fadE2 Resolved · high auto-curated

H37Rv Rv0154c · MTBC0 mtbc0_000165 · 403 aa · 182333–183544 (-) · RefSeq NP_214668.1

Annotation: from legacy to revised

Legacy (H37Rv / Mycobrowser)acyl-CoA dehydrogenase FadE2
MTBC0 PGAP re-annotationacyl-CoA dehydrogenase
Revised (this work)Acyl-CoA dehydrogenase. Pfam: Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17).

Auto-curated: this verdict and function were generated by rules from PGAP + Pfam + Foldseek and have not been hand-reviewed.

Curated reference (UniProt)

UniProt P96831 SwissProt · reviewed · Evidence at protein level
UniProt nameProbable acyl-CoA dehydrogenase FadE2
EC (curated) EC 1.3.99.-

Functional vocabulary (eggNOG-mapper, orthology transfer)

COG category I Lipid transport and metabolism
Preferred namefadE2
eggNOG descriptionacyl-CoA dehydrogenase
Orthologous groupCOG1960
EC number EC 1.3.8.7
KEGG orthology K00249
KEGG pathways map00071, map00280, map00410, map00640, map01100, map01110, map01130, map01200, map01212, map03320
KEGG modules M00013, M00036, M00087

Orthology-based transfer (eggNOG 5.0.2, diamond). EC/KO/GO/CAZy are computed annotations, not manual curation; cross-check against the primary literature before treating a specific reaction as established.

Conservation & selection (intra-MTBC, 145 209 strains)

pN/pS 0.161 · strong purifying
Polymorphic sites (≥ 0.1% of strains) 20 synonymous, 10 missense, 0 nonsense, 2 frameshift
Disruption 2 distinct premature-stop/frameshift site(s); most common in 0.11% of strains (164) · clonal

pN/pS from segregating SNPs (singletons removed) normalised by possible sites. Low pN/pS = purifying selection (a strong signal that a "hypothetical" is a real, constrained gene). A high pN/pS is ambiguous: relaxed constraint or positive selection (drug resistance, antigenic variation) inflate it; e.g. rpoB/katG/pncA score high here for resistance, not loss of function. A clonal disruption (one allele over a clade) suggests lineage pseudogenisation; a convergent one (many independent alleles) is typical of resistance loss-of-function.

Domains (Pfam, hmmscan --cut_ga)

PfamAccessioni-EvalueResiduesDescription
Acyl-CoA_dh_MPF02770.25 1.5e-19128–228 Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1PF00441.30 8.9e-43240–389 Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_2PF08028.17 9.9e-17256–365 Acyl-CoA dehydrogenase, C-terminal domain

Functional interaction network (STRING v12, guilt-by-association)

Closest characterised functional partner: fadE36 (acyl-CoA dehydrogenase FadE36), high confidence from genomic context alone (score 981 excluding text-mining).

PartnerProductScoreNo text-miningChannels (≥400)
Rv3761c fadE36 acyl-CoA dehydrogenase FadE36 981 981 ctx fusion:900 cooccurence:774
Rv2790c ltp1 lipid-transfer protein 943 942 database:900
Rv0860 fadB fatty oxidation protein FadB 928 922 coexpression:647 database:750
Rv2502c accD1 acetyl-/propionyl-CoA carboxylase subunit beta 925 921 database:900
Rv0153c ptbB phosphotyrosine protein phosphatase 920 920 ctx neighborhood:882
Rv0400c fadE7 acyl-CoA dehydrogenase FadE7 905 906 database:900
Rv0632c echA3 enoyl-CoA hydratase EchA3 886 882 database:750
Rv3774 echA21 enoyl-CoA hydratase EchA21 854 846 database:750
Rv1070c echA8 enoyl-CoA hydratase EchA8 851 846 database:750
Rv0673 echA4 enoyl-CoA hydratase EchA4 850 845 database:750
Rv3373 echA18 enoyl-CoA hydratase 850 845 database:750
Rv3039c echA17 enoyl-CoA hydratase EchA17 850 845 database:750
Rv0905 echA6 enoyl-CoA hydratase EchA6 850 845 database:750
Rv1472 echA12 enoyl-CoA hydratase EchA12 850 845 database:750
Rv2679 echA15 enoyl-CoA hydratase EchA15 850 845 database:750

STRING combines evidence channels (neighborhood, fusion, cooccurrence, coexpression, experimental, database, text-mining) into a 0–1000 score. The ctx badge marks edges carried by the genomic-context channels (conserved neighborhood, fusion, phylogenetic co-occurrence), which are independent of orthology and structure and the strongest signal for an unknown gene. The no text-mining column recomputes the score from data alone, so a link that does not depend on the literature is visible. Association is a function hypothesis, not proof: corroborate with the operon context and the primary literature before assigning a function.

Evidence

  • Legacy H37Rv annotation: acyl-CoA dehydrogenase FadE2
  • MTBC0 PGAP product: acyl-CoA dehydrogenase
  • Pfam (hmmscan --cut_ga): Acyl-CoA_dh_M PF02770.25 (E=1e-19), Acyl-CoA_dh_1 PF00441.30 (E=9e-43), Acyl-CoA_dh_2 PF08028.17 (E=1e-16)
  • (auto-curated by rules from PGAP + Pfam + Foldseek; not hand-reviewed)

Sources

  • Ancestral sequence & coordinates: Harrison LB et al. (2024), An imputed ancestral reference genome for the MTBC, doi:10.1101/2023.09.07.556366
  • Product annotation: NCBI PGAP on MTBC0; legacy from H37Rv NC_000962.3 (RefSeq NP_214668.1)
  • Domains: Pfam-A via hmmscan --cut_ga — Acyl-CoA_dh_M (PF02770.25), Acyl-CoA_dh_1 (PF00441.30), Acyl-CoA_dh_2 (PF08028.17)
  • Sequence-level signal: ESM Atlas (EvolutionaryScale × BioHub) — exploratory
  • Controlled vocabulary: eggNOG-mapper 2.1.12 (Cantalapiedra et al. 2021, doi:10.1093/molbev/msab293), eggNOG 5.0 DB (Huerta-Cepas et al. 2019) — OG COG1960
  • Curated reference: UniProt P96831 (SwissProt, reviewed; Evidence at protein level)
  • Intra-MTBC selection: pN/pS and disruption from SPDI variants of 145 209 MTBC strains (this work, local collection vs H37Rv NC_000962.3)
  • Interaction network: STRING v12.0 (Szklarczyk et al. 2023, doi:10.1093/nar/gkac1000), taxon 83332, CC-BY 4.0 — 125 functional partner(s); context anchor fadE36
  • Primary literature: none located yet; annotation rests on the domain/homology sources above.

Ancestral MTBC0 protein sequence

>mtbc0_000165|Rv0154c|fadE2
MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPIIEELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHGHCEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRVRNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT