Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2224d Rv2224d |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| panB Rv2225 |
mtbc0_002363 |
3-methyl-2-oxobutanoate hydroxymethyltransferase | 3-methyl-2-oxobutanoate hydroxymethyltransferase. Pfam: Pantoate_transf (PF02548.22). | Pantoate_transf |
Resolved |
| Rv2226 Rv2226 |
mtbc0_002364 |
hypothetical protein | CYTH and CHAD domain-containing protein. Pfam: CYTH (PF01928.27), CHAD (PF05235.20). | CYTH CHAD |
Family assigned |
| Rv2227 Rv2227 |
- |
hypothetical protein | Contains Oxygenase-NA (PF09859.16) domain(s); putative function inferred from the domain architecture. | Oxygenase-NA |
Family assigned |
| Rv2228c Rv2228c |
- |
multifunctional RNASE H/alpha-ribazole phosphatase/acid phosphatase | Multifunctional RNASE H/alpha-ribazole phosphatase/acid phosphatase. Pfam: RNase_H (PF00075.31), RVT_3 (PF13456.13), His_Phos_1 (PF00300.28). | RNase_H RVT_3 His_Phos_1 |
Resolved |
| Rv2229c Rv2229c |
mtbc0_002368 |
hypothetical protein | Zinc ribbon domain-containing protein. Pfam: CT398_CC (PF24481.3), Zn_ribbon_9 (PF02591.21). | CT398_CC Zn_ribbon_9 |
Family assigned |
| Rv2230c Rv2230c |
mtbc0_002369 |
GTP cyclohydrolase | Nif3-like dinuclear metal center hexameric protein. | DUF34_NIF3 |
Resolved |
| vapC16 Rv2231A |
- |
ribonuclease VapC16 | Ribonuclease VapC16. | Resolved | |
| vapB16 Rv2231B |
- |
antitoxin VapB16 | Antitoxin VapB16. | Resolved | |
| cobC Rv2231c |
- |
aminotransferase | Aminotransferase. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Resolved |
| ptkA Rv2232 |
- |
protein tyrosine kinase transcriptional regulator PtkA | Protein tyrosine kinase transcriptional regulator PtkA. Pfam: Hydrolase (PF00702.33), HAD_2 (PF13419.13), HAD (PF12710.14), Hydrolase_like (PF13242.13). | Hydrolase HAD_2 HAD Hydrolase_like |
Family assigned |
| ptpA Rv2234 |
mtbc0_002374 |
protein-tyrosine-phosphatase | Protein-tyrosine-phosphatase. Pfam: LMWPc (PF01451.28). | LMWPc |
Resolved |
| Rv2235 Rv2235 |
mtbc0_002375 |
transmembrane protein | SURF1 family protein. Pfam: SURF1 (PF02104.21). | SURF1 |
Family assigned |
| cobD Rv2236c |
mtbc0_002376 |
cobalamin biosynthesis transmembrane protein CobD | Cobalamin biosynthesis protein. Pfam: CobD_Cbib (PF03186.19). | CobD_Cbib |
Resolved |
| Rv2237 Rv2237 |
- |
hypothetical protein | Contains MPAB_Lcp_cat (PF09995.16) domain(s); putative function inferred from the domain architecture. | MPAB_Lcp_cat |
Family assigned |
| Rv2237A Rv2237A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| ahpE Rv2238c |
mtbc0_002380 |
peroxiredoxin | Peroxiredoxin AhpE. Pfam: AhpC-TSA (PF00578.28), Redoxin (PF08534.17). | AhpC-TSA Redoxin |
Resolved |
| Rv2239c Rv2239c |
- |
hypothetical protein | S-adenosyl-methionine (SAM)-dependent methyltransferase fold. RefSeq leaves it 'hypothetical protein' (Pfam DUF3052). The AlphaFold model superposes on an O-methyltransferase bound to the product SAH (PDB 8bif; Foldseek prob 1.0, E 2e-5, TM 0.55). STRING context: peroxiredoxin ahpE (Rv2238c). A SAM-MTase fold assignment; the acceptor substrate is not determined. | DUF3052 |
Family assigned |
| Rv2240c Rv2240c |
mtbc0_002382 |
hypothetical protein | Contains Rv2240c (PF27150.1) domain(s); putative function inferred from the domain architecture. | Rv2240c |
Family assigned |
| aceE Rv2241 |
- |
pyruvate dehydrogenase E1 component | Pyruvate dehydrogenase E1 component. Pfam: PDH_E1_N (PF28598.1), Transketolase_N (PF00456.27), PDH_E1_M (PF17831.6), Transketolase_C_1 (PF22613.2). | PDH_E1_N Transketolase_N PDH_E1_M Transketolase_C_1 |
Resolved |
| Rv2242 Rv2242 |
mtbc0_002384 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| fabD Rv2243 |
mtbc0_002385 |
malonyl CoA-acyl carrier protein transacylase | Malonyl CoA-acyl carrier protein transacylase. Pfam: Acyl_transf_1 (PF00698.27). | Acyl_transf_1 |
Resolved |
| acpM Rv2244 |
mtbc0_002386 |
meromycolate extension acyl carrier protein | Meromycolate extension acyl carrier protein AcpM. Pfam: PP-binding (PF00550.32). | PP-binding |
Resolved |
| kasA Rv2245 |
mtbc0_002387 |
3-oxoacyl-ACP synthase 1 | 3-oxoacyl-ACP synthase KasA. Pfam: ketoacyl-synt (PF00109.33), Thiolase_N (PF00108.30), Ketoacyl-synt_C (PF02801.29). | ketoacyl-synt Thiolase_N Ketoacyl-synt_C |
Resolved |
| kasB Rv2246 |
- |
3-oxoacyl-ACP synthase 2 | 3-oxoacyl-ACP synthase 2. Pfam: ketoacyl-synt (PF00109.33), Thiolase_N (PF00108.30), Ketoacyl-synt_C (PF02801.29). | ketoacyl-synt Thiolase_N Ketoacyl-synt_C |
Resolved |
| accD6 Rv2247 |
mtbc0_002389 |
acetyl-/propionyl-CoA carboxylase subunit beta | Acyl-CoA carboxylase subunit beta. Pfam: Carboxyl_trans (PF01039.28), ACCA (PF03255.20), MdcE (PF06833.17). | Carboxyl_trans ACCA MdcE |
Family assigned |
| Rv2248 Rv2248 |
- |
hypothetical protein | Contains AbiEi_1 (PF09407.17) domain(s); putative function inferred from the domain architecture. | AbiEi_1 |
Family assigned |
| glpD1 Rv2249c |
mtbc0_002391 |
glycerol-3-phosphate dehydrogenase | Glycerol-3-phosphate dehydrogenase/oxidase. Pfam: DAO (PF01266.31), FAD_binding_2 (PF00890.31), DAO_C (PF16901.11). | DAO FAD_binding_2 DAO_C |
Resolved |
| Rv2250A Rv2250A |
|
Possible flavoprotein | Electron acceptor | Family assigned | |
| Rv2250c Rv2250c |
mtbc0_002392 |
HTH-type transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv2251 Rv2251 |
- |
flavoprotein | Flavoprotein. Pfam: FAD_binding_4 (PF01565.29), FAD-oxidase_C (PF02913.25). | FAD_binding_4 FAD-oxidase_C |
Resolved |
| Rv2252 Rv2252 |
mtbc0_002394 |
diacylglycerol kinase | Diacylglycerol kinase. Pfam: DAGK_cat (PF00781.30), YegS_C (PF19279.5). | DAGK_cat YegS_C |
Resolved |
| Rv2253 Rv2253 |
mtbc0_002395 |
hypothetical protein | Membrane protein with a PknI-sensor-domain-like extracytoplasmic sensor fold; distinct from PknI/Rv2914c (fold-paralogue safeguard). Same sensor fold as Rv3491. | Family assigned | |
| Rv2254c Rv2254c |
mtbc0_002396 |
integral membrane protein | LysE family transporter. | Family assigned | |
| Rv2255c Rv2255c |
|
Hypothetical protein | — | Still unknown | |
| Rv2256a Rv2256a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2256c Rv2256c |
- |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF3145. Function unknown. Foldseek best (non-significant) hit: 6bwo-assembly1_A LarC2, the C-terminal domain of a cyclometallase invo (prob 0.77, TM 0.32). | DUF3145 |
Still unknown |
| Rv2257c Rv2257c |
mtbc0_002400 |
hypothetical protein | Serine hydrolase domain-containing protein. Pfam: Beta-lactamase (PF00144.30). | Beta-lactamase |
Family assigned |
| Rv2258c Rv2258c |
mtbc0_002401 |
transcriptional regulator | Class I SAM-dependent methyltransferase. Pfam: WHD_Rv2258c (PF21320.4), Methyltransf_23 (PF13489.13), MTS (PF05175.21), PrmA (PF06325.20), PCMT (PF01135.26), Methyltransf_31 (PF13847.13), Ubie_methyltran (PF01209.25), Methyltransf_2 (PF00891.25), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19), Methyltransf_11 (PF08241.19). | WHD_Rv2258c Methyltransf_23 MTS PrmA PCMT Methyltransf_31 Ubie_methyltran Methyltransf_2 Methyltransf_25 Methyltransf_12 Methyltransf_11 |
Resolved |
| mscR Rv2259 |
mtbc0_002402 |
S-nitrosomycothiol reductase MscR | S-(hydroxymethyl)mycothiol dehydrogenase. Pfam: ADH_N (PF08240.18), ADH_zinc_N (PF00107.33), ADH_zinc_N_2 (PF13602.13). | ADH_N ADH_zinc_N ADH_zinc_N_2 |
Resolved |
| Rv2260 Rv2260 |
mtbc0_002403 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| Rv2261c Rv2261c |
|
Conserved hypothetical protein | Transfers the fatty acyl group on membrane lipoproteins | CN_hydrolase |
Family assigned |
| Rv2262c Rv2262c |
|
Conserved hypothetical protein | Transfers the fatty acyl group on membrane lipoproteins | LNT_N |
Family assigned |
| Rv2263 Rv2263 |
mtbc0_002405 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), Epimerase (PF01370.28), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short Epimerase KR adh_short_C2 |
Family assigned |
| Rv2264c Rv2264c |
mtbc0_002406 |
hypothetical protein | Hsp70 family protein. Pfam: HSP70 (PF00012.27). | HSP70 |
Family assigned |
| Rv2265 Rv2265 |
mtbc0_002407 |
integral membrane protein | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| cyp124 Rv2266 |
mtbc0_002408 |
cytochrome P450 Cyp124 | Methyl-branched lipid omega-hydroxylase Cyp124. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2267c Rv2267c |
mtbc0_002409 |
hypothetical protein | Sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| cyp128 Rv2268c |
mtbc0_002410 |
cytochrome P450 Cyp128 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2269c Rv2269c |
mtbc0_002411 |
hypothetical protein | Gene of the sulfomenaquinone (SMK) biosynthetic operon. RefSeq leaves it of unknown function. Rv2269c is part of the operon (with the sulfotransferase stf3 and the cytochrome P450 cyp128) producing SMK, an MTBC-specific virulence-modulating menaquinone derivative; rv2269c shows promoter activity, while cyp128 and stf3 are sufficient for SMK biosynthesis (Sogi 2016). Specific role unfixed. | Family assigned |