Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3771c Rv3771c |
mtbc0_003996 |
hypothetical protein | Transposase (eggNOG COG3677, IS-family transposase; COG category L). A mobile-element function, not a host-metabolic gene. | Family assigned | |
| Rv3773c Rv3773c |
mtbc0_004000 |
hypothetical protein | TIGR03086 family metal-binding protein. | Family assigned | |
| Rv3776 Rv3776 |
- |
hypothetical protein | HNH endonuclease of the 13E12-repeat family (eggNOG COG1403, COG category V). RefSeq leaves it 'hypothetical protein'. HNH nuclease motif; target undetermined. | DUF222 |
Family assigned |
| bpa Rv3780 |
mtbc0_004008 |
hypothetical protein | Proteasome activator protein Bpa. Pfam: BPA (PF10759.15). | BPA |
Resolved |
| Rv3785 Rv3785 |
mtbc0_004013 |
hypothetical protein | Contains Rv3785_N (PF27209.1) domain(s); putative function inferred from the domain architecture. | Rv3785_N |
Family assigned |
| Rv3786c Rv3786c |
mtbc0_004014 |
hypothetical protein | Peptidoglycan DD-metalloendopeptidase family protein. Pfam: Peptidase_M23 (PF01551.30). | Peptidase_M23 |
Family assigned |
| Rv3788 Rv3788 |
mtbc0_004016 |
hypothetical protein | GreA/GreB family elongation factor. Pfam: GreA_GreB (PF01272.26). | GreA_GreB |
Family assigned |
| Rv3796 Rv3796 |
- |
hypothetical protein | Contains Lactamase_B (PF00753.34), Anti-Pycsar_Apyc1 (PF23023.2), Lactamase_B_2 (PF12706.14) domain(s); putative function inferred from the domain architecture. | Lactamase_B Anti-Pycsar_Apyc1 Lactamase_B_2 |
Family assigned |
| Rv3811 Rv3811 |
- |
hypothetical protein | Contains Rv3811_N (PF27503.1), Amidase_2 (PF01510.31), LGFP (PF08310.18) domain(s); putative function inferred from the domain architecture. | Rv3811_N Amidase_2 LGFP |
Family assigned |
| Rv3813c Rv3813c |
mtbc0_004042 |
hypothetical protein | Cof-type HAD-IIB family hydrolase. Pfam: Hydrolase_3 (PF08282.19), S6PP (PF05116.20). | Hydrolase_3 S6PP |
Family assigned |
| Rv3818 Rv3818 |
mtbc0_004047 |
hypothetical protein | MBL fold metallo-hydrolase. Pfam: Lactamase_B_3 (PF13483.13), SCP2_Rv3818 (PF25451.2), Rieske (PF00355.33). | Lactamase_B_3 SCP2_Rv3818 Rieske |
Resolved |
| Rv3819 Rv3819 |
mtbc0_004048 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dcx-assembly1_A Crystal structure of a duf1696 family protein with a (prob 0.99, TM 0.50). | Still unknown | |
| chp1 Rv3822 |
mtbc0_004051 |
hypothetical protein | Sulfolipid-1 biosynthesis membrane-anchored acyltransferase Chp1. Pfam: PE-PPE (PF08237.18). | PE-PPE |
Resolved |
| Rv3831 Rv3831 |
mtbc0_004060 |
hypothetical protein | Polytopic integral membrane protein with 5 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2834 |
Family assigned |
| Rv3832c Rv3832c |
mtbc0_004061 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), RrnaAD (PF00398.27), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). | Methyltransf_23 RrnaAD Methyltransf_11 Methyltransf_25 Methyltransf_12 |
Family assigned |
| Rv3835 Rv3835 |
mtbc0_004064 |
hypothetical protein | Septum formation family protein. Pfam: Septum_form (PF13845.12). | Septum_form |
Family assigned |
| Rv3836 Rv3836 |
mtbc0_004065 |
hypothetical protein | Metallopeptidase family protein. Pfam: Zincin_1 (PF06262.18). | Zincin_1 |
Family assigned |
| Rv3839 Rv3839 |
mtbc0_004069 |
hypothetical protein | Heme-homeostasis regulator: the principal driver of the Rv3839-Rv3840 operon that down-regulates endogenous heme biosynthesis under nitric-oxide and iron-limitation stress (Quirk 2026). It carries a DUF2470/DRI (Domain Related to Iron) regulatory module - the GluTR-binding-protein domain, also found in HugZ - and lies immediately upstream of bacterioferritin bfrB (Rv3841), in an operon with the transcriptional regulator Rv3840. The fold-paralogue safeguard is passed: it is not a copy of the genuine glutamyl-tRNA reductase HemA/Rv0509 but shares only the regulatory DUF2470 domain. RefSeq left this locus uncharacterised; the structure-guided hypothesis (heme/iron homeostasis) was confirmed experimentally by Quirk 2026 while the companion study was in progress - a RefSeq-behind case and an independent validation of the approach. | DUF2470 |
Resolved |
| Rv3845 Rv3845 |
mtbc0_004077 |
hypothetical protein | IS110 family transposase. | Family assigned | |
| Rv3847 Rv3847 |
mtbc0_004080 |
hypothetical protein | Peptidase name UNVERIFIED. The label comes from an unreviewed UniProt entry and from nothing else: no Pfam domain, no eggNOG description, no publication mentioning this locus, and — decisively — our structural layer does NOT support it, every AlphaFold-model match being non-significant (best probability 0.12, against orange-carotenoid-protein domains). Function undetermined; the previous wording 'Peptidase.' asserted more than any layer carries. | Resolved | |
| Rv3850 Rv3850 |
mtbc0_004083 |
hypothetical protein | DUF6474 family protein. | DUF6474 |
Family assigned |
| Rv3856c Rv3856c |
mtbc0_004089 |
hypothetical protein | PHP domain-containing protein. Pfam: HHH_8 (PF14716.14), PHP (PF02811.27). | HHH_8 PHP |
Family assigned |
| Rv3860 Rv3860 |
mtbc0_004093 |
hypothetical protein | ATPase. Pfam: CbiA (PF01656.30). | CbiA |
Resolved |
| Rv3861 Rv3861 |
mtbc0_004094 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3863 Rv3863 |
- |
hypothetical protein | Contains MSMEG_6518_N (PF27182.1) domain(s); putative function inferred from the domain architecture. | MSMEG_6518_N |
Family assigned |
| Rv3896c Rv3896c |
mtbc0_004130 |
hypothetical protein | Transglycosylase. | Resolved | |
| Rv3897c Rv3897c |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv3898c Rv3898c |
mtbc0_004131 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5sva-assembly1_T Mediator-RNA Polymerase II Pre-Initiation Complex (prob 0.38, TM 0.59). | Still unknown | |
| Rv3899c Rv3899c |
- |
hypothetical protein | Secreted protein (found in culture filtrate), conserved across mycobacteria, with an X-ray crystal structure of fragment 184-410 that defines a new protein family (an alpha/beta/alpha sandwich + alpha-helix bundle; no structures for homologues previously known). Immunoglobulin-like, candidate vaccine antigen. Molecular function unknown. (UniProt auto-name 'Tat' is a database artefact and is not adopted.) | DUF5632 DUF5631 |
Family assigned |
| Rv3900c Rv3900c |
mtbc0_004133 |
hypothetical protein | ESAT-6-like (WXG100) / ESX-PE-PPE superfamily protein associated with the Type VII (ESX) secretion system (four-helical-bundle, WXG motif) RefSeq leaves this locus uncharacterised. | Family assigned | |
| ift Rv3902c |
mtbc0_004136 |
hypothetical protein | IFT, the immunity factor for the tuberculosis necrotizing toxin (TNT), the antitoxin/immunity partner of the CpnT-TNT system (Pfam Imm61 PF15598). The TNT-IFT pair was characterised by Sun 2015. (RefSeq already names this locus; included for completeness of the CpnT-TNT module.) | Imm61 |
Resolved |
| cpnT Rv3903c |
mtbc0_004137 |
hypothetical protein | Outer membrane channel protein/necrotizing toxin glycohydrolase CpnT. Pfam: WXG100_2 (PF25547.2), TNT (PF14021.13). | WXG100_2 TNT |
Resolved |
| Rv3906c Rv3906c |
mtbc0_004140 |
hypothetical protein | Pullulanase. | Resolved | |
| Rv3909 Rv3909 |
mtbc0_004143 |
hypothetical protein | Conserved hypothetical protein; DUF domain(s) DUF6049. Function unknown. | DUF6049 |
Still unknown |
| Rv3916c Rv3916c |
mtbc0_004150 |
hypothetical protein | Acetyltransferase. | Resolved | |
| Rv3920c Rv3920c |
mtbc0_004154 |
hypothetical protein | R3H domain-containing nucleic acid-binding protein. Pfam: R3H (PF01424.29). | R3H |
Family assigned |