Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| mazE3 Rv1103c |
- |
antitoxin MazE3 | Antitoxin MazE3. | Resolved | |
| Rv1106c Rv1106c |
mtbc0_001188 |
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase | 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase. Pfam: KR (PF08659.17), RmlD_sub_bind (PF04321.24), NmrA (PF05368.20), Epimerase (PF01370.28), Polysacc_synt_2 (PF02719.22), 3Beta_HSD (PF01073.26), GDP_Man_Dehyd (PF16363.12), NAD_binding_10 (PF13460.13), NAD_binding_4 (PF07993.19). | KR RmlD_sub_bind NmrA Epimerase Polysacc_synt_2 3Beta_HSD GDP_Man_Dehyd NAD_binding_10 NAD_binding_4 |
Resolved |
| xseB Rv1107c |
mtbc0_001189 |
exodeoxyribonuclease VII small subunit | Exodeoxyribonuclease VII small subunit. Pfam: Exonuc_VII_S (PF02609.22). | Exonuc_VII_S |
Family assigned |
| xseA Rv1108c |
mtbc0_001190 |
exodeoxyribonuclease VII large subunit | Exodeoxyribonuclease VII large subunit. Pfam: tRNA_anti_2 (PF13742.13), Exonuc_VII_L (PF02601.21). | tRNA_anti_2 Exonuc_VII_L |
Family assigned |
| Rv1109c Rv1109c |
mtbc0_001191 |
hypothetical protein | Lipid droplet-associated protein. Pfam: Rv1109c_N (PF27128.1), DUF8129 (PF26450.2). | Rv1109c_N DUF8129 |
Resolved |
| lytB2 Rv1110 |
- |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. Pfam: LYTB (PF02401.24). | LYTB |
Resolved |
| Rv1111c Rv1111c |
mtbc0_001193 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF6542 |
Family assigned |
| ychF Rv1112 |
mtbc0_001194 |
GTP-binding protein | Redox-regulated ATPase YchF. Pfam: MMR_HSR1 (PF01926.30), FeoB_N (PF02421.25), YchF-GTPase_C (PF06071.20). | MMR_HSR1 FeoB_N YchF-GTPase_C |
Resolved |
| vapB32 Rv1113 |
mtbc0_001195 |
antitoxin VapB32 | Type II toxin-antitoxin system VapB family antitoxin. Pfam: VapB_antitoxin (PF09957.16). | VapB_antitoxin |
Family assigned |
| vapC32 Rv1114 |
mtbc0_001196 |
ribonuclease VapC32 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv1115 Rv1115 |
mtbc0_001197 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8gra-assembly1_G Structure of Type VI secretion system cargo delivery (prob 0.01, TM 0.14). | Still unknown | |
| Rv1116 Rv1116 |
mtbc0_001198 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1117 Rv1117 |
mtbc0_001200 |
hypothetical protein | Putative quinol monooxygenase. Pfam: ABM (PF03992.23). | ABM |
Family assigned |
| Rv1118c Rv1118c |
- |
hypothetical protein | Circularly permuted NlpC/P60 (YaeF/YiiX-family) cysteine amidase with a structurally competent Cys234-His97 catalytic dyad (Glu115 a candidate third member). RefSeq leaves this locus 'hypothetical protein'; here it is re-annotated by structure-guided active-site mapping. The catalytic histidine partner of the nucleophile Cys234 is His97 (Sgamma-Ndelta1 = 3.6 A on the ESMFold model, 2.9 A on AlphaFold3), invisible to sequence proximity because the fold is circularly permuted - the three sequence-proximal histidines lie 7-23 A away. HHpred matches the permuted Peptidase_C92 / YaeF-YiiX family (>=99.7%) and lipid-acting permuted members (LRAT, H-REV107), and the 86%-hydrophobic pocket points to an N-acyl-amino-acid / lipoprotein amide substrate rather than a peptidoglycan muropeptide. Distinct from the five canonical peptidoglycan-hydrolase NlpC/P60 enzymes of H37Rv (Rv0024, RipA, RipB, RipD, Rv2190c). Catalytic codons essentially invariant across ~250,724 MTBC genomes. A structural prediction, not a biochemical assay. | Resolved | |
| Rv1119c Rv1119c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv1120c Rv1120c |
- |
hypothetical protein | Contains Guanylate_cyc (PF00211.26) domain(s); putative function inferred from the domain architecture. | Guanylate_cyc |
Family assigned |
| zwf1 Rv1121 |
- |
glucose-6-phosphate 1-dehydrogenase | Glucose-6-phosphate 1-dehydrogenase. Pfam: G6PD_N (PF00479.29), G6PD_C (PF02781.22). | G6PD_N G6PD_C |
Resolved |
| gnd2 Rv1122 |
mtbc0_001205 |
6-phosphogluconate dehydrogenase (decarboxylating) | Decarboxylating 6-phosphogluconate dehydrogenase. Pfam: NAD_binding_2 (PF03446.22), F420_oxidored (PF03807.24), TrkA_N (PF02254.25), 6PGD (PF00393.25). | NAD_binding_2 F420_oxidored TrkA_N 6PGD |
Resolved |
| bpoB Rv1123c |
- |
peroxidase BpoB | Peroxidase BpoB. Pfam: Hydrolase_4 (PF12146.16), Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Hydrolase_4 Abhydrolase_1 Abhydrolase_6 |
Resolved |
| ephC Rv1124 |
- |
epoxide hydrolase EphC | Epoxide hydrolase EphC. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv1125 Rv1125 |
mtbc0_001208 |
hypothetical protein | WS/DGAT domain-containing protein. Pfam: WS_DGAT_C (PF06974.19). | WS_DGAT_C |
Family assigned |
| Rv1126c Rv1126c |
mtbc0_001209 |
hypothetical protein | MarR family transcriptional regulator. | Family assigned | |
| ppdK Rv1127c |
mtbc0_001210 |
pyruvate, phosphate dikinase PpdK | Pyruvate%2C phosphate dikinase. Pfam: PPDK_N (PF01326.25), PEP-utilizers (PF00391.30). | PPDK_N PEP-utilizers |
Resolved |
| Rv1128c Rv1128c |
- |
hypothetical protein | HNH-family endonuclease / nuclease (modification-dependent restriction-endonuclease or nuclease effector of a defense system); COG defense category V RefSeq leaves this locus uncharacterised. | DUF222 |
Family assigned |
| Rv1129c Rv1129c |
mtbc0_001212 |
transcriptional regulator | Short-chain fatty acyl-CoA regulator family protein. Pfam: HTH_31 (PF13560.13), HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20), ScfRs (PF09856.15). | HTH_31 HTH_3 Peptidase_M78 ScfRs |
Family assigned |
| prpD Rv1130 |
- |
2-methylcitrate dehydratase | 2-methylcitrate dehydratase. Pfam: MmgE_PrpD_N (PF03972.20), MmgE_PrpD_C (PF19305.5). | MmgE_PrpD_N MmgE_PrpD_C |
Resolved |
| prpC Rv1131 |
mtbc0_001214 |
methylcitrate synthase PrpC | 2-methylcitrate synthase. Pfam: Citrate_synt (PF00285.27). | Citrate_synt |
Resolved |
| Rv1132 Rv1132 |
mtbc0_001215 |
hypothetical protein | Polytopic integral membrane protein with 11 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3556 |
Family assigned |
| metE Rv1133c |
mtbc0_001216 |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. Pfam: Meth_synt_1 (PF08267.19), Meth_synt_2 (PF01717.25). | Meth_synt_1 Meth_synt_2 |
Resolved |
| Rv1134 Rv1134 |
mtbc0_001217 |
hypothetical protein | YCII-related domain protein (eggNOG COG3795, nucleotide-metabolism COG category F). RefSeq leaves it 'hypothetical protein'. A defined domain family of still-uncertain biochemical function. | Family assigned | |
| PPE16 Rv1135c |
- |
PPE family protein PPE16 | PPE family protein PPE16. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv1138a Rv1138a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3qxi-assembly1_A Crystal structure of enoyl-CoA hydratase EchA1 from M (prob 0.44, TM 0.54). | Still unknown | |
| Rv1138c Rv1138c |
mtbc0_001223 |
oxidoreductase | NAD(P)/FAD-dependent oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), FAD_binding_2 (PF00890.31). | FAD_binding_3 FAD_binding_2 |
Resolved |
| Rv1139c Rv1139c |
mtbc0_001224 |
hypothetical protein | Isoprenylcysteine carboxyl methyltransferase family protein. Pfam: ICMT (PF04140.20), PEMT (PF04191.19). | ICMT PEMT |
Family assigned |
| Rv1140 Rv1140 |
- |
integral membrane protein | Integral membrane protein. Pfam: Rce1-like (PF02517.22). | Rce1-like |
Family assigned |
| echA11 Rv1141c |
mtbc0_001226 |
enoyl-CoA hydratase EchA11 | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| echA10 Rv1142c |
mtbc0_001227 |
enoyl-CoA hydratase EchA10 | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| mcr Rv1143 |
mtbc0_001228 |
alpha-methylacyl-CoA racemase | Alpha-methylacyl-CoA racemase. Pfam: CoA_transf_3 (PF02515.23). | CoA_transf_3 |
Resolved |
| Rv1144 Rv1144 |
mtbc0_001229 |
oxidoreductase | 3-hydroxyacyl-CoA dehydrogenase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13). | adh_short KR Epimerase adh_short_C2 |
Resolved |
| Rv1145 Rv1145 |
- |
transmembrane transport protein | Transmembrane transport protein. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv1146 Rv1146 |
- |
transmembrane transport protein | Transmembrane transport protein. Pfam: MMPL (PF03176.22). | MMPL |
Resolved |
| Rv1147 Rv1147 |
mtbc0_001232 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Family assigned |
| Rv1148c Rv1148c |
- |
hypothetical protein | Contains DUF222 (PF02720.23), HNH (PF01844.30) domain(s); putative function inferred from the domain architecture. | DUF222 HNH |
Family assigned |
| Rv1149 Rv1149 |
- |
transposase | Transposase. | DUF4096 |
Resolved |
| cobB Rv1151c |
mtbc0_001237 |
NAD-dependent protein deacylase | NAD-dependent protein deacylase. Pfam: SIR2 (PF02146.24). | SIR2 |
Resolved |
| Rv1152 Rv1152 |
mtbc0_001238 |
transcriptional regulator | GntR family transcriptional regulator. Pfam: GntR (PF00392.28). | GntR |
Family assigned |
| omt Rv1153c |
mtbc0_001239 |
O-methyltransferase | Class I SAM-dependent methyltransferase. Pfam: LCM (PF04072.21). | LCM |
Resolved |
| Rv1154c Rv1154c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 2hiy-assembly1_B The structure of conserved bacterial protein SP0830 from Strept (prob 1.00, TM 0.79). Structure-based, putative. | DUF1697 |
Family assigned |
| Rv1155 Rv1155 |
mtbc0_001241 |
pyridoxine/pyridoxamine 5'-phosphate oxidase | PPOX class F420-dependent oxidoreductase. Pfam: PNPOx_N (PF01243.28). | PNPOx_N |
Resolved |
| Rv1155a Rv1155a |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5302. Function unknown. | DUF5302 |
Still unknown |