Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2263 Rv2263 |
mtbc0_002405 |
oxidoreductase | SDR family oxidoreductase. Pfam: adh_short (PF00106.32), Epimerase (PF01370.28), KR (PF08659.17), adh_short_C2 (PF13561.13). | adh_short Epimerase KR adh_short_C2 |
Family assigned |
| Rv2264c Rv2264c |
mtbc0_002406 |
hypothetical protein | Hsp70 family protein. Pfam: HSP70 (PF00012.27). | HSP70 |
Family assigned |
| Rv2265 Rv2265 |
mtbc0_002407 |
integral membrane protein | MFS transporter. Pfam: MFS_1 (PF07690.22). | MFS_1 |
Resolved |
| cyp124 Rv2266 |
mtbc0_002408 |
cytochrome P450 Cyp124 | Methyl-branched lipid omega-hydroxylase Cyp124. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2267c Rv2267c |
mtbc0_002409 |
hypothetical protein | Sulfotransferase. Pfam: Sulfotransfer_1 (PF00685.34), Sulfotransfer_3 (PF13469.13). | Sulfotransfer_1 Sulfotransfer_3 |
Resolved |
| cyp128 Rv2268c |
mtbc0_002410 |
cytochrome P450 Cyp128 | Cytochrome P450. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2269c Rv2269c |
mtbc0_002411 |
hypothetical protein | Gene of the sulfomenaquinone (SMK) biosynthetic operon. RefSeq leaves it of unknown function. Rv2269c is part of the operon (with the sulfotransferase stf3 and the cytochrome P450 cyp128) producing SMK, an MTBC-specific virulence-modulating menaquinone derivative; rv2269c shows promoter activity, while cyp128 and stf3 are sufficient for SMK biosynthesis (Sogi 2016). Specific role unfixed. | Family assigned | |
| lppN Rv2270 |
mtbc0_002412 |
lipoprotein LppN | Lipoprotein LppN of the mycobacterial cell envelope; peptides derived from it bind alveolar epithelial (A549) and monocyte-derived (U937) cells and inhibit mycobacterial entry in vitro, implicating it in host-cell adhesion/invasion. Precise molecular function unfixed. | Family assigned | |
| Rv2271 Rv2271 |
mtbc0_002413 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF2695. Function unknown. Foldseek best (non-significant) hit: 7kuw-assembly1_A High-throughput design and refinement of stable prote (prob 0.04, TM 0.37). | DUF2695 |
Still unknown |
| Rv2272 Rv2272 |
mtbc0_002414 |
transmembrane protein | YidH family protein. | DUF202 |
Family assigned |
| Rv2273 Rv2273 |
mtbc0_002415 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF202. Function unknown. | DUF202 |
Still unknown |
| mazE8 Rv2274A |
- |
antitoxin MazE8 | Antitoxin MazE8. | Resolved | |
| mazF8 Rv2274c |
mtbc0_002416 |
toxin MazF8 | Toxin. | Resolved | |
| Rv2275 Rv2275 |
- |
cyclo(L-tyrosyl-L-tyrosyl) synthase | Cyclo(L-tyrosyl-L-tyrosyl) synthase. Pfam: CDPS (PF16715.12). | CDPS |
Resolved |
| cyp121 Rv2276 |
mtbc0_002419 |
cytochrome P450 Cyp121 | Mycocyclosin synthase Cyp121. Pfam: p450 (PF00067.28). | p450 |
Resolved |
| Rv2277c Rv2277c |
- |
glycerolphosphodiesterase | Glycerolphosphodiesterase. Pfam: GDPD (PF03009.24). | GDPD |
Resolved |
| pitB Rv2281 |
mtbc0_002422 |
phosphate permease | Anion permease. Pfam: PHO4 (PF01384.26). | PHO4 |
Resolved |
| Rv2282c Rv2282c |
mtbc0_002423 |
LysR family HTH-type transcriptional regulator | LysR family transcriptional regulator. Pfam: HTH_1 (PF00126.34), LysR_substrate (PF03466.26). | HTH_1 LysR_substrate |
Family assigned |
| Rv2283 Rv2283 |
mtbc0_002424 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| lipM Rv2284 |
mtbc0_002425 |
esterase LipM | Alpha/beta hydrolase. Pfam: COesterase (PF00135.35), BD-FAE (PF20434.6), Abhydrolase_3 (PF07859.20), Peptidase_S9 (PF00326.28). | COesterase BD-FAE Abhydrolase_3 Peptidase_S9 |
Family assigned |
| Rv2285 Rv2285 |
mtbc0_002426 |
diacylglycerol acyltransferase | Wax ester/triacylglycerol synthase family O-acyltransferase. Pfam: WS_DGAT_cat (PF03007.22), WS_DGAT_C (PF06974.19). | WS_DGAT_cat WS_DGAT_C |
Family assigned |
| Rv2286c Rv2286c |
mtbc0_002427 |
hypothetical protein | DsbA family protein. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| yjcE Rv2287 |
- |
Na(+)/H(+) transporter | Na(+)/H(+) transporter. Pfam: Na_H_Exchanger (PF00999.27). | Na_H_Exchanger |
Resolved |
| Rv2288 Rv2288 |
mtbc0_002429 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| cdh Rv2289 |
mtbc0_002430 |
CDP-diacylglycerol pyrophosphatase | CDP-diacylglycerol diphosphatase. Pfam: CDH (PF02611.21). | CDH |
Resolved |
| lppO Rv2290 |
mtbc0_002431 |
lipoprotein LppO | Lipoprotein LpqH. Pfam: Myco_19_kDa (PF05481.18). | Myco_19_kDa |
Resolved |
| sseB Rv2291 |
mtbc0_002432 |
thiosulfate sulfurtransferase SseB | Sulfurtransferase. Pfam: Rhodanese (PF00581.26). | Rhodanese |
Resolved |
| Rv2292c Rv2292c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2293c Rv2293c |
- |
hypothetical protein | Contains PNP_UDP_1 (PF01048.27) domain(s); putative function inferred from the domain architecture. | PNP_UDP_1 |
Family assigned |
| Rv2294 Rv2294 |
mtbc0_002434 |
cystathionine beta-lyase | MalY/PatB family protein. Pfam: Aminotran_1_2 (PF00155.28). | Aminotran_1_2 |
Family assigned |
| Rv2295 Rv2295 |
mtbc0_002435 |
hypothetical protein | CbrC family protein. | UPF0167 |
Family assigned |
| Rv2296 Rv2296 |
mtbc0_002436 |
haloalkane dehalogenase | Haloalkane dehalogenase. Pfam: Abhydrolase_1 (PF00561.27), Abhydrolase_6 (PF12697.14). | Abhydrolase_1 Abhydrolase_6 |
Resolved |
| Rv2297 Rv2297 |
mtbc0_002437 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2298 Rv2298 |
mtbc0_002438 |
oxidoreductase | Aldo/keto reductase. Pfam: Aldo_ket_red (PF00248.28). | Aldo_ket_red |
Resolved |
| htpG Rv2299c |
mtbc0_002439 |
chaperone protein HtpG | Molecular chaperone HtpG. Pfam: HATPase_c_3 (PF13589.13), HATPase_c (PF02518.32), HSP90 (PF00183.24). | HATPase_c_3 HATPase_c HSP90 |
Resolved |
| Rv2300c Rv2300c |
- |
metallo-hydrolase | Metallo-hydrolase. Pfam: Lactamase_B (PF00753.34). | Lactamase_B |
Resolved |
| cut2 Rv2301 |
mtbc0_002441 |
cutinase | Cutinase family protein. Pfam: Cutinase (PF01083.29). | Cutinase |
Family assigned |
| Rv2302 Rv2302 |
mtbc0_002442 |
hypothetical protein | Conserved hypothetical protein with an NMR-determined solution structure: a five-strand antiparallel beta-sheet core with one C-terminal alpha-helix, with no high structural similarity to known proteins (a possible novel fold). Up-regulated under starvation and heat-shock; structural homolog of Rv0569. Biochemical function unknown. | DUF1918 |
Family assigned |
| Rv2303c Rv2303c |
mtbc0_002443 |
antibiotic-resistance protein | Amidohydrolase family protein. Pfam: Amidohydro_2 (PF04909.21). | Amidohydro_2 |
Family assigned |
| Rv2304c Rv2304c |
mtbc0_002444 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2305 Rv2305 |
mtbc0_002445 |
hypothetical protein | Condensation/epimerization-domain-like fold of the non-ribosomal peptide synthetase (NRPS) superfamily. RefSeq leaves it 'hypothetical protein'. The AlphaFold model superposes strongly on an NRPS epimerization domain (PDB 6ta8; Foldseek prob 1.0, E 3e-21, TM 0.67), and eggNOG places it near D-alanyl carrier / D-Ala-D-Ala chemistry (COG Q, secondary metabolism). Fold/family assignment; the catalysed step and substrate are undemonstrated. | Family assigned | |
| Rv2307A Rv2307A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7nhl-assembly1_2 VgaA-LC, an antibiotic resistance ABCF, in complex wi (prob 0.03, TM 0.37). | Still unknown | |
| Rv2307B Rv2307B |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 2mf6-assembly1_C Solution NMR structure of Chimeric Avidin, ChiAVD(I11 (prob 0.28, TM 0.63). | Still unknown | |
| Rv2307D Rv2307D |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2307c Rv2307c |
mtbc0_002447 |
hypothetical protein | Alpha/beta hydrolase. Pfam: Abhydrolase_1 (PF00561.27), Hydrolase_4 (PF12146.16). | Abhydrolase_1 Hydrolase_4 |
Family assigned |
| Rv2308 Rv2308 |
mtbc0_002452 |
hypothetical protein | DUF433 domain-containing protein. | DUF433 |
Family assigned |
| Rv2308a Rv2308a |
- |
hypothetical protein | 3'-5' exonuclease of the DEDDh / RNase-T superfamily (Mut-7-like exoribonuclease fold); nuclease activity RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv2309A Rv2309A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 8by2-assembly1_B Structure of the K+/H+ exchanger KefC with GSH. (prob 0.06, TM 0.58). | Still unknown | |
| Rv2310 Rv2310 |
- |
excisionase | Excisionase. Pfam: HTH_17 (PF12728.14). | HTH_17 |
Resolved |
| Rv2311 Rv2311 |
- |
hypothetical protein | Contains SH3_Rv2311 (PF27170.1) domain(s); putative function inferred from the domain architecture. | SH3_Rv2311 |
Family assigned |