Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3354 Rv3354 |
mtbc0_003569 |
hypothetical protein | Secreted protein kinase effector that targets the host COP9 signalosome to suppress apoptosis. RefSeq leaves it 'hypothetical'. Rv3354 is secreted into mononuclear phagocytes and is required for virulence; it targets the JAMM metalloprotease domain of COP9-signalosome subunit 5 (CSN5), destabilising cullin-RING ubiquitin-ligase activity and suppressing apoptosis (Danelishvili 2014). A secreted protein with a signal sequence conserved in M. leprae. | DUF732 |
Resolved |
| Rv3360 Rv3360 |
mtbc0_003575 |
hypothetical protein | FHA domain-containing protein. Pfam: FHA (PF00498.32). | FHA |
Family assigned |
| mfpA Rv3361c |
mtbc0_003576 |
hypothetical protein | Pentapeptide repeat protein MfpA. Pfam: Pentapeptide_3 (PF13576.13), Pentapeptide (PF00805.29). | Pentapeptide_3 Pentapeptide |
Resolved |
| Rv3363c Rv3363c |
mtbc0_003578 |
hypothetical protein | MarR-family DNA-binding transcriptional regulator (eggNOG COG1846, transcription COG category K). A winged-HTH transcriptional regulator; regulon undetermined. | DUF742 |
Family assigned |
| Rv3364c Rv3364c |
mtbc0_003579 |
hypothetical protein | Serine protease inhibitor. Pfam: Robl_LC7 (PF03259.24). | Robl_LC7 |
Resolved |
| Rv3365c Rv3365c |
mtbc0_003580 |
hypothetical protein | Sensor histidine kinase. Pfam: DUF8316 (PF26990.1), HATPase_c (PF02518.32). | DUF8316 HATPase_c |
Resolved |
| Rv3369 Rv3369 |
- |
hypothetical protein | Contains PNPOx_N (PF01243.28) domain(s); putative function inferred from the domain architecture. | PNPOx_N |
Family assigned |
| Rv3394c Rv3394c |
mtbc0_003606 |
hypothetical protein | DNA polymerase Y family protein. Pfam: IMS (PF00817.26). | IMS |
Family assigned |
| Rv3395c Rv3395c |
mtbc0_003607 |
hypothetical protein | Contains MT3502_N (PF27531.1), Rv3395c_C (PF27314.1) domain(s); putative function inferred from the domain architecture. | MT3502_N Rv3395c_C |
Family assigned |
| Rv3402c Rv3402c |
mtbc0_003616 |
hypothetical protein | DegT/DnrJ/EryC1/StrS family aminotransferase. Pfam: DegT_DnrJ_EryC1 (PF01041.24). | DegT_DnrJ_EryC1 |
Family assigned |
| Rv3403c Rv3403c |
mtbc0_003617 |
hypothetical protein | FAD/NAD(P)-binding protein. Pfam: NAD_binding_9 (PF13454.13). | NAD_binding_9 |
Family assigned |
| Rv3404c Rv3404c |
mtbc0_003618 |
hypothetical protein | DTDP-4-amino-4%2C6-dideoxyglucose formyltransferase. Pfam: Formyl_trans_N (PF00551.25), N_formyltrans_C (PF18216.7). | Formyl_trans_N N_formyltrans_C |
Resolved |
| Rv3412 Rv3412 |
mtbc0_003626 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5319. Function unknown. | DUF5319 |
Still unknown |
| Rv3415c Rv3415c |
mtbc0_003629 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rsv-assembly1_A Rap from bacteriophage Phi3T in presence of pheromone RRGHTAS (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| tsaB Rv3421c |
mtbc0_003635 |
hypothetical protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB. Pfam: TsaD (PF00814.32). | TsaD |
Family assigned |
| Rv3424c Rv3424c |
mtbc0_003639 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3430a Rv3430a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3438 Rv3438 |
mtbc0_003657 |
hypothetical protein | Alpha/beta-hydrolase-FOLD protein of the dienelactone-hydrolase / cutinase-like branch: the AlphaFold model matches a polyester hydrolase, GlacPETase (TM 0.78), and an LCC-type cutinase (TM 0.73); eggNOG describes the group as 'dienelactone hydrolase'. Putative hydrolase — fold-level only, no verified catalytic triad, no publication on this locus. | Family assigned | |
| Rv3439c Rv3439c |
mtbc0_003658 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-PE-PPE superfamily protein associated with the Type VII (ESX) secretion system; conserved four-helical-bundle/WXG domain within a large (467 aa) protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3440c Rv3440c |
mtbc0_003659 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5los-assembly1_A Piriformospora indica PIIN_05872 (prob 0.96, TM 0.86). Structure-based, putative. | Family assigned | |
| Rv3446c Rv3446c |
mtbc0_003665 |
hypothetical protein | Type VII secretion-associated protein. | Family assigned | |
| Rv3463 Rv3463 |
mtbc0_003681 |
hypothetical protein | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv3466 Rv3466 |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv3467 Rv3467 |
- |
hypothetical protein | HNH-family endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| Rv3471c Rv3471c |
- |
hypothetical protein | Contains Cupin_2 (PF07883.18) domain(s); putative function inferred from the domain architecture. | Cupin_2 |
Family assigned |
| Rv3472 Rv3472 |
mtbc0_003689 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_4 (PF13577.13), DUF4440 (PF14534.13). | SnoaL_4 DUF4440 |
Family assigned |
| Rv3483c Rv3483c |
mtbc0_003698 |
hypothetical protein | LppP/LprE family lipoprotein. Pfam: Lipoprotein_21 (PF14041.12). | Lipoprotein_21 |
Family assigned |
| cpsA Rv3484 |
mtbc0_003699 |
hypothetical protein | LCP family protein. Pfam: LytR_cpsA_psr (PF03816.20), LytR_C (PF13399.12). | LytR_cpsA_psr LytR_C |
Family assigned |
| Rv3486 Rv3486 |
mtbc0_003701 |
hypothetical protein | DoxX family protein. Pfam: DoxX (PF07681.18). | DoxX |
Family assigned |
| Rv3488 Rv3488 |
mtbc0_003703 |
hypothetical protein | PadR family transcriptional regulator. Pfam: PadR (PF03551.21). | PadR |
Family assigned |
| Rv3489 Rv3489 |
mtbc0_003704 |
hypothetical protein | Conserved protein co-transcribed with otsA (trehalose-6-phosphate synthase) under purifying selection. Contextual candidate: associated with trehalose biosynthesis / metabolism. Its molecular role is not established. | Family assigned | |
| Rv3491 Rv3491 |
mtbc0_003706 |
hypothetical protein | Membrane-anchored protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard); ligand/partner undetermined RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3510c Rv3510c |
mtbc0_003725 |
hypothetical protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |
| Rv3517 Rv3517 |
mtbc0_003733 |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| Rv3519 Rv3519 |
mtbc0_003735 |
hypothetical protein | Acetoacetate decarboxylase family protein. Pfam: ADC (PF06314.17). | ADC |
Family assigned |
| Rv3521 Rv3521 |
- |
hypothetical protein | Contains OB_ChsH2_C (PF01796.24) domain(s); putative function inferred from the domain architecture. | OB_ChsH2_C |
Family assigned |
| Rv3527 Rv3527 |
mtbc0_003743 |
hypothetical protein | Candidate accessory of the cholesterol-catabolism module and, more specifically, a candidate ferredoxin / iron-sulfur electron-transfer partner of the KshAB 3-ketosteroid 9alpha-hydroxylase. Rv3527 is the immediate genomic neighbour of kshA (Rv3526), co-occurs phylogenetically with the KstR1 ring-degradation regulon, and is under purifying selection on 145,209 MTBC genomes (6 segregating sites; a real, conserved gene). Structure-based refinement: of its 25 nearest ESM-Atlas neighbours, 11 are annotated as ferredoxins, and the protein carries a Cys78-x-x-Cys81 motif plus distal cysteines (Cys38/Cys107/Cys126) compatible with an Fe-S cluster. Because KshA is a Rieske [2Fe-2S] monooxygenase that depends on electron transfer, an electron-transfer ferredoxin role is mechanistically coherent. A guilt-by-association plus structural-homology hypothesis; the molecular function (electron transfer to KshAB) remains experimentally undemonstrated, so the verdict is kept 'dark'. Decisive test: co-folding Rv3527 with KshA/KshB (AlphaFold-multimer). | Family assigned | |
| Rv3528c Rv3528c |
mtbc0_003744 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 7pga-assembly2_D Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions (prob 1.00, TM 0.55). Structure-based, putative. | Family assigned | |
| Rv3529c Rv3529c |
mtbc0_003746 |
hypothetical protein | TLR2-mediated response inhibitor. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| Rv3531c Rv3531c |
mtbc0_003748 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 3u07-assembly2_B Crystal Structure of the VPA0106 protein from Vibrio parahaemol (prob 1.00, TM 0.41). Structure-based, putative. | Family assigned | |
| chsH1 Rv3541c |
mtbc0_003758 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit beta ChsH1. | Family assigned | |
| chsH2 Rv3542c |
mtbc0_003759 |
hypothetical protein | 3-oxo-23%2C24-bisnorchol-4%2C17(20)-dien-22-oyl-CoA hydratase subunit alpha ChsH2. Pfam: FAS1_DH_region (PF13452.12), OB_ChsH2_C (PF01796.24). | FAS1_DH_region OB_ChsH2_C |
Family assigned |
| Rv3555c Rv3555c |
mtbc0_003772 |
hypothetical protein | DUF559 domain-containing protein. Pfam: AbiEi_1 (PF09407.17), DUF559 (PF04480.19). | AbiEi_1 DUF559 |
Family assigned |
| Rv3566A Rv3566A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8xt2-assembly1_Lg Cryo-EM structure of the human 55S mitoribosome with (prob 0.01, TM 0.22). | Still unknown | |
| Rv3572 Rv3572 |
mtbc0_003791 |
hypothetical protein | Candidate accessory component of the cholesterol-catabolism module, coupled to the 3-ketosteroid 9alpha-hydroxylase sub-module (KshB, Rv3571). Rv3572 is the immediate genomic neighbour of kshB on H37Rv and is phylogenetically and contextually associated (STRING context-driven, text-mining excluded) with kshB and the ring-degradation core (hsaB, hsaD, hsaC, hsaA). It is under purifying selection on 145,209 MTBC genomes (3 synonymous / 4 missense segregating sites; a real, conserved gene). No dedicated functional study of Rv3572 exists in the published TB literature. The association to the cholesterol module is strong; the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Family assigned | |
| Rv3577 Rv3577 |
- |
hypothetical protein | Binuclear metallo-beta-lactamase (MBL)-fold metallo-hydrolase of the UPF0173/UlaG family (InterPro IPR050114), substrate unassigned. RefSeq leaves it 'hypothetical protein'. The MBL HxHxDH motif (His74-His76-Asp78-His79) was confirmed as a genuine two-metal centre by co-folding the chain with two metal ions on AlphaFold Server (independent Zn and Fe jobs, top model iPTM 0.98): the ions bind a single bridged binuclear site 3.2-3.4 A apart, partitioned into a three-histidine metal (His74/His76/His137) and an aspartate-plus-two-histidine metal (Asp78/His79/His235), with identical geometry for Zn or Fe. HHpred top hits (>=99.8%) are UPF0173/UlaG metal-dependent hydrolases (UlaG 2wyl; COG2220). The fold-paralogue safeguard withholds the RNase Z (held by Rv2407) and glyoxalase II (Rv0634c/Rv2581c) labels: only the fold-level family is claimed. The six metal ligands are effectively invariant across ~250,724 genomes (most frequent non-synonymous ligand variant 0.0032%). A structural prediction, not a biochemical assay. | Resolved | |
| Rv3594 Rv3594 |
mtbc0_003813 |
hypothetical protein | N-acetylmuramoyl-L-alanine amidase. Pfam: Amidase_2 (PF01510.31), Rv3766_C (PF27131.1). | Amidase_2 Rv3766_C |
Resolved |
| Rv3599c Rv3599c |
|
Hypothetical short protein | — | Still unknown | |
| Rv3603c Rv3603c |
mtbc0_003821 |
hypothetical protein | Rossmann-like and DUF2520 domain-containing protein. Pfam: Rossmann-like (PF10727.16), F420_oxidored (PF03807.24), DUF2520 (PF10728.15). | Rossmann-like F420_oxidored DUF2520 |
Family assigned |
| Rv3605c Rv3605c |
mtbc0_003823 |
hypothetical protein | Polytopic integral membrane protein with 4 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3180 |
Family assigned |