Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pfkA Rv3010c |
mtbc0_003199 |
6-phosphofructokinase | ATP-dependent 6-phosphofructokinase. Pfam: PFK (PF00365.26). | PFK |
Resolved |
| gatA Rv3011c |
mtbc0_003200 |
glutamyl-tRNA(GLN) amidotransferase subunit A | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA. Pfam: Amidase (PF01425.27). | Amidase |
Family assigned |
| gatC Rv3012c |
mtbc0_003201 |
glutamyl-tRNA(GLN) amidotransferase subunit C | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC. Pfam: GatC (PF02686.21). | GatC |
Family assigned |
| Rv3013 Rv3013 |
mtbc0_003202 |
hypothetical protein | RelA/SpoT-homolog (RSH) family protein (eggNOG COG0317, signal-transduction COG category KT): a (p)ppGpp-metabolism / small-alarmone-synthetase-domain protein. The auto-curation mislabelled it "amino acid-binding protein"; the COG0317 orthology specifically places it in the RelA/SpoT (p)ppGpp synthetase/hydrolase family. At 218 aa it is distinct from the two characterised M. tuberculosis bifunctional synthetases Rel (Rv2583c, 790 aa) and RelZ (RNase-HII-fused, ~500 aa); a candidate additional (p)ppGpp-metabolism enzyme / SAS, role (synthetase vs hydrolase) undetermined. | Family assigned | |
| ligA Rv3014c |
mtbc0_003203 |
DNA ligase A | NAD-dependent DNA ligase LigA. Pfam: Nlig-Ia (PF22745.3), DNA_ligase_aden (PF01653.24), OB_DNA_ligase (PF03120.23), DNA_ligase_ZBD (PF03119.22), HHH_2 (PF12826.14), HHH_5 (PF14520.13), HHH (PF00633.30), BRCT (PF00533.34), PTCB-BRCT (PF12738.14). | Nlig-Ia DNA_ligase_aden OB_DNA_ligase DNA_ligase_ZBD HHH_2 HHH_5 HHH BRCT PTCB-BRCT |
Resolved |
| Rv3015c Rv3015c |
mtbc0_003204 |
hypothetical protein | Methionine synthase. Pfam: Meth_synt_2 (PF01717.25). | Meth_synt_2 |
Resolved |
| lpqA Rv3016 |
mtbc0_003205 |
lipoprotein LpqA | Sensor domain-containing protein. Pfam: PknH_C (PF14032.13). | PknH_C |
Family assigned |
| esxQ Rv3017c |
mtbc0_003206 |
ESAT-6 like protein EsxQ | Type VII secretion system ESX-3 effector EsxQ. | Resolved | |
| PPE46 Rv3018c |
- |
PPE family protein PPE46 | PPE family protein PPE46. Pfam: PPE (PF00823.26), PPE-PPW (PF18878.6). | PPE PPE-PPW |
Family assigned |
| esxR Rv3019c |
mtbc0_003210 |
ESAT-6 like protein EsxR | WXG100 family type VII secretion target. Pfam: WXG100 (PF06013.19). | WXG100 |
Family assigned |
| esxS Rv3020c |
- |
ESAT-6 like protein EsxS | ESAT-6 like protein EsxS. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| PE29 Rv3022A |
- |
PE family protein PE29 | PE family protein PE29. Pfam: PE (PF00934.26). | PE |
Family assigned |
| Rv3023c Rv3023c |
- |
transposase | Transposase. Pfam: Transposase_mut (PF00872.25). | Transposase_mut |
Resolved |
| trmU Rv3024c |
mtbc0_003215 |
tRNA-specific 2-thiouridylase | TRNA 2-thiouridine(34) synthase MnmA. Pfam: tRNA_Me_trans (PF03054.23), ThiI (PF02568.21), tRNA_Me_trans_M (PF20259.4), tRNA_Me_trans_C (PF20258.5). | tRNA_Me_trans ThiI tRNA_Me_trans_M tRNA_Me_trans_C |
Resolved |
| iscS Rv3025c |
mtbc0_003216 |
cysteine desulfurase | Cysteine desulfurase family protein. Pfam: Aminotran_5 (PF00266.26), Beta_elim_lyase (PF01212.28). | Aminotran_5 Beta_elim_lyase |
Family assigned |
| Rv3026c Rv3026c |
mtbc0_003217 |
hypothetical protein | Lysophospholipid acyltransferase family protein. Pfam: Acyltransferase (PF01553.27). | Acyltransferase |
Family assigned |
| Rv3027c Rv3027c |
mtbc0_003218 |
GCN5-like N-acetyltransferase | GNAT family N-acetyltransferase. Pfam: Acetyltransf_5 (PF13444.13). | Acetyltransf_5 |
Family assigned |
| fixB Rv3028c |
mtbc0_003219 |
electron transfer flavoprotein subunit alpha | Electron transfer flavoprotein subunit alpha/FixB family protein. Pfam: ETF (PF01012.28), ETF_alpha (PF00766.26). | ETF ETF_alpha |
Family assigned |
| fixA Rv3029c |
mtbc0_003220 |
electron transfer flavoprotein subunit beta | Electron transfer flavoprotein subunit beta/FixA family protein. Pfam: ETF (PF01012.28). | ETF |
Family assigned |
| Rv3030 Rv3030 |
mtbc0_003221 |
S-adenosylmethionine-dependent methyltransferase | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), Methyltransf_31 (PF13847.13), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19), Methyltransf_12 (PF08242.19). | Methyltransf_23 Methyltransf_31 Methyltransf_25 Methyltransf_11 Methyltransf_12 |
Family assigned |
| Rv3031 Rv3031 |
mtbc0_003222 |
1,4-alpha-glucan-branching protein | Glycoside hydrolase family 57 protein. Pfam: Glyco_hydro_57 (PF03065.21), BE_C (PF09210.17). | Glyco_hydro_57 BE_C |
Family assigned |
| Rv3032 Rv3032 |
mtbc0_003223 |
glycogen synthase | Glycogen synthase. Pfam: Glyco_transf_5 (PF08323.18), Glyco_transf_4 (PF13439.13), Glyco_trans_4_4 (PF13579.13), GT4-conflict (PF20706.4), Glycos_transf_1 (PF00534.27), Glyco_trans_1_4 (PF13692.13), Glyco_trans_1_2 (PF13524.13). | Glyco_transf_5 Glyco_transf_4 Glyco_trans_4_4 GT4-conflict Glycos_transf_1 Glyco_trans_1_4 Glyco_trans_1_2 |
Resolved |
| Rv3032A Rv3032A |
- |
hypothetical protein | Membrane metalloprotease-like fold (YxkI-like). RefSeq leaves it 'hypothetical protein'. | Family assigned | |
| Rv3033 Rv3033 |
mtbc0_003225 |
hypothetical protein | Secreted anti-apoptotic virulence factor. RefSeq leaves it 'hypothetical'. Rv3033 represses the intrinsic (caspase-9-mediated) but not the extrinsic apoptotic pathway in infected macrophages, blocking both mitochondrial cytochrome-c release and ER-stress (PERK) activation, thereby promoting bacillary survival (Zhang 2018). | DUF4333 |
Resolved |
| Rv3034c Rv3034c |
- |
acetyltransferase | Acetyltransferase. Pfam: Hexapep (PF00132.31). | Hexapep |
Resolved |
| Rv3035 Rv3035 |
- |
hypothetical protein | Contains PQQ_2 (PF13360.14) domain(s); putative function inferred from the domain architecture. | PQQ_2 |
Family assigned |
| TB22.2 Rv3036c |
mtbc0_003228 |
hypothetical protein | RsiV family protein. | DUF3298 |
Family assigned |
| Rv3037c Rv3037c |
- |
S-adenosylmethionine-dependent methyltransferase | S-adenosylmethionine-dependent methyltransferase. Pfam: Thump_like (PF18096.7). | Thump_like |
Resolved |
| Rv3038c Rv3038c |
mtbc0_003230 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Ubie_methyltran (PF01209.25), Methyltransf_31 (PF13847.13), Methyltransf_23 (PF13489.13), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). | Ubie_methyltran Methyltransf_31 Methyltransf_23 Methyltransf_11 Methyltransf_25 Methyltransf_12 |
Family assigned |
| echA17 Rv3039c |
mtbc0_003231 |
enoyl-CoA hydratase EchA17 | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| Rv3040c Rv3040c |
mtbc0_003232 |
hypothetical protein | NUDIX hydrolase. | Resolved | |
| Rv3041c Rv3041c |
mtbc0_003233 |
ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13). | ABC_tran AAA_21 |
Family assigned |
| serB2 Rv3042c |
mtbc0_003234 |
phosphoserine phosphatase SerB | Phosphoserine phosphatase SerB. Pfam: ACT_6 (PF13740.13), ACT_PSP_2 (PF21086.4), Hydrolase (PF00702.33), HAD (PF12710.14), Hydrolase_3 (PF08282.19). | ACT_6 ACT_PSP_2 Hydrolase HAD Hydrolase_3 |
Resolved |
| ctaD Rv3043c |
mtbc0_003235 |
cytochrome C oxidase cytochrome 1 | Cytochrome c oxidase subunit I. Pfam: COX1 (PF00115.26). | COX1 |
Family assigned |
| fecB Rv3044 |
mtbc0_003236 |
FeIII-dicitrate-binding periplasmic lipoprotein | Iron-siderophore ABC transporter substrate-binding protein. Pfam: Peripla_BP_2 (PF01497.24). | Peripla_BP_2 |
Family assigned |
| adhC Rv3045 |
mtbc0_003237 |
NADP-dependent alcohol dehydrogenase | NAD(P)-dependent alcohol dehydrogenase. Pfam: ADH_N (PF08240.18), ADH_zinc_N (PF00107.33). | ADH_N ADH_zinc_N |
Resolved |
| Rv3046c Rv3046c |
mtbc0_003238 |
hypothetical protein | Member of the DUF3349 (PF11829) protein superfamily, predominant in Mycobacterium and Rhodococcus. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes on the solved DUF3349 structure MSMEG_1053 (PDB 2lky; Foldseek prob 1.0, E 2e-4), a five-alpha-helix bundle; same superfamily as Rv0543c (already curated). Genus-restricted fold of unknown biochemical function. | DUF3349 |
Family assigned |
| Rv3047c Rv3047c |
mtbc0_003239 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5y5z-assembly1_Y V/A-type ATPase/synthase from Thermus thermophilus, r (prob 0.06, TM 0.40). | Still unknown | |
| nrdF2 Rv3048c |
- |
ribonucleoside-diphosphate reductase subunit beta NrdF2 | Ribonucleoside-diphosphate reductase subunit beta NrdF2. Pfam: Ribonuc_red_sm (PF00268.28). | Ribonuc_red_sm |
Family assigned |
| Rv3049c Rv3049c |
mtbc0_003241 |
monooxygenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: FMO-like (PF00743.26), Pyr_redox_3 (PF13738.13), NAD_binding_8 (PF13450.13), Lys_Orn_oxgnase (PF13434.13). | FMO-like Pyr_redox_3 NAD_binding_8 Lys_Orn_oxgnase |
Resolved |
| Rv3050c Rv3050c |
mtbc0_003242 |
AsnC family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| nrdE Rv3051c |
- |
ribonucleoside-diphosphate reductase subunit alpha | Ribonucleoside-diphosphate reductase subunit alpha. Pfam: RNR_N (PF08343.16), Ribonuc_red_lgN (PF00317.27), Ribonuc_red_lgC (PF02867.21). | RNR_N Ribonuc_red_lgN Ribonuc_red_lgC |
Family assigned |
| nrdI Rv3052c |
mtbc0_003244 |
NrdI protein | Class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI. Pfam: Flavodoxin_NdrI (PF07972.17). | Flavodoxin_NdrI |
Resolved |
| nrdH Rv3053c |
mtbc0_003245 |
glutaredoxin electron transport protein NrdH | Redoxin NrdH. Pfam: Glutaredoxin (PF00462.31). | Glutaredoxin |
Resolved |
| Rv3054c Rv3054c |
mtbc0_003246 |
hypothetical protein | NADPH-dependent FMN reductase. Pfam: FMN_red (PF03358.21), Flavodoxin_2 (PF02525.23). | FMN_red Flavodoxin_2 |
Resolved |
| Rv3055 Rv3055 |
mtbc0_003247 |
TetR family transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| dinP Rv3056 |
mtbc0_003248 |
DNA polymerase IV 2 | DNA polymerase IV. Pfam: IMS (PF00817.26), IMS_C (PF11799.14). | IMS IMS_C |
Resolved |
| Rv3057c Rv3057c |
mtbc0_003249 |
short chain alcohol dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13). | adh_short KR Epimerase adh_short_C2 |
Family assigned |
| Rv3058c Rv3058c |
mtbc0_003250 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), EthR_C (PF21313.3). | TetR_N EthR_C |
Family assigned |
| cyp136 Rv3059 |
mtbc0_003251 |
cytochrome P450 Cyp136 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |