ncRv0179 MTB000105
ncRNA Putative small regulatory RNA
This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.
Location
209683–209841 (+ strand), 159 nt, on H37Rv
(NC_000962.3).
Overlaps: Rv0179c.
Upstream neighbour Rv0178
(11 bp).
Downstream neighbour Rv0180c
(1051 bp).
Intra-MTBC variation
| Genomes surveyed | 145,209 |
| Variable sites | 101 |
| Variants reaching 0.1 % of genomes | 0 |
| Carriers of the most widespread variant | 33 |
Coverage control
Variant density inside this RNA: 63.5 sites/100 bp, versus 65.6 in the flanking ±500 bp (GC 68.6 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.
Verdict: COUVERTURE OK -> invariance biologique plausible
Read with care: constraint is not function. This RNA mutates like its surroundings, but no variant spreads through the population — which is evidence of selection acting on it, not evidence of what it does. Secondary-structure pairing was tested across the RNA set and did not explain this constraint.
Predicted secondary structure
66.7 % of bases are paired in the minimum-free-energy fold (106 paired, 53 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).
Literature no publication
No mention of 'ncRv0179' anywhere in the TB literature corpus. This RNA carries no widespread variant across 145,209 MTBC genomes and passes the coverage control, yet nobody has studied it.
Read with care. Constraint is not function: an invariant RNA is a candidate, with neither a known target nor a demonstrated role.
Sweep: tbmonitor TB corpus (~330k PubMed abstracts), name sweep of 2026-08-10; positive controls MTS2823 (6 papers), mcr11 (3), Mcr7 (2) all returned hits, so a zero here is a measured absence and not a broken query.
Legacy record
Supported by sRNA-Seq in H37Rv (see DeJesus et al. 2017)
Sources
- Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
- Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
- Secondary structure: ViennaRNA 2.7.2, MFE fold.