Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3412 Rv3412 |
mtbc0_003626 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5319. Function unknown. | DUF5319 |
Still unknown |
| rsdA Rv3413c |
mtbc0_003627 |
anti-sigma-D factor RsdA | Anti-sigma D factor RsdA. Pfam: RsdA_SigD_bd (PF16751.11). | RsdA_SigD_bd |
Resolved |
| sigD Rv3414c |
- |
ECF RNA polymerase sigma factor SigD | ECF RNA polymerase sigma factor SigD. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Resolved |
| Rv3415c Rv3415c |
mtbc0_003629 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rsv-assembly1_A Rap from bacteriophage Phi3T in presence of pheromone RRGHTAS (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| whiB3 Rv3416 |
mtbc0_003630 |
redox-responsive transcriptional regulator WhiB3 | Redox-responsive transcriptional regulator WhiB3. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| groEL1 Rv3417c |
mtbc0_003631 |
chaperonin GroEL | Chaperonin GroEL. Pfam: Cpn60_TCP1 (PF00118.30). | Cpn60_TCP1 |
Resolved |
| groES Rv3418c |
- |
chaperonin GroES | Chaperonin GroES. Pfam: Cpn10 (PF00166.27). | Cpn10 |
Resolved |
| gcp Rv3419c |
mtbc0_003633 |
O-sialoglycoprotein endopeptidase | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD. Pfam: TsaD (PF00814.32), HypF_C_2 (PF22521.3). | TsaD HypF_C_2 |
Family assigned |
| rimI Rv3420c |
mtbc0_003634 |
ribosomal-protein-alanine acetyltransferase RimI | Ribosomal protein S18-alanine N-acetyltransferase. Pfam: Acetyltransf_1 (PF00583.32), Acetyltransf_10 (PF13673.14), Acetyltransf_7 (PF13508.14), FR47 (PF08445.17). | Acetyltransf_1 Acetyltransf_10 Acetyltransf_7 FR47 |
Resolved |
| tsaB Rv3421c |
mtbc0_003635 |
hypothetical protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB. Pfam: TsaD (PF00814.32). | TsaD |
Family assigned |
| tsaE Rv3422c |
mtbc0_003636 |
tRNA threonylcarbamoyladenosine biosynthesis protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE. Pfam: TsaE (PF02367.24). | TsaE |
Family assigned |
| alr Rv3423c |
- |
alanine racemase | Alanine racemase. Pfam: Ala_racemase_N (PF01168.27), Ala_racemase_C (PF00842.28). | Ala_racemase_N Ala_racemase_C |
Resolved |
| Rv3424c Rv3424c |
mtbc0_003639 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PPE57 Rv3425 |
- |
PPE family protein PPE57 | PPE family protein PPE57. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| PPE58 Rv3426 |
- |
PPE family protein PPE58 | PPE family protein PPE58. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| istB Rv3427c |
mtbc0_003642 |
transposase | IS21-like element ISMt2 family helper ATPase IstB. Pfam: IstB_IS21 (PF01695.24), Bac_DnaA (PF00308.25), AAA (PF00004.36). | IstB_IS21 Bac_DnaA AAA |
Family assigned |
| Rv3428c Rv3428c |
- |
transposase | Transposase. Pfam: rve (PF00665.33), Mu-transpos_C_2 (PF22483.3). | rve Mu-transpos_C_2 |
Resolved |
| PPE59 Rv3429 |
- |
PPE family protein PPE59 | PPE family protein PPE59. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| Rv3430a Rv3430a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3430c Rv3430c |
- |
transposase | Transposase. Pfam: rve (PF00665.33), rve_3 (PF13683.13). | rve rve_3 |
Resolved |
| gadB Rv3432c |
mtbc0_003651 |
glutamate decarboxylase GadB | Glutamate decarboxylase. Pfam: Pyridoxal_deC (PF00282.26). | Pyridoxal_deC |
Resolved |
| Rv3433c Rv3433c |
mtbc0_003652 |
bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase | NAD(P)H-hydrate dehydratase. Pfam: YjeF_N (PF03853.22), Carb_kinase (PF01256.23). | YjeF_N Carb_kinase |
Resolved |
| Rv3434c Rv3434c |
mtbc0_003653 |
transmembrane protein | Rhomboid-like protein. Pfam: Rhomboid_2 (PF20401.4). | Rhomboid_2 |
Family assigned |
| Rv3435c Rv3435c |
mtbc0_003654 |
transmembrane protein | Cell-wall-associated virulence protein, conserved in pathogenic but not non-pathogenic mycobacteria. RefSeq leaves it of unknown function. Heterologous expression shows Rv3435c is a cell-wall-related protein that alters colony morphology and fatty-acid levels, enhances stress resistance, inhibits inflammatory-cytokine secretion and host-cell apoptosis, and promotes intramacrophage/in-vivo survival (Zhao 2023, Liu 2025). Molecular function unfixed. | DUF4436 |
Family assigned |
| glmS Rv3436c |
mtbc0_003655 |
glucosamine--fructose-6-phosphate aminotransferase | Glutamine--fructose-6-phosphate transaminase (isomerizing). Pfam: GATase_6 (PF13522.12), GATase_7 (PF13537.12), SIS (PF01380.28). | GATase_6 GATase_7 SIS |
Resolved |
| Rv3437 Rv3437 |
mtbc0_003656 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF2510. Function unknown. | DUF2510 |
Still unknown |
| Rv3438 Rv3438 |
mtbc0_003657 |
hypothetical protein | Alpha/beta hydrolase. | Family assigned | |
| Rv3439c Rv3439c |
mtbc0_003658 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-PE-PPE superfamily protein associated with the Type VII (ESX) secretion system; conserved four-helical-bundle/WXG domain within a large (467 aa) protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3440c Rv3440c |
mtbc0_003659 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5los-assembly1_A Piriformospora indica PIIN_05872 (prob 0.96, TM 0.86). Structure-based, putative. | Family assigned | |
| mrsA Rv3441c |
mtbc0_003660 |
phosphoglucosamine mutase | Phosphoglucosamine mutase. Pfam: PGM_PMM_I (PF02878.23), PGM_PMM_II (PF02879.23), PGM_PMM_III (PF02880.23), PGM_PMM_IV (PF00408.27). | PGM_PMM_I PGM_PMM_II PGM_PMM_III PGM_PMM_IV |
Resolved |
| rpsI Rv3442c |
mtbc0_003661 |
30S ribosomal protein S9 | 30S ribosomal protein S9. Pfam: Ribosomal_S9 (PF00380.26). | Ribosomal_S9 |
Resolved |
| rplM Rv3443c |
mtbc0_003662 |
50S ribosomal protein L13 | 50S ribosomal protein L13. Pfam: Ribosomal_L13 (PF00572.25). | Ribosomal_L13 |
Resolved |
| esxT Rv3444c |
mtbc0_003663 |
ESAT-6 like protein EsxT | WXG100 family type VII secretion target. Pfam: WXG100 (PF06013.19). | WXG100 |
Family assigned |
| esxU Rv3445c |
mtbc0_003664 |
ESAT-6 like protein EsxU | Type VII secretion system ESX-4 protein EsxU. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| Rv3446c Rv3446c |
mtbc0_003665 |
hypothetical protein | Type VII secretion-associated protein. | Family assigned | |
| eccC4 Rv3447c |
mtbc0_003666 |
ESX-4 secretion system protein EccC4 | Type VII secretion system ESX-4 FtsK/SpoIIIE family ATPase EccC4. Pfam: FtsK_SpoIIIE (PF01580.25). | FtsK_SpoIIIE |
Family assigned |
| eccD4 Rv3448 |
mtbc0_003667 |
ESX-4 secretion system protein EccD4 | Type VII secretion system ESX-4 subunit EccD4. Pfam: YukD (PF08817.17), EccD (PF19053.7). | YukD EccD |
Family assigned |
| mycP4 Rv3449 |
mtbc0_003668 |
membrane-anchored mycosin | Type VII secretion system ESX-4 serine protease mycosin MycP4. Pfam: Peptidase_S8 (PF00082.28). | Peptidase_S8 |
Resolved |
| eccB4 Rv3450c |
mtbc0_003669 |
ESX-4 secretion system protein EccB4 | Type VII secretion system ESX-4 subunit EccB4. Pfam: T7SS_ESX1_EccB (PF05108.19). | T7SS_ESX1_EccB |
Family assigned |
| cut3 Rv3451 |
mtbc0_003670 |
cutinase | Cutinase family protein. Pfam: Cutinase (PF01083.29). | Cutinase |
Family assigned |
| cut4 Rv3452 |
mtbc0_003671 |
cutinase | Cutinase Cut4. Pfam: Cutinase (PF01083.29). | Cutinase |
Resolved |
| truA Rv3455c |
- |
tRNA pseudouridine synthase A | TRNA pseudouridine synthase A. Pfam: PseudoU_synth_1 (PF01416.26). | PseudoU_synth_1 |
Resolved |
| rplQ Rv3456c |
mtbc0_003674 |
50S ribosomal protein L17 | 50S ribosomal protein L17. Pfam: Ribosomal_L17 (PF01196.25). | Ribosomal_L17 |
Resolved |
| rpoA Rv3457c |
mtbc0_003675 |
DNA-directed RNA polymerase subunit alpha | DNA-directed RNA polymerase subunit alpha. Pfam: RNA_pol_L (PF01193.30), RNA_pol_A_bac (PF01000.32), RNA_pol_A_CTD (PF03118.22). | RNA_pol_L RNA_pol_A_bac RNA_pol_A_CTD |
Family assigned |
| rpsD Rv3458c |
mtbc0_003676 |
30S ribosomal protein S4 | 30S ribosomal protein S4. Pfam: Ribosomal_S4 (PF00163.25), S4 (PF01479.31). | Ribosomal_S4 S4 |
Resolved |
| rpsK Rv3459c |
mtbc0_003677 |
30S ribosomal protein S11 | 30S ribosomal protein S11. Pfam: Ribosomal_S11 (PF00411.25). | Ribosomal_S11 |
Resolved |
| rpsM Rv3460c |
mtbc0_003678 |
30S ribosomal protein S13 | 30S ribosomal protein S13. Pfam: Ribosomal_S13 (PF00416.28). | Ribosomal_S13 |
Resolved |
| rpmJ Rv3461c |
mtbc0_003679 |
50S ribosomal protein L36 | 50S ribosomal protein L36. Pfam: Ribosomal_L36 (PF00444.24). | Ribosomal_L36 |
Resolved |
| infA Rv3462c |
- |
translation initiation factor IF-1 | Translation initiation factor IF-1. Pfam: eIF-1a (PF01176.26). | eIF-1a |
Resolved |
| Rv3463 Rv3463 |
mtbc0_003681 |
hypothetical protein | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |