Genes
1051 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2405 Rv2405 |
- |
hypothetical protein | Contains PemK_toxin (PF02452.24) domain(s); putative function inferred from the domain architecture. | PemK_toxin |
Family assigned |
| Rv2406c Rv2406c |
mtbc0_002562 |
hypothetical protein | CBS domain-containing protein. Pfam: CBS (PF00571.34). | CBS |
Family assigned |
| Rv2409c Rv2409c |
mtbc0_002565 |
hypothetical protein | Transglutaminase family protein. Pfam: Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26). | Bact_transglu_N Transglut_core |
Family assigned |
| Rv2410c Rv2410c |
mtbc0_002566 |
hypothetical protein | Alpha-E domain-containing protein. Pfam: Alpha-E (PF04168.18). | Alpha-E |
Family assigned |
| Rv2411c Rv2411c |
mtbc0_002567 |
hypothetical protein | Circularly permuted type 2 ATP-grasp protein. Pfam: CP_ATPgrasp_1 (PF04174.19), CP_ATPgrasp_2 (PF14403.12). | CP_ATPgrasp_1 CP_ATPgrasp_2 |
Resolved |
| Rv2413c Rv2413c |
mtbc0_002569 |
hypothetical protein | DNA polymerase III subunit delta. Pfam: DNA_pol3_delta_C (PF21694.3). | DNA_pol3_delta_C |
Family assigned |
| Rv2414c Rv2414c |
mtbc0_002570 |
hypothetical protein | ComEC/Rec2 family competence protein. Pfam: Competence (PF03772.22). | Competence |
Family assigned |
| Rv2415c Rv2415c |
mtbc0_002571 |
hypothetical protein | ComEA family DNA-binding protein. Pfam: SLBB (PF10531.16), HHH_3 (PF12836.14), HHH (PF00633.30). | SLBB HHH_3 HHH |
Family assigned |
| octT Rv2418c |
mtbc0_002574 |
hypothetical protein | Diglucosylglycerate octanoyltransferase. | Resolved | |
| rsfS Rv2420c |
mtbc0_002576 |
hypothetical protein | Ribosome silencing factor. Pfam: RsfS (PF02410.22). | RsfS |
Resolved |
| Rv2422 Rv2422 |
mtbc0_002579 |
hypothetical protein | Predicted toxin of a type II toxin-antitoxin (TA) system (eggNOG COG1848). RefSeq leaves it 'hypothetical protein'. Note: the Rv2421c-Rv2422 region also harbours a cryptic beta-lactam-binding ORF (Kumar 2017); the eggNOG orthology points to a TA-toxin fold for Rv2422 itself. Family-level; the cognate antitoxin and activity are undetermined. | Family assigned | |
| Rv2423 Rv2423 |
mtbc0_002580 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: MTS (PF05175.21), Methyltransf_23 (PF13489.13), TehB (PF03848.21), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | MTS Methyltransf_23 TehB Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv2425c Rv2425c |
mtbc0_002582 |
hypothetical protein | VWA domain-containing protein. Pfam: VWA_CoxE (PF05762.21). | VWA_CoxE |
Family assigned |
| Rv2426c Rv2426c |
mtbc0_002583 |
hypothetical protein | MoxR family ATPase. Pfam: AAA_5 (PF07728.21), AAA (PF00004.36), AAA_2 (PF07724.21). | AAA_5 AAA AAA_2 |
Family assigned |
| Rv2432c Rv2432c |
mtbc0_002590 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3e90-assembly3_C West Nile vi rus NS2B-NS3protease in complexed with i (prob 0.03, TM 0.44). | Still unknown | |
| nrtS Rv2433c |
mtbc0_002591 |
hypothetical protein | Nitrate/nitrite transporter NrtS. | Resolved | |
| Rv2438A Rv2438A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2451 Rv2451 |
mtbc0_002610 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2452c Rv2452c |
mtbc0_002611 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2466c Rv2466c |
mtbc0_002627 |
hypothetical protein | Rv2466c family mycothiol-dependent reductase. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| Rv2468A Rv2468A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2468c Rv2468c |
- |
hypothetical protein | Immunomodulatory / T-cell costimulatory protein: binds integrin VLA-5 (alpha5beta1) via an RGD motif and costimulates T cells. NOTE: a Foldseek hit to the cytochrome bcc:aa3 fold is a FALSE POSITIVE (the Mtb cytochrome bcc is qcrCAB, not this gene). | DUF5130 |
Resolved |
| Rv2469c Rv2469c |
mtbc0_002631 |
hypothetical protein | HNH endonuclease. Pfam: HNH (PF01844.30), HNH_5 (PF14279.13). | HNH HNH_5 |
Resolved |
| Rv2472 Rv2472 |
mtbc0_002634 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7n51-assembly1_A Structure of a bacterial gasdermin from Vitiosangium (prob 0.03, TM 0.46). | Still unknown | |
| Rv2473 Rv2473 |
mtbc0_002635 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5xsj-assembly1_L XylFII-LytSN complex (prob 0.97, TM 0.45). | Still unknown | |
| Rv2474c Rv2474c |
mtbc0_002636 |
hypothetical protein | DnaN/beta-sliding-clamp-like fold; distinct from the genuine DNA polymerase III beta clamp dnaN/Rv0002 (fold-paralogue safeguard). Function of this paralogue undetermined. | DUF8010 DUF8185 |
Family assigned |
| Rv2475c Rv2475c |
mtbc0_002637 |
hypothetical protein | Thioesterase family protein. Pfam: Acyl-ACP_TE_C (PF20791.4), 4HBT_2 (PF13279.13). | Acyl-ACP_TE_C 4HBT_2 |
Family assigned |
| Rv2478c Rv2478c |
- |
hypothetical protein | Contains SSB (PF00436.32) domain(s); putative function inferred from the domain architecture. | SSB |
Family assigned |
| Rv2481c Rv2481c |
mtbc0_002641 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2489c Rv2489c |
mtbc0_002650 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2490a Rv2490a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2491 Rv2491 |
mtbc0_002653 |
hypothetical protein | TIGR00725 family protein. Pfam: LDcluster4 (PF18306.7). | LDcluster4 |
Family assigned |
| Rv2492 Rv2492 |
mtbc0_002654 |
hypothetical protein | Thymidylate-synthase (TS)-superfamily (hydroxymethyl)transferase acting on a deoxyuridylate-type nucleotide, a distinct non-essential locus separate from the essential thymidylate synthases ThyA/ThyX. RefSeq leaves it 'hypothetical protein'. The model superposes on MilA (a CMP hydroxymethyltransferase, PDB 5b6d) with a complete catalytic constellation at the nucleotide (nucleophile Cys151, phosphate-binding Arg175, base-reading Asp178, ribose-binding His222/Tyr224); HHpred places it 100% in the thymidylate-synthase / dCMP-hydroxymethylase superfamily. The specificity residues reassign the substrate away from the template's cytidylate: Asn186 (vs MilA Asp186) and Ser176 (deoxy-type) point to a (deoxy)uridylate (dUMP-type) substrate with one-carbon chemistry on the pyrimidine C5. Vertically conserved through the human and animal MTBC and M. canettii (an earlier anti-phage-defence hypothesis is rejected). A structural prediction; substrate narrowed, not fixed. | Resolved | |
| Rv2507 Rv2507 |
mtbc0_002669 |
hypothetical protein | MmpS family transport accessory protein. Pfam: Mycobact_memb (PF05423.19). | Mycobact_memb |
Family assigned |
| Rv2510c Rv2510c |
mtbc0_002672 |
hypothetical protein | DUF853 domain-containing protein. Pfam: HerA_C (PF05872.19), DUF87 (PF01935.24), TrwB_AAD_bind (PF10412.16). | HerA_C DUF87 TrwB_AAD_bind |
Family assigned |
| Rv2512a Rv2512a |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7jt2-assembly1_q 70S ribosome stalled on long mRNA with ArfB bound in (prob 0.03, TM 0.26). | Still unknown | |
| Rv2513 Rv2513 |
mtbc0_002676 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2514c Rv2514c |
mtbc0_002677 |
hypothetical protein | DUF4411 family protein. | DUF4411 |
Family assigned |
| Rv2515c Rv2515c |
mtbc0_002678 |
hypothetical protein | XRE family transcriptional regulator. Pfam: HTH_3 (PF01381.29), Peptidase_M78 (PF06114.20). | HTH_3 Peptidase_M78 |
Family assigned |
| Rv2516c Rv2516c |
mtbc0_002679 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7b90-assembly1_E Circular permutant of ribosomal protein S6, P54-55 tr (prob 0.99, TM 0.64). | Still unknown | |
| Rv2517c Rv2517c |
mtbc0_002680 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7ax2-assembly1_A Crystal structure of the computationally designed Sco (prob 0.51, TM 0.79). | Still unknown | |
| Rv2522c Rv2522c |
mtbc0_002686 |
hypothetical protein | Dipeptidase. Pfam: Peptidase_M20 (PF01546.34), M20_dimer (PF07687.20). | Peptidase_M20 M20_dimer |
Resolved |
| Rv2525c Rv2525c |
mtbc0_002689 |
hypothetical protein | DUF1906 domain-containing protein. Pfam: Rv2525c_GlyHyd-like (PF08924.18). | Rv2525c_GlyHyd-like |
Family assigned |
| Rv2529 Rv2529 |
- |
hypothetical protein | Contains ERCC4 (PF02732.22), Lsr2_DNA-bd (PF23359.2) domain(s); putative function inferred from the domain architecture. | ERCC4 Lsr2_DNA-bd |
Family assigned |
| Rv2532c Rv2532c |
mtbc0_002698 |
hypothetical protein | Antitermination protein NusB. | Resolved | |
| Rv2541 Rv2541 |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3zbh-assembly1_B Geobacillus thermodenitrificans EsxA crystal form I (prob 1.00, TM 0.78). | Still unknown | |
| Rv2542 Rv2542 |
mtbc0_002708 |
hypothetical protein | Alpha/beta hydrolase family protein. Pfam: Abhydrolase_8 (PF06259.19). | Abhydrolase_8 |
Family assigned |
| Rv2548A Rv2548A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2551c Rv2551c |
mtbc0_002719 |
hypothetical protein | A24 family peptidase. Pfam: Peptidase_A24 (PF01478.24). | Peptidase_A24 |
Family assigned |
| Rv2556c Rv2556c |
mtbc0_002724 |
hypothetical protein | Secondary thiamine-phosphate synthase enzyme YjbQ. Pfam: YjbQ (PF01894.23). | YjbQ |
Resolved |