Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| nuoJ Rv3154 |
mtbc0_003352 |
NADH-quinone oxidoreductase subunit J | NADH-quinone oxidoreductase subunit J. Pfam: Oxidored_q3 (PF00499.26). | Oxidored_q3 |
Family assigned |
| nuoK Rv3155 |
mtbc0_003353 |
NADH-quinone oxidoreductase subunit K | NADH-quinone oxidoreductase subunit NuoK. Pfam: Oxidored_q2 (PF00420.30). | Oxidored_q2 |
Family assigned |
| nuoL Rv3156 |
mtbc0_003354 |
NADH-quinone oxidoreductase subunit L | NADH-quinone oxidoreductase subunit L. Pfam: Proton_antipo_N (PF00662.27), Proton_antipo_M (PF00361.26). | Proton_antipo_N Proton_antipo_M |
Family assigned |
| nuoM Rv3157 |
mtbc0_003355 |
NADH-quinone oxidoreductase subunit M | NADH-quinone oxidoreductase subunit M. Pfam: Proton_antipo_M (PF00361.26). | Proton_antipo_M |
Family assigned |
| nuoN Rv3158 |
mtbc0_003356 |
NADH-quinone oxidoreductase subunit N | NADH-quinone oxidoreductase subunit NuoN. Pfam: Proton_antipo_M (PF00361.26). | Proton_antipo_M |
Family assigned |
| PPE53 Rv3159c |
- |
PPE family protein PPE53 | PPE family protein PPE53. Pfam: PPE (PF00823.26), Pentapeptide_2 (PF01469.25). | PPE Pentapeptide_2 |
Family assigned |
| Rv3160c Rv3160c |
mtbc0_003359 |
TetR family transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv3161c Rv3161c |
mtbc0_003360 |
dioxygenase | Aromatic ring-hydroxylating dioxygenase subunit alpha. Pfam: Rieske (PF00355.33), Ring_hydroxyl_A (PF00848.26). | Rieske Ring_hydroxyl_A |
Family assigned |
| Rv3162c Rv3162c |
mtbc0_003361 |
integral membrane protein | Integral membrane protein. | Family assigned | |
| Rv3163c Rv3163c |
mtbc0_003362 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF58. Function unknown. | DUF58 |
Still unknown |
| moxR3 Rv3164c |
mtbc0_003363 |
methanol dehydrogenase transcriptional regulator MoxR | MoxR family ATPase. Pfam: bpMoxR (PF20030.6), Sigma54_activat (PF00158.33), AAA_3 (PF07726.18), AAA_5 (PF07728.21), AAA (PF00004.36), AAA_lid_2 (PF17863.8). | bpMoxR Sigma54_activat AAA_3 AAA_5 AAA AAA_lid_2 |
Family assigned |
| Rv3165c Rv3165c |
mtbc0_003364 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3166c Rv3166c |
mtbc0_003365 |
hypothetical protein | Cell-surface protein (immuno-EM); its high-activity binding peptides bind A549 and U937 cells and inhibit mycobacterial invasion (by up to 94%), implicating it in host-cell adhesion/invasion. Pfam DUF4129. Molecular function unfixed. | DUF4129 |
Family assigned |
| Rv3167c Rv3167c |
mtbc0_003366 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30), TetR_C_11 (PF16859.11). | TetR_N TetR_C_11 |
Family assigned |
| Rv3168 Rv3168 |
mtbc0_003367 |
aminoglycoside phosphotransferase | Phosphotransferase family protein. Pfam: APH (PF01636.30). | APH |
Family assigned |
| Rv3169 Rv3169 |
mtbc0_003368 |
hypothetical protein | NTF2-like / SnoaL-like superfamily enzyme (polyketide cyclase / steroid-lyase / [4+2]-Diels-Alderase fold). RefSeq leaves it 'hypothetical protein'. Strongest match to 25-phosphosteroid lyase (steroid/cholesterol degradation); a candidate steroid/lipid-processing lyase-cyclase, though the precise substrate within this functionally diverse superfamily is undetermined. RefSeq leaves this locus uncharacterised. | Family assigned | |
| aofH Rv3170 |
mtbc0_003369 |
flavin-containing monoamine oxidase | Flavin monoamine oxidase family protein. Pfam: DAO (PF01266.31), Pyr_redox_2 (PF07992.21), FAD_binding_2 (PF00890.31), FAD_oxidored (PF12831.14), NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | DAO Pyr_redox_2 FAD_binding_2 FAD_oxidored NAD_binding_8 Amino_oxidase |
Family assigned |
| hpx Rv3171c |
- |
non-heme haloperoxidase Hpx | Non-heme haloperoxidase Hpx. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16), Abhydrolase_6 (PF12697.14), Abhydrolase_4 (PF08386.17). | Abhydrolase_1 Hydrolase_4 Abhydrolase_6 Abhydrolase_4 |
Resolved |
| Rv3172c Rv3172c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7s5n-assembly2_D Crystal Structure of a Putative uncharacterized prote (prob 1.00, TM 0.93). | Still unknown | |
| Rv3173c Rv3173c |
mtbc0_003372 |
TetR/Acr family transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv3174 Rv3174 |
mtbc0_003373 |
short-chain dehydrogenase/reductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), adh_short_C2 (PF13561.13). | adh_short adh_short_C2 |
Family assigned |
| Rv3175 Rv3175 |
mtbc0_003374 |
amidase | Amidase. Pfam: Amidase (PF01425.27). | Amidase |
Resolved |
| mesT Rv3176c |
- |
epoxide hydrolase MesT | Epoxide hydrolase MesT. Pfam: Abhydrolase_6 (PF12697.14), Abhydrolase_1 (PF00561.27). | Abhydrolase_6 Abhydrolase_1 |
Resolved |
| Rv3177 Rv3177 |
mtbc0_003376 |
peroxidase | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Abhydrolase_6 Hydrolase_4 |
Family assigned |
| Rv3178 Rv3178 |
- |
nitroreductase | Nitroreductase. Pfam: F420H2_quin_red (PF04075.21). | F420H2_quin_red |
Resolved |
| Rv3178a Rv3178a |
- |
hypothetical protein | Minimal nucleotidyltransferase of the polymerase-beta-like superfamily (HHpred COG1669 95.7%, E=0.16, with strongly converging hits to putative/minimal nucleotidyltransferases and to MntA-type nucleotidyltransferase antitoxins). Confident fold assignment. Genomic context does NOT support a toxin-antitoxin antitoxin role (Rv3178a is a singleton flanked by a nitroreductase and an AAA ATPase at 239/287 bp, no adjacent toxin), so most likely a standalone nucleotidyltransferase; the precise substrate/acceptor remains undefined. | Resolved | |
| Rv3179 Rv3179 |
mtbc0_003380 |
hypothetical protein | ATP-binding protein. Pfam: AAA_14 (PF13173.13), DUF4143 (PF13635.13). | AAA_14 DUF4143 |
Family assigned |
| Rv3180c Rv3180c |
mtbc0_003381 |
ribonuclease VapC45 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv3181c Rv3181c |
mtbc0_003382 |
antitoxin VapB45 | Type II toxin-antitoxin system Phd/YefM family antitoxin. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Family assigned |
| Rv3182 Rv3182 |
mtbc0_003383 |
hypothetical protein | Type II toxin-antitoxin system RelE/ParE family toxin. Pfam: Gp49 (PF05973.21). | Gp49 |
Family assigned |
| Rv3183 Rv3183 |
mtbc0_003384 |
transcriptional regulator | XRE family transcriptional regulator. Pfam: HTH_37 (PF13744.13), HTH_31 (PF13560.13), HTH_3 (PF01381.29). | HTH_37 HTH_31 HTH_3 |
Family assigned |
| Rv3188 Rv3188 |
mtbc0_003385 |
hypothetical protein | Predicted Xre/MbcA/ParS-type antitoxin, proposed antitoxin of a RES-Xre pair Rv3188-Rv3189. RefSeq names only the toxin-binding-domain protein; the pairing is a structural prediction awaiting experimental confirmation. | Family assigned | |
| Rv3189 Rv3189 |
mtbc0_003386 |
hypothetical protein | RES family NAD+ phosphorylase. Pfam: RES (PF08808.18). | RES |
Family assigned |
| Rv3190A Rv3190A |
- |
hypothetical protein | Tentatively a small DNA-binding module of the ribbon-helix-helix / HTH type: several converging HHpred hits (~72-75%) to ParB C-terminal, the CcdA post-segregation antitoxin, a plasmid ribbon-helix-helix DNA-binding protein and ECF sigma factors. LOW confidence (no hit >95%; the top LOV-domain hit at 91% is a short 18-column match, likely spurious). Flanked by an IS30-family transposase (Rv3191c), so possibly an IS-associated DNA-binding peptide; NOT asserted as a toxin-antitoxin antitoxin (no adjacent toxin). A lead to validate. | Family assigned | |
| Rv3190c Rv3190c |
mtbc0_003387 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3191c Rv3191c |
mtbc0_003390 |
transposase | IS30 family transposase. Pfam: HTH_38 (PF13936.13), HTH_23 (PF13384.13), rve (PF00665.33). | HTH_38 HTH_23 rve |
Family assigned |
| Rv3192 Rv3192 |
- |
hypothetical protein | Contains Bac_luciferase (PF00296.27) domain(s); putative function inferred from the domain architecture. | Bac_luciferase |
Family assigned |
| Rv3193c Rv3193c |
mtbc0_003394 |
transmembrane protein | UPF0182 family protein. | UPF0182 |
Family assigned |
| Rv3194c Rv3194c |
mtbc0_003395 |
hypothetical protein | PDZ domain-containing protein. Pfam: PDZ_2 (PF13180.13), Lon_C (PF05362.20). | PDZ_2 Lon_C |
Family assigned |
| Rv3195 Rv3195 |
mtbc0_003396 |
hypothetical protein | Zinc-dependent metalloprotease. Pfam: Zincin_2 (PF10103.16). | Zincin_2 |
Resolved |
| Rv3196 Rv3196 |
- |
hypothetical protein | Probable ThiF/MoeB/E1-family adenylyltransferase of undetermined substrate; NOT a YcaO heterocyclase. RefSeq leaves it 'hypothetical protein'. A strong Foldseek hit to the cyanobactin heterocyclase TruD (4bs9, query-normalised TM-score 0.72) is a normalised-TM-score artefact: the alignment covers only the N-terminal scaffold (TruD residues 3-321), stops before the YcaO catalytic domain, and the target-normalised TM-score is 0.33 (~38% coverage); none of the YcaO catalytic residues lies in the aligned region. HHpred re-routes it (>=99.9%) to standalone adenylyltransferases (MccB, PaaA) and the ThiF/MoeB/E1-like adenylation superfamily, within which the CxxC pair (C208/C211) matches the MoeB-type zinc motif. A RiPP role is independently improbable (no precursor-peptide cassette, maturation protease, or TfuA in H37Rv). A worked example of the normalised-TM-score trap. | Family assigned | |
| Rv3196A Rv3196A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4jq5-assembly2_H Crystal structure of the human Nup49CCS2+3* coiled-co (prob 0.66, TM 0.87). | Still unknown | |
| Rv3197 Rv3197 |
mtbc0_003399 |
ABC transporter ATP-binding protein | AarF/ABC1/UbiB kinase family protein. Pfam: ABC1 (PF03109.23), APH (PF01636.30). | ABC1 APH |
Family assigned |
| whiB7 Rv3197A |
- |
transcriptional regulator WhiB7 | Transcriptional regulator WhiB7. Pfam: Whib (PF02467.22), AT_hook (PF02178.25). | Whib AT_hook |
Family assigned |
| Rv3198A Rv3198A |
- |
glutaredoxin protein | Glutaredoxin protein. Pfam: Glutaredoxin (PF00462.31). | Glutaredoxin |
Resolved |
| uvrD2 Rv3198c |
mtbc0_003401 |
ATP-dependent DNA helicase UvrD | ATP-dependent DNA helicase UvrD2. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), HRDC (PF00570.29). | UvrD-helicase AAA_19 UvrD_C HRDC |
Resolved |
| nudC Rv3199c |
mtbc0_003403 |
NADH pyrophosphatase | NAD(+) diphosphatase. Pfam: NUDIX-like (PF09296.18), Zn_ribbon_NUD (PF09297.17), NUDIX (PF00293.35). | NUDIX-like Zn_ribbon_NUD NUDIX |
Resolved |
| Rv3200c Rv3200c |
mtbc0_003404 |
transmembrane cation transporter | Potassium channel family protein. Pfam: Ion_trans_2 (PF07885.23), TrkA_N (PF02254.25). | Ion_trans_2 TrkA_N |
Family assigned |
| adnB Rv3201c |
mtbc0_003405 |
ATP-dependent DNA helicase | ATP-dependent DNA helicase AdnB. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), PDDEXK_1 (PF12705.14). | UvrD-helicase AAA_19 UvrD_C PDDEXK_1 |
Resolved |
| Rv3202a Rv3202a |
- |
hypothetical protein | Belongs to a conserved Mycobacterium-specific protein family (Pfam PF29473, the 'Rv3202A family', HHpred 99.6%). This is a self-named family (built from Rv3202A and its homologues) with NO known function, so the assignment confirms it is a genuine conserved family (not a spurious ORF) but the molecular function remains unknown (DUF-like). | Family assigned |