Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv1086 Rv1086 |
mtbc0_001166 |
(2Z,6E)-farnesyl diphosphate synthase | Undecaprenyl diphosphate synthase family protein. Pfam: Prenyltransf (PF01255.25). | Prenyltransf |
Family assigned |
| PE_PGRS21 Rv1087 |
- |
PE-PGRS family protein PE_PGRS21 | PE-PGRS family protein PE_PGRS21. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1087A Rv1087A |
|
Conserved hypothetical protein | transferase activity, transferring alkyl or aryl (other than methyl) groups | Prenyltransf |
Family assigned |
| PE9 Rv1088 |
- |
PE family protein PE9 | PE family protein PE9. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv1088a Rv1088a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PE10 Rv1089 |
|
PE family protein PE10 | PE family protein PE10 | Family assigned | |
| celA2a Rv1089A |
|
Probable cellulase CelA2a (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) | The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose [catalytic activity:endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose]. | Family assigned | |
| celA2b Rv1090 |
|
Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) | The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) exocellobiohydrolases that cut the dissaccharide cellobiose from the nonreducing end of the cellulose polymer chain; (3) beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose [catalytic activity:endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose]. | Glyco_hydro_12 |
Family assigned |
| PE_PGRS22 Rv1091 |
- |
PE-PGRS family protein PE_PGRS22 | PE-PGRS family protein PE_PGRS22. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| coaA Rv1092c |
- |
pantothenate kinase | Pantothenate kinase. Pfam: PRK (PF00485.25). | PRK |
Resolved |
| glyA1 Rv1093 |
- |
serine hydroxymethyltransferase | Serine hydroxymethyltransferase. Pfam: SHMT (PF00464.26). | SHMT |
Resolved |
| desA2 Rv1094 |
mtbc0_001177 |
acyl-ACP desaturase DesA | Acyl-ACP desaturase. Pfam: FA_desaturase_2 (PF03405.21). | FA_desaturase_2 |
Resolved |
| phoH2 Rv1095 |
mtbc0_001178 |
phosphate starvation-inducible protein PsiH | PhoH family protein. Pfam: PIN_4 (PF13638.13), PhoH (PF02562.23). | PIN_4 PhoH |
Family assigned |
| Rv1096 Rv1096 |
mtbc0_001179 |
glycosyl hydrolase | Polysaccharide deacetylase family protein. Pfam: Polysacc_deac_1 (PF01522.27). | Polysacc_deac_1 |
Family assigned |
| Rv1097c Rv1097c |
mtbc0_001180 |
hypothetical protein | Apa-like fold (fibronectin-binding protein Apa, PDB 5ZX9); putative adhesin / secreted protein. | Family assigned | |
| fum Rv1098c |
mtbc0_001181 |
fumarate hydratase | Class II fumarate hydratase. Pfam: Lyase_1 (PF00206.26), FumaraseC_C (PF10415.15). | Lyase_1 FumaraseC_C |
Resolved |
| glpX Rv1099c |
mtbc0_001182 |
fructose 1,6-bisphosphatase | Class II fructose-bisphosphatase. Pfam: FBPase_glpX (PF03320.19). | FBPase_glpX |
Resolved |
| Rv1100 Rv1100 |
- |
hypothetical protein | Candidate anti-sigma-factor regulatory protein of the RseB/MucB family (envelope-stress ECF-sigma-factor regulation): the two top HHpred hits are RseB (sigma-E regulator) 93.65% and MucB (AlgU regulator) 89.1%, the same anti-sigma-regulator family, clearly above the membrane-protein noise floor. CAVEAT: E-values modest (2.5/14), and there is NO STRING/genomic corroboration with any sigma/anti-sigma system; Rv1100 is a 1-TM membrane protein (vs periplasmic RseB), quasi-invariant across 145,209 genomes (3 segregating sites — too few to test pN/pS, so neither relaxed nor purifying selection is demonstrated). Fold-level candidate, function uncertain. RefSeq leaves this locus uncharacterised. | DUF4245 |
Family assigned |
| Rv1101c Rv1101c |
mtbc0_001184 |
hypothetical protein | AI-2E family transporter. Pfam: AI-2E_transport (PF01594.23). | AI-2E_transport |
Family assigned |
| mazF3 Rv1102c |
mtbc0_001185 |
mRNA interferase MazF3 | Type II toxin-antitoxin system toxin endoribonuclease MazF3. Pfam: PemK_toxin (PF02452.24). | PemK_toxin |
Resolved |
| mazE3 Rv1103c |
- |
antitoxin MazE3 | Antitoxin MazE3. | Resolved | |
| Rv1106c Rv1106c |
mtbc0_001188 |
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase | 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase. Pfam: KR (PF08659.17), RmlD_sub_bind (PF04321.24), NmrA (PF05368.20), Epimerase (PF01370.28), Polysacc_synt_2 (PF02719.22), 3Beta_HSD (PF01073.26), GDP_Man_Dehyd (PF16363.12), NAD_binding_10 (PF13460.13), NAD_binding_4 (PF07993.19). | KR RmlD_sub_bind NmrA Epimerase Polysacc_synt_2 3Beta_HSD GDP_Man_Dehyd NAD_binding_10 NAD_binding_4 |
Resolved |
| xseB Rv1107c |
mtbc0_001189 |
exodeoxyribonuclease VII small subunit | Exodeoxyribonuclease VII small subunit. Pfam: Exonuc_VII_S (PF02609.22). | Exonuc_VII_S |
Family assigned |
| xseA Rv1108c |
mtbc0_001190 |
exodeoxyribonuclease VII large subunit | Exodeoxyribonuclease VII large subunit. Pfam: tRNA_anti_2 (PF13742.13), Exonuc_VII_L (PF02601.21). | tRNA_anti_2 Exonuc_VII_L |
Family assigned |
| Rv1109c Rv1109c |
mtbc0_001191 |
hypothetical protein | Lipid droplet-associated protein. Pfam: Rv1109c_N (PF27128.1), DUF8129 (PF26450.2). | Rv1109c_N DUF8129 |
Resolved |
| lytB2 Rv1110 |
- |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. Pfam: LYTB (PF02401.24). | LYTB |
Resolved |
| Rv1111c Rv1111c |
mtbc0_001193 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF6542 |
Family assigned |
| ychF Rv1112 |
mtbc0_001194 |
GTP-binding protein | Redox-regulated ATPase YchF. Pfam: MMR_HSR1 (PF01926.30), FeoB_N (PF02421.25), YchF-GTPase_C (PF06071.20). | MMR_HSR1 FeoB_N YchF-GTPase_C |
Resolved |
| vapB32 Rv1113 |
mtbc0_001195 |
antitoxin VapB32 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Family assigned |
| vapC32 Rv1114 |
mtbc0_001196 |
ribonuclease VapC32 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv1115 Rv1115 |
mtbc0_001197 |
hypothetical protein | NlpC/P60-family cell-wall peptidase (eggNOG COG0791, peptidoglycan endopeptidase/amidase; cell-envelope COG category M). RefSeq leaves it 'hypothetical protein'. Peptidoglycan-hydrolase fold; in-vivo role undetermined. | Family assigned | |
| Rv1116 Rv1116 |
mtbc0_001198 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1117 Rv1117 |
mtbc0_001200 |
hypothetical protein | Putative quinol monooxygenase. Pfam: ABM (PF03992.23). | ABM |
Family assigned |
| Rv1118c Rv1118c |
- |
hypothetical protein | Circularly permuted NlpC/P60 (YaeF/YiiX-family) cysteine amidase with a structurally competent Cys234-His97 catalytic dyad (Glu115 a candidate third member). RefSeq leaves this locus 'hypothetical protein'; here it is re-annotated by structure-guided active-site mapping. The catalytic histidine partner of the nucleophile Cys234 is His97 (Sgamma-Ndelta1 = 3.6 A on the ESMFold model, 2.9 A on AlphaFold3), invisible to sequence proximity because the fold is circularly permuted - the three sequence-proximal histidines lie 7-23 A away. HHpred matches the permuted Peptidase_C92 / YaeF-YiiX family (>=99.7%) and lipid-acting permuted members (LRAT, H-REV107), and the 86%-hydrophobic pocket points to an N-acyl-amino-acid / lipoprotein amide substrate rather than a peptidoglycan muropeptide. Distinct from the five canonical peptidoglycan-hydrolase NlpC/P60 enzymes of H37Rv (Rv0024, RipA, RipB, RipD, Rv2190c). Catalytic codons essentially invariant across ~250,724 MTBC genomes. A structural prediction, not a biochemical assay. | Resolved | |
| Rv1119c Rv1119c |
- |
hypothetical protein | Class III adenylyl/guanylyl cyclase domain (eggNOG COG2114, nucleotide-cyclase; COG category T) - one of the many M. tuberculosis class-III cyclases. Short ORF (partial-domain match); regulatory role undetermined. | Family assigned | |
| Rv1120c Rv1120c |
- |
hypothetical protein | Contains Guanylate_cyc (PF00211.26) domain(s); putative function inferred from the domain architecture. | Guanylate_cyc |
Family assigned |
| zwf1 Rv1121 |
- |
glucose-6-phosphate 1-dehydrogenase | Glucose-6-phosphate 1-dehydrogenase. Pfam: G6PD_N (PF00479.29), G6PD_C (PF02781.22). | G6PD_N G6PD_C |
Resolved |
| gnd2 Rv1122 |
mtbc0_001205 |
6-phosphogluconate dehydrogenase (decarboxylating) | Decarboxylating 6-phosphogluconate dehydrogenase. Pfam: NAD_binding_2 (PF03446.22), F420_oxidored (PF03807.24), TrkA_N (PF02254.25), 6PGD (PF00393.25). | NAD_binding_2 F420_oxidored TrkA_N 6PGD |
Resolved |
| bpoB Rv1123c |
- |
peroxidase BpoB | Peroxidase BpoB. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Resolved |
| ephC Rv1124 |
- |
epoxide hydrolase EphC | Epoxide hydrolase EphC. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv1125 Rv1125 |
mtbc0_001208 |
hypothetical protein | WS/DGAT domain-containing protein. Pfam: WS_DGAT_C (PF06974.19). | WS_DGAT_C |
Family assigned |
| Rv1126c Rv1126c |
mtbc0_001209 |
hypothetical protein | MarR family transcriptional regulator. | Family assigned | |
| ppdK Rv1127c |
mtbc0_001210 |
pyruvate, phosphate dikinase PpdK | Pyruvate%2C phosphate dikinase. Pfam: PPDK_N (PF01326.25), PEP-utilizers (PF00391.30). | PPDK_N PEP-utilizers |
Resolved |
| Rv1128c Rv1128c |
- |
hypothetical protein | HNH-family endonuclease / nuclease (modification-dependent restriction-endonuclease or nuclease effector of a defense system); COG defense category V RefSeq leaves this locus uncharacterised. | DUF222 |
Family assigned |
| Rv1129c Rv1129c |
mtbc0_001212 |
transcriptional regulator | Short-chain fatty acyl-CoA regulator family protein. Pfam: HTH_31 (PF13560.13), HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20), ScfRs (PF09856.15). | HTH_31 HTH_3 Peptidase_M78 ScfRs |
Family assigned |
| prpD Rv1130 |
- |
2-methylcitrate dehydratase | 2-methylcitrate dehydratase. Pfam: MmgE_PrpD_N (PF03972.20), MmgE_PrpD_C (PF19305.5). | MmgE_PrpD_N MmgE_PrpD_C |
Resolved |
| prpC Rv1131 |
mtbc0_001214 |
methylcitrate synthase PrpC | 2-methylcitrate synthase. Pfam: Citrate_synt (PF00285.27). | Citrate_synt |
Resolved |
| Rv1132 Rv1132 |
mtbc0_001215 |
hypothetical protein | Polytopic integral membrane protein with 11 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3556 |
Family assigned |
| metE Rv1133c |
mtbc0_001216 |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. Pfam: Meth_synt_1 (PF08267.19), Meth_synt_2 (PF01717.25). | Meth_synt_1 Meth_synt_2 |
Resolved |
| Rv1134 Rv1134 |
mtbc0_001217 |
hypothetical protein | YCII-related domain protein (eggNOG COG3795, nucleotide-metabolism COG category F). RefSeq leaves it 'hypothetical protein'. A defined domain family of still-uncertain biochemical function. | Family assigned |