Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| pstS1 Rv0934 |
- |
phosphate ABC transporter substrate-binding lipoprotein PstS | Phosphate ABC transporter substrate-binding lipoprotein PstS. Pfam: PBP_like_2 (PF12849.13), SBP_bac_1 (PF01547.31). | PBP_like_2 SBP_bac_1 |
Family assigned |
| pstC1 Rv0935 |
- |
phosphate ABC transporter permease PstC | Phosphate ABC transporter permease PstC. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| pstA2 Rv0936 |
mtbc0_000994 |
phosphate ABC transporter permease PstA | Phosphate ABC transporter permease PstA. Pfam: BPD_transp_1 (PF00528.28). | BPD_transp_1 |
Family assigned |
| mku Rv0937c |
mtbc0_000995 |
non-homologous end joining protein Ku | Ku protein. Pfam: Ku (PF02735.23). | Ku |
Resolved |
| ligD Rv0938 |
mtbc0_000996 |
multifunctional non-homologous end joining DNA repair protein/ATP dependent DNA ligase LigD | ATP-dependent DNA ligase. Pfam: LigD_Prim-Pol (PF21686.4), DNA_primase_S (PF01896.26), LigD_N (PF13298.13), DNA_ligase_A_M (PF01068.27), DNA_ligase_A_C (PF04679.22). | LigD_Prim-Pol DNA_primase_S LigD_N DNA_ligase_A_M DNA_ligase_A_C |
Resolved |
| Rv0939 Rv0939 |
mtbc0_000997 |
bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/cyclase/dehydrase | Fumarylacetoacetate hydrolase family protein. Pfam: FAA_hydrolase (PF01557.24), Lactamase_B (PF00753.34). | FAA_hydrolase Lactamase_B |
Family assigned |
| Rv0940c Rv0940c |
mtbc0_000998 |
oxidoreductase | TIGR03619 family F420-dependent LLM class oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Family assigned |
| Rv0941c Rv0941c |
mtbc0_000999 |
hypothetical protein | STAS domain-containing protein. Pfam: STAS (PF01740.27). | STAS |
Family assigned |
| Rv0942 Rv0942 |
mtbc0_001000 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF8092. Function unknown. Foldseek best (non-significant) hit: 7va4-assembly1_D Telomeric tetranucleosome in open state (prob 0.06, TM 0.28). | DUF8092 |
Still unknown |
| Rv0943c Rv0943c |
mtbc0_001002 |
monooxygenase | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv0944 Rv0944 |
- |
formamidopyrimidine-DNA glycosylase | Formamidopyrimidine-DNA glycosylase. Pfam: H2TH (PF06831.20), zf-FPG_IleRS (PF06827.21). | H2TH zf-FPG_IleRS |
Resolved |
| Rv0945 Rv0945 |
- |
oxidoreductase | Oxidoreductase. Pfam: SDR (PF23441.1), adh_short (PF00106.32), KR (PF08659.17), Epimerase (PF01370.28), adh_short_C2 (PF13561.13). | SDR adh_short KR Epimerase adh_short_C2 |
Resolved |
| pgi Rv0946c |
mtbc0_001009 |
glucose-6-phosphate isomerase | Glucose-6-phosphate isomerase. Pfam: PGI (PF00342.25). | PGI |
Resolved |
| Rv0948c Rv0948c |
mtbc0_001012 |
chorismate mutase | Chorismate mutase. Pfam: CM_2 (PF01817.27). | CM_2 |
Resolved |
| uvrD1 Rv0949 |
- |
ATP-dependent DNA helicase UvrD | ATP-dependent DNA helicase UvrD. Pfam: UvrD-helicase (PF00580.28), AAA_19 (PF13245.13), UvrD_C (PF13361.13), UvrD_C_2 (PF13538.13), PcrA_UvrD_tudor (PF21196.4). | UvrD-helicase AAA_19 UvrD_C UvrD_C_2 PcrA_UvrD_tudor |
Resolved |
| Rv0950c Rv0950c |
mtbc0_001014 |
hypothetical protein | M23 family metallopeptidase. Pfam: Peptidase_M23 (PF01551.30). | Peptidase_M23 |
Family assigned |
| sucC Rv0951 |
mtbc0_001015 |
succinyl-CoA ligase subunit beta | ADP-forming succinate--CoA ligase subunit beta. Pfam: ATP-grasp_2 (PF08442.16), ATP-grasp_5 (PF13549.12), CPSase_L_D2 (PF02786.23), Ligase_CoA (PF00549.25). | ATP-grasp_2 ATP-grasp_5 CPSase_L_D2 Ligase_CoA |
Family assigned |
| sucD Rv0952 |
- |
succinyl-CoA ligase subunit alpha | Succinyl-CoA ligase subunit alpha. Pfam: CoA_binding (PF02629.26), Succ_CoA_lig (PF13607.12), Ligase_CoA (PF00549.25). | CoA_binding Succ_CoA_lig Ligase_CoA |
Family assigned |
| Rv0953c Rv0953c |
mtbc0_001017 |
oxidoreductase | LLM class F420-dependent oxidoreductase. Pfam: Bac_luciferase (PF00296.27). | Bac_luciferase |
Resolved |
| Rv0954 Rv0954 |
mtbc0_001018 |
transmembrane protein | Component of the mycobacterial cell-division complex (divisome). RefSeq leaves this locus 'hypothetical protein'. The previously uncharacterised Rv0954 protein localises to the mid-cell during cell division and interacts with the division-related proteins LamA, PbpA and PknH; transposon mutagenesis shows genetic interactions with cell-division genes, indicating that Rv0954 participates in cell division and is a candidate divisome component (Wang & Ehrt 2021). Also identified as a glycoprotein of the cell envelope. Experimentally characterised. | DUF5336 |
Resolved |
| Rv0955 Rv0955 |
mtbc0_001019 |
integral membrane protein | DUF6350 family protein. Pfam: PerM (PF19877.5). | PerM |
Family assigned |
| purN Rv0956 |
mtbc0_001020 |
phosphoribosylglycinamide formyltransferase PurN | Phosphoribosylglycinamide formyltransferase. Pfam: Formyl_trans_N (PF00551.25). | Formyl_trans_N |
Resolved |
| purH Rv0957 |
mtbc0_001021 |
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosinemonophosphate cyclohydrolase | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. Pfam: MGS (PF02142.28), AICARFT_IMPCHas (PF01808.25). | MGS AICARFT_IMPCHas |
Resolved |
| Rv0958 Rv0958 |
mtbc0_001022 |
magnesium chelatase | ATP-binding protein. Pfam: Sigma54_activat (PF00158.33). | Sigma54_activat |
Family assigned |
| Rv0959 Rv0959 |
mtbc0_001023 |
hypothetical protein | VWA domain-containing protein. Pfam: Mb0984_helical (PF27532.1), Rv0959_3rd (PF27098.1). | Mb0984_helical Rv0959_3rd |
Family assigned |
| vapB9 Rv0959A |
- |
antitoxin VapB9 | Antitoxin VapB9. | Resolved | |
| vapC9 Rv0960 |
mtbc0_001025 |
ribonuclease VapC9 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| Rv0961 Rv0961 |
mtbc0_001026 |
integral membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| lprP Rv0962c |
mtbc0_001027 |
lipoprotein LprP | LppA family lipoprotein. Pfam: LppA (PF16708.11). | LppA |
Family assigned |
| Rv0963c Rv0963c |
- |
hypothetical protein | Contains Abhydrolase_8 (PF06259.19) domain(s); putative function inferred from the domain architecture. | Abhydrolase_8 |
Family assigned |
| Rv0964c Rv0964c |
- |
hypothetical protein | Alpha/beta-hydrolase-fold protein (eggNOG COG1071). RefSeq leaves it 'hypothetical protein'. A hydrolase fold; specific catalytic activity undetermined. | Family assigned | |
| Rv0965c Rv0965c |
mtbc0_001031 |
hypothetical protein | ESX/WXG100-like secreted fold (matches EsxB, PDB 4J7K, TM 0.82); putative ESX-secreted protein. | Family assigned | |
| Rv0966c Rv0966c |
mtbc0_001032 |
hypothetical protein | DUF1707; Foldseek hits non-conclusive (moderate TM). Function unknown. | DUF1707 |
Still unknown |
| csoR Rv0967 |
mtbc0_001033 |
copper-sensing transcriptional repressor CsoR | Copper-sensing transcriptional repressor CsoR. Pfam: Trns_repr_metal (PF02583.23). | Trns_repr_metal |
Resolved |
| Rv0968 Rv0968 |
mtbc0_001034 |
hypothetical protein | DUF1490 family protein. | DUF1490 |
Family assigned |
| ctpV Rv0969 |
mtbc0_001035 |
copper-exporting ATPase | Copper-translocating P-type ATPase. Pfam: E1-E2_ATPase (PF00122.26), Hydrolase (PF00702.33). | E1-E2_ATPase Hydrolase |
Resolved |
| Rv0970 Rv0970 |
mtbc0_001036 |
integral membrane protein | Polytopic membrane protein (6 predicted TM helices) co-transcribed with ctpV, a P-type metal-transporting ATPase (copper), under purifying selection. Contextual candidate: associated with metal (copper) transport / homeostasis. Its molecular role is not established. | DUF5134 |
Family assigned |
| echA7 Rv0971c |
mtbc0_001037 |
enoyl-CoA hydratase EchA7 | Enoyl-CoA hydratase family protein. Pfam: ECH_1 (PF00378.26), ECH_2 (PF16113.11). | ECH_1 ECH_2 |
Family assigned |
| fadE12 Rv0972c |
mtbc0_001038 |
acyl-CoA dehydrogenase fadE12 | Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Resolved |
| accA2 Rv0973c |
mtbc0_001039 |
acetyl/propionyl-CoA carboxylase subuit alpha | Biotin carboxylase N-terminal domain-containing protein. Pfam: Biotin_carb_N (PF00289.29), CPSase_L_D2 (PF02786.23), Dala_Dala_lig_C (PF07478.19), Biotin_carb_C (PF02785.26), BT_MCC_alpha (PF21139.4), Biotin_lipoyl (PF00364.29). | Biotin_carb_N CPSase_L_D2 Dala_Dala_lig_C Biotin_carb_C BT_MCC_alpha Biotin_lipoyl |
Family assigned |
| accD2 Rv0974c |
mtbc0_001040 |
acetyl-/propionyl-CoA carboxylase subunit beta | Acyl-CoA carboxylase subunit beta. Pfam: ACCA (PF03255.20), Carboxyl_trans (PF01039.28). | ACCA Carboxyl_trans |
Family assigned |
| fadE13 Rv0975c |
mtbc0_001041 |
acyl-CoA dehydrogenase FadE13 | Acyl-CoA dehydrogenase family protein. Pfam: Acyl-CoA_dh_N (PF02771.22), Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17). | Acyl-CoA_dh_N Acyl-CoA_dh_M Acyl-CoA_dh_1 Acyl-CoA_dh_2 |
Family assigned |
| Rv0976c Rv0976c |
mtbc0_001042 |
hypothetical protein | Acyclic terpene utilization AtuA family protein. Pfam: AtuA (PF07287.18), AtuA_ferredoxin (PF23544.2). | AtuA AtuA_ferredoxin |
Family assigned |
| PE_PGRS16 Rv0977 |
- |
PE-PGRS family protein PE_PGRS16 | PE-PGRS family protein PE_PGRS16. Pfam: PE (PF00934.26), PGRS (PF21526.3), PE-PGRS_C (PF20729.3). | PE PGRS PE-PGRS_C |
Family assigned |
| PE_PGRS17 Rv0978c |
- |
PE-PGRS family protein PE_PGRS17 | PE-PGRS family protein PE_PGRS17. Pfam: PE (PF00934.26), PGRS (PF21526.3), NHL (PF01436.28). | PE PGRS NHL |
Family assigned |
| rpmF Rv0979A |
- |
50S ribosomal protein L32 | 50S ribosomal protein L32. Pfam: Ribosomal_L32p (PF01783.30). | Ribosomal_L32p |
Resolved |
| Rv0979c Rv0979c |
mtbc0_001047 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 4dqz-assembly1_B Crystal Structure of C-terminal Half of Bacterial Hen (prob 0.20, TM 0.53). | Still unknown | |
| PE_PGRS18 Rv0980c |
- |
PE-PGRS family protein PE_PGRS18 | PE-PGRS family protein PE_PGRS18. Pfam: PE (PF00934.26), PGRS (PF21526.3), NHL (PF01436.28). | PE PGRS NHL |
Family assigned |
| mprA Rv0981 |
mtbc0_001052 |
two-component response regulator MrpA | Two-component system response regulator MprA. Pfam: Response_reg (PF00072.31), Trans_reg_C (PF00486.35). | Response_reg Trans_reg_C |
Resolved |
| mprB Rv0982 |
mtbc0_001053 |
two component histidine-protein kinase/phosphatase MprB | Two-component system sensor histidine kinase MprB. Pfam: HAMP (PF00672.31), HisKA (PF00512.32), HATPase_c (PF02518.32). | HAMP HisKA HATPase_c |
Resolved |