MTS1082 MTB000076

ncRNA Putative small regulatory RNA

This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.

Location

1547129–1547268 (+ strand), 140 nt, on H37Rv (NC_000962.3). Overlaps: Rv1374c. Upstream neighbour Rv1373 (137 bp). Downstream neighbour Rv1375 (564 bp).

Intra-MTBC variation

Coverage control

Variant density inside this RNA: 82.9 sites/100 bp, versus 72.8 in the flanking ±500 bp (GC 62.1 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.

Verdict: n/a (a des variants communs)

Predicted secondary structure

67.1 % of bases are paired in the minimum-free-energy fold (94 paired, 46 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).

Literature cited

Quantified in a named diagnostic-biomarker sRNA panel (qRT-PCR on plasma or culture supernatant of TB patients); no functional characterisation of this sRNA specifically.

Read with care. Detected in a biomarker assay is not a demonstrated function — same distinction as an antigen status not being a molecular function (P16.16a, Rv2627c).

• Han X, Li T, Fan Y, Wang X, Gu W, Lu W, Yin Y, Meng Q, Zhang W, Zhao J, Zhang F, Fu Y (2021) Screening of 20 Mycobacterium tuberculosis sRNAs in plasma for detection of active pulmonary tuberculosis. Tuberculosis. doi:10.1016/j.tube.2021.102086, PMID 34090184.

Sweep: tbmonitor TB corpus (~330k PubMed abstracts), single grouped UNION-ALL sweep of 2026-08-17 over the 72 ncRNA never previously searched; positive controls MTS2823 (6 papers), mcr11 (3), mcr7 (2) all returned their known hits, so a zero here is a measured absence and not a broken query.

Legacy record

MTS1082, putative small regulatory RNA (See Arnvig et al., 2011), ends not mapped, ~150 bp band detected by Northern blot.

Sources

• Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
• Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
• Secondary structure: ViennaRNA 2.7.2, MFE fold.

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