Genes
3906 genes matched.
| Gene | MTBC0 | Legacy (H37Rv) | MTBC0 PGAP / revised | Pfam | Verdict |
|---|---|---|---|---|---|
| Rv3819 Rv3819 |
mtbc0_004048 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. Foldseek best (non-significant) hit: 3dcx-assembly1_A Crystal structure of a duf1696 family protein with a (prob 0.99, TM 0.50). | Still unknown | |
| papA2 Rv3820c |
- |
trehalose-2-sulfate acyltransferase | Trehalose-2-sulfate acyltransferase. Pfam: Condensation (PF00668.26). | Condensation |
Resolved |
| sap Rv3821 |
mtbc0_004050 |
integral membrane protein | Sulfolipid-1 biosynthesis transporter Sap. Pfam: SfLAP (PF11139.15). | SfLAP |
Resolved |
| chp1 Rv3822 |
mtbc0_004051 |
hypothetical protein | Sulfolipid-1 biosynthesis membrane-anchored acyltransferase Chp1. Pfam: PE-PPE (PF08237.18). | PE-PPE |
Resolved |
| mmpL8 Rv3823c |
mtbc0_004052 |
integral membrane transport protein MmpL8 | Sulfolipid-1 RND transporter MmpL8. Pfam: MMPL (PF03176.22), Sterol-sensing (PF12349.15). | MMPL Sterol-sensing |
Resolved |
| papA1 Rv3824c |
mtbc0_004053 |
acyltransferase | Acyltransferase PapA1. Pfam: Condensation (PF00668.26). | Condensation |
Resolved |
| pks2 Rv3825c |
mtbc0_004054 |
phthioceranic/hydroxyphthioceranic acid synthase | Phthioceranic/hydroxyphthioceranic acid synthase. Pfam: ketoacyl-synt (PF00109.33), Thiolase_N (PF00108.30), Ketoacyl-synt_C (PF02801.29), KAsynt_C_assoc (PF16197.12), CurL-like_PKS_C (PF22621.3), RhiE-like_linker (PF22336.3), Acyl_transf_1 (PF00698.27), PKS_DH_N (PF21089.4), PS-DH (PF14765.13), ADH_N (PF08240.18), ADH_zinc_N (PF00107.33), ADH_zinc_N_2 (PF13602.13), KR (PF08659.17), adh_short (PF00106.32), PP-binding (PF00550.32). | ketoacyl-synt Thiolase_N Ketoacyl-synt_C KAsynt_C_assoc CurL-like_PKS_C RhiE-like_linker Acyl_transf_1 PKS_DH_N PS-DH ADH_N ADH_zinc_N ADH_zinc_N_2 KR adh_short PP-binding |
Resolved |
| fadD23 Rv3826 |
mtbc0_004055 |
long-chain-fatty-acid--CoA ligase FadD23 | Long-chain-fatty-acid--CoA ligase FadD23. Pfam: AMP-binding (PF00501.35), AMP-dom_DIP2-like (PF23024.2). | AMP-binding AMP-dom_DIP2-like |
Resolved |
| Rv3827c Rv3827c |
- |
transposase | Transposase. Pfam: HTH_OrfB_IS605 (PF12323.15), OrfB_IS605 (PF01385.26). | HTH_OrfB_IS605 OrfB_IS605 |
Resolved |
| Rv3828c Rv3828c |
- |
resolvase | Resolvase. Pfam: Resolvase (PF00239.27). | Resolvase |
Resolved |
| Rv3829c Rv3829c |
mtbc0_004058 |
dehydrogenase | NAD(P)/FAD-dependent oxidoreductase. Pfam: NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | NAD_binding_8 Amino_oxidase |
Resolved |
| Rv3830c Rv3830c |
mtbc0_004059 |
TetR family transcriptional regulator | TetR/AcrR family transcriptional regulator. Pfam: TetR_N (PF00440.30). | TetR_N |
Family assigned |
| Rv3831 Rv3831 |
mtbc0_004060 |
hypothetical protein | Polytopic integral membrane protein with 5 predicted transmembrane helices (DeepTMHMM). RefSeq leaves it 'hypothetical protein'. A topological feature consistent with a membrane transporter/permease or membrane-embedded enzyme; the transported substrate and molecular function are undetermined. | DUF2834 |
Family assigned |
| Rv3832c Rv3832c |
mtbc0_004061 |
hypothetical protein | Methyltransferase domain-containing protein. Pfam: Methyltransf_23 (PF13489.13), RrnaAD (PF00398.27), Methyltransf_11 (PF08241.19), Methyltransf_25 (PF13649.13), Methyltransf_12 (PF08242.19). | Methyltransf_23 RrnaAD Methyltransf_11 Methyltransf_25 Methyltransf_12 |
Family assigned |
| Rv3833 Rv3833 |
mtbc0_004062 |
AraC family transcriptional regulator | Helix-turn-helix transcriptional regulator. Pfam: Cupin_2 (PF07883.18), AraC_binding (PF02311.26), HTH_AraC (PF00165.30), HTH_18 (PF12833.14). | Cupin_2 AraC_binding HTH_AraC HTH_18 |
Family assigned |
| serS Rv3834c |
mtbc0_004063 |
serine--tRNA ligase | Serine--tRNA ligase. Pfam: Seryl_tRNA_N (PF02403.28), tRNA-synt_2b (PF00587.31). | Seryl_tRNA_N tRNA-synt_2b |
Resolved |
| Rv3835 Rv3835 |
mtbc0_004064 |
hypothetical protein | Septum formation family protein. Pfam: Septum_form (PF13845.12). | Septum_form |
Family assigned |
| Rv3836 Rv3836 |
mtbc0_004065 |
hypothetical protein | Metallopeptidase family protein. Pfam: Zincin_1 (PF06262.18). | Zincin_1 |
Family assigned |
| Rv3837c Rv3837c |
mtbc0_004067 |
phosphoglycerate mutase | Histidine phosphatase family protein. Pfam: His_Phos_1 (PF00300.28). | His_Phos_1 |
Family assigned |
| pheA Rv3838c |
mtbc0_004068 |
prephenate dehydratase | Prephenate dehydratase. Pfam: PDT (PF00800.24), ACT (PF01842.32). | PDT ACT |
Resolved |
| Rv3839 Rv3839 |
mtbc0_004069 |
hypothetical protein | Heme-homeostasis regulator: the principal driver of the Rv3839-Rv3840 operon that down-regulates endogenous heme biosynthesis under nitric-oxide and iron-limitation stress (Quirk 2026). It carries a DUF2470/DRI (Domain Related to Iron) regulatory module - the GluTR-binding-protein domain, also found in HugZ - and lies immediately upstream of bacterioferritin bfrB (Rv3841), in an operon with the transcriptional regulator Rv3840. The fold-paralogue safeguard is passed: it is not a copy of the genuine glutamyl-tRNA reductase HemA/Rv0509 but shares only the regulatory DUF2470 domain. RefSeq left this locus uncharacterised; the structure-guided hypothesis (heme/iron homeostasis) was confirmed experimentally by Quirk 2026 while the companion study was in progress - a RefSeq-behind case and an independent validation of the approach. | DUF2470 |
Resolved |
| Rv3840 Rv3840 |
- |
transcriptional regulator | Transcriptional regulator. Pfam: LytR_cpsA_psr (PF03816.20). | LytR_cpsA_psr |
Family assigned |
| bfrB Rv3841 |
mtbc0_004071 |
bacterioferritin BfrB | Ferritin BfrB. Pfam: Ferritin (PF00210.31), Rubrerythrin (PF02915.24). | Ferritin Rubrerythrin |
Resolved |
| glpQ1 Rv3842c |
mtbc0_004072 |
glycerophosphoryl diester phosphodiesterase | Glycerophosphodiester phosphodiesterase. Pfam: GDPD (PF03009.24). | GDPD |
Resolved |
| Rv3843c Rv3843c |
mtbc0_004073 |
transmembrane protein | FimV-like motility/cell-envelope-associated protein (eggNOG COG3170, COG categories N/U), a peptidoglycan-binding protein linked to type-IV-pilus assembly in other bacteria. Family-level; M. tuberculosis role undetermined. | DUF4328 |
Family assigned |
| Rv3844 Rv3844 |
- |
transposase | Transposase. Pfam: DEDD_Tnp_IS110 (PF01548.24). | DEDD_Tnp_IS110 |
Resolved |
| Rv3845 Rv3845 |
mtbc0_003561 |
hypothetical protein | IS110 family transposase. | Family assigned | |
| sodA Rv3846 |
mtbc0_004079 |
superoxide dismutase | Superoxide dismutase. Pfam: Sod_Fe_N (PF00081.28), Sod_Fe_C (PF02777.24). | Sod_Fe_N Sod_Fe_C |
Resolved |
| Rv3847 Rv3847 |
mtbc0_004080 |
hypothetical protein | Peptidase. | Resolved | |
| Rv3848 Rv3848 |
mtbc0_004081 |
transmembrane protein | TMEM165/GDT1 family protein. Pfam: GDT1 (PF01169.25). | GDT1 |
Family assigned |
| espR Rv3849 |
mtbc0_004082 |
ESX-1 transcriptional regulator EspR | Type VII secretion system ESX-1 transcriptional regulator EspR. | Family assigned | |
| Rv3850 Rv3850 |
mtbc0_004083 |
hypothetical protein | DUF6474 family protein. | DUF6474 |
Family assigned |
| Rv3851 Rv3851 |
mtbc0_004084 |
membrane protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| hns Rv3852 |
mtbc0_004085 |
histone-like protein Hns | Histone-like protein Hns. | Family assigned | |
| rraA Rv3853 |
mtbc0_004086 |
RNase E regulator RraA | Ribonuclease E activity regulator RraA. Pfam: RraA-like (PF03737.22). | RraA-like |
Resolved |
| ethA Rv3854c |
mtbc0_004087 |
monooxygenase EthA | FAD-containing monooxygenase EthA. Pfam: Pyr_redox_2 (PF07992.21), Pyr_redox_3 (PF13738.13), NAD_binding_8 (PF13450.13), FMO-like (PF00743.26). | Pyr_redox_2 Pyr_redox_3 NAD_binding_8 FMO-like |
Resolved |
| ethR Rv3855 |
mtbc0_004088 |
HTH-type transcriptional repressor EthR | HTH-type transcriptional regulator EthR. Pfam: TetR_N (PF00440.30), EthR_C (PF21313.3). | TetR_N EthR_C |
Family assigned |
| Rv3856c Rv3856c |
mtbc0_004089 |
hypothetical protein | PHP domain-containing protein. Pfam: HHH_8 (PF14716.14), PHP (PF02811.27). | HHH_8 PHP |
Family assigned |
| Rv3857c Rv3857c |
- |
membrane protein | Membrane protein. | Family assigned | |
| gltD Rv3858c |
mtbc0_004091 |
glutamate synthase small subunit | Glutamate synthase subunit beta. Pfam: Fer4_20 (PF14691.12), Pyr_redox_2 (PF07992.21), FAD_binding_3 (PF01494.26), Pyr_redox (PF00070.34), FAD_oxidored (PF12831.14), DAO (PF01266.31), FAD_binding_2 (PF00890.31), NAD_binding_8 (PF13450.13), Amino_oxidase (PF01593.31). | Fer4_20 Pyr_redox_2 FAD_binding_3 Pyr_redox FAD_oxidored DAO FAD_binding_2 NAD_binding_8 Amino_oxidase |
Family assigned |
| gltB Rv3859c |
mtbc0_004092 |
glutamate synthase large subunit | Glutamate synthase large subunit. Pfam: GATase_2 (PF00310.27), Glu_syn_central (PF04898.21), Glu_synthase (PF01645.24), GXGXG (PF01493.26). | GATase_2 Glu_syn_central Glu_synthase GXGXG |
Family assigned |
| Rv3860 Rv3860 |
mtbc0_004093 |
hypothetical protein | ATPase. Pfam: CbiA (PF01656.30). | CbiA |
Resolved |
| Rv3861 Rv3861 |
mtbc0_004094 |
hypothetical protein | Conserved hypothetical protein; no recognised domain. Function unknown. | Still unknown | |
| whiB6 Rv3862c |
- |
transcriptional regulator WhiB6 | Transcriptional regulator WhiB6. Pfam: Whib (PF02467.22). | Whib |
Family assigned |
| Rv3863 Rv3863 |
- |
hypothetical protein | Contains MSMEG_6518_N (PF27182.1) domain(s); putative function inferred from the domain architecture. | MSMEG_6518_N |
Family assigned |
| espE Rv3864 |
mtbc0_004097 |
ESX-1 secretion-associated protein EspE | Type VII secretion system ESX-1 associated protein EspE. Pfam: EspA_EspE (PF18879.7). | EspA_EspE |
Resolved |
| espF Rv3865 |
mtbc0_004098 |
ESX-1 secretion-associated protein EspF | Type VII secretion system ESX-1 associated protein EspF. Pfam: T7SS_ESX_EspC (PF10824.15). | T7SS_ESX_EspC |
Resolved |
| espG1 Rv3866 |
mtbc0_004099 |
ESX-1 secretion-associated protein EspG | Type VII secretion system ESX-1 adaptor EspG1. Pfam: ESX-1_EspG (PF14011.12). | ESX-1_EspG |
Resolved |
| espH Rv3867 |
mtbc0_004100 |
ESX-1 secretion-associated protein EspH | Type VII secretion system ESX-1 associated protein EspH. | Resolved | |
| eccA1 Rv3868 |
mtbc0_004101 |
ESX-1 secretion system protein EccA1 | Type VII secretion system ESX-1 AAA family ATPase EccA1. Pfam: T7SS_EccA1_N (PF21545.4), Mg_chelatase (PF01078.28), AAA (PF00004.36), AAA_lid_6 (PF17866.9). | T7SS_EccA1_N Mg_chelatase AAA AAA_lid_6 |
Family assigned |