Genes
1086 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv2312 Rv2312 |
mtbc0_002460 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dz1-assembly1_A Crystal structure of Dihydrodipicolinate Synthase fro (prob 0.01, TM 0.27). | Still unknown | |
| Rv2313c Rv2313c |
mtbc0_002461 |
hypothetical protein | Carboxymuconolactone decarboxylase family protein. | Family assigned | |
| Rv2314c Rv2314c |
mtbc0_002462 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_3rd |
Family assigned |
| Rv2315c Rv2315c |
mtbc0_002463 |
hypothetical protein | TldD/PmbA family protein. Pfam: PmbA_TldD_1st (PF01523.22), PmbA_TldD_3rd (PF19289.5). | PmbA_TldD_1st PmbA_TldD_3rd |
Family assigned |
| Rv2323c Rv2323c |
- |
hypothetical protein | Contains DDAH_eukar (PF19420.6) domain(s); putative function inferred from the domain architecture. | DDAH_eukar |
Family assigned |
| Rv2325c Rv2325c |
mtbc0_002473 |
hypothetical protein | CbiQ family ECF transporter T component. Pfam: CbiQ (PF02361.22). | CbiQ |
Family assigned |
| Rv2327 Rv2327 |
mtbc0_002475 |
hypothetical protein | MarR family winged helix-turn-helix transcriptional regulator. Pfam: MarR_2 (PF12802.14), MarR (PF01047.29), HTH_27 (PF13463.13). | MarR_2 MarR HTH_27 |
Family assigned |
| Rv2331 Rv2331 |
mtbc0_002480 |
hypothetical protein | Molybdopterin-containing oxidoreductase-family domain (eggNOG COG0243, EC 1.17.1.9/1.8.1.2; energy-metabolism COG category C). Short ORF matching the molybdopterin oxidoreductase family; complete enzyme context undetermined. | Family assigned | |
| Rv2331A Rv2331A |
- |
hypothetical protein | FAD-binding oxidoreductase domain (eggNOG COG0369, monooxygenase/reductase EC set; COG category P). A flavin-binding domain; full enzymatic role undetermined. | Family assigned | |
| tyzA Rv2336 |
mtbc0_002486 |
hypothetical protein | Amino-acid N-acyltransferase TyzA of the tyz cluster; N-acylates L-Tyr/L-Phe with lauroyl-CoA in acyl-oxazolone (tyrazolone) biosynthesis (Grigg 2023). | Resolved | |
| tyzC Rv2337c |
mtbc0_002487 |
hypothetical protein | TyzC, a flavin-dependent oxidase (FDO) of the nitroreductase (NTR) superfamily acting in acyl-oxazolone biosynthesis. RefSeq leaves this locus 'hypothetical protein'. In the tyz cluster, TyzC catalyses the O2-dependent desaturation of the N-acyl-L-Tyr produced by TyzA, while TyzB (a ThiF homolog) catalyses its ATP-dependent cyclisation to the acyl-oxazolone; the substrate preferences of TyzB/TyzC set the identity of the final lipid (Grigg 2023). This work expands the NTR superfamily to a set of broadly distributed FDOs (five in Mtb) that desaturate lipid species. Experimentally characterised enzyme. | Resolved | |
| Rv2342 Rv2342 |
mtbc0_002494 |
hypothetical protein | Candidate accessory component of the cell-wall arabinan / arabinogalactan biosynthesis machinery (Emb/Aft arabinofuranosyltransferases), coupled to the AftB/AftC arabinofuranosyltransferases (terminal and alpha1->3-branching steps of cell-wall arabinan). Rv2342 is a STRING context partner by phylogenetic cooccurrence (not a genomic neighbour) of Rv3802c:762;aftC:757;Rv1476:752;aftB:742;Rv1610:741;lpqB:715;Rv0227c:694 (context-driven, text-mining excluded). It is under purifying selection on 145,209 MTBC genomes (7 segregating sites). No dedicated functional study of Rv2342 exists in the published TB literature. The association to the module is supported (permutation p~0.001, verdict core); the specific molecular role of the accessory remains undemonstrated (a guilt-by-association hypothesis, not a biochemical assignment). | Family assigned | |
| Rv2348c Rv2348c |
mtbc0_002500 |
hypothetical protein | T-cell-stimulating antigen used (with EspC and EspF) in an ESAT-6-free IGRA; a non-synonymous variant (I101M) shows a genome-to-genome association with human PRDM15. Despite this immunological/genetic characterisation, its molecular function remains unknown (verdict kept 'dark'). | Family assigned | |
| Rv2360c Rv2360c |
mtbc0_002512 |
hypothetical protein | Small dimeric alpha/beta fold of the CesT/SycE/YbjN structural superfamily (the SCOP "type III secretion system chaperone-like" fold, shared by T3SS effector chaperones, YbjN-type regulatory/adaptor proteins, and several uncharacterised DUFs). The molecular function is open: it is definitively NOT a type III secretion chaperone (M. tuberculosis has no T3SS) and could be a secretion chaperone/adaptor (M. tuberculosis does use T7SS/ESX chaperones) OR a YbjN-like regulatory protein. RefSeq leaves it hypothetical. | Family assigned | |
| Rv2365c Rv2365c |
mtbc0_002517 |
hypothetical protein | Cytidine deaminase. Pfam: CDL (PF26947.1). | CDL |
Resolved |
| Rv2369c Rv2369c |
mtbc0_002521 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2370c Rv2370c |
mtbc0_002522 |
hypothetical protein | PucR family transcriptional regulator. Pfam: GGDEF_2 (PF17853.7), HTH_30 (PF13556.13). | GGDEF_2 HTH_30 |
Family assigned |
| Rv2375 Rv2375 |
mtbc0_002527 |
hypothetical protein | VapB22, the antitoxin of the VapBC22 type II module (Pfam VapB PF23719). RefSeq names only 'VapB family antitoxin'; VapBC22 is required for pathogenesis (Agarwal 2020). | VapB |
Resolved |
| mbtH Rv2377c |
mtbc0_002529 |
hypothetical protein | Mycobactin NRPS accessory protein MbtH. Pfam: MbtH (PF03621.19). | MbtH |
Resolved |
| Rv2386a Rv2386a |
- |
hypothetical protein | Sm-like fold (SCOP b.38.1.6) small protein of the DUF903 / YgdI-YgdR family (a large converging cascade of HHpred hits at 90-94%; plus the self-named Mtb family PF29823 at 99.95%). Confident fold and family assignment. The DUF903 family is generically annotated as putative lipoproteins, but our own DeepTMHMM prediction sees Rv2386a as globular (no signal peptide / lipobox), so the lipoprotein label is NOT supported here. The molecular function of this family is not established. | Family assigned | |
| Rv2387 Rv2387 |
mtbc0_002540 |
hypothetical protein | Sodium-dependent bicarbonate transport family permease. Pfam: Sbt_1 (PF05982.18). | Sbt_1 |
Family assigned |
| Rv2390c Rv2390c |
mtbc0_002543 |
hypothetical protein | No Pfam domain above threshold; Foldseek indicates a fold similar to 8rta-assembly1_G Arches-protomer complex full-length structure (TrwJ/VirB8) from (prob 1.00, TM 0.65). Structure-based, putative. | Family assigned | |
| Rv2401 Rv2401 |
mtbc0_002556 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2405 Rv2405 |
- |
hypothetical protein | Orphan PemK/MazF-fold protein (Pfam PemK_toxin PF02452). Surfaced as a TA candidate by its endoRNase fold, but it is NOT the characterised mt-PemK toxin (that is Rv3098A) and it has no adjacent cognate antitoxin. Reported as a paralogue-of-fold caution: a PemK-fold does not by itself establish an active TA toxin. Pairing and activity unconfirmed. | PemK_toxin |
Family assigned |
| Rv2406c Rv2406c |
mtbc0_002562 |
hypothetical protein | CBS domain-containing protein. Pfam: CBS (PF00571.34). | CBS |
Family assigned |
| Rv2409c Rv2409c |
mtbc0_002565 |
hypothetical protein | Transglutaminase family protein. Pfam: Bact_transglu_N (PF08379.16), Transglut_core (PF01841.26). | Bact_transglu_N Transglut_core |
Family assigned |
| Rv2410c Rv2410c |
mtbc0_002566 |
hypothetical protein | Alpha-E domain-containing protein. Pfam: Alpha-E (PF04168.18). | Alpha-E |
Family assigned |
| Rv2411c Rv2411c |
mtbc0_002567 |
hypothetical protein | Circularly permuted type 2 ATP-grasp protein. Pfam: CP_ATPgrasp_1 (PF04174.19), CP_ATPgrasp_2 (PF14403.12). | CP_ATPgrasp_1 CP_ATPgrasp_2 |
Resolved |
| Rv2413c Rv2413c |
mtbc0_002569 |
hypothetical protein | DNA polymerase III subunit delta. Pfam: DNA_pol3_delta_C (PF21694.3). | DNA_pol3_delta_C |
Family assigned |
| Rv2414c Rv2414c |
mtbc0_002570 |
hypothetical protein | ComEC/Rec2 family competence protein. Pfam: Competence (PF03772.22). | Competence |
Family assigned |
| Rv2415c Rv2415c |
mtbc0_002571 |
hypothetical protein | ComEA family DNA-binding protein. Pfam: SLBB (PF10531.16), HHH_3 (PF12836.14), HHH (PF00633.30). | SLBB HHH_3 HHH |
Family assigned |
| octT Rv2418c |
mtbc0_002574 |
hypothetical protein | Diglucosylglycerate octanoyltransferase. | Resolved | |
| rsfS Rv2420c |
mtbc0_002576 |
hypothetical protein | Ribosome silencing factor. Pfam: RsfS (PF02410.22). | RsfS |
Resolved |
| Rv2422 Rv2422 |
mtbc0_002579 |
hypothetical protein | Predicted toxin of a type II toxin-antitoxin (TA) system (eggNOG COG1848). RefSeq leaves it 'hypothetical protein'. Note: the Rv2421c-Rv2422 region also harbours a cryptic beta-lactam-binding ORF (Kumar 2017); the eggNOG orthology points to a TA-toxin fold for Rv2422 itself. Family-level; the cognate antitoxin and activity are undetermined. | Family assigned | |
| Rv2423 Rv2423 |
mtbc0_002580 |
hypothetical protein | Class I SAM-dependent methyltransferase. Pfam: MTS (PF05175.21), Methyltransf_23 (PF13489.13), TehB (PF03848.21), Methyltransf_25 (PF13649.13), Methyltransf_11 (PF08241.19). | MTS Methyltransf_23 TehB Methyltransf_25 Methyltransf_11 |
Resolved |
| Rv2425c Rv2425c |
mtbc0_002582 |
hypothetical protein | VWA domain-containing protein. Pfam: VWA_CoxE (PF05762.21). | VWA_CoxE |
Family assigned |
| Rv2426c Rv2426c |
mtbc0_002583 |
hypothetical protein | MoxR family ATPase. Pfam: AAA_5 (PF07728.21), AAA (PF00004.36), AAA_2 (PF07724.21). | AAA_5 AAA AAA_2 |
Family assigned |
| Rv2432c Rv2432c |
mtbc0_002590 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3e90-assembly3_C West Nile vi rus NS2B-NS3protease in complexed with i (prob 0.03, TM 0.44). | Still unknown | |
| nrtS Rv2433c |
mtbc0_002591 |
hypothetical protein | Nitrate/nitrite transporter NrtS. | Resolved | |
| Rv2438A Rv2438A |
- |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2451 Rv2451 |
mtbc0_002610 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2452c Rv2452c |
mtbc0_002611 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| Rv2466c Rv2466c |
mtbc0_002627 |
hypothetical protein | Rv2466c family mycothiol-dependent reductase. Pfam: DSBA (PF01323.27), Rv2466c-like (PF22234.3). | DSBA Rv2466c-like |
Family assigned |
| Rv2468A Rv2468A |
- |
hypothetical protein | Membrane protein with a strong STRING experimental association (score 997) to ctaD, a subunit of the cytochrome c (aa3) oxidase of the respiratory bcc:aa3 supercomplex. Contextual candidate: a small accessory / partner component of the cytochrome c oxidase. CAVEAT: the bcc:aa3 supercomplex carries many uncharacterised small TM subunits and is a known promiscuity sink, so this is a guilt-by-association candidate to validate, not an assigned subunit. | Family assigned | |
| Rv2468c Rv2468c |
- |
hypothetical protein | Immunomodulatory / T-cell costimulatory protein: binds integrin VLA-5 (alpha5beta1) via an RGD motif and costimulates T cells. NOTE: a Foldseek hit to the cytochrome bcc:aa3 fold is a FALSE POSITIVE (the Mtb cytochrome bcc is qcrCAB, not this gene). | DUF5130 |
Resolved |
| Rv2469c Rv2469c |
mtbc0_002631 |
hypothetical protein | HNH endonuclease. Pfam: HNH (PF01844.30), HNH_5 (PF14279.13). | HNH HNH_5 |
Resolved |
| Rv2472 Rv2472 |
mtbc0_002634 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 7n51-assembly1_A Structure of a bacterial gasdermin from Vitiosangium (prob 0.03, TM 0.46). | Still unknown | |
| Rv2473 Rv2473 |
mtbc0_002635 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 5xsj-assembly1_L XylFII-LytSN complex (prob 0.97, TM 0.45). | Still unknown | |
| Rv2474c Rv2474c |
mtbc0_002636 |
hypothetical protein | DnaN/beta-sliding-clamp-like fold; distinct from the genuine DNA polymerase III beta clamp dnaN/Rv0002 (fold-paralogue safeguard). Function of this paralogue undetermined. | DUF8010 DUF8185 |
Family assigned |
| Rv2475c Rv2475c |
mtbc0_002637 |
hypothetical protein | Thioesterase family protein. Pfam: Acyl-ACP_TE_C (PF20791.4), 4HBT_2 (PF13279.13). | Acyl-ACP_TE_C 4HBT_2 |
Family assigned |