Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| PE16 Rv1430 |
- |
PE family protein PE16 | PE family protein PE16. Pfam: PE (PF00934.26), PE-PPE (PF08237.18). | PE PE-PPE |
Family assigned |
| Rv1431 Rv1431 |
mtbc0_001531 |
hypothetical protein | Polytopic integral membrane protein with 11 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF3556 |
Family assigned |
| Rv1432 Rv1432 |
mtbc0_001532 |
dehydrogenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: FAD_binding_3 (PF01494.26), DAO (PF01266.31), Thi4 (PF01946.24), FAD_oxidored (PF12831.14), NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | FAD_binding_3 DAO Thi4 FAD_oxidored NAD_binding_8 Amino_oxidase |
Resolved |
| ldtMt3 Rv1433 |
mtbc0_001533 |
hypothetical protein | L%2CD-transpeptidase LdtMt3. Pfam: Big_10 (PF17964.8), YkuD (PF03734.20). | Big_10 YkuD |
Resolved |
| Rv1434 Rv1434 |
mtbc0_001534 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| hsr1 Rv1435c |
mtbc0_001535 |
hypothetical protein | Hsr1 (host splicing regulator 1), a secreted virulence factor that disrupts host snRNP biogenesis. RefSeq leaves it 'hypothetical'. Secreted Rv1435c/hsr1 targets specific exon-skipping events and facilitates a direct interaction between Mtb phagosomes and U5 snRNA and SNRPF; genetic deletion reverses the splicing changes and attenuates growth ex vivo and in vivo (Chauhan 2025). | Resolved | |
| gap Rv1436 |
mtbc0_001536 |
glyceraldehyde 3-phosphate dehydrogenase | Type I glyceraldehyde-3-phosphate dehydrogenase. Pfam: Gp_dh_N (PF00044.31), Gp_dh_C (PF02800.26). | Gp_dh_N Gp_dh_C |
Resolved |
| pgk Rv1437 |
mtbc0_001537 |
phosphoglycerate kinase | Phosphoglycerate kinase. Pfam: PGK (PF00162.25). | PGK |
Resolved |
| tpi Rv1438 |
mtbc0_001538 |
triosephosphate isomerase | Triose-phosphate isomerase. Pfam: TIM (PF00121.25). | TIM |
Resolved |
| Rv1439c Rv1439c |
mtbc0_001540 |
hypothetical protein | Nuclear transport factor 2 family protein. Pfam: SnoaL_2 (PF12680.14). | SnoaL_2 |
Family assigned |
| secG Rv1440 |
mtbc0_001541 |
protein-export membrane protein SecG | Preprotein translocase subunit SecG. Pfam: SecG (PF03840.20). | SecG |
Family assigned |
| PE_PGRS26 Rv1441c |
- |
PE-PGRS family protein PE_PGRS26 | PE-PGRS family protein PE_PGRS26. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| bisC Rv1442 |
mtbc0_001543 |
biotin sulfoxide reductase BisC | Molybdopterin guanine dinucleotide-containing S/N-oxide reductase. Pfam: Molybdopterin_N (PF18364.7), Molybdopterin (PF00384.28), Molydop_binding (PF01568.28). | Molybdopterin_N Molybdopterin Molydop_binding |
Resolved |
| Rv1443c Rv1443c |
- |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 1z94-assembly1_A X-Ray Crystal Structure of Protein CV1439 from Chromobacterium (prob 1.00, TM 0.76). Structure-based, putative. | DUF8410 |
Family assigned |
| Rv1444c Rv1444c |
- |
hypothetical protein | Conserved protein co-transcribed with devB (6-phosphogluconolactonase) and opcA (the OpcA glucose-6-phosphate-dehydrogenase assembly/activator) in the oxidative pentose-phosphate operon, under purifying selection. Contextual candidate: associated with the oxidative pentose-phosphate pathway. Its molecular role is not established. | Family assigned | |
| devB Rv1445c |
mtbc0_001547 |
6-phosphogluconolactonase | 6-phosphogluconolactonase. Pfam: Glucosamine_iso (PF01182.27). | Glucosamine_iso |
Resolved |
| opcA Rv1446c |
mtbc0_001548 |
OXPP cycle protein OpcA | Glucose-6-phosphate dehydrogenase assembly protein OpcA. Pfam: OpcA_G6PD_assem (PF10128.16), OpcA_G6PD_C (PF20171.4). | OpcA_G6PD_assem OpcA_G6PD_C |
Resolved |
| zwf2 Rv1447c |
mtbc0_001549 |
glucose-6-phosphate 1-dehydrogenase | Glucose-6-phosphate dehydrogenase. Pfam: G6PD_N (PF00479.29), G6PD_C (PF02781.22). | G6PD_N G6PD_C |
Resolved |
| tal Rv1448c |
mtbc0_001550 |
transaldolase | Transaldolase. Pfam: TAL_FSA (PF00923.26). | TAL_FSA |
Resolved |
| tkt Rv1449c |
mtbc0_001551 |
transketolase | Transketolase. Pfam: Transketolase_N (PF00456.27), Transket_pyr (PF02779.30), Transketolase_C_1 (PF22613.2), Transketolase_C (PF02780.26). | Transketolase_N Transket_pyr Transketolase_C_1 Transketolase_C |
Resolved |
| PE_PGRS27 Rv1450c |
- |
PE-PGRS family protein PE_PGRS27 | PE-PGRS family protein PE_PGRS27. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| ctaB Rv1451 |
mtbc0_001553 |
protoheme IX farnesyltransferase | Heme o synthase. Pfam: UbiA (PF01040.24). | UbiA |
Resolved |
| PE_PGRS28 Rv1452c |
- |
PE-PGRS family protein PE_PGRS28 | PE-PGRS family protein PE_PGRS28. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| Rv1453 Rv1453 |
mtbc0_001555 |
transcriptional activator protein | PucR family transcriptional regulator. Pfam: RsbRD_N (PF14361.13), GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | RsbRD_N GGDEF_2 HTH_30 |
Family assigned |
| qor Rv1454c |
mtbc0_001556 |
quinone reductase | Quinone oxidoreductase. Pfam: ADH_N (PF08240.18), ADH_zinc_N (PF00107.33), ADH_zinc_N_2 (PF13602.13). | ADH_N ADH_zinc_N ADH_zinc_N_2 |
Resolved |
| Rv1455 Rv1455 |
mtbc0_001557 |
hypothetical protein | Contains DcsG_N (PF27100.1) domain(s); putative function inferred from the domain architecture. | DcsG_N |
Family assigned |
| Rv1456c Rv1456c |
mtbc0_001558 |
antibiotic ABC transporter permease | Heme A synthase. Pfam: COX15-CtaA (PF02628.21). | COX15-CtaA |
Resolved |
| Rv1457c Rv1457c |
mtbc0_001559 |
antibiotic ABC transporter permease | ABC transporter permease. Pfam: ABC2_membrane (PF01061.30), ABC2_membrane_3 (PF12698.14). | ABC2_membrane ABC2_membrane_3 |
Family assigned |
| Rv1458c Rv1458c |
mtbc0_001560 |
antibiotic ABC transporter ATP-binding protein | ABC transporter ATP-binding protein. Pfam: ABC_tran (PF00005.34), AAA_21 (PF13304.13). | ABC_tran AAA_21 |
Family assigned |
| mptB Rv1459c |
mtbc0_001561 |
alpha-(1->6)-mannopyranosyltransferase | Polyprenol phosphomannose-dependent alpha 1%2C6 mannosyltransferase MptB. Pfam: MptA_B_family (PF26314.1), MptB_C (PF27547.1). | MptA_B_family MptB_C |
Resolved |
| sufR Rv1460 |
mtbc0_001562 |
transcriptional regulator | Suf operon transcriptional regulator SufR. Pfam: HTH_20 (PF12840.14), HTH_24 (PF13412.13), HTH_5 (PF01022.27), HTH_11 (PF08279.19). | HTH_20 HTH_24 HTH_5 HTH_11 |
Family assigned |
| sufB Rv1461 |
mtbc0_001563 |
hypothetical protein | Intein-containing Fe-S cluster assembly protein SufB. Pfam: SufBD_N (PF19295.6), SUFBD_core (PF01458.24). | SufBD_N SUFBD_core |
Resolved |
| sufD Rv1462 |
mtbc0_001564 |
hypothetical protein | Fe-S cluster assembly protein SufD. Pfam: SUFBD_core (PF01458.24). | SUFBD_core |
Resolved |
| sufC Rv1463 |
mtbc0_001565 |
ABC transporter ATP-binding protein | Fe-S cluster assembly ATPase SufC. Pfam: ABC_tran (PF00005.34). | ABC_tran |
Resolved |
| csd Rv1464 |
mtbc0_001566 |
cysteine desulfurase | Cysteine desulfurase. Pfam: Aminotran_5 (PF00266.26). | Aminotran_5 |
Resolved |
| Rv1465 Rv1465 |
mtbc0_001567 |
nitrogen fixation related protein | SUF system NifU family Fe-S cluster assembly protein. Pfam: NifU_N (PF01592.22). | NifU_N |
Family assigned |
| Rv1466 Rv1466 |
mtbc0_001568 |
hypothetical protein | Metal-sulfur cluster assembly factor. Pfam: FeS_assembly_P (PF01883.25). | FeS_assembly_P |
Resolved |
| fadE15 Rv1467c |
mtbc0_001569 |
acyl-CoA dehydrogenase | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_C (PF12806.13). | Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_C |
Resolved |
| PE_PGRS29 Rv1468c |
- |
PE-PGRS family protein PE_PGRS29 | PE-PGRS family protein PE_PGRS29. Pfam: PE (PF00934.26), PGRS (PF21526.3). | PE PGRS |
Family assigned |
| ctpD Rv1469 |
mtbc0_001571 |
cobalt/nickel-exporting P-type ATPase | Cobalt-translocating P-type ATPase CtpD. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Resolved |
| trxA Rv1470 |
mtbc0_001572 |
thioredoxin TrxA | Thioredoxin family protein. Pfam: Thioredoxin (PF00085.27). | Thioredoxin |
Family assigned |
| trxB1 Rv1471 |
- |
thioredoxin | Thioredoxin. Pfam: Thioredoxin (PF00085.27), Thioredoxin_2 (PF13098.14). | Thioredoxin Thioredoxin_2 |
Resolved |
| echA12 Rv1472 |
mtbc0_001574 |
enoyl-CoA hydratase EchA12 | Enoyl-CoA hydratase. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Resolved |
| Rv1473 Rv1473 |
mtbc0_001575 |
macrolide ABC transporter ATP-binding protein | Macrolide ABC transporter ATP-binding protein. Pfam: ABC_tran_Xtn (PF12848.14), ABC_tran (PF00005.34), AAA_21 (PF13304.13). | ABC_tran_Xtn ABC_tran AAA_21 |
Family assigned |
| Rv1473A Rv1473A |
- |
transcriptional regulator | Transcriptional regulator. Pfam: HTH_58 (PF19575.6). | HTH_58 |
Family assigned |
| Rv1474c Rv1474c |
mtbc0_001577 |
transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| acn Rv1475c |
mtbc0_001578 |
iron-regulated aconitate hydratase | Iron-regulated aconitate hydratase Acn. Pfam: Aconitase (PF00330.26), Aconitase_C (PF00694.26). | Aconitase Aconitase_C |
Resolved |
| Rv1476 Rv1476 |
mtbc0_001579 |
membrane protein | DUF6676 family protein. Pfam: Rv1476 (PF20381.5). | Rv1476 |
Family assigned |
| ripA Rv1477 |
mtbc0_001580 |
peptidoglycan endopeptidase RipA | NlpC/P60 family peptidoglycan endopeptidase RipA. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Family assigned |
| ripB Rv1478 |
mtbc0_001581 |
peptidoglycan endopeptidase RipB | NlpC/P60 family peptidoglycan endopeptidase RipB. Pfam: NLPC_P60 (PF00877.26). | NLPC_P60 |
Family assigned |