Genes
3974 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3401 Rv3401 |
mtbc0_003614 |
glycosyl hydrolase | Glycoside hydrolase family 65 protein. Pfam: Glyco_hydro_65N (PF03636.22), Glyco_hydro_65m (PF03632.22), Glyco_hydro_65C (PF03633.21). | Glyco_hydro_65N Glyco_hydro_65m Glyco_hydro_65C |
Family assigned |
| Rv3402c Rv3402c |
mtbc0_003616 |
hypothetical protein | DegT/DnrJ/EryC1/StrS family aminotransferase. Pfam: DegT_DnrJ_EryC1 (PF01041.24). | DegT_DnrJ_EryC1 |
Family assigned |
| Rv3403c Rv3403c |
mtbc0_003617 |
hypothetical protein | FAD/NAD(P)-binding protein. Pfam: NAD_binding_9 (PF13454.13). | NAD_binding_9 |
Family assigned |
| Rv3404c Rv3404c |
mtbc0_003618 |
hypothetical protein | DTDP-4-amino-4%2C6-dideoxyglucose formyltransferase. Pfam: Formyl_trans_N (PF00551.25), N_formyltrans_C (PF18216.7). | Formyl_trans_N N_formyltrans_C |
Resolved |
| Rv3405c Rv3405c |
mtbc0_003619 |
HTH-type transcriptional regulator | Helix-turn-helix domain-containing protein. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv3406 Rv3406 |
mtbc0_003620 |
dioxygenase | Alpha-ketoglutarate-dependent sulfate ester dioxygenase. Pfam: TauD (PF02668.23). | TauD |
Resolved |
| vapB47 Rv3407 |
- |
antitoxin VapB47 | Antitoxin VapB47. Pfam: PhdYeFM_antitox (PF02604.27). | PhdYeFM_antitox |
Resolved |
| vapC47 Rv3408 |
mtbc0_003622 |
ribonuclease VapC47 | Type II toxin-antitoxin system VapC family toxin. Pfam: PIN (PF01850.28). | PIN |
Family assigned |
| choD Rv3409c |
mtbc0_003623 |
cholesterol oxidase | Cholesterol oxidase. Pfam: FAD_binding_2 (PF00890.31), NAD_binding_8 (PF13450.13), GMC_oxred_N (PF00732.26), GMC_oxred_C (PF05199.20). | FAD_binding_2 NAD_binding_8 GMC_oxred_N GMC_oxred_C |
Resolved |
| guaB3 Rv3410c |
mtbc0_003624 |
oxidoreductase | GuaB3 family IMP dehydrogenase-related protein. Pfam: IMPDH (PF00478.32), FMN_dh (PF01070.25). | IMPDH FMN_dh |
Family assigned |
| guaB2 Rv3411c |
mtbc0_003625 |
inosine-5'-monophosphate dehydrogenase | IMP dehydrogenase. Pfam: IMPDH (PF00478.32), CBS (PF00571.34). | IMPDH CBS |
Resolved |
| Rv3412 Rv3412 |
mtbc0_003626 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF5319. Function unknown. | DUF5319 |
Still unknown |
| rsdA Rv3413c |
mtbc0_003627 |
anti-sigma-D factor RsdA | Anti-sigma D factor RsdA. Pfam: RsdA_SigD_bd (PF16751.11). | RsdA_SigD_bd |
Resolved |
| sigD Rv3414c |
- |
ECF RNA polymerase sigma factor SigD | ECF RNA polymerase sigma factor SigD. Pfam: Sigma70_r2 (PF04542.21), Sigma70_r4_2 (PF08281.19), Sigma70_r4 (PF04545.23). | Sigma70_r2 Sigma70_r4_2 Sigma70_r4 |
Resolved |
| Rv3415c Rv3415c |
mtbc0_003629 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rsv-assembly1_A Rap from bacteriophage Phi3T in presence of pheromone RRGHTAS (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| whiB3 Rv3416 |
mtbc0_003630 |
redox-responsive transcriptional regulator WhiB3 | Redox-responsive transcriptional regulator WhiB3. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| groEL1 Rv3417c |
mtbc0_003631 |
chaperonin GroEL | Chaperonin GroEL. Pfam: Cpn60_TCP1 (PF00118.30). | Cpn60_TCP1 |
Resolved |
| groES Rv3418c |
- |
chaperonin GroES | Chaperonin GroES. Pfam: Cpn10 (PF00166.27). | Cpn10 |
Resolved |
| gcp Rv3419c |
mtbc0_003633 |
O-sialoglycoprotein endopeptidase | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD. Pfam: TsaD (PF00814.32), HypF_C_2 (PF22521.3). | TsaD HypF_C_2 |
Family assigned |
| rimI Rv3420c |
mtbc0_003634 |
ribosomal-protein-alanine acetyltransferase RimI | Ribosomal protein S18-alanine N-acetyltransferase. Pfam: Acetyltransf_1 (PF00583.32), Acetyltransf_10 (PF13673.14), Acetyltransf_7 (PF13508.14), FR47 (PF08445.17). | Acetyltransf_1 Acetyltransf_10 Acetyltransf_7 FR47 |
Resolved |
| tsaB Rv3421c |
mtbc0_003635 |
hypothetical protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB. Pfam: TsaD (PF00814.32). | TsaD |
Family assigned |
| tsaE Rv3422c |
mtbc0_003636 |
tRNA threonylcarbamoyladenosine biosynthesis protein | TRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE. Pfam: TsaE (PF02367.24). | TsaE |
Family assigned |
| alr Rv3423c |
- |
alanine racemase | Alanine racemase. Pfam: Ala_racemase_N (PF01168.27), Ala_racemase_C (PF00842.28). | Ala_racemase_N Ala_racemase_C |
Resolved |
| Rv3424c Rv3424c |
mtbc0_003639 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| PPE57 Rv3425 |
- |
PPE family protein PPE57 | PPE family protein PPE57. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| PPE58 Rv3426 |
- |
PPE family protein PPE58 | PPE family protein PPE58. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| istB Rv3427c |
mtbc0_003642 |
transposase | IS21-like element ISMt2 family helper ATPase IstB. Pfam: IstB_IS21 (PF01695.24), Bac_DnaA (PF00308.25), AAA (PF00004.36). | IstB_IS21 Bac_DnaA AAA |
Family assigned |
| Rv3428c Rv3428c |
- |
transposase | Transposase. Pfam: rve (PF00665.33), Mu-transpos_C_2 (PF22483.3). | rve Mu-transpos_C_2 |
Resolved |
| PPE59 Rv3429 |
- |
PPE family protein PPE59 | PPE family protein PPE59. Pfam: PPE (PF00823.26). | PPE |
Family assigned |
| Rv3430a Rv3430a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3430c Rv3430c |
- |
transposase | Transposase. Pfam: rve (PF00665.33), rve_3 (PF13683.13). | rve rve_3 |
Resolved |
| gadB Rv3432c |
mtbc0_003651 |
glutamate decarboxylase GadB | Glutamate decarboxylase. Pfam: Pyridoxal_deC (PF00282.26). | Pyridoxal_deC |
Resolved |
| Rv3433c Rv3433c |
mtbc0_003652 |
bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase | NAD(P)H-hydrate dehydratase. Pfam: YjeF_N (PF03853.22), Carb_kinase (PF01256.23). | YjeF_N Carb_kinase |
Resolved |
| Rv3434c Rv3434c |
mtbc0_003653 |
transmembrane protein | Rhomboid-like protein. Pfam: Rhomboid_2 (PF20401.4). | Rhomboid_2 |
Family assigned |
| Rv3435c Rv3435c |
mtbc0_003654 |
transmembrane protein | Cell-wall-associated virulence protein, conserved in pathogenic but not non-pathogenic mycobacteria. RefSeq leaves it of unknown function. Heterologous expression shows Rv3435c is a cell-wall-related protein that alters colony morphology and fatty-acid levels, enhances stress resistance, inhibits inflammatory-cytokine secretion and host-cell apoptosis, and promotes intramacrophage/in-vivo survival (Zhao 2023, Liu 2025). Molecular function unfixed. | DUF4436 |
Family assigned |
| glmS Rv3436c |
mtbc0_003655 |
glucosamine--fructose-6-phosphate aminotransferase | Glutamine--fructose-6-phosphate transaminase (isomerizing). Pfam: GATase_6 (PF13522.12), GATase_7 (PF13537.12), SIS (PF01380.28). | GATase_6 GATase_7 SIS |
Resolved |
| Rv3437 Rv3437 |
mtbc0_003656 |
transmembrane protein | Conserved hypothetical protein; DUF domain(s) DUF2510. Function unknown. | DUF2510 |
Still unknown |
| Rv3438 Rv3438 |
mtbc0_003657 |
hypothetical protein | Alpha/beta-hydrolase-FOLD protein of the dienelactone-hydrolase / cutinase-like branch: the AlphaFold model matches a polyester hydrolase, GlacPETase (TM 0.78), and an LCC-type cutinase (TM 0.73); eggNOG describes the group as 'dienelactone hydrolase'. Putative hydrolase — fold-level only, no verified catalytic triad, no publication on this locus. | Family assigned | |
| Rv3439c Rv3439c |
mtbc0_003658 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-PE-PPE superfamily protein associated with the Type VII (ESX) secretion system; conserved four-helical-bundle/WXG domain within a large (467 aa) protein RefSeq leaves this locus uncharacterised. | Family assigned | |
| Rv3440c Rv3440c |
mtbc0_003659 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 5los-assembly1_A Piriformospora indica PIIN_05872 (prob 0.96, TM 0.86). Structure-based, putative. | Family assigned | |
| mrsA Rv3441c |
mtbc0_003660 |
phosphoglucosamine mutase | Phosphoglucosamine mutase. Pfam: PGM_PMM_I (PF02878.23), PGM_PMM_II (PF02879.23), PGM_PMM_III (PF02880.23), PGM_PMM_IV (PF00408.27). | PGM_PMM_I PGM_PMM_II PGM_PMM_III PGM_PMM_IV |
Resolved |
| rpsI Rv3442c |
mtbc0_003661 |
30S ribosomal protein S9 | 30S ribosomal protein S9. Pfam: Ribosomal_S9 (PF00380.26). | Ribosomal_S9 |
Resolved |
| rplM Rv3443c |
mtbc0_003662 |
50S ribosomal protein L13 | 50S ribosomal protein L13. Pfam: Ribosomal_L13 (PF00572.25). | Ribosomal_L13 |
Resolved |
| esxT Rv3444c |
mtbc0_003663 |
ESAT-6 like protein EsxT | WXG100 family type VII secretion target. Pfam: WXG100 (PF06013.19). | WXG100 |
Family assigned |
| esxU Rv3445c |
mtbc0_003664 |
ESAT-6 like protein EsxU | Type VII secretion system ESX-4 protein EsxU. Pfam: WXG100 (PF06013.19). | WXG100 |
Resolved |
| Rv3446c Rv3446c |
mtbc0_003665 |
hypothetical protein | Type VII secretion-associated protein. | Family assigned | |
| eccC4 Rv3447c |
mtbc0_003666 |
ESX-4 secretion system protein EccC4 | Type VII secretion system ESX-4 FtsK/SpoIIIE family ATPase EccC4. Pfam: FtsK_SpoIIIE (PF01580.25). | FtsK_SpoIIIE |
Family assigned |
| eccD4 Rv3448 |
mtbc0_003667 |
ESX-4 secretion system protein EccD4 | Type VII secretion system ESX-4 subunit EccD4. Pfam: YukD (PF08817.17), EccD (PF19053.7). | YukD EccD |
Family assigned |
| mycP4 Rv3449 |
mtbc0_003668 |
membrane-anchored mycosin | Type VII secretion system ESX-4 serine protease mycosin MycP4. Pfam: Peptidase_S8 (PF00082.28). | Peptidase_S8 |
Resolved |
| eccB4 Rv3450c |
mtbc0_003669 |
ESX-4 secretion system protein EccB4 | Type VII secretion system ESX-4 subunit EccB4. Pfam: T7SS_ESX1_EccB (PF05108.19). | T7SS_ESX1_EccB |
Family assigned |