156.34), Erythro_esteras (PF05139.20). | Pribosyltran Erythro_esteras |
Family assigned |
| hspX Rv2031c |
mtbc0_002164 |
alpha-crystallin | Alpha-crystallin HspX. Pfam: HSP20 (PF00011.28), ArsA_HSP20 (PF17886.8). | HSP20 ArsA_HSP20 |
Resolved |
| acg Rv2032 |
mtbc0_002165 |
NAD(P)H nitroreductase | FMN-binding protein Acg. | Family assigned | |
| Rv2033c Rv2033c |
mtbc0_002166 |
hypothetical protein | 5'-3' exoribonuclease / diribonuclease of the TrpH/YciV (RNase AM) family, a metallophosphoesterase-fold RNase (eggNOG COG0613). Named nuclease family; exact in-vivo RNA substrate undetermined. | DUF3097_N DUF3097_C |
Family assigned |
| Rv2034 Rv2034 |
mtbc0_002167 |
ArsR family HTH-type transcriptional repressor | Metalloregulator ArsR/SmtB family transcription factor. Pfam: HTH_20 (PF12840.14), HTH_5 (PF01022.27), MarR_2 (PF12802.14). | HTH_20 HTH_5 MarR_2 |
Family assigned |
| Rv2035 Rv2035 |
mtbc0_002168 |
hypothetical protein | SRPBCC family protein. Pfam: AHSA1 (PF08327.18). | AHSA1 |
Family assigned |
| Rv2036 Rv2036 |
mtbc0_002169 |
hypothetical protein | Maleylpyruvate isomerase family mycothiol-dependent enzyme. Pfam: MDMPI_N (PF11716.14). | MDMPI_N |
Family assigned |
| Rv2037c Rv2037c |
mtbc0_002170 |
transmembrane protein | Patatin-like phospholipase family protein. Pfam: Patatin (PF01734.28). | Patatin |
Family assigned |
| ugpC Rv2038c |
mtbc0_002171 |
sugar ABC transporter ATP-binding protein | Sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC. Pfam: ABC_tran (PF00005.34), OB_MalK (PF17912.8), TOBE_2 (PF08402.17). | ABC_tran OB_MalK TOBE_2 |
Family assigned |
| Rv2039c Rv2039c |
mtbc0_002172 |
sugar ABC transporter permease | Carbohydrate ABC transporter permease. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| Rv2040c Rv2040c |
mtbc0_002173 |
sugar ABC transporter permease | Sugar ABC transporter permease. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| Rv2041c Rv2041c |
mtbc0_002174 |
sugar ABC transporter substrate-binding lipoprotein | Sugar ABC transporter substrate-binding protein. Pfam: SBP_bac_1 (PF01547.31), SBP_bac_8 (PF13416.12). | SBP_bac_1 SBP_bac_8 |
Family assigned |
| Rv2042c Rv2042c |
mtbc0_002175 |
hypothetical protein | Ketosteroid isomerase family protein. Pfam: NTF2 (PF02136.27), SnoaL_2 (PF12680.14). | NTF2 SnoaL_2 |
Family assigned |
| pncA Rv2043c |
mtbc0_002176 |
pyrazinamidase/nicotinamidase PncA | Pyrazinamidase PncA. Pfam: Isochorismatase (PF00857.27). | Isochorismatase |
Resolved |
| Rv2044c Rv2044c |
- |
hypothetical protein | Polytopic integral membrane protein with 3 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2784 |
Family assigned |
| lipT Rv2045c |
- |
carboxylesterase LipT | Carboxylesterase LipT. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20). | COesterase BD-FAE Abhydrolase_3 |
Resolved |
| lppI Rv2046 |
mtbc0_002179 |
lipoprotein LppI | Conserved lipoprotein LppI; interacts physically and site-specifically with the virulence-associated lipid-transport protein LprG (at the entrance to its lipid-binding pocket), implicating it in outer-membrane lipid assembly/transport. Substrate/precise activity unfixed. | Family assigned | |
| Rv2047c Rv2047c |
mtbc0_002180 |
hypothetical protein | Sugar epimerase family protein. Pfam: Epimerase (PF01370.28), 3Beta_HSD (PF01073.26), NAD_binding_10 (PF13460.13), Rph_4th (PF27448.1), PEP-utilizers (PF00391.30). | Epimerase 3Beta_HSD NAD_binding_10 Rph_4th PEP-utilizers |
Family assigned |
| pks12 Rv2048c |
mtbc0_002181 |
polyketide synthase | Type I polyketide synthase. Pfam: Ketoacyl-synt_C (PF02801.29), KAsynt_C_assoc (PF16197.12), CurL-like_PKS_C (PF22621.3), RhiE-like_linker (PF22336.3), Acyl_transf_1 (PF00698.27), PKS_DH_N (PF21089.4), ADH_N (PF08240.18), ADH_zinc_N (PF00107.33), KR (PF08659.17), Epimerase (PF01370.28), PP-binding (PF00550.32), ketoacyl-synt (PF00109.33), PS-DH (PF14765.13), SpnB_Rossmann (PF22953.4), ADH_zinc_N_2 (PF13602.13), adh_short (PF00106.32). | Ketoacyl-synt_C KAsynt_C_assoc CurL-like_PKS_C RhiE-like_linker Acyl_transf_1 PKS_DH_N ADH_N ADH_zinc_N KR Epimerase PP-binding ketoacyl-synt PS-DH SpnB_Rossmann ADH_zinc_N_2 adh_short |
Resolved |
| Rv2049c Rv2049c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5lcy-assembly1_C Formaldehyde-Responsive Regulator FrmR E64H variant from Salmon (prob 1.00, TM 0.90). Structure-based, putative. | Family assigned | |
| rbpA Rv2050 |
mtbc0_002183 |
RNA polymerase-binding protein RbpA | RNA polymerase-binding protein RbpA. Pfam: RbpA (PF13397.13). | RbpA |
Family assigned |
| ppm1 Rv2051c |
mtbc0_002184 |
polyprenol-monophosphomannose synthase | Apolipoprotein N-acyltransferase. Pfam: LNT_N (PF20154.5), CN_hydrolase (PF00795.28), Glycos_transf_2 (PF00535.33). | LNT_N CN_hydrolase Glycos_transf_2 |
Resolved |
| Rv2052c Rv2052c |
mtbc0_002185 |
hypothetical protein | Amidohydrolase. Pfam: Amidohydro_3 (PF07969.18). | Amidohydro_3 |
Resolved |
| fxsA Rv2053c |
mtbc0_002186 |
transmembrane protein FxsA | FxsA family protein. Pfam: FxsA (PF04186.19). | FxsA |
Family assigned |
| Rv2054 Rv2054 |
mtbc0_002187 |
hypothetical protein | Dienelactone hydrolase family protein. Pfam: DLH (PF01738.25). | DLH |
Family assigned |
| rpsR2 Rv2055c |
mtbc0_002188 |
30S ribosomal protein S18 | 30S ribosomal protein S18. Pfam: Ribosomal_S18 (PF01084.27). | Ribosomal_S18 |
Resolved |
| rpsN2 Rv2056c |
mtbc0_002189 |
30S ribosomal protein S14 | 30S ribosomal protein S14. Pfam: Ribosomal_S14 (PF00253.28). | Ribosomal_S14 |
Resolved |
| rpmG1 Rv2057c |
- |
50S ribosomal protein L33 | 50S ribosomal protein L33. Pfam: Ribosomal_L33 (PF00471.27). | Ribosomal_L33 |
Resolved |
| rpmB2 Rv2058c |
mtbc0_002191 |
50S ribosomal protein L28 | 50S ribosomal protein L28. Pfam: Ribosomal_L28 (PF00830.25). | Ribosomal_L28 |
Resolved |
| Rv2059 Rv2059 |
- |
hypothetical protein | Contains ZnuA (PF01297.23) domain(s); putative function inferred from the domain architecture. | ZnuA |
Family assigned |
| Rv2060 Rv2060 |
- |
integral membrane protein | Integral membrane protein. Pfam: ABC-3 (PF00950.23). | ABC-3 |
Family assigned |